Detailed information for compound 1411156

Basic information

Technical information
  • TDR Targets ID: 1411156
  • Name: N-[3-[[2-[1-(3-acetylphenyl)tetrazol-5-yl]sul fanylacetyl]amino]phenyl]furan-2-carboxamide
  • MW: 462.481 | Formula: C22H18N6O4S
  • H donors: 2 H acceptors: 6 LogP: 2.89 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)NC(=O)c1ccco1)CSc1nnnn1c1cccc(c1)C(=O)C
  • InChi: 1S/C22H18N6O4S/c1-14(29)15-5-2-8-18(11-15)28-22(25-26-27-28)33-13-20(30)23-16-6-3-7-17(12-16)24-21(31)19-9-4-10-32-19/h2-12H,13H2,1H3,(H,23,30)(H,24,31)
  • InChiKey: KYPFCACRAYOTQL-UHFFFAOYSA-N  


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Synonyms

  • N-[3-[[2-[[1-(3-acetylphenyl)-5-tetrazolyl]thio]-1-oxoethyl]amino]phenyl]-2-furancarboxamide
  • N-[3-[[2-[[1-(3-acetylphenyl)tetrazol-5-yl]thio]acetyl]amino]phenyl]-2-furamide
  • N-[3-[2-[[1-(3-ethanoylphenyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanoylamino]phenyl]furan-2-carboxamide
  • Furan-2-carboxylic acid (3-{2-[1-(3-acetyl-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetylamino}-phenyl)-amide
  • ASN 05836327
  • MLS000889300
  • SMR000005666
  • MLS000034442

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0095 0.0089
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0059 0.0053
Brugia malayi pyruvate kinase 0.0204 0.2034 0.2038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0135
Mycobacterium ulcerans beta-lactamase 0.0036 0.0302 0.0286
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0583 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0059 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Echinococcus multilocularis pyruvate kinase 0.0498 0.5051 0.5047
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0228 0.021
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0095 0.0076
Echinococcus multilocularis pyruvate kinase 0.0765 0.7803 0.7801
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0059 0.0053
Mycobacterium tuberculosis Conserved protein 0.0036 0.0302 0.0298
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0095 0.0076
Loa Loa (eye worm) pyruvate kinase 0.0204 0.2034 0.2038
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0059 0.004
Loa Loa (eye worm) hypothetical protein 0.097 0.9903 1
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0059 0.004
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0153 0.0135
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0228 0.021
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0302 0.0286
Echinococcus multilocularis protein patched 0.0042 0.0366 0.036
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0392 0.039
Toxoplasma gondii ABC1 family protein 0.0036 0.0302 0.0286
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0059 0.0053
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0302 0.0286
Schistosoma mansoni apoferritin-2 0.001 0.0039 0.0032
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0392 0.0543
Chlamydia trachomatis pyruvate kinase 0.097 0.9903 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0059 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0059 0.004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0392 0.0377
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0302 0.0298
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0292 0.0275
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0039 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0302 0.0299
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0302 0.0286
Loa Loa (eye worm) beta-lactamase 0.0036 0.0302 0.0286
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0059 0.0052
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0059 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0095 0.0089
Loa Loa (eye worm) hypothetical protein 0.0676 0.6886 0.6948
Brugia malayi isocitrate dehydrogenase 0.0016 0.0095 0.0076
Echinococcus granulosus pyruvate kinase 0.0498 0.5051 0.5097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0095 0.0089
Brugia malayi TAR-binding protein 0.0063 0.0583 0.057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0059 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0302 0.0305
Toxoplasma gondii pyruvate kinase PyK1 0.097 0.9903 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.002 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0302 0.0296
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0406 0.4104 0.4144
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0228 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0491 0.0477
Schistosoma mansoni apoferritin-2 0.001 0.0039 0.0032
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0095 0.0088
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.002 0.0012
Trichomonas vaginalis ferritin, putative 0.001 0.0039 0.0039
Echinococcus granulosus pyruvate kinase 0.097 0.9903 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0228 0.021
Trypanosoma brucei pyruvate phosphate dikinase 0.0406 0.4104 0.4132
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0286
Echinococcus granulosus expressed protein 0.001 0.0039 0.0032
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0012
Mycobacterium tuberculosis Conserved protein 0.0036 0.0302 0.0298
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0583 0.057
Trichomonas vaginalis esterase, putative 0.0036 0.0302 0.0305
Mycobacterium tuberculosis Conserved protein 0.0036 0.0302 0.0298
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0059 0.0053
Entamoeba histolytica hypothetical protein 0.0035 0.0292 0.0396
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0302 0.0305
Schistosoma mansoni patched 1 0.0042 0.0366 0.0364
Entamoeba histolytica pyruvate kinase, putative 0.0676 0.6886 1
Schistosoma mansoni pyruvate kinase 0.0498 0.5051 0.5097
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0228 0.021
Brugia malayi ecdysteroid receptor 0.0012 0.0059 0.004
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0583 0.0582
Brugia malayi beta-lactamase family protein 0.0036 0.0302 0.0286
Brugia malayi RNA binding protein 0.0063 0.0583 0.057
Echinococcus multilocularis expressed conserved protein 0.0092 0.0881 0.0875
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0392 0.0377
Onchocerca volvulus 0.0036 0.0302 0.0286
Schistosoma mansoni transcription factor btf3 0.0035 0.0292 0.0288
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0059 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1376 0.137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0059 0.0053
Loa Loa (eye worm) pyruvate kinase 0.097 0.9903 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0141 0.0135
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0095 0.0076
Echinococcus granulosus microtubule associated protein 2 0.0833 0.85 0.8582
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0059 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0228 0.021
Onchocerca volvulus 0.0029 0.0228 0.021
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0293 0.295 0.2965
Echinococcus granulosus pyruvate kinase 0.0498 0.5051 0.5097
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0039 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0059 0.004
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Echinococcus multilocularis pyruvate kinase 0.0498 0.5051 0.5047
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0366 0.0364
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0059 0.0052
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0095 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0228 0.0303
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0059 0.004
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.85 0.8499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0059 0.004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0958 0.0962
Brugia malayi beta-lactamase 0.0036 0.0302 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0392 0.0396
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0292 0.0275
Brugia malayi beta-NAC-like protein 0.0035 0.0292 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0583 0.0582
Schistosoma mansoni hypothetical protein 0.0041 0.0351 0.0348
Schistosoma mansoni hypothetical protein 0.0408 0.4126 0.4163
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0141 0.0135
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0059 0.004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0059 0.004
Schistosoma mansoni hypothetical protein 0.0041 0.0351 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0302 0.0286
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0583 0.0582
Loa Loa (eye worm) RNA binding protein 0.0063 0.0583 0.057
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0302 0.0305
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.002 0.0012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0302 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.021
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0286
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0059 0.0052
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0095 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0059 0.004
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.002 0.0013
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0366 0.0351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0302 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0302 0.0305
Leishmania major pyruvate phosphate dikinase, putative 0.0406 0.4104 0.4132
Plasmodium vivax pyruvate kinase 2, putative 0.0498 0.5051 0.509
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0153 0.0135
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0095 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0292 0.0295
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0024 0.0005
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.002 0.0012
Schistosoma mansoni cpg binding protein 0.003 0.0244 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0059 0.004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0366 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0059 0.004
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0366 0.036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0059 0.0053
Plasmodium falciparum pyruvate kinase 2 0.0498 0.5051 0.509
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0302 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0286
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0292 0.0396
Schistosoma mansoni ferritin 0.001 0.0039 0.0032
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0039 0.0019
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0392 0.0386
Mycobacterium leprae PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK 0.0406 0.4104 0.4132
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0366 0.037
Echinococcus granulosus pyruvate kinase 0.097 0.9903 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0059 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.097 0.9903 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.002 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0141 0.0135
Brugia malayi beta-lactamase family protein 0.0036 0.0302 0.0286
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0228 0.0303
Mycobacterium ulcerans hypothetical protein 0.0406 0.4104 0.4132
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0392 0.039
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.002 0.0012
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0406 0.4104 0.4144
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0059 0.004
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0392 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0059 0.004
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0095 0.0076
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0095 0.0076
Onchocerca volvulus Pyruvate kinase homolog 0.097 0.9903 1
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.002 0.0013
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0943 0.0934
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.002 0.0012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0153 0.0147
Giardia lamblia Pyruvate kinase 0.0498 0.5051 0.4898
Plasmodium vivax pyruvate kinase, putative 0.097 0.9903 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0292 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0059 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0228 0.021
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0095 0.0089
Leishmania major basic transcription factor 3a, putative 0.0035 0.0292 0.0275
Schistosoma mansoni hypothetical protein 0.0041 0.0351 0.0348
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0292 0.0275
Trichomonas vaginalis pyruvate kinase, putative 0.097 0.9903 1
Mycobacterium tuberculosis Probable pyruvate, phosphate dikinase PpdK 0.0406 0.4104 0.4139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Echinococcus multilocularis pyruvate kinase 0.0498 0.5051 0.5047
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0292 0.0275
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0302 0.0298
Echinococcus multilocularis dnaJ subfamily B 0.0408 0.4126 0.4123
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0392 0.0396
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0292 0.0275
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0406 0.4104 0.4132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0018
Echinococcus granulosus transcription factor btf3 0.0035 0.0292 0.0288
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0583 0.057
Leishmania major hypothetical protein, conserved 0.0036 0.0302 0.0286
Loa Loa (eye worm) pyruvate kinase 0.097 0.9903 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0228 0.021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0059 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.097 0.9903 1
Loa Loa (eye worm) pyruvate kinase 0.097 0.9903 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.0583 0.0582
Plasmodium falciparum pyruvate kinase 0.097 0.9903 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0095 0.009
Mycobacterium ulcerans lipase LipD 0.0036 0.0302 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0228 0.0222
Brugia malayi pyruvate kinase, muscle isozyme 0.0204 0.2034 0.2038
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0059 0.0052
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0039 0.0031
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0023 0.0004
Brugia malayi nuclear receptor NHR-88 0.0012 0.0059 0.004
Treponema pallidum pyruvate phosphate dikinase 0.0406 0.4104 1
Echinococcus granulosus dnaJ subfamily B 0.0408 0.4126 0.4163
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0059 0.0053
Leishmania major pyruvate kinase 0.097 0.9903 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2291 0.2308
Trypanosoma brucei pyruvate kinase 1 0.097 0.9903 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.097 0.9903 1
Onchocerca volvulus 0.0029 0.0228 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0302 0.0305
Loa Loa (eye worm) hypothetical protein 0.0098 0.0943 0.0934
Brugia malayi Pyruvate kinase, muscle isozyme 0.097 0.9903 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0059 0.004
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.85 0.8582
Schistosoma mansoni cpg binding protein 0.003 0.0244 0.0241
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0286
Onchocerca volvulus 0.0012 0.0059 0.004
Brugia malayi CXXC zinc finger family protein 0.0029 0.0228 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0141 0.0135
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.002 0.002
Echinococcus granulosus pyruvate kinase 0.0498 0.5051 0.5097
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0059 0.0053
Brugia malayi steroid hormone receptor 0.0012 0.0059 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Schistosoma mansoni ferritin 0.001 0.0039 0.0032
Schistosoma mansoni ferritin 0.001 0.0039 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0153 0.0135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0059 0.0053
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0302 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0059 0.004
Trichomonas vaginalis pyruvate kinase, putative 0.097 0.9903 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0095 0.0076
Mycobacterium ulcerans pyruvate phosphate dikinase 0.0406 0.4104 0.4132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0558 0.0557
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0302 0.0286
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0095 0.0076
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0943 0.1344
Loa Loa (eye worm) hypothetical protein 0.0045 0.0392 0.0377
Trypanosoma cruzi pyruvate kinase 2, putative 0.097 0.9903 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0059 0.004
Echinococcus multilocularis transcription factor btf3 0.0035 0.0292 0.0285
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0366 0.0364
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0392 0.0377
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0059 0.0052
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0302 0.0286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0302 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0059 0.0053
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0012
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0095 0.0076
Chlamydia trachomatis PTS system PEP phosphotransferase 0.0406 0.4104 0.4052
Wolbachia endosymbiont of Brugia malayi pyruvate phosphate dikinase 0.0406 0.4104 1
Echinococcus multilocularis pyruvate kinase 0.097 0.9903 0.9903
Schistosoma mansoni ferritin light chain 0.001 0.0039 0.0032
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0943 0.0937
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0059 0.0053
Echinococcus granulosus expressed conserved protein 0.0092 0.0881 0.0884
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.097 0.9903 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0583 0.0582
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0406 0.4104 0.4132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0059 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0059 0.004
Echinococcus multilocularis pyruvate kinase 0.097 0.9903 0.9903
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0095 0.0076
Echinococcus granulosus cpg binding protein 0.003 0.0244 0.0241
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0059 0.0053
Echinococcus multilocularis cpg binding protein 0.003 0.0244 0.0238
Brugia malayi Pyruvate kinase, M2 isozyme 0.097 0.9903 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0428 0.0421
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.002 0.002
Giardia lamblia Pyruvate, phosphate dikinase 0.0406 0.4104 0.3902
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.021
Brugia malayi nuclear hormone receptor 0.0012 0.0059 0.004
Giardia lamblia Pyruvate kinase 0.097 0.9903 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0059 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0095 0.0089
Brugia malayi CHE-14 protein 0.0042 0.0366 0.0351
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0153 0.0135
Mycobacterium leprae Probable lipase LipE 0.0036 0.0302 0.0286
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0059 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0228 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0228 0.021
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0302 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0059 0.004
Schistosoma mansoni coup transcription factor 0.0012 0.0059 0.0053
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0583 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0059 0.004
Echinococcus multilocularis ferritin 0.001 0.0039 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0228 0.021
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0392 0.039
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0583 0.0582
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0392 0.039
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0392 0.0386
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0302 0.0299
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0059 0.0053
Loa Loa (eye worm) hypothetical protein 0.0052 0.0464 0.0449
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.002 0.0012
Mycobacterium ulcerans hypothetical protein 0.0036 0.0302 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0302 0.0286
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0039 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0228 0.021
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0292 0.0275
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0392 0.0377
Trypanosoma cruzi pyruvate kinase 2, putative 0.097 0.9903 1
Schistosoma mansoni cpg binding protein 0.0029 0.0228 0.0224
Trypanosoma brucei pyruvate kinase 1, putative 0.097 0.9903 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0406 0.4104 0.4139
Schistosoma mansoni hypothetical protein 0.0041 0.0351 0.0348
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0943 0.0946
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0059 0.0052
Leishmania major pyruvate kinase 0.097 0.9903 1
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0406 0.4104 0.4144
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0228 0.021
Mycobacterium ulcerans pyruvate kinase 0.097 0.9903 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0059 0.0052
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0059 0.004
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0392 0.039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0392 0.0396
Entamoeba histolytica pyruvate phosphate dikinase 0.0406 0.4104 0.5947
Toxoplasma gondii pyruvate kinase PyKII 0.0498 0.5051 0.509
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0302 0.0299
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0392 0.0386
Schistosoma mansoni pyruvate kinase 0.097 0.9903 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0059 0.004
Schistosoma mansoni pyruvate kinase 0.097 0.9903 1
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1376 0.1384
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0059 0.0052
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0292 0.0275
Echinococcus granulosus ferritin 0.001 0.0039 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0228 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0012
Schistosoma mansoni ferritin 0.001 0.0039 0.0032
Mycobacterium ulcerans hypothetical protein 0.0029 0.0228 0.021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0228 0.0303
Loa Loa (eye worm) pyruvate kinase-PB 0.0676 0.6886 0.6948
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.004
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0228 0.0222
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0302 0.0298
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0292 0.0295
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0302 0.0298
Onchocerca volvulus 0.0036 0.0302 0.0286
Echinococcus multilocularis expressed protein 0.001 0.0039 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0228 0.021
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0406 0.4104 0.4144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0059 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0228 0.021
Onchocerca volvulus 0.0036 0.0302 0.0286
Schistosoma mansoni ferritin light chain 0.001 0.0039 0.0032

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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