Detailed information for compound 1411622

Basic information

Technical information
  • TDR Targets ID: 1411622
  • Name: [2-(piperidine-1-carbonylamino)phenyl] piperi dine-1-carboxylate
  • MW: 331.409 | Formula: C18H25N3O3
  • H donors: 1 H acceptors: 2 LogP: 2.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCC1)Nc1ccccc1OC(=O)N1CCCCC1
  • InChi: 1S/C18H25N3O3/c22-17(20-11-5-1-6-12-20)19-15-9-3-4-10-16(15)24-18(23)21-13-7-2-8-14-21/h3-4,9-10H,1-2,5-8,11-14H2,(H,19,22)
  • InChiKey: YWNYFPSPHJWIED-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-piperidinecarboxylic acid [2-[[oxo-(1-piperidyl)methyl]amino]phenyl] ester
  • piperidine-1-carboxylic acid [2-(piperidine-1-carbonylamino)phenyl] ester
  • [2-(piperidin-1-ylcarbonylamino)phenyl] piperidine-1-carboxylate
  • BAS 03429904
  • Piperidine-1-carboxylic acid 2-[(piperidine-1-carbonyl)-amino]-phenyl ester
  • ZINC00317856
  • MLS000112209
  • SMR000108124
  • Oprea1_411102
  • Oprea1_599746

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0652 0.0652
Echinococcus multilocularis pyruvate kinase 0.051 0.4047 0.4047
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0171 0.0213
Echinococcus multilocularis transcription factor btf3 0.0037 0.0138 0.0138
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0564 0.0701
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0193 0.0193
Echinococcus granulosus peregrin 0.0033 0.0104 0.0104
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.001 0.0013
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0107 0.0133
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0626 0.0778
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Loa Loa (eye worm) RNA binding protein 0.0067 0.0386 0.0479
Echinococcus granulosus heat shock protein 90 0.0093 0.0599 0.0599
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0107 0.0107
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0181 0.0181
Brugia malayi CXXC zinc finger family protein 0.0086 0.0547 0.068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0171 0.0171
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Brugia malayi hypothetical protein 0.0147 0.1044 0.1298
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0066 0.0082
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0652 0.0652
Echinococcus multilocularis pyruvate kinase 0.0994 0.8043 0.8043
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0386 0.0386
Brugia malayi nuclear receptor RXR 0.0022 0.0012 0.0015
Mycobacterium leprae PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK 0.0416 0.3267 0.4062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0171 0.0171
Echinococcus granulosus pyruvate kinase 0.0994 0.8043 0.8043
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0416 0.3267 0.4062
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0012
Toxoplasma gondii pyruvate kinase PyKII 0.051 0.4047 0.5032
Brugia malayi beta-NAC-like protein 0.0037 0.0138 0.0172
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0349 0.0435
Echinococcus granulosus Niemann Pick C1 protein 0.0295 0.2266 0.2266
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0012 0.0012
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0066 0.0082
Loa Loa (eye worm) hypothetical protein 0.0096 0.0626 0.0778
Mycobacterium leprae Probable pyruvate kinase PykA 0.0994 0.8043 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0171 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0171 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0626 0.0778
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0147 0.0183
Brugia malayi steroid hormone receptor 0.0041 0.0171 0.0213
Onchocerca volvulus 0.0041 0.0171 0.0213
Brugia malayi hypothetical protein 0.0022 0.0012 0.0015
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0049 0.024 0.0298
Echinococcus multilocularis Niemann Pick C1 protein 0.0295 0.2266 0.2266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0092 0.0092
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0206 0.1535 0.1909
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0107 0.0133
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0096 0.0626 0.0778
Schistosoma mansoni hypothetical protein 0.0507 0.4021 0.4021
Schistosoma mansoni hypothetical protein 0.0085 0.0537 0.0537
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0171 0.0171
Brugia malayi hypothetical protein 0.0073 0.0434 0.054
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Onchocerca volvulus Pyruvate kinase homolog 0.0994 0.8043 1
Schistosoma mansoni bromodomain containing protein 0.0071 0.0417 0.0417
Trypanosoma brucei pyruvate kinase 1 0.0994 0.8043 1
Wolbachia endosymbiont of Brugia malayi pyruvate phosphate dikinase 0.0416 0.3267 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0107 0.0107
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0141 0.0141
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0096 0.0626 0.0778
Leishmania major hypothetical protein, conserved 0.0038 0.0147 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0626 0.0778
Trypanosoma cruzi pyruvate kinase 2, putative 0.0994 0.8043 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.023 0.023
Giardia lamblia PHD finger protein 15 0.003 0.0083 0.0104
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0066 0.0119
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0386 0.0386
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0066 0.0082
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0011 0.0011
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0171 0.0213
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0171 0.0171
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0171 0.0171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0054 0.0054
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Onchocerca volvulus 0.0028 0.0066 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0434 0.0434
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.011 0.0137
Mycobacterium tuberculosis Conserved protein 0.0038 0.0147 0.0183
Toxoplasma gondii pyruvate kinase PyK1 0.0994 0.8043 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0066 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0082
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0147 0.0183
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0193 0.024
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.011
Schistosoma mansoni pyruvate kinase 0.0994 0.8043 0.8043
Loa Loa (eye worm) hypothetical protein 0.0096 0.0626 0.0778
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0147 0.0183
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0034 0.0042
Entamoeba histolytica heat shock protein 90, putative 0.0113 0.0765 0.1377
Plasmodium falciparum heat shock protein 90, putative 0.0207 0.1543 0.1918
Brugia malayi heat shock protein 90 0.0113 0.0765 0.0952
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0066 0.0082
Onchocerca volvulus Alhambra homolog 0.003 0.0083 0.0104
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0136 0.0136
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0138 0.0172
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0138 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0171 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0171 0.0213
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0107 0.0133
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0416 0.3267 0.4062
Trichomonas vaginalis pyruvate kinase, putative 0.0994 0.8043 1
Leishmania major pyruvate kinase 0.0994 0.8043 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0386 0.0386
Mycobacterium ulcerans pyruvate kinase 0.0994 0.8043 1
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0138 0.0172
Brugia malayi nuclear receptor NHR-88 0.0041 0.0171 0.0213
Echinococcus granulosus pyruvate kinase 0.0994 0.8043 0.8043
Trypanosoma cruzi heat shock protein 85, putative 0.0113 0.0765 0.0952
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Mycobacterium ulcerans hypothetical protein 0.0416 0.3267 0.4062
Onchocerca volvulus Pyruvate kinase homolog 0.0994 0.8043 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0083 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0393 0.0489
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0171 0.0213
Echinococcus multilocularis pyruvate kinase 0.051 0.4047 0.4047
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0107 0.0133
Plasmodium vivax pyruvate kinase 2, putative 0.051 0.4047 0.5032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0171 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0171 0.0213
Echinococcus multilocularis zinc finger protein 0.0025 0.0042 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0171 0.0171
Giardia lamblia Pyruvate kinase 0.0994 0.8043 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0012 0.0012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0107 0.0133
Loa Loa (eye worm) pyruvate kinase 0.0209 0.1563 0.1943
Trypanosoma cruzi Heat shock protein 83, putative 0.0113 0.0765 0.0952
Loa Loa (eye worm) pyruvate kinase 0.0994 0.8043 1
Echinococcus multilocularis peregrin 0.0033 0.0104 0.0104
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0066 0.0082
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0054 0.0054
Chlamydia trachomatis pyruvate kinase 0.0994 0.8043 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0147 0.0183
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0426 0.0529
Entamoeba histolytica acyl-coA synthetase, putative 0.0096 0.0626 0.1126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0096 0.0626 0.0778
Onchocerca volvulus 0.0147 0.1044 0.1298
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0067 0.0067
Onchocerca volvulus 0.0096 0.0626 0.0778
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0626 0.0778
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0107 0.0107
Onchocerca volvulus 0.0028 0.0066 0.0082
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0171 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0015
Brugia malayi Pyruvate kinase, muscle isozyme 0.0994 0.8043 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0171 0.0171
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0171 0.0171
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0416 0.3267 0.4062
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0107 0.0133
Trichomonas vaginalis endoplasmin, putative 0.0075 0.0449 0.0559
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0386 0.0479
Plasmodium falciparum pyruvate kinase 0.0994 0.8043 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Brugia malayi hypothetical protein 0.0022 0.0012 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0171 0.0213
Schistosoma mansoni heat shock protein 0.0113 0.0765 0.0765
Loa Loa (eye worm) endoplasmin 0.0113 0.0765 0.0952
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0183 0.1348 0.1348
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0171 0.0171
Echinococcus granulosus pyruvate kinase 0.051 0.4047 0.4047
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0171 0.0213
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Trichomonas vaginalis heat shock protein, putative 0.0075 0.0449 0.0559
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0147 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0626 0.0778
Schistosoma mansoni coup transcription factor 0.0041 0.0171 0.0171
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0066 0.0082
Loa Loa (eye worm) hypothetical protein 0.0048 0.023 0.0286
Echinococcus granulosus heat shock protein 0.0113 0.0765 0.0765
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0012 0.0015
Trypanosoma cruzi heat shock protein 85, putative 0.0113 0.0765 0.0952
Trypanosoma cruzi heat shock protein 90, putative 0.0113 0.0765 0.0952
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0171 0.0213
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0171 0.0213
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0083 0.0104
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0147 0.0183
Echinococcus multilocularis protein dispatched 1 0.0101 0.0667 0.0667
Onchocerca volvulus 0.0086 0.0547 0.068
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0097 0.0631 0.0785
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0067 0.0067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0416 0.3267 0.4062
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0171 0.0171
Echinococcus granulosus endoplasmin 0.0097 0.0631 0.0631
Giardia lamblia Heat shock protein HSP 90-alpha 0.0093 0.0599 0.0744
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0015
Schistosoma mansoni hypothetical protein 0.0021 0.001 0.001
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0066 0.0082
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0097 0.0631 0.1932
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0171 0.0171
Brugia malayi jmjC domain containing protein 0.0044 0.0193 0.024
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0066 0.0082
Onchocerca volvulus 0.0038 0.0147 0.0183
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0434 0.0434
Mycobacterium ulcerans lipase LipD 0.0038 0.0147 0.0183
Loa Loa (eye worm) hypothetical protein 0.0994 0.8043 1
Schistosoma mansoni hypothetical protein 0.003 0.0083 0.0083
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Loa Loa (eye worm) hypothetical protein 0.0088 0.0564 0.0701
Giardia lamblia Pyruvate kinase 0.051 0.4047 0.5032
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0096 0.0626 0.0778
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0147 0.0183
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0097 0.0631 0.0785
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.1838 0.2285
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0066 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0547 0.068
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Treponema pallidum fructose-bisphosphate aldolase 0.0571 0.4551 1
Trichomonas vaginalis pyruvate kinase, putative 0.0994 0.8043 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0193 0.0193
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.6785 0.6785
Entamoeba histolytica hypothetical protein 0.0073 0.0434 0.0781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0171 0.0213
Plasmodium vivax endoplasmin, putative 0.0113 0.0765 0.0952
Brugia malayi PHD-finger family protein 0.003 0.0083 0.0104
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.0529
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0066 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0171 0.0213
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0058 0.0315 0.0315
Echinococcus granulosus pyruvate kinase 0.051 0.4047 0.4047
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0147 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0183
Loa Loa (eye worm) heat shock protein 75 0.0058 0.0315 0.0392
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Trypanosoma brucei heat shock protein 84, putative 0.0058 0.0315 0.0392
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0626 0.0778
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0107 0.0133
Echinococcus multilocularis endoplasmin 0.0097 0.0631 0.0631
Brugia malayi pyruvate kinase, muscle isozyme 0.0209 0.1563 0.1943
Trichomonas vaginalis heat shock protein, putative 0.0093 0.0599 0.0744
Trichomonas vaginalis heat shock protein, putative 0.0097 0.0631 0.0785
Loa Loa (eye worm) pyruvate kinase-PB 0.0693 0.5559 0.6912
Onchocerca volvulus 0.0038 0.0147 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0171 0.0213
Echinococcus granulosus transcription factor btf3 0.0037 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.0529
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Brugia malayi ecdysteroid receptor 0.0041 0.0171 0.0213
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Trypanosoma brucei pyruvate phosphate dikinase 0.0416 0.3267 0.4062
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0147 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0138 0.0172
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0066 0.0082
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0066 0.0082
Brugia malayi PHD-finger family protein 0.0031 0.0088 0.0109
Plasmodium falciparum phd finger protein, putative 0.003 0.0083 0.0104
Loa Loa (eye worm) hypothetical protein 0.0693 0.5559 0.6912
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Loa Loa (eye worm) hypothetical protein 0.0108 0.0728 0.0905
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0147 0.0183
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0107 0.0133
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0626 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0171 0.0213
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0386 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0138 0.0172
Loa Loa (eye worm) oxidoreductase 0.0028 0.0066 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0239 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0171 0.0213
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Trichomonas vaginalis heat shock protein, putative 0.0113 0.0765 0.0952
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Brugia malayi TAR-binding protein 0.0067 0.0386 0.0479
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0054 0.0068
Echinococcus granulosus expressed conserved protein 0.0194 0.1432 0.1432
Schistosoma mansoni zinc finger protein 0.0025 0.0042 0.0042
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0011 0.0011
Echinococcus multilocularis heat shock protein 90 0.0093 0.0599 0.0599
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0058 0.0315 0.0315
Plasmodium falciparum endoplasmin, putative 0.0075 0.0449 0.0559
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0107 0.0133
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0083 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0386 0.0386
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0147 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0626 0.0778
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0066 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.0083 0.0517 0.0643
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0171 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0393 0.0489
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0138 0.0172
Brugia malayi F/Y-rich N-terminus family protein 0.0038 0.015 0.0186
Schistosoma mansoni hypothetical protein 0.1231 1 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0066 0.0082
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0147 0.0183
Treponema pallidum heat shock protein 90 0.0097 0.0631 0.1387
Loa Loa (eye worm) beta-lactamase 0.0038 0.0147 0.0183
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.0529
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0066 0.0082
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0066 0.0082
Mycobacterium ulcerans hypothetical protein 0.0038 0.0147 0.0183
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0138 0.0172
Plasmodium falciparum heat shock protein 90 0.0113 0.0765 0.0952
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0012 0.0015
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0096 0.0626 0.0778
Entamoeba histolytica pyruvate kinase, putative 0.0693 0.5559 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Mycobacterium ulcerans pyruvate phosphate dikinase 0.0416 0.3267 0.4062
Brugia malayi CHE-14 protein 0.0088 0.0564 0.0701
Trypanosoma cruzi heat shock protein 90, putative 0.0093 0.0599 0.0744
Brugia malayi jmjC domain containing protein 0.0099 0.0652 0.0811
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0171 0.0213
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0067 0.0067
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0994 0.8043 1
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0171 0.0213
Echinococcus multilocularis protein patched 0.0088 0.0564 0.0564
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0147 0.0183
Trypanosoma brucei Heat shock protein 83, putative 0.0113 0.0765 0.0952
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0171 0.0171
Echinococcus granulosus heat shock protein 90 0.0113 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.004 0.0162 0.0202
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0066 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0386 0.0479
Giardia lamblia Pyruvate, phosphate dikinase 0.0416 0.3267 0.4062
Toxoplasma gondii heat shock protein 90, putative 0.0113 0.0765 0.0952
Schistosoma mansoni cpg binding protein 0.0086 0.0547 0.0547
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0066 0.0082
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.0599 0.0744
Loa Loa (eye worm) pyruvate kinase 0.0994 0.8043 1
Brugia malayi RNA binding protein 0.0067 0.0386 0.0479
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0171 0.0171
Trypanosoma cruzi pyruvate kinase 2, putative 0.0994 0.8043 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0107 0.0107
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0107 0.0133
Echinococcus multilocularis Niemann Pick C1 protein 0.0206 0.1535 0.1535
Brugia malayi beta-lactamase family protein 0.0038 0.0147 0.0183
Plasmodium vivax heat shock protein 86, putative 0.0113 0.0765 0.0952
Toxoplasma gondii Hsp90 domain-containing protein 0.0207 0.1543 0.1918
Schistosoma mansoni transcription factor btf3 0.0037 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0147 0.1044 0.1298
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0083 0.0083
Echinococcus multilocularis expressed conserved protein 0.0194 0.1432 0.1432
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0171 0.0171
Mycobacterium ulcerans heat shock protein 90 0.0097 0.0631 0.0785
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0171 0.0171
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0096 0.0626 0.0778
Trichomonas vaginalis heat shock protein, putative 0.0097 0.0631 0.0785
Trypanosoma cruzi heat shock protein, putative 0.0058 0.0315 0.0392
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0093 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0171 0.0171
Brugia malayi nuclear hormone receptor 0.0041 0.0171 0.0213
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0171 0.0171
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0147 0.0183
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0147 0.0183
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0066 0.0066
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0626 0.0778
Onchocerca volvulus 0.0048 0.023 0.0286
Leishmania major pyruvate kinase 0.0994 0.8043 1
Schistosoma mansoni endoplasmin 0.0113 0.0765 0.0765
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0066 0.0082
Trypanosoma cruzi heat shock protein 90, putative 0.0058 0.0316 0.0393
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0147 0.0183
Brugia malayi follicle stimulating hormone receptor 0.0287 0.2203 0.274
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0147 0.0183
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0206 0.1535 0.2762
Brugia malayi Hsp90 protein 0.0058 0.0315 0.0392
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.0529
Brugia malayi Niemann-Pick C1 protein precursor 0.0206 0.1535 0.1909
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0147 0.0147
Echinococcus multilocularis dnaJ subfamily B 0.1231 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0015
Leishmania major pyruvate phosphate dikinase, putative 0.0416 0.3267 0.4062
Echinococcus granulosus tumor protein p63 0.0328 0.2541 0.2541
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Schistosoma mansoni hypothetical protein 0.0507 0.4021 0.4021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0066 0.0082
Chlamydia trachomatis PTS system PEP phosphotransferase 0.0416 0.3267 0.4062
Echinococcus granulosus Niemann Pick C1 protein 0.0206 0.1535 0.1535
Loa Loa (eye worm) hypothetical protein 0.0042 0.0183 0.0227
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0066 0.0082
Entamoeba histolytica hypothetical protein 0.0073 0.0434 0.0781
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0171 0.0171
Plasmodium vivax heat shock protein 90, putative 0.0058 0.0315 0.0392
Mycobacterium leprae Probable lipase LipE 0.0038 0.0147 0.0183
Plasmodium falciparum heat shock protein 90, putative 0.0054 0.0283 0.0351
Mycobacterium tuberculosis Conserved protein 0.0038 0.0147 0.0183
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0213
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0066 0.0082
Brugia malayi Bromodomain containing protein 0.0033 0.0104 0.0129
Schistosoma mansoni hypothetical protein 0.0085 0.0537 0.0537
Trypanosoma cruzi heat shock protein 85, putative 0.0113 0.0765 0.0952
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0147 0.0147
Echinococcus multilocularis pyruvate kinase 0.051 0.4047 0.4047
Mycobacterium tuberculosis Probable pyruvate, phosphate dikinase PpdK 0.0416 0.3267 0.4062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0193 0.0193
Brugia malayi Pyruvate kinase, M2 isozyme 0.0994 0.8043 1
Schistosoma mansoni patched 1 0.0088 0.0564 0.0564
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0107 0.0133
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0434 0.0434
Schistosoma mansoni cpg binding protein 0.0093 0.0604 0.0604
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0171 0.0171
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0066 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0096 0.0626 0.0778
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0564 0.0564
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0097 0.0631 0.0785
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0386 0.0386
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0066 0.0082
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0279 0.2138 0.2658
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0066 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0066 0.0082
Onchocerca volvulus 0.0028 0.0066 0.0082
Brugia malayi Bromodomain containing protein 0.004 0.0162 0.0201
Leishmania major 4-coumarate:coa ligase-like protein 0.0096 0.0626 0.0778
Onchocerca volvulus 0.0038 0.0147 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0239 0.0297
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0564 0.0564
Leishmania major basic transcription factor 3a, putative 0.0037 0.0138 0.0172
Onchocerca volvulus Pyruvate kinase homolog 0.0994 0.8043 1
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0564 0.0701
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0083 0.0104
Trypanosoma brucei heat shock protein 90, putative 0.0113 0.0765 0.0952
Plasmodium falciparum pyruvate kinase 2 0.051 0.4047 0.5032
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0171 0.0213
Echinococcus granulosus geminin 0.0507 0.4021 0.4021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0171 0.0213
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.4551 0.8187
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0073 0.044 0.0547
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0426 0.0529
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0183
Loa Loa (eye worm) pyruvate kinase 0.0994 0.8043 1
Trichomonas vaginalis esterase, putative 0.0038 0.0147 0.0183
Entamoeba histolytica hypothetical protein 0.0037 0.0138 0.0249
Toxoplasma gondii histone lysine methyltransferase SET1 0.0166 0.1206 0.15
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0066 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0626 0.1126
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0386 0.0386
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0107 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0096 0.0626 0.0778
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0147 0.0183
Echinococcus multilocularis geminin 0.0507 0.4021 0.4021
Schistosoma mansoni pyruvate kinase 0.0994 0.8043 0.8043
Plasmodium vivax hypothetical protein, conserved 0.003 0.0083 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0183
Echinococcus granulosus pyruvate kinase 0.051 0.4047 0.4047
Schistosoma mansoni cpg binding protein 0.0093 0.0604 0.0604
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0171 0.0171
Brugia malayi beta-lactamase 0.0038 0.0147 0.0183
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0066 0.0082
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0066 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0066 0.0082
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0066 0.0082
Onchocerca volvulus 0.0028 0.0066 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Mycobacterium tuberculosis Conserved protein 0.0038 0.0147 0.0183
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0058 0.0315 0.0567
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0066 0.0082
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Echinococcus multilocularis heat shock protein 0.0113 0.0765 0.0765
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0066 0.0082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0107 0.0107
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0386 0.0386
Giardia lamblia Fructose-bisphosphate aldolase 0.0571 0.4551 0.5658
Loa Loa (eye worm) hypothetical protein 0.0072 0.0426 0.0529
Brugia malayi beta-lactamase family protein 0.0038 0.0147 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0138 0.0172
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0209 0.1562 0.1562
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0393 0.0489
Entamoeba histolytica hypothetical protein 0.0073 0.0434 0.0781
Schistosoma mansoni endoplasmin 0.0113 0.0765 0.0765
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0066 0.0082
Leishmania major heat shock protein, putative 0.0058 0.0315 0.0392
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0393 0.0489
Schistosoma mansoni heat shock protein 0.0058 0.0315 0.0315
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0484 0.0484
Schistosoma mansoni hypothetical protein 0.0085 0.0537 0.0537
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0287 0.2203 0.274
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0171 0.0171
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0138 0.0249
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0147 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0171 0.0213
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0011 0.0011
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0058 0.0315 0.0392
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Toxoplasma gondii heat shock protein HSP90 0.0113 0.0765 0.0952
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0183
Echinococcus multilocularis cpg binding protein 0.0093 0.0604 0.0604
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0066 0.0082
Mycobacterium ulcerans beta-lactamase 0.0038 0.0147 0.0183
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0426 0.0529
Echinococcus granulosus tar DNA binding protein 0.0067 0.0386 0.0386
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0083 0.0083
Brugia malayi isocitrate dehydrogenase 0.0033 0.0107 0.0133
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0181 0.0181
Echinococcus granulosus zinc finger protein 0.0025 0.0042 0.0042
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0279 0.2138 0.2658
Loa Loa (eye worm) hypothetical protein 0.0038 0.0147 0.0183
Echinococcus multilocularis tumor protein p63 0.0328 0.2541 0.2541
Schistosoma mansoni heat shock protein 0.0113 0.0765 0.0765
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0301 0.2318 0.2881
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Treponema pallidum pyruvate phosphate dikinase 0.0416 0.3267 0.7179
Trypanosoma brucei heat shock protein 90, putative 0.0113 0.0765 0.0952
Mycobacterium ulcerans hypothetical protein 0.0096 0.0626 0.0778
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0147 0.0183
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0171 0.0213
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0066 0.0082
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0171 0.0171
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0171 0.0213
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0416 0.3267 0.4062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0104
Giardia lamblia Heat shock protein HSP 90-alpha 0.0113 0.0765 0.0952
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0571 0.4551 0.8187
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0066 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0171 0.0213
Trypanosoma brucei pyruvate kinase 1, putative 0.0994 0.8043 1
Plasmodium vivax pyruvate kinase, putative 0.0994 0.8043 1
Brugia malayi Endoplasmin precursor 0.0113 0.0765 0.0952
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0564 0.0564
Schistosoma mansoni pyruvate kinase 0.051 0.4047 0.4047
Plasmodium vivax heat shock protein, putative 0.0207 0.1543 0.1918
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Echinococcus granulosus cpg binding protein 0.0093 0.0604 0.0604
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0138 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0571 0.4551 0.5658
Schistosoma mansoni hypothetical protein 0.0073 0.0434 0.0434
Brugia malayi pyruvate kinase 0.0209 0.1563 0.1943
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0426 0.0529
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.0137
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0426 0.0529
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0107 0.0133
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0147 0.0183
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0066 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0096 0.0626 0.1126
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0066 0.0082
Loa Loa (eye worm) hypothetical protein 0.0052 0.0262 0.0326
Trypanosoma brucei heat shock protein, putative 0.0113 0.0765 0.0952
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Echinococcus multilocularis heat shock protein 90 0.0113 0.0765 0.0765
Loa Loa (eye worm) heat shock protein 90 0.0113 0.0765 0.0952
Entamoeba histolytica heat shock protein 90, putative 0.0113 0.0765 0.1377
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0066 0.0082
Giardia lamblia Grp94/Hsp90 0.0097 0.0631 0.0785
Echinococcus multilocularis pyruvate kinase 0.0994 0.8043 0.8043
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0386 0.0479
Loa Loa (eye worm) hypothetical protein 0.0049 0.0239 0.0297
Schistosoma mansoni hypothetical protein 0.0085 0.0537 0.0537
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0147 0.0183
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0171 0.0171
Leishmania major heat shock protein 83-1 0.0113 0.0765 0.0952
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0279 0.2138 0.2658
Entamoeba histolytica pyruvate phosphate dikinase 0.0416 0.3267 0.5878
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0239 0.0297
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0416 0.3267 0.4062
Entamoeba histolytica hypothetical protein 0.0073 0.0434 0.0781
Echinococcus multilocularis pyruvate kinase 0.0785 0.6313 0.6313
Toxoplasma gondii heat shock protein 75, putative 0.0058 0.0315 0.0392
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0138 0.0172
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0147 0.0183
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0066 0.0082
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0283 0.0351
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0171 0.0213
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0147 0.0183
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0066 0.0082
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0416 0.3267 0.4062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0171 0.0171

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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