Detailed information for compound 100089

Basic information

Technical information
  • TDR Targets ID: 100089
  • Name: 2-chloro-9-[(3,4-dichlorophenyl)methyl]-N,N-d imethylpurin-6-amine
  • MW: 356.638 | Formula: C14H12Cl3N5
  • H donors: 0 H acceptors: 3 LogP: 4.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1nc(N(C)C)c2c(n1)n(cn2)Cc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C14H12Cl3N5/c1-21(2)12-11-13(20-14(17)19-12)22(7-18-11)6-8-3-4-9(15)10(16)5-8/h3-5,7H,6H2,1-2H3
  • InChiKey: UXZRHGZAUJYLRH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-chloro-9-[(3,4-dichlorophenyl)methyl]-N,N-dimethyl-purin-6-amine
  • 2-chloro-9-[(3,4-dichlorophenyl)methyl]-N,N-dimethyl-6-purinamine
  • [2-chloro-9-(3,4-dichlorobenzyl)purin-6-yl]-dimethyl-amine
  • 115204-65-4
  • 9H-Purin-6-amine, 2-chloro-9-((3,4-dichlorophenyl)methyl)-N,N-dimethyl-
  • 9H-Purin-6-amine, 2-chloro-9-[(3,4-dichlorophenyl)methyl]-N,N-dimethyl-
  • AIDS-211821
  • AIDS211821

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0073 0.038
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0137 0.0176
Echinococcus multilocularis thyroid hormone receptor alpha 0.0134 0.1833 0.2749
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.2022 1
Brugia malayi Carboxylesterase family protein 0.0047 0.0553 0.0835
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0814 0.186
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0171 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0375 0.0832
Echinococcus multilocularis tar DNA binding protein 0.0066 0.083 0.1246
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0814 0.1229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0241 0.0519
Giardia lamblia GTOR 0.0044 0.0509 0.0895
Mycobacterium tuberculosis Probable oxidoreductase 0.0021 0.0171 0.0069
Brugia malayi Thioredoxin reductase 0.0062 0.0771 0.1164
Loa Loa (eye worm) acetylcholinesterase 1 0.0279 0.3996 0.6034
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0553 0.115
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0164 0.0338
Brugia malayi Animal haem peroxidase family protein 0.0235 0.3339 0.5043
Onchocerca volvulus 0.0047 0.0553 0.1315
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0171 0.0784
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Echinococcus granulosus neuroligin 0.0047 0.0553 0.0829
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Echinococcus multilocularis neuropeptide s receptor 0.046 0.6667 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.083 0.1727
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0233 0.1237
Loa Loa (eye worm) hypothetical protein 0.0279 0.3996 0.6034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0207 0.044
Loa Loa (eye worm) carboxylesterase 0.0047 0.0553 0.0835
Mycobacterium ulcerans beta-lactamase 0.0107 0.1441 0.6971
Entamoeba histolytica hypothetical protein 0.0111 0.1494 0.3449
Schistosoma mansoni hypothetical protein 0.0142 0.1958 0.4074
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.2022 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1441 0.2176
Brugia malayi Animal haem peroxidase family protein 0.0235 0.3339 0.5043
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0137 0.083
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0341 0.203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Loa Loa (eye worm) hypothetical protein 0.0312 0.4471 0.6752
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0137 0.0081
Brugia malayi Carboxylesterase family protein 0.0279 0.3996 0.6034
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0814 0.559
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0171 0.0356
Schistosoma mansoni thyroid hormone receptor 0.0134 0.1833 0.3812
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0827 0.125
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0171 0.0356
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0021 0.0171 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0029 0.0023
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0073 0.0151
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0073 0.038
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0171 0.073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0279 0.0608
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0073 0.0109
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Onchocerca volvulus Peroxidase homolog 0.0235 0.3339 0.794
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0553 0.0454
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.0553 0.0829
Echinococcus granulosus neuropeptide s receptor 0.046 0.6667 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0171 0.0353
Brugia malayi Blistered cuticle protein 3 0.0235 0.3339 0.5043
Loa Loa (eye worm) TAR-binding protein 0.0066 0.083 0.1254
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0137 0.0205
Schistosoma mansoni hypothetical protein 0.0066 0.0827 0.1721
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Schistosoma mansoni ap endonuclease 0.0019 0.0137 0.0285
Loa Loa (eye worm) hypothetical protein 0.0142 0.1958 0.2958
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.0771 0.0675
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0137 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Schistosoma mansoni hypothetical protein 0.0334 0.4808 1
Leishmania major hypothetical protein, conserved 0.0026 0.0233 0.1509
Brugia malayi glutathione reductase 0.0062 0.0771 0.1164
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.4294 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0207 0.044
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0814 0.559
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.1033 0.7041
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.1033 0.1549
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.0553 0.115
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0509 0.3444
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0137 0.0276
Brugia malayi hypothetical protein 0.0235 0.3339 0.5043
Onchocerca volvulus Peroxidase homolog 0.0235 0.3339 0.794
Schistosoma mansoni hypothetical protein 0.0066 0.0827 0.1721
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0164 0.0245
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Schistosoma mansoni hypothetical protein 0.0111 0.1494 0.3107
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1441 0.6971
Onchocerca volvulus Peroxidasin homolog 0.0235 0.3339 0.794
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0553 0.0454
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1634 0.2467
Toxoplasma gondii ABC1 family protein 0.0107 0.1441 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0509 0.0768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0073 0.011
Brugia malayi MH2 domain containing protein 0.012 0.1634 0.2467
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0125 0.0748
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1441 0.1352
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1441 0.2998
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0163 0.1014
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0233 0.1509
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Brugia malayi Carboxylesterase family protein 0.0047 0.0553 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1212 0.2522
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0713 0.3176
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1212 0.1831
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0073 0.038
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0207 0.044
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.1033 0.1549
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1441 0.6971
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0024 0.0035
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.0771 0.5286
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Echinococcus granulosus acetylcholinesterase 0.0279 0.3996 0.5993
Trichomonas vaginalis esterase, putative 0.0107 0.1441 0.3327
Onchocerca volvulus Chorion peroxidase homolog 0.0235 0.3339 0.794
Schistosoma mansoni hypothetical protein 0.0012 0.0024 0.0049
Onchocerca volvulus 0.0235 0.3339 0.794
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0713 0.1069
Loa Loa (eye worm) hypothetical protein 0.0107 0.1441 0.2176
Schistosoma mansoni thyroid hormone receptor 0.0134 0.1833 0.3812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0509 0.1146
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.0771 0.5135
Schistosoma mansoni tar DNA-binding protein 0.0066 0.083 0.1727
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0713 0.3176
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0259 0.0814
Schistosoma mansoni tar DNA-binding protein 0.0066 0.083 0.1727
Echinococcus granulosus expressed protein 0.0017 0.0103 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0827 0.1241
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0626 0.0529
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 0.2218
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0171 0.0356
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0073 0.011
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1686 0.2528
Brugia malayi TAR-binding protein 0.0066 0.083 0.1254
Trichomonas vaginalis ferritin, putative 0.0017 0.0103 0.0197
Brugia malayi Calcitonin receptor-like protein seb-1 0.0208 0.2933 0.443
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Echinococcus granulosus geminin 0.0334 0.4808 0.7211
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.1958 0.2958
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0164 0.0338
Loa Loa (eye worm) animal heme peroxidase 0.0235 0.3339 0.5043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1212 0.1819
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Loa Loa (eye worm) RNA binding protein 0.0066 0.083 0.1254
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1441 0.1352
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.1033 0.4843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.1033 0.7041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0553 0.115
Leishmania major trypanothione reductase 0.0062 0.0771 0.5286
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0827 0.125
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.0553 0.0829
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0279 0.3996 0.8311
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0171 0.0498
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0171 0.0258
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0171 0.0069
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1441 0.2162
Brugia malayi Carboxylesterase family protein 0.0279 0.3996 0.6034
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0073 0.038
Entamoeba histolytica hypothetical protein 0.0111 0.1494 0.3449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0259 0.0373
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0137 0.083
Echinococcus granulosus neuropeptide receptor A26 0.046 0.6667 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1441 0.2176
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0814 0.1229
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0171 0.0256
Brugia malayi Animal haem peroxidase family protein 0.0235 0.3339 0.5043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1441 0.2998
Plasmodium falciparum thioredoxin reductase 0.0021 0.0171 0.0498
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.1033 0.7036
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0827 0.1241
Treponema pallidum NADH oxidase 0.0021 0.0171 0.0162
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1441 0.2176
Loa Loa (eye worm) animal heme peroxidase 0.0235 0.3339 0.5043
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0171 0.1069
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0171 0.0353
Schistosoma mansoni peroxidasin 0.0235 0.3339 0.6945
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0814 0.1221
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0626 0.0939
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.0553 0.1249
Brugia malayi hypothetical protein 0.0111 0.1494 0.2256
Echinococcus granulosus protein cereblon 0.0294 0.4205 0.6308
Mycobacterium tuberculosis Conserved protein 0.0107 0.1441 0.1352
Onchocerca volvulus 0.0047 0.0553 0.1315
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.1494 0.224
Trypanosoma brucei trypanothione reductase 0.0062 0.0771 0.5286
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.0553 0.0829
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0171 0.08
Onchocerca volvulus 0.0107 0.1441 0.3427
Onchocerca volvulus 0.0107 0.1441 0.3427
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0771 0.1156
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0171 0.08
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0409 0.0614
Echinococcus multilocularis GPCR, family 2 0.0066 0.0827 0.1241
Brugia malayi beta-lactamase 0.0107 0.1441 0.2176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0073 0.0126
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0814 0.1693
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0233 0.1187
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0375 0.2505
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0713 0.4878
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0827 0.125
Onchocerca volvulus 0.0047 0.0553 0.1315
Schistosoma mansoni gliotactin 0.0047 0.0553 0.115
Entamoeba histolytica hypothetical protein 0.0111 0.1494 0.3449
Echinococcus granulosus tar DNA binding protein 0.0066 0.083 0.1246
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0208 0.2933 0.443
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0814 0.559
Brugia malayi hypothetical protein 0.0026 0.0233 0.0353
Schistosoma mansoni hypothetical protein 0.0334 0.4808 1
Echinococcus granulosus carboxylesterase 5A 0.0279 0.3996 0.5993
Onchocerca volvulus 0.0047 0.0553 0.1315
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Schistosoma mansoni ferritin 0.0017 0.0103 0.0214
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0375 0.2505
Onchocerca volvulus Protein cereblon homolog 0.0294 0.4205 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1441 0.1352
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0509 0.0763
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0137 0.0207
Schistosoma mansoni apoferritin-2 0.0017 0.0103 0.0214
Loa Loa (eye worm) carboxylesterase 0.0279 0.3996 0.6034
Loa Loa (eye worm) RecQ helicase 0.0021 0.0164 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1212 0.1819
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1212 0.1831
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0171 0.1069
Loa Loa (eye worm) glutathione reductase 0.0062 0.0771 0.1164
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0024 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0066 0.083 0.1727
Loa Loa (eye worm) hypothetical protein 0.008 0.1033 0.1559
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0233 0.1187
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.0553 0.0829
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0171 0.1069
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Brugia malayi beta-lactamase family protein 0.0107 0.1441 0.2176
Brugia malayi follicle stimulating hormone receptor 0.0457 0.6622 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0259 0.1473
Echinococcus granulosus ferritin 0.0017 0.0103 0.0155
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.083 0.1254
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0137 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0713 0.1482
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.4294 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0509 0.3444
Onchocerca volvulus 0.0107 0.1441 0.3427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1212 0.1819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0098 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0206 0.0439
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0171 0.0082
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0375 0.2505
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1441 0.6971
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0137 0.0276
Brugia malayi Peroxidasin 0.0235 0.3339 0.5043
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1686 0.2528
Onchocerca volvulus Peroxidasin homolog 0.0235 0.3339 0.794
Schistosoma mansoni hypothetical protein 0.0124 0.1686 0.3506
Echinococcus granulosus GPCR family 2 0.0066 0.0827 0.1241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0375 0.0832
Leishmania major hypothetical protein, conserved 0.0107 0.1441 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0137 0.0363
Toxoplasma gondii hypothetical protein 0.0027 0.0259 0.1441
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0137 0.0276
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1441 0.2162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1212 0.1819
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1212 0.2522
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.0553 0.0829
Loa Loa (eye worm) hypothetical protein 0.0017 0.0101 0.0152
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0021 0.0171 0.0069
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1441 0.3327
Brugia malayi hypothetical protein 0.0294 0.4205 0.6351
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0171 0.1069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0245 0.0528
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1441 0.1352
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0171 0.1069
Mycobacterium ulcerans carboxylesterase, LipT 0.0047 0.0553 0.2344
Echinococcus granulosus peroxidasin 0.0235 0.3339 0.5009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.4294 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0233 0.1253
Echinococcus multilocularis acetylcholinesterase 0.0279 0.3996 0.5993
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.0553 0.0454
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.4294 1
Mycobacterium tuberculosis Conserved protein 0.0107 0.1441 0.1352
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Plasmodium vivax glutathione reductase, putative 0.0062 0.0771 0.5135
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1441 0.1352
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0509 0.3444
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1634 0.2467
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Echinococcus multilocularis carboxylesterase 5A 0.0279 0.3996 0.5993
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0171 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0375 0.0832
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0827 0.1241
Echinococcus granulosus bloom syndrome protein 0.0021 0.0164 0.0245
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1441 1
Toxoplasma gondii thioredoxin reductase 0.0062 0.0771 0.5144
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0509 0.0763
Schistosoma mansoni acetylcholinesterase 0.0047 0.0553 0.115
Loa Loa (eye worm) blistered cuticle protein 3 0.0235 0.3339 0.5043
Echinococcus multilocularis acetylcholinesterase 0.0279 0.3996 0.5993
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0208 0.2933 0.443
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0509 0.1146
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 0.4843
Echinococcus multilocularis expressed protein 0.0017 0.0103 0.0155
Loa Loa (eye worm) hypothetical protein 0.0208 0.2933 0.443
Loa Loa (eye worm) beta-lactamase 0.0107 0.1441 0.2176
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0713 0.1076
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0509 0.0768
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0626 0.2725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0375 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0073 0.0126
Mycobacterium tuberculosis Conserved protein 0.0107 0.1441 0.1352
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.1033 0.2148
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0509 0.3444
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1441 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0771 0.1156
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0171 0.073
Plasmodium falciparum glutathione reductase 0.0062 0.0771 0.7111
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0509 0.3444
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0409 0.0614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0137 0.083
Mycobacterium ulcerans lipase LipD 0.0107 0.1441 0.6971
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.0553 0.1249
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1441 0.1352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0375 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0073 0.0126
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.083 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1212 0.2522
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0713 0.1069
Schistosoma mansoni ap endonuclease 0.0019 0.0137 0.0285
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0827 0.1241
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.1494 0.3107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0171 0.1069
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0137 0.083
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0655 0.0989
Schistosoma mansoni apoferritin-2 0.0017 0.0103 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0241 0.0519
Loa Loa (eye worm) hypothetical protein 0.0235 0.3339 0.5043
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0626 0.0939
Brugia malayi RNA binding protein 0.0066 0.083 0.1254
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1441 0.3327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Echinococcus multilocularis protein cereblon 0.0294 0.4205 0.6308
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0713 0.0616
Onchocerca volvulus 0.0047 0.0553 0.1315
Onchocerca volvulus 0.0235 0.3339 0.794
Brugia malayi Carboxylesterase family protein 0.0047 0.0553 0.0835
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0553 0.115
Loa Loa (eye worm) hypothetical protein 0.0294 0.4205 0.6351
Echinococcus multilocularis peroxidasin 0.0235 0.3339 0.5009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0086 0.0131
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0171 0.1069
Echinococcus multilocularis ferritin 0.0017 0.0103 0.0155
Brugia malayi beta-lactamase family protein 0.0107 0.1441 0.2176
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1441 1
Schistosoma mansoni hypothetical protein 0.0294 0.4205 0.8747
Mycobacterium leprae Probable lipase LipE 0.0107 0.1441 0.6971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0073 0.0126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0413 0.0922
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.0553 0.0829
Brugia malayi Animal haem peroxidase family protein 0.0235 0.3339 0.5043
Schistosoma mansoni peroxidasin 0.0235 0.3339 0.6945
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0171 0.0256
Brugia malayi Animal haem peroxidase family protein 0.0235 0.3339 0.5043
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1441 0.3327
Loa Loa (eye worm) carboxylesterase 0.0047 0.0553 0.0835
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0171 0.1069
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0073 0.0109
Brugia malayi hypothetical protein 0.0017 0.0099 0.0149
Loa Loa (eye worm) hypothetical protein 0.0047 0.0553 0.0835
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0171 0.0353
Onchocerca volvulus 0.0235 0.3339 0.794
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0293 0.0641
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0814 0.559
Loa Loa (eye worm) hypothetical protein 0.0066 0.0827 0.125
Loa Loa (eye worm) hypothetical protein 0.0107 0.1441 0.2176
Brugia malayi Carboxylesterase family protein 0.0047 0.0553 0.0835
Plasmodium falciparum thioredoxin reductase 0.0062 0.0771 0.7111
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.2022 0.1939
Toxoplasma gondii exonuclease III APE 0.0019 0.0137 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0073 0.0126
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1441 0.2176
Schistosoma mansoni ferritin 0.0017 0.0103 0.0214
Loa Loa (eye worm) hypothetical protein 0.0107 0.1441 0.2176
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0171 0.0498
Schistosoma mansoni hypothetical protein 0.0066 0.0827 0.1721
Plasmodium falciparum glutathione reductase 0.0021 0.0171 0.0498
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0233 0.1509
Mycobacterium ulcerans hypothetical protein 0.0107 0.1441 0.6971
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0259 0.1425
Echinococcus multilocularis geminin 0.0334 0.4808 0.7211
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1441 0.1352
Schistosoma mansoni ferritin 0.0017 0.0103 0.0214
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0509 0.1146
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0233 0.1509
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0164 0.0247
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.6622 1
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.0771 0.1164
Schistosoma mansoni ferritin light chain 0.0017 0.0103 0.0214
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0137 0.0122
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.6667 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0814 0.1221
Echinococcus granulosus acetylcholinesterase 0.0279 0.3996 0.5993
Schistosoma mansoni ferritin light chain 0.0017 0.0103 0.0214
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0137 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0206 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0341 0.0753
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1441 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0073 0.038
Loa Loa (eye worm) animal heme peroxidase 0.0235 0.3339 0.5043
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0137 0.0034
Loa Loa (eye worm) hypothetical protein 0.0107 0.1441 0.2176
Brugia malayi hypothetical protein 0.0047 0.0553 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0207 0.044
Loa Loa (eye worm) animal heme peroxidase 0.0235 0.3339 0.5043
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0171 0.0784
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0626 0.0529
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0509 0.3444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Brugia malayi hypothetical protein 0.012 0.1625 0.2454
Schistosoma mansoni tar DNA-binding protein 0.0066 0.083 0.1727
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.0553 0.115
Entamoeba histolytica hypothetical protein 0.0111 0.1494 0.3449
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.1494 0.224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.4294 1
Onchocerca volvulus Dual oxidase homolog 0.0235 0.3339 0.794
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0086 0.0131
Entamoeba histolytica hypothetical protein, conserved 0.0294 0.4205 0.9793
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.1033 0.4843
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1441 0.3327
Schistosoma mansoni hypothetical protein 0.0066 0.0827 0.1721
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0073 0.038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0233 0.0353
Echinococcus multilocularis neuroligin 0.0047 0.0553 0.0829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0206 0.0439
Brugia malayi Probable ClpP-like protease 0.008 0.1033 0.1559
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1441 0.3327
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0021 0.0171 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0509 0.1146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0245 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0509 0.1146
Schistosoma mansoni ferritin 0.0017 0.0103 0.0214
Loa Loa (eye worm) hypothetical protein 0.0279 0.3996 0.6034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0245 0.0528
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0509 0.1058

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.32 uM In vitro activity against Rhinovirus type 1B by plaque inhibition assay. ChEMBL. 2845083

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.