Detailed information for compound 100386

Basic information

Technical information
  • TDR Targets ID: 100386
  • Name: dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro -1-benzoxepine-4-carbonyl]amino]phenyl]methyl ]-(thian-4-yl)azanium iodide
  • MW: 640.618 | Formula: C32H37IN2O2S
  • H donors: 1 H acceptors: 1 LogP: 7.18 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)c1ccc2c(c1)C=C(CCO2)C(=O)Nc1ccc(cc1)C[N+](C1CCSCC1)(C)C.[I-]
  • InChi: 1S/C32H36N2O2S.HI/c1-23-4-8-25(9-5-23)26-10-13-31-28(20-26)21-27(14-17-36-31)32(35)33-29-11-6-24(7-12-29)22-34(2,3)30-15-18-37-19-16-30;/h4-13,20-21,30H,14-19,22H2,1-3H3;1H
  • InChiKey: UEJHWWWMSWUXEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dimethyl-[[4-[[7-(p-tolyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-tetrahydrothiopyran-4-yl-ammonium iodide
  • dimethyl-[[4-[[oxo-[7-(p-tolyl)-2,3-dihydro-1-benzoxepin-4-yl]methyl]amino]phenyl]methyl]-(4-tetrahydrothiopyranyl)ammonium iodide
  • dimethyl-[[4-[[7-(4-methylphenyl)-2,3-dihydro-1-benzoxepin-4-yl]carbonylamino]phenyl]methyl]-(thian-4-yl)azanium iodide
  • dimethyl-[4-[[7-(p-tolyl)-2,3-dihydro-1-benzoxepine-4-carbonyl]amino]benzyl]-tetrahydrothiopyran-4-yl-ammonium iodide
  • dimethyl-[[4-[[7-(4-methylphenyl)2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-(thian-4-yl)azanium iodide
  • dimethyl-[[4-[[7-(p-tolyl)2,3-dihydro-1-benzoxepine-4-carbonyl]amino]phenyl]methyl]-tetrahydrothiopyran-4-yl-ammonium iodide
  • dimethyl-[4-[[7-(p-tolyl)2,3-dihydro-1-benzoxepine-4-carbonyl]amino]benzyl]-tetrahydrothiopyran-4-yl-ammonium iodide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1254
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0107 0.0107
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0013 0.0187 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0011 0.0145 0.0145
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0107 0.0107
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0107 0.0107
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.101 0.1188
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0187 0.022
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0007 0.0033 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0107 0.0107
Brugia malayi Smad1 0.002 0.0411 0.0484
Loa Loa (eye worm) hypothetical protein 0.0041 0.101 0.101
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.101 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0007 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1234 0.1234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0013 0.0187 0.0187
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0107 0.0107
Brugia malayi photoreceptor-specific nuclear receptor 0.0013 0.0187 0.022
Trichomonas vaginalis esterase, putative 0.0041 0.101 1
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Echinococcus granulosus neuropeptide s receptor 0.001 0.0107 0.0107
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0107 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0014 0.0014
Brugia malayi Thioredoxin reductase 0.0032 0.0759 0.0892
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0073 0.1961 0.2494
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0107 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0013 0.0187 0.0187
Echinococcus granulosus mothers against decapentaplegic 6 0.0009 0.0084 0.0084
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0033 0.0773 0.0773
Onchocerca volvulus Protein ultraspiracle homolog 0.0013 0.0187 0.1115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Schistosoma mansoni adenoreceptor 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Onchocerca volvulus 0.001 0.0107 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0013 0.0187 0.022
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0008 0.0059 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0013 0.0187 0.022
Trypanosoma brucei trypanothione reductase 0.0032 0.0759 0.212
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0107 0.0107
Brugia malayi glutathione reductase 0.0032 0.0759 0.0892
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0107 0.0107
Echinococcus granulosus sphingosine kinase 1 0.0145 0.4069 0.4069
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0073 0.1961 0.7992
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0107 0.0126
Schistosoma mansoni Smad4 0.0009 0.0084 0.0084
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0107 0.0107
Brugia malayi putative neuropeptide receptor 0.001 0.0107 0.0126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0107 0.0107
Schistosoma mansoni TGF-beta signal transducer Smad2 0.002 0.0411 0.0411
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1254
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Schistosoma mansoni amine GPCR 0.001 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0013 0.0187 0.022
Plasmodium falciparum glutathione reductase 0.0011 0.0145 0.1875
Loa Loa (eye worm) hypothetical protein 0.0007 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0347 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis FTZ F1 alpha 0.0013 0.0187 0.0187
Brugia malayi Dopamine receptor 0.001 0.0107 0.0126
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0013 0.0187 0.0187
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0107 0.0107
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0593 0.5868
Schistosoma mansoni amine GPCR 0.001 0.0107 0.0107
Schistosoma mansoni sphingoid long chain base kinase 0.0145 0.4069 0.4069
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1234 0.1234
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.0197 0.1945
Echinococcus multilocularis orexin receptor type 2 0.001 0.0107 0.0107
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0011 0.0145 0.0145
Schistosoma mansoni coup transcription factor 0.0013 0.0187 0.0187
Echinococcus multilocularis geminin 0.0105 0.2885 0.2885
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0013 0.0187 0.0187
Brugia malayi mothers against decapentaplegic homolog 3 0.0009 0.0084 0.0099
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0759 0.7455
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0007 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0296 0.8501 0.8501
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0107 0.0107
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0013 0.0187 0.0187
Brugia malayi Serotonin receptor 0.001 0.0107 0.0126
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0521 0.0521
Loa Loa (eye worm) nuclear factor I 0.0011 0.0147 0.0147
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.101 0.101
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Schistosoma mansoni amine GPCR 0.001 0.0107 0.0107
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0107 0.0107
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0593 0.5868
Trichomonas vaginalis mercuric reductase, putative 0.0011 0.0145 0.1435
Brugia malayi larval opioid receptor 0.001 0.0107 0.0126
Echinococcus granulosus serotonin receptor 0.001 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0105 0.2885 0.2885
Brugia malayi Calcitonin receptor-like protein seb-1 0.0023 0.0495 0.0582
Echinococcus granulosus tm gpcr rhodopsin 0.0275 0.789 0.789
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0107 0.0107
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0521 0.5059
Schistosoma mansoni opsin-like receptor 0.001 0.0107 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Trichomonas vaginalis glutathione reductase, putative 0.0011 0.0145 0.1435
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0013 0.0187 0.0187
Echinococcus granulosus mothers against decapentaplegic 5 0.002 0.0411 0.0411
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0107 0.0107
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0107 0.0107
Schistosoma mansoni biogenic amine receptor 0.001 0.0107 0.0107
Echinococcus granulosus g protein coupled receptor 0.001 0.0107 0.0107
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0187 0.022
Brugia malayi MH2 domain containing protein 0.0009 0.0084 0.0099
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0197 0.1945
Echinococcus granulosus TGF beta signal transducer SmadC 0.002 0.0411 0.0411
Schistosoma mansoni ran 0.0024 0.0521 0.0521
Mycobacterium tuberculosis Conserved protein 0.0145 0.4069 0.5389
Schistosoma mansoni hypothetical protein 0.0007 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0041 0.101 0.101
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0773 0.2161
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0107 0.0107
Schistosoma mansoni histamine h1 receptor 0.001 0.0107 0.0107
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0107 0.0107
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0107 0.0107
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0011 0.0145 0.1875
Mycobacterium ulcerans lipase LipD 0.0041 0.101 0.2205
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Echinococcus granulosus orexin receptor type 2 0.001 0.0107 0.0107
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0521 0.6744
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0107 0.0107
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0107 0.0107
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Onchocerca volvulus 0.001 0.0107 0.0249
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0107 0.0107
Echinococcus granulosus mothers against decapentaplegic 2 0.0009 0.0084 0.0084
Brugia malayi G-protein coupled receptor 0.001 0.0107 0.0126
Brugia malayi latrophilin 2 splice variant baaae 0.0016 0.0281 0.0331
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0275 0.789 0.789
Schistosoma mansoni opsin-like receptor 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Loa Loa (eye worm) RecQ helicase 0.0013 0.0197 0.0197
Brugia malayi Steroid receptor seven-up type 2 0.0013 0.0187 0.022
Brugia malayi ORL1-like opioid receptor 0.001 0.0107 0.0126
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0107 0.0107
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0074 0.0737
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0107 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0013 0.0187 0.022
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0107 0.0126
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0081 0.22 0.2823
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0107 0.0107
Brugia malayi neuropeptide F receptor 0.001 0.0107 0.0126
Treponema pallidum NADH oxidase 0.0011 0.0145 0.5
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0011 0.0145 0.1435
Schistosoma mansoni hypothetical protein 0.0007 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0013 0.0187 0.0187
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0107 0.0126
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0187 0.0187
Onchocerca volvulus 0.001 0.0107 0.0249
Schistosoma mansoni sphingosine kinase A B 0.0145 0.4069 0.4069
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0107 0.0107
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0107 0.0107
Schistosoma mansoni amine GPCR 0.001 0.0107 0.0107
Plasmodium falciparum thioredoxin reductase 0.0011 0.0145 0.1875
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Toxoplasma gondii ABC1 family protein 0.0041 0.101 1
Schistosoma mansoni importin beta-1 0.0033 0.0773 0.0773
Echinococcus multilocularis serotonin receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis g protein coupled receptor 0.001 0.0107 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0187 0.0187
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0107 0.0107
Brugia malayi hypothetical protein 0.0007 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.101 0.2205
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0065 0.1717 0.1717
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.101 0.1188
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.001 0.0107 0.0107
Leishmania major hypothetical protein, conserved 0.0041 0.101 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.101 0.1188
Brugia malayi nuclear receptor RXR 0.0007 0.0014 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.101 0.1188
Echinococcus multilocularis somatostatin receptor 0.001 0.0107 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0007 0.0033 0.0033
Loa Loa (eye worm) MH2 domain-containing protein 0.0296 0.8501 0.8501
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis fmrfamide receptor 0.001 0.0107 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0013 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.101 0.1188
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Echinococcus multilocularis Smad4 0.002 0.0411 0.0411
Echinococcus multilocularis ecdysone induced protein 78C 0.0013 0.0187 0.0187
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0521 0.5059
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0011 0.0145 0.1875
Brugia malayi nuclear receptor NHR-88 0.0013 0.0187 0.022
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1254
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0041 0.101 0.101
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0013 0.0187 0.022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0013 0.0187 0.0187
Plasmodium falciparum thioredoxin reductase 0.0032 0.0759 0.981
Brugia malayi ecdysteroid receptor 0.0013 0.0187 0.022
Echinococcus granulosus FTZ F1 alpha 0.0013 0.0187 0.0187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1234 0.1234
Schistosoma mansoni smad 0.0009 0.0084 0.0084
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0521 0.5161
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0107 0.0107
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0107 0.0107
Brugia malayi Importin beta-1 subunit 0.0033 0.0773 0.091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1234 0.1451
Echinococcus multilocularis allatostatin A receptor 0.001 0.0107 0.0107
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.0145 0.5
Schistosoma mansoni hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni neuropeptide receptor 0.001 0.0107 0.0107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0013 0.0187 0.0187
Entamoeba histolytica hypothetical protein, conserved 0.0145 0.4069 1
Brugia malayi nuclear hormone receptor 0.0013 0.0187 0.022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0013 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis sex peptide receptor 0.001 0.0107 0.0107
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0759 0.7508
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.101 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0081 0.22 0.2823
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0773 0.7653
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1234 0.1234
Onchocerca volvulus 0.0041 0.101 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0013 0.0187 0.0187
Echinococcus multilocularis fmrfamide receptor 0.001 0.0107 0.0107
Echinococcus granulosus Smad4 0.002 0.0411 0.0411
Echinococcus granulosus geminin 0.0105 0.2885 0.2885
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0411 0.0411
Schistosoma mansoni steroid hormone receptor ad4bp 0.0013 0.0187 0.0187
Onchocerca volvulus 0.001 0.0107 0.0249
Echinococcus multilocularis sphingosine kinase 1 0.0145 0.4069 0.4069
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0107 0.0107
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0521 0.0521
Schistosoma mansoni amine GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) steroid hormone receptor 0.0013 0.0187 0.0187
Loa Loa (eye worm) glutathione reductase 0.0032 0.0759 0.0759
Schistosoma mansoni smad 0.002 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Brugia malayi beta-lactamase 0.0041 0.101 0.1189
Trypanosoma cruzi trypanothione reductase, putative 0.0011 0.0145 0.1254
Echinococcus multilocularis neuropeptide receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0107 0.0107
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0107 0.0126
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0145 0.0405
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.0187 0.022
Schistosoma mansoni neuropeptide receptor 0.001 0.0107 0.0107
Plasmodium falciparum glutathione reductase 0.0032 0.0759 0.981
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.101 0.1188
Plasmodium vivax glutathione reductase, putative 0.0032 0.0759 0.7508
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.0145 0.5
Brugia malayi AKH receptor 0.001 0.0107 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0281 0.0281
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0107 0.0107
Echinococcus granulosus sex peptide receptor 0.001 0.0107 0.0107
Schistosoma mansoni neuropeptide receptor 0.001 0.0107 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0009 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Echinococcus multilocularis g protein coupled receptor 0.001 0.0107 0.0107
Plasmodium falciparum importin beta, putative 0.0033 0.0773 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Echinococcus multilocularis thioredoxin glutathione reductase 0.0032 0.0759 0.0759
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0107 0.0107
Toxoplasma gondii NADPH-glutathione reductase 0.0011 0.0145 0.1435
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus granulosus g protein coupled receptor 0.001 0.0107 0.0107
Brugia malayi Latrophilin receptor protein 2 0.0007 0.0033 0.0039
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0107 0.0126
Brugia malayi RNA, U transporter 1 0.0093 0.2531 0.2978
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0013 0.0187 0.0187
Echinococcus granulosus GPCR family 2 0.0007 0.0033 0.0033
Schistosoma mansoni biogenic amine receptor 0.001 0.0107 0.0107
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0107 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0187 0.0187
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0107 0.0126
Brugia malayi hypothetical protein 0.0007 0.0014 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0011 0.0145 0.1435
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0593 0.5868
Brugia malayi steroid hormone receptor 0.0013 0.0187 0.022
Entamoeba histolytica hypothetical protein 0.0026 0.0593 0.1457
Onchocerca volvulus 0.0041 0.101 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0023 0.0495 0.0495
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Brugia malayi beta-lactamase family protein 0.0041 0.101 0.1189
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0013 0.0187 0.0187
Mycobacterium tuberculosis Probable reductase 0.0073 0.1961 0.2494
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0073 0.1961 0.2494
Brugia malayi beta-lactamase family protein 0.0041 0.101 0.1189
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0013 0.0187 0.0187
Leishmania major trypanothione reductase 0.0032 0.0759 0.7508
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.101 1
Brugia malayi Serotonin receptor 0.001 0.0107 0.0126
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0084 0.0084
Loa Loa (eye worm) beta-lactamase 0.0041 0.101 0.101
Brugia malayi sulfakinin receptor protein 0.001 0.0107 0.0126
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0011 0.0145 0.0405
Mycobacterium ulcerans hypothetical protein 0.0145 0.4069 1
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0107 0.0107
Trichomonas vaginalis DNA helicase recq, putative 0.0007 0.0021 0.0208
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0013 0.0187 0.0187
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0011 0.0145 0.1435
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0011 0.0145 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0013 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0041 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0021 0.0208
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0187 0.0187
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0107 0.0107
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0107 0.0107
Echinococcus granulosus hypothetical protein 0.001 0.0107 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0013 0.0187 0.1115
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0145 0.1254
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0013 0.0187 0.0187
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0073 0.1961 0.2494
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0081 0.22 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.002 0.0411 0.0411
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0107 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0107 0.0107
Loa Loa (eye worm) Smad1 0.002 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Brugia malayi MH2 domain containing protein 0.002 0.0411 0.0484
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0007 0.0033 0.0033
Mycobacterium tuberculosis Probable oxidoreductase 0.0081 0.22 0.2823
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0007 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0041 0.101 0.101
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0107 0.0107
Mycobacterium ulcerans beta-lactamase 0.0041 0.101 0.2205
Leishmania major importin beta-1 subunit, putative 0.0026 0.0593 0.5868
Mycobacterium ulcerans hypothetical protein 0.0041 0.101 0.2205
Schistosoma mansoni smad1 5 8 and 0.002 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus granulosus neuropeptide receptor 0.001 0.0107 0.0107
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0011 0.0151 0.195
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0521 0.5161
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0107 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Schistosoma mansoni ran 0.0024 0.0521 0.0521
Onchocerca volvulus 0.001 0.0107 0.0249
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.101 0.1189
Schistosoma mansoni hypothetical protein 0.0007 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0008 0.0059 0.0069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0145 0.0405
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0105 0.2885 0.2885
Onchocerca volvulus 0.001 0.0107 0.0249
Echinococcus multilocularis TGF beta signal transducer SmadC 0.002 0.0411 0.0411
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.101 0.1188
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.101 0.101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.0187 0.022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0495 0.0495
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0084 0.0084
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0011 0.0145 0.1435
Entamoeba histolytica Ran family GTPase 0.0024 0.0521 0.1282
Echinococcus multilocularis smad 0.002 0.0411 0.0411
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0023 0.0495 0.0582
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0107 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.101 1
Brugia malayi MH1 domain containing protein 0.002 0.0411 0.0484
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0071 0.0707
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1234 0.1234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0013 0.0187 0.0187
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.101 0.1188
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0011 0.0145 0.0405
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0107 0.0107
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1435
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0011 0.0145 0.0145
Mycobacterium tuberculosis Conserved protein 0.0041 0.101 0.1188
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0007 0.0014 0.0014
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0011 0.0145 0.1435
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1254
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.101 1
Echinococcus granulosus g-protein coupled receptor 0.001 0.0107 0.0107
Echinococcus multilocularis serotonin receptor 0.001 0.0107 0.0107
Echinococcus granulosus fmrfamide receptor 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0014
Onchocerca volvulus 0.001 0.0107 0.0249
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0107 0.0107
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0107 0.0107
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1435
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Loa Loa (eye worm) hypothetical protein 0.0041 0.101 0.101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0073 0.1961 0.2494
Schistosoma mansoni hypothetical protein 0.0016 0.0281 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0187 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0107 0.0107
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0107 0.0107
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0117 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0013 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0187 0.022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0107 0.0107
Brugia malayi RE15519p 0.001 0.0107 0.0126
Echinococcus granulosus smad 0.002 0.0411 0.0411
Brugia malayi Melatonin receptor type 1A 0.001 0.0107 0.0126
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.101 0.101
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0013 0.0187 0.1115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1254
Schistosoma mansoni smad1 5 8 and 0.002 0.0411 0.0411
Echinococcus multilocularis snurportin 1 0.0347 1 1
Brugia malayi MH1 domain containing protein 0.0011 0.0147 0.0173
Schistosoma mansoni hypothetical protein 0.0007 0.0033 0.0033
Brugia malayi G-protein coupled receptor 0.001 0.0107 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.101 0.101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0013 0.0187 0.0187
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0107 0.0107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.101 0.101
Echinococcus granulosus ecdysone induced protein 78C 0.0013 0.0187 0.0187
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0011 0.0145 0.0171
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0773 0.0773
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0007 0.0033 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0187 0.0187
Echinococcus granulosus thioredoxin glutathione reductase 0.0032 0.0759 0.0759
Echinococcus granulosus g protein coupled receptor 0.001 0.0107 0.0107
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0107 0.0107
Schistosoma mansoni Smad4 0.0009 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni biogenic amine receptor 0.001 0.0107 0.0107
Brugia malayi MH1 domain containing protein 0.002 0.0411 0.0484
Brugia malayi MH1 domain containing protein 0.0011 0.0147 0.0173
Onchocerca volvulus 0.001 0.0107 0.0249
Echinococcus granulosus bloom syndrome protein 0.0013 0.0197 0.0197
Echinococcus multilocularis g protein coupled receptor 0.001 0.0107 0.0107
Echinococcus granulosus neuropeptide receptor 0.001 0.0107 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.101 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0007 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Trypanosoma brucei RNA helicase, putative 0.0128 0.3579 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0013 0.0187 0.022
Brugia malayi G protein-coupled receptor 0.001 0.0107 0.0126
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0107 0.0107
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0021 0.0059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.7427 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0593 0.5781
Echinococcus multilocularis neuropeptide receptor 0.001 0.0107 0.0107
Brugia malayi MH2 domain containing protein 0.002 0.0411 0.0484
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0521 0.1457
Schistosoma mansoni retinoic acid receptor RXR 0.0013 0.0187 0.0187
Echinococcus granulosus somatostatin receptor 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0107 0.0107
Onchocerca volvulus 0.0013 0.0187 0.1115
Schistosoma mansoni hypothetical protein 0.0128 0.3579 0.3579
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.0197 0.0231
Echinococcus multilocularis GPCR, family 2 0.0007 0.0033 0.0033
Echinococcus multilocularis mothers against decapentaplegic 2 0.0009 0.0084 0.0084
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Brugia malayi GnHR receptor homolog 0.001 0.0107 0.0126
Schistosoma mansoni smad1 5 8 and 0.002 0.0411 0.0411
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0014 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0041 0.101 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0013 0.0187 0.0187
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0521 0.0613
Loa Loa (eye worm) hypothetical protein 0.0145 0.4069 0.4069
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0007 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Brugia malayi Dopamine receptor protein 1 0.001 0.0107 0.0126
Schistosoma mansoni RAR-like nuclear receptor 0.0013 0.0187 0.0187
Schistosoma mansoni myosin xvIII 0.001 0.0107 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0773 0.2161
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0107 0.0107
Onchocerca volvulus 0.001 0.0107 0.0249
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0145 0.1254
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0014
Mycobacterium tuberculosis Conserved protein 0.0041 0.101 0.1188
Loa Loa (eye worm) hypothetical protein 0.0011 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.101 0.2205
Toxoplasma gondii thioredoxin reductase 0.0032 0.0759 0.7508
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0187 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1234 0.1234
Brugia malayi Dopamine receptor protein 2 0.001 0.0107 0.0126
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0759 0.0759
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0107 0.0107
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0107 0.0107
Schistosoma mansoni Smad4 0.002 0.0411 0.0411
Echinococcus granulosus importin subunit beta 1 0.0033 0.0773 0.0773
Echinococcus multilocularis bloom syndrome protein 0.0013 0.0197 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.0187 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0145 0.1254
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0032 0.0759 0.0843
Trichomonas vaginalis ran, putative 0.0024 0.0521 0.5161
Schistosoma mansoni hypothetical protein 0.001 0.0107 0.0107
Mycobacterium tuberculosis Probable dehydrogenase 0.0073 0.1961 0.2494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1234 0.1234
Echinococcus granulosus allatostatin A receptor 0.001 0.0107 0.0107
Brugia malayi follicle stimulating hormone receptor 0.001 0.0107 0.0126
Brugia malayi hypothetical protein 0.001 0.0107 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.101 1
Onchocerca volvulus 0.001 0.0107 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0107 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0013 0.0187 0.0187
Schistosoma mansoni opsin-like receptor 0.001 0.0107 0.0107
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0521 1
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.101 0.2823
Brugia malayi MH2 domain containing protein 0.0296 0.8501 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0009 0.0084 0.0084
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0107 0.0107
Schistosoma mansoni neuropeptide receptor 0.001 0.0107 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0107 0.0126
Leishmania major GTP-binding protein, putative 0.0024 0.0521 0.5161
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0107 0.0107
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0107 0.0249
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0107 0.0249
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1234 0.1234
Entamoeba histolytica recQ family helicase, putative 0.0007 0.0021 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0107 0.0107
Onchocerca volvulus 0.0041 0.101 1
Brugia malayi neuropeptide F receptor 0.001 0.0107 0.0126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0107 0.0107
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0107 0.0107
Echinococcus multilocularis thyroid hormone receptor alpha 0.0013 0.0187 0.0187
Plasmodium vivax importin-beta 2, putative 0.0033 0.0773 0.7653

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0031 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717
IC50 (binding) = 0.0031 uM Inhibitory effect on Chemokine binding to C-C chemokine receptor type 5 using [125I]-RANTES ChEMBL. 10821717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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