TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.357 | Formula: C13H21N2O2PS
H donors: 3 H acceptors: 2 LogP: -0.75 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(P(=O)(C(=S)NCCc1ccccc1)O)N
InChi: 1S/C13H21N2O2PS/c1-2-6-12(14)18(16,17)13(19)15-10-9-11-7-4-3-5-8-11/h3-5,7-8,12H,2,6,9-10,14H2,1H3,(H,15,19)(H,16,17)
InChiKey: LQIWHBSGUQTHAU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Aminopeptidase N	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127217	All targets in OG5_127217
Loa Loa (eye worm)	peptidase family M1 containing protein	Get druggable targets OG5_127217	All targets in OG5_127217
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127217	All targets in OG5_127217
Onchocerca volvulus		Get druggable targets OG5_127217	All targets in OG5_127217
Schistosoma japonicum	ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative	Get druggable targets OG5_127217	All targets in OG5_127217
Brugia malayi	Peptidase family M1 containing protein	Get druggable targets OG5_127217	All targets in OG5_127217
Echinococcus multilocularis	aminopeptidase N	Get druggable targets OG5_127217	All targets in OG5_127217
Echinococcus granulosus	aminopeptidase N	Get druggable targets OG5_127217	All targets in OG5_127217

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	981 aa	29.2 %
Echinococcus granulosus	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	975 aa	29.1 %
Onchocerca volvulus		Aminopeptidase N	963 aa	893 aa	32.0 %
Echinococcus multilocularis	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	988 aa	28.5 %
Echinococcus multilocularis	puromycin sensitive aminopeptidase	Aminopeptidase N	963 aa	981 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyroid hormone receptor	0.0556	0.2502	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0321	0.1368	0.2946
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0068	0.0148	0.0202
Onchocerca volvulus		0.0042	0.0023	0.0029
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0019	0.0026
Schistosoma mansoni	tar DNA-binding protein	0.0599	0.2713	0.3704
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0019	0.0038
Trypanosoma brucei	Aminopeptidase M1, putative	0.0042	0.0023	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0307	0.066
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0189	0.0259
Schistosoma mansoni	transcription factor LCR-F1	0.0411	0.1804	0.2463
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0041	0.0019	0.0038
Leishmania major	mitochondrial DNA polymerase beta	0.0356	0.1537	1
Brugia malayi	Peptidase family M1 containing protein	0.0143	0.0511	0.1098
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0189	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0041	0.0019	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0129	0.0442	0.277
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0439	0.0944
Schistosoma mansoni	intermediate filament proteins	0.0287	0.1207	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0464	0.0997
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0041	0.0019	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.033	0.1413	0.9182
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0168	0.0632	0.4054
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0048	0.0053	0.0217
Trypanosoma brucei	DNA polymerase IV, putative	0.0048	0.0053	0.0247
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0019	0.0026
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Leishmania major	cathepsin L-like protease	0.0129	0.0442	0.277
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Echinococcus granulosus	smad	0.0068	0.0148	0.0202
Echinococcus multilocularis	dna polymerase kappa	0.0048	0.0053	0.0073
Schistosoma mansoni	tar DNA-binding protein	0.0599	0.2713	0.3704
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0189	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0129	0.0442	0.277
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0464	0.0997
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0019	0.0038
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.005	0.0061	0.0299
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0041	0.0019	0.0026
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0149	0.054	0.0737
Schistosoma mansoni	cellular tumor antigen P53	0.021	0.0833	0.1137
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0019	0.0038
Brugia malayi	Smad1	0.0068	0.0148	0.0316
Onchocerca volvulus		0.0143	0.0511	0.3526
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0041	0.0019	0.0026
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.033	0.1413	0.3044
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0139	0.0489	0.0668
Echinococcus multilocularis	GPCR, family 2	0.0148	0.0536	0.0732
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0149	0.054	0.29
Brugia malayi	intermediate filament protein	0.0287	0.1207	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0042	0.0023	0.0031
Echinococcus multilocularis	Smad4	0.0068	0.0148	0.0202
Loa Loa (eye worm)	hypothetical protein	0.033	0.1413	0.3044
Schistosoma mansoni	microtubule-associated protein tau	0.1555	0.7325	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0041	0.0019	0.0026
Echinococcus granulosus	GPCR family 2	0.0148	0.0536	0.0732
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.033	0.1413	0.136
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0139	0.0489	0.0668
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0556	0.2502	0.3416
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0222	0.0475
Schistosoma mansoni	retinoic acid receptor RXR	0.0041	0.0019	0.0026
Brugia malayi	Probable ClpP-like protease	0.0077	0.0189	0.0406
Mycobacterium ulcerans	hypothetical protein	0.033	0.1413	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0356	0.1537	1
Mycobacterium ulcerans	glutaminase	0.0296	0.1247	0.8805
Echinococcus granulosus	tumor protein p63	0.1434	0.6743	0.9205
Entamoeba histolytica	hypothetical protein	0.0411	0.1804	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0116	0.0379	0.0814
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0019	0.0026
Trypanosoma brucei	Aminopeptidase M1, putative	0.0042	0.0023	0.0049
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0189	0.0943
Brugia malayi	MH2 domain containing protein	0.0068	0.0148	0.0316
Loa Loa (eye worm)	MH1 domain-containing protein	0.0068	0.0148	0.0316
Loa Loa (eye worm)	hypothetical protein	0.033	0.1413	0.3044
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0041	0.0019	0.0026
Onchocerca volvulus		0.0287	0.1207	0.852
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0356	0.1537	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0048	0.0053	0.0217
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.033	0.1413	0.136
Schistosoma mansoni	smad1 5 8 and	0.0068	0.0148	0.0202
Leishmania major	hypothetical protein, conserved	0.0083	0.0222	0.1313
Brugia malayi	MH1 domain containing protein	0.0068	0.0148	0.0316
Loa Loa (eye worm)	hypothetical protein	0.033	0.1413	0.3044
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0149	0.054	0.3412
Loa Loa (eye worm)	hypothetical protein	0.021	0.0833	0.1793
Echinococcus granulosus	lamin	0.0287	0.1207	0.1647
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0053	0.0199
Plasmodium vivax	hypothetical protein, conserved	0.033	0.1413	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0041	0.0019	0.0038
Echinococcus granulosus	aminopeptidase N	0.0143	0.0511	0.0697
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0411	0.1804	0.2463
Echinococcus multilocularis	smad	0.0068	0.0148	0.0202
Schistosoma mansoni	hypothetical protein	0.0148	0.0536	0.0732
Leishmania major	cathepsin L-like protease	0.0129	0.0442	0.277
Echinococcus multilocularis	microtubule associated protein 2	0.1555	0.7325	1
Schistosoma mansoni	hypothetical protein	0.0411	0.1804	0.2463
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0149	0.054	0.1161
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0041	0.0019	0.0038
Loa Loa (eye worm)	MH2 domain-containing protein	0.0068	0.0148	0.0316
Mycobacterium leprae	conserved hypothetical protein	0.033	0.1413	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0148	0.0536	0.1153
Echinococcus granulosus	microtubule associated protein 2	0.1555	0.7325	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Echinococcus granulosus	tar DNA binding protein	0.0599	0.2713	0.3704
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0062	0.0085
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.033	0.1413	0.1929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Trichomonas vaginalis	glutaminase, putative	0.0296	0.1247	0.8805
Brugia malayi	steroid hormone receptor	0.0041	0.0019	0.0038
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0041	0.0019	0.0026
Trichomonas vaginalis	penicillin-binding protein, putative	0.033	0.1413	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0154	0.0563	0.1211
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0148	0.0536	0.0732
Mycobacterium tuberculosis	Conserved protein	0.033	0.1413	0.136
Brugia malayi	beta-lactamase family protein	0.033	0.1413	0.3044
Trypanosoma cruzi	hypothetical protein, conserved	0.033	0.1413	0.9182
Trypanosoma cruzi	PAB1-binding protein , putative	0.0083	0.0222	0.1313
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0514	0.2303	0.3144
Brugia malayi	TAR-binding protein	0.0599	0.2713	0.5847
Loa Loa (eye worm)	beta-lactamase	0.033	0.1413	0.3044
Brugia malayi	Latrophilin receptor protein 2	0.0148	0.0536	0.1153
Brugia malayi	hypothetical protein	0.0083	0.0222	0.0475
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.005	0.0061	0.0251
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0189	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0469	0.2084	0.4491
Schistosoma mansoni	smad1 5 8 and	0.0068	0.0148	0.0202
Echinococcus granulosus	dna polymerase kappa	0.0048	0.0053	0.0073
Onchocerca volvulus		0.033	0.1413	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0068	0.0148	0.0202
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0149	0.054	0.3445
Echinococcus granulosus	ecdysone induced protein 78C	0.0041	0.0019	0.0026
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0356	0.1537	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0189	0.0406
Echinococcus multilocularis	tar DNA binding protein	0.0599	0.2713	0.3704
Schistosoma mansoni	lamin	0.0287	0.1207	0.1647
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0041	0.0019	0.0026
Trichomonas vaginalis	penicillin-binding protein, putative	0.033	0.1413	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0041	0.0019	0.0038
Loa Loa (eye worm)	intermediate filament protein	0.0287	0.1207	0.2599
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0149	0.054	0.3412
Brugia malayi	beta-lactamase	0.033	0.1413	0.3044
Trypanosoma cruzi	cysteine peptidase, putative	0.0129	0.0442	0.277
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Entamoeba histolytica	hypothetical protein	0.0411	0.1804	1
Brugia malayi	MH2 domain containing protein	0.0068	0.0148	0.0316
Mycobacterium tuberculosis	Probable hydrolase	0.033	0.1413	0.136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0053	0.0199
Loa Loa (eye worm)	aminopeptidase N	0.0042	0.0023	0.0047
Loa Loa (eye worm)	glutaminase	0.0296	0.1247	0.2686
Schistosoma mansoni	hypothetical protein	0.0148	0.0536	0.0732
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0041	0.0019	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0148	0.0536	0.1153
Echinococcus multilocularis	aminopeptidase N	0.0143	0.0511	0.0697
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.033	0.1413	1
Echinococcus multilocularis	transcription factor Dp 1	0.0086	0.0236	0.0323
Trypanosoma brucei	PAB1-binding protein , putative	0.0083	0.0222	0.1355
Schistosoma mansoni	Smad4	0.0068	0.0148	0.0202
Onchocerca volvulus		0.033	0.1413	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0053	0.0199
Schistosoma mansoni	smad1 5 8 and	0.0068	0.0148	0.0202
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Brugia malayi	Peptidase family M1 containing protein	0.0042	0.0023	0.0047
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0041	0.0019	0.0038
Trichomonas vaginalis	esterase, putative	0.033	0.1413	1
Echinococcus multilocularis	tumor protein p63	0.1434	0.6743	0.9205
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0041	0.0019	0.0026
Schistosoma mansoni	hypothetical protein	0.0148	0.0536	0.0732
Brugia malayi	glutaminase DH11.1	0.0296	0.1247	0.2686
Mycobacterium ulcerans	DNA polymerase IV	0.0048	0.0053	0.0217
Leishmania major	hypothetical protein, conserved	0.033	0.1413	0.9182
Schistosoma mansoni	tar DNA-binding protein	0.0599	0.2713	0.3704
Brugia malayi	photoreceptor-specific nuclear receptor	0.0041	0.0019	0.0038
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0053	0.0199
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0068	0.0148	0.0202
Brugia malayi	hypothetical protein	0.0042	0.0023	0.0047
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.033	0.1413	0.3044
Mycobacterium tuberculosis	Probable esterase LipL	0.033	0.1413	0.136
Trypanosoma cruzi	major cysteine proteinase, putative	0.0101	0.0309	0.1889
Entamoeba histolytica	hypothetical protein	0.0411	0.1804	1
Loa Loa (eye worm)	glutaminase 2	0.0296	0.1247	0.2686
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0019	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Echinococcus multilocularis	beta LACTamase domain containing family member	0.033	0.1413	0.1929
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0469	0.2084	0.4491
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.005	0.0061	0.0251
Leishmania major	cathepsin L-like protease	0.0129	0.0442	0.277
Mycobacterium ulcerans	esterase/lipase LipP	0.033	0.1413	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0019	0.0038
Brugia malayi	MH2 domain containing protein	0.0998	0.4639	1
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0489	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0282	0.1181	0.2544
Echinococcus multilocularis	lamin dm0	0.0287	0.1207	0.1647
Loa Loa (eye worm)	hypothetical protein	0.033	0.1413	0.3044
Loa Loa (eye worm)	hypothetical protein	0.033	0.1413	0.3044
Schistosoma mansoni	tar DNA-binding protein	0.0599	0.2713	0.3704
Echinococcus granulosus	intermediate filament protein	0.0287	0.1207	0.1647
Mycobacterium tuberculosis	Conserved protein	0.033	0.1413	0.136
Onchocerca volvulus		0.0287	0.1207	0.852
Mycobacterium tuberculosis	Probable lipase LipD	0.033	0.1413	0.136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Brugia malayi	RNA recognition motif domain containing protein	0.0599	0.2713	0.5847
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Brugia malayi	cytoplasmic intermediate filament protein	0.0154	0.0563	0.1211
Mycobacterium ulcerans	DNA polymerase IV	0.0048	0.0053	0.0217
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0149	0.054	0.0737
Echinococcus multilocularis	lamin	0.0287	0.1207	0.1647
Brugia malayi	MH1 domain containing protein	0.0068	0.0148	0.0316
Loa Loa (eye worm)	steroid hormone receptor	0.0041	0.0019	0.0038
Schistosoma mansoni	thyroid hormone receptor	0.0556	0.2502	0.3416
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0168	0.0632	0.4025
Trichomonas vaginalis	D-aminoacylase, putative	0.033	0.1413	1
Brugia malayi	Steroid receptor seven-up type 2	0.0041	0.0019	0.0038
Loa Loa (eye worm)	hypothetical protein	0.033	0.1413	0.3044
Echinococcus multilocularis	ecdysone induced protein 78C	0.0041	0.0019	0.0026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0061	0.0114	0.06
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0149	0.054	0.0737
Echinococcus granulosus	lamin dm0	0.0287	0.1207	0.1647
Echinococcus granulosus	mothers against decapentaplegic 5	0.0068	0.0148	0.0202
Brugia malayi	beta-lactamase family protein	0.033	0.1413	0.3044
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0187	0.0724	0.0666
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0042	0.0023	0.0031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Echinococcus granulosus	transcription factor Dp 1	0.0086	0.0236	0.0323
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0041	0.0019	0.0026
Mycobacterium tuberculosis	Conserved protein	0.033	0.1413	0.136
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0287	0.1207	0.2599
Loa Loa (eye worm)	MH2 domain-containing protein	0.0998	0.4639	1
Loa Loa (eye worm)	hypothetical protein	0.0287	0.1207	0.2599
Trypanosoma brucei	DNA polymerase IV, putative	0.0048	0.0053	0.0247
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0053	0.0247
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.033	0.1413	0.136
Loa Loa (eye worm)	TAR-binding protein	0.0599	0.2713	0.5847
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0041	0.0019	0.0026
Brugia malayi	nuclear hormone receptor	0.0041	0.0019	0.0038
Brugia malayi	latrophilin 2 splice variant baaae	0.0321	0.1368	0.2946
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0041	0.0019	0.0026
Schistosoma mansoni	hypothetical protein	0.0514	0.2303	0.3144
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0514	0.2303	0.3144
Echinococcus multilocularis	musashi	0.0287	0.1207	0.1647
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0189	0.0705
Mycobacterium leprae	Probable lipase LipE	0.033	0.1413	1
Onchocerca volvulus		0.033	0.1413	1
Schistosoma mansoni	tar DNA-binding protein	0.0599	0.2713	0.3704
Schistosoma mansoni	hypothetical protein	0.0148	0.0536	0.0732
Loa Loa (eye worm)	Smad1	0.0068	0.0148	0.0316
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0149	0.054	0.3412
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0148	0.0536	0.0732
Schistosoma mansoni	RAR-like nuclear receptor	0.0041	0.0019	0.0026
Schistosoma mansoni	coup transcription factor	0.0041	0.0019	0.0026
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0041	0.0019	0.0038
Brugia malayi	hypothetical protein	0.0054	0.0079	0.0168
Echinococcus granulosus	Smad4	0.0068	0.0148	0.0202
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0041	0.0019	0.0026
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0148	0.0536	0.0732
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0041	0.0019	0.0038
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0189	0.5
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0062	0.0085
Schistosoma mansoni	glutaminase	0.0296	0.1247	0.1702
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0061	0.0251
Schistosoma mansoni	smad	0.0068	0.0148	0.0202
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0041	0.0019	0.0038
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0019	0.0038
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0189	0.0259
Trichomonas vaginalis	D-aminoacylase, putative	0.033	0.1413	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0019	0.0038
Brugia malayi	hypothetical protein	0.0411	0.1804	0.3888
Mycobacterium tuberculosis	Probable lipase LipE	0.033	0.1413	0.136
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0469	0.2084	0.4491
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0041	0.0019	0.0038
Loa Loa (eye worm)	RNA binding protein	0.0599	0.2713	0.5847
Brugia malayi	Intermediate filament tail domain containing protein	0.0287	0.1207	0.2599
Trypanosoma cruzi	PAB1-binding protein , putative	0.0083	0.0222	0.1313
Trypanosoma cruzi	cruzipain precursor, putative	0.0129	0.0442	0.277
Entamoeba histolytica	hypothetical protein	0.0411	0.1804	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0148	0.0536	0.0732
Onchocerca volvulus		0.021	0.0833	0.5839
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0149	0.054	0.1161
Echinococcus multilocularis	FTZ F1 alpha	0.0041	0.0019	0.0026
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0118	0.0388	0.2413
Toxoplasma gondii	LsmAD domain-containing protein	0.0083	0.0222	0.0951
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0189	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0536	0.1153
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0189	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0041	0.0019	0.0026
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.0023	0.0031
Brugia malayi	ecdysteroid receptor	0.0041	0.0019	0.0038
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0189	0.0705
Echinococcus granulosus	FTZ F1 alpha	0.0041	0.0019	0.0026
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0041	0.0019	0.0026
Plasmodium falciparum	ataxin-2 like protein, putative	0.0083	0.0222	1
Trichomonas vaginalis	D-aminoacylase, putative	0.033	0.1413	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0019	0.0026
Plasmodium vivax	ataxin-2 like protein, putative	0.0083	0.0222	0.0265
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0042	0.0023	0.0049
Toxoplasma gondii	ABC1 family protein	0.033	0.1413	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0041	0.0019	0.0038
Schistosoma mansoni	hypothetical protein	0.0321	0.1368	0.1867
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0041	0.0019	0.0026
Loa Loa (eye worm)	transcription factor SMAD2	0.0998	0.4639	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0129	0.0442	0.2805
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0599	0.2713	0.5847
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0019	0.0026
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0469	0.2084	0.4491
Echinococcus granulosus	beta LACTamase domain containing family member	0.033	0.1413	0.1929
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0068	0.0148	0.0202
Brugia malayi	RNA binding protein	0.0599	0.2713	0.5847
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.0019	0.0026
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0041	0.0019	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Plasmodium falciparum	ataxin-2 like protein, putative	0.0083	0.0222	1
Brugia malayi	nuclear receptor NHR-88	0.0041	0.0019	0.0038
Mycobacterium ulcerans	hypothetical protein	0.0187	0.0724	0.5044
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0019	0.0038
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0042	0.0023	0.0031
Mycobacterium ulcerans	lipase LipD	0.033	0.1413	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0041	0.0019	0.0038
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.0189	0.0259
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0411	0.1804	0.2463
Trypanosoma brucei	hypothetical protein, conserved	0.033	0.1413	0.9186
Schistosoma mansoni	lamin	0.0287	0.1207	0.1647
Mycobacterium ulcerans	beta-lactamase	0.033	0.1413	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.033	0.1413	0.1929
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0168	0.0632	0.4025

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.28 uM	Inhibition of pig kidney aminopeptidase N	ChEMBL.	18524593
INH (binding)	= 1.35 uM	Inhibition of pig aminopeptidase N assessed as ACC fluorophore released after 30 mins using Alanine ACC as substrate	ChEMBL.	20307982
INH (binding)	= 2.55 uM	Inhibition of rat aminopeptidase N assessed as ACC fluorophore released after 30 mins using Alanine ACC as substrate	ChEMBL.	20307982
INH (binding)	= 3.6 uM	Inhibition of human aminopeptidase N assessed as ACC fluorophore released after 30 mins using Alanine ACC as substrate	ChEMBL.	20307982

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL511878

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1007050