TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.237 | Formula: C19H14BrN3O3
H donors: 2 H acceptors: 5 LogP: 3.49 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccc2c(c1)c(ncn2)Nc1cccc(c1)Br)/C=C/C(=O)O
InChi: 1S/C19H14BrN3O3/c20-13-2-1-3-14(10-13)23-19-16-9-12(4-6-17(16)21-11-22-19)8-15(24)5-7-18(25)26/h1-7,9-11H,8H2,(H,25,26)(H,21,22,23)/b7-5+
InChiKey: NVSHPIRDGRDDOB-FNORWQNLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	alpha tubulin	0.0426	0.7762	0.7762
Echinococcus granulosus	Tubulin beta 2C chain	0.0533	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0426	0.7762	0.7762
Loa Loa (eye worm)	tubulin beta chain	0.0533	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0426	0.7762	0.7363
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Plasmodium falciparum	tubulin gamma chain	0.0298	0.5068	0.4188
Trichomonas vaginalis	tubulin beta chain, putative	0.0169	0.2342	0.0974
Trypanosoma brucei	beta tubulin	0.0533	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Loa Loa (eye worm)	tubulin beta chain	0.013	0.1515	0.1515
Schistosoma mansoni	alpha tubulin	0.0426	0.7762	0.7762
Loa Loa (eye worm)	alpha-tubulin	0.0426	0.7762	0.7762
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0426	0.7762	0.7363
Brugia malayi	Cell division protein ftsZ	0.013	0.1515	0.1515
Schistosoma mansoni	tubulin subunit beta	0.0533	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0297	0.5036	0.5036
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Echinococcus granulosus	tubulin subunit TubB	0.0426	0.7762	0.7762
Loa Loa (eye worm)	tubulin alpha 2	0.0297	0.5036	0.5036
Echinococcus multilocularis	Tubulin beta 2C chain	0.0533	1	1
Echinococcus granulosus	tubulin alpha chain	0.0426	0.7762	0.7762
Trypanosoma brucei	beta tubulin	0.0533	1	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.0804	0.0804
Trichomonas vaginalis	tubulin, putative	0.0533	1	1
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Schistosoma mansoni	tyrosine kinase	0.0097	0.0826	0.0826
Brugia malayi	Tubulin alpha-2 chain	0.0426	0.7762	0.7762
Schistosoma mansoni	tubulin subunit beta	0.0533	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.013	0.1515	0.5
Trypanosoma brucei	tubulin gamma chain	0.0298	0.5068	0.4188
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0533	1	1
Echinococcus multilocularis	tubulin alpha	0.0298	0.5068	0.5068
Echinococcus granulosus	tubulin beta 4A class IVa	0.0533	1	1
Giardia lamblia	Beta tubulin	0.0533	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0426	0.7762	0.7363
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.258	0.258
Plasmodium vivax	tubulin alpha chain, putative	0.0426	0.7762	0.7363
Echinococcus granulosus	tubulin alpha 3 chain	0.0426	0.7762	0.7762
Brugia malayi	Tubulin alpha chain	0.013	0.1515	0.1515
Entamoeba histolytica	tubulin alpha-1 chain	0.0426	0.7762	0.5463
Echinococcus multilocularis	tubulin alpha 1C chain	0.0426	0.7762	0.7762
Echinococcus multilocularis	tubulin alpha 3 chain	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Brugia malayi	alpha-tubulin	0.0426	0.7762	0.7762
Trichomonas vaginalis	tubulin beta chain, putative	0.0426	0.7762	0.7363
Trypanosoma brucei	beta tubulin	0.0533	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0426	0.7762	0.7363
Echinococcus granulosus	tubulin alpha 3 chain	0.0426	0.7762	0.7762
Echinococcus multilocularis	tubulin subunit beta	0.0533	1	1
Leishmania major	beta tubulin	0.0533	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.258	0.258
Brugia malayi	Tubulin beta chain	0.0169	0.2342	0.2342
Echinococcus granulosus	tubulin alpha 1C chain	0.0426	0.7762	0.7762
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0297	0.5036	0.5036
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.0826	0.0826
Leishmania major	beta tubulin	0.0533	1	1
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.0826	0.0826
Echinococcus multilocularis	tubulin alpha chain	0.0426	0.7762	0.7762
Giardia lamblia	Alpha-tubulin	0.0426	0.7762	0.7363
Giardia lamblia	Gamma tubulin	0.0298	0.5068	0.4188
Leishmania major	gamma-tubulin	0.0298	0.5068	0.4188
Giardia lamblia	Beta tubulin	0.0533	1	1
Brugia malayi	Tubulin beta chain	0.013	0.1515	0.1515
Brugia malayi	beta-tubulin, identical	0.0533	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0533	1	1
Echinococcus granulosus	beta tubulin	0.0533	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0426	0.7762	0.5463
Trichomonas vaginalis	tubulin alpha chain, putative	0.0533	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.013	0.1515	0.5
Toxoplasma gondii	alpha tubulin TUBA1	0.0426	0.7762	0.7363
Loa Loa (eye worm)	hypothetical protein	0.0426	0.7762	0.7762
Trypanosoma brucei	alpha tubulin	0.0426	0.7762	0.7363
Brugia malayi	Tubulin alpha-2 chain	0.0426	0.7762	0.7762
Echinococcus granulosus	tubulin alpha chain	0.0426	0.7762	0.7762
Echinococcus multilocularis	peroxisome assembly protein 26	0.0426	0.7762	0.7762
Echinococcus multilocularis	hypothetical protein	0.0426	0.7762	0.7762
Echinococcus granulosus	Tubulin alpha 1 chain	0.0426	0.7762	0.7762
Schistosoma mansoni	tubulin subunit delta	0.013	0.1515	0.1515
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0533	1	1
Echinococcus granulosus	beta tubulin	0.0533	1	1
Echinococcus granulosus	tubulin alpha chain	0.0426	0.7762	0.7762
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0258	0.4209	0.3175
Echinococcus multilocularis	tubulin alpha chain	0.0426	0.7762	0.7762
Plasmodium vivax	tubulin epsilon chain, putative	0.0298	0.5068	0.4188
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0169	0.2342	0.0974
Brugia malayi	Tubulin gamma chain	0.0298	0.5068	0.5068
Trypanosoma brucei	alpha tubulin	0.0426	0.7762	0.7363
Loa Loa (eye worm)	tubulin alpha 2	0.0128	0.1483	0.1483
Trichomonas vaginalis	tubulin alpha chain, putative	0.0298	0.5068	0.4188
Schistosoma mansoni	tyrosine kinase	0.0096	0.0804	0.0804
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.0826	0.0826
Echinococcus granulosus	tubulin gamma 1 chain	0.0298	0.5068	0.5068
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0297	0.5036	0.4149
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Trypanosoma brucei	alpha tubulin	0.0426	0.7762	0.7363
Echinococcus granulosus	tubulin beta 1 chain	0.0533	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0426	0.7762	0.7762
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Echinococcus multilocularis	tubulin alpha chain	0.0426	0.7762	0.7762
Echinococcus granulosus	tubulin alpha 1C chain	0.0426	0.7762	0.7762
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0426	0.7762	0.7762
Trichomonas vaginalis	tubulin beta chain, putative	0.0426	0.7762	0.7363
Loa Loa (eye worm)	hypothetical protein	0.0258	0.4209	0.4209
Loa Loa (eye worm)	BEN-1 protein	0.0533	1	1
Echinococcus granulosus	tubulin alpha chain	0.0426	0.7762	0.7762
Trypanosoma cruzi	alpha tubulin, putative	0.0426	0.7762	0.7363
Loa Loa (eye worm)	tubulin alpha chain	0.0426	0.7762	0.7762
Brugia malayi	tubulin alpha chain - mouse	0.0426	0.7762	0.7762
Schistosoma mansoni	tubulin subunit beta	0.0533	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0298	0.5068	0.5068
Loa Loa (eye worm)	BEN-1 protein	0.0533	1	1
Onchocerca volvulus		0.0169	0.2342	0.5
Trypanosoma brucei	beta tubulin	0.0298	0.5068	0.4188
Echinococcus granulosus	tubulin delta chain	0.013	0.1515	0.1515
Trichomonas vaginalis	tubulin, putative	0.0169	0.2342	0.0974
Leishmania major	beta tubulin	0.0533	1	1
Leishmania major	beta tubulin	0.0533	1	1
Toxoplasma gondii	beta tubulin	0.0533	1	1
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Schistosoma mansoni	tyrosine kinase	0.0096	0.0804	0.0804
Leishmania major	beta tubulin	0.0533	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Loa Loa (eye worm)	tubulin beta-2A chain	0.0533	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0533	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0298	0.5068	0.4188
Schistosoma mansoni	tubulin subunit beta	0.0533	1	1
Echinococcus multilocularis	beta tubulin	0.0533	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0533	1	1
Schistosoma mansoni	tyrosine kinase	0.018	0.258	0.258
Plasmodium vivax	tubulin alpha chain, putative	0.0426	0.7762	0.7363
Trypanosoma brucei	epsilon tubulin	0.0298	0.5068	0.4188
Echinococcus multilocularis	tubulin alpha 1C chain	0.0426	0.7762	0.7762
Echinococcus multilocularis	tubulin subunit TubB	0.0426	0.7762	0.7762
Schistosoma mansoni	tubulin subunit beta	0.0533	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0426	0.7762	0.7762
Echinococcus multilocularis	Tubulin beta 2C chain	0.0533	1	1
Loa Loa (eye worm)	beta-tubulin	0.0533	1	1
Leishmania major	beta tubulin	0.0533	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.258	0.258
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0426	0.7762	0.7363
Leishmania major	beta tubulin	0.0533	1	1
Echinococcus granulosus	tubulin epsilon chain	0.0298	0.5068	0.5068
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0258	0.4209	0.4209
Leishmania major	epsilon tubulin, putative	0.0298	0.5068	0.4188
Echinococcus multilocularis	tubulin delta chain	0.013	0.1515	0.1515
Entamoeba histolytica	tubulin family protein	0.0533	1	1
Leishmania major	beta tubulin	0.0533	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0533	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0426	0.7762	0.7762
Schistosoma mansoni	tyrosine kinase	0.0097	0.0826	0.0826
Toxoplasma gondii	alpha-tubulin I, putative	0.0426	0.7762	0.7363
Plasmodium falciparum	alpha tubulin 1	0.0426	0.7762	0.7363
Trichomonas vaginalis	tubulin gamma chain, putative	0.0533	1	1
Schistosoma mansoni	tubulin subunit beta	0.0533	1	1
Schistosoma mansoni	alpha tubulin	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0426	0.7762	0.7762
Toxoplasma gondii	beta-1 tubulin, putative	0.0533	1	1
Schistosoma mansoni	tubulin subunit alpha	0.013	0.1515	0.1515
Plasmodium vivax	tubulin gamma chain, putative	0.0298	0.5068	0.4188
Leishmania major	beta tubulin	0.0533	1	1
Schistosoma mansoni	tubulin subunit gamma	0.0298	0.5068	0.5068
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Echinococcus granulosus	alpha tubulin	0.0426	0.7762	0.7762
Echinococcus multilocularis	tubulin gamma 1 chain	0.0298	0.5068	0.5068
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0426	0.7762	0.7762
Trypanosoma brucei	beta tubulin	0.0533	1	1
Plasmodium falciparum	alpha tubulin 2	0.0426	0.7762	0.7363
Trichomonas vaginalis	tubulin gamma chain, putative	0.0298	0.5068	0.4188
Brugia malayi	tubulin alpha-2 chain	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0298	0.5068	0.5068
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0426	0.7762	0.7762
Schistosoma mansoni	tubulin subunit epsilon	0.0298	0.5068	0.5068
Leishmania major	beta tubulin	0.0533	1	1
Trypanosoma cruzi	beta tubulin, putative	0.0533	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0533	1	1
Giardia lamblia	Beta tubulin	0.0533	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0533	1	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.013	0.1515	0.5
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0298	0.5068	0.4188
Echinococcus granulosus	Tubulin beta 2C chain	0.0533	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0533	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0533	1	1
Echinococcus multilocularis	beta tubulin	0.0533	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0533	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0169	0.2342	0.0974
Echinococcus granulosus	Tubulin alpha 1 chain	0.0426	0.7762	0.7762
Mycobacterium leprae	cell division protein FtsZ	0.013	0.1515	0.5
Echinococcus granulosus	tubulin alpha chain	0.0426	0.7762	0.7762
Trichomonas vaginalis	tubulin alpha chain, putative	0.0169	0.2342	0.0974
Brugia malayi	Tubulin alpha chain	0.0426	0.7762	0.7762
Echinococcus multilocularis	Tubulin beta 2C chain	0.0533	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0298	0.5068	0.4188
Trichomonas vaginalis	tubulin beta chain, putative	0.0426	0.7762	0.7363
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0426	0.7762	0.7762
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.258	0.258
Trypanosoma brucei	epsilon tubulin	0.0298	0.5068	0.4188
Leishmania major	beta tubulin	0.0533	1	1
Entamoeba histolytica	tubulin family protein	0.0533	1	1
Trypanosoma brucei	alpha tubulin, putative	0.0169	0.2342	0.0974
Plasmodium falciparum	tubulin beta chain	0.0533	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0169	0.2342	0.0974
Echinococcus multilocularis	tubulin alpha chain	0.0426	0.7762	0.7762
Leishmania major	beta tubulin	0.0533	1	1
Treponema pallidum	cell division protein FtsZ	0.013	0.1515	0.5
Trichomonas vaginalis	tubulin, putative	0.0169	0.2342	0.0974
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Plasmodium falciparum	tubulin epsilon chain, putative	0.0298	0.5068	0.4188
Trichomonas vaginalis	tubulin gamma chain, putative	0.0298	0.5068	0.4188
Leishmania major	alpha tubulin	0.0426	0.7762	0.7363
Trypanosoma brucei	alpha tubulin	0.0426	0.7762	0.7363
Echinococcus granulosus	tubulin subunit beta	0.0533	1	1
Schistosoma mansoni	tubulin subunit beta	0.013	0.1515	0.1515
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0426	0.7762	0.7363
Echinococcus multilocularis	tubulin alpha chain	0.0426	0.7762	0.7762
Toxoplasma gondii	beta-tubulin, putative	0.0533	1	1
Trypanosoma brucei	epsilon tubulin	0.0298	0.5068	0.4188
Echinococcus multilocularis	Tubulin beta 2C chain	0.0533	1	1
Giardia lamblia	Alpha-tubulin	0.0426	0.7762	0.7363
Echinococcus granulosus	tubulin alpha	0.0298	0.5068	0.5068
Loa Loa (eye worm)	tubulin beta-1 chain	0.0533	1	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.5036	0.5036
Trypanosoma cruzi	epsilon tubulin, putative	0.0298	0.5068	0.4188

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9.43	Inhibition of human recombinant EGFR	ChEMBL.	19170633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL510396

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1011137