Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.4309 | 0.6674 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0041 | 0.001 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0086 | 0.008 | 0.008 |
Brugia malayi | Pre-SET motif family protein | 0.021 | 0.0274 | 0.0274 |
Echinococcus multilocularis | smad | 0.0086 | 0.008 | 0.0111 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.025 | 0.0244 |
Brugia malayi | MH1 domain containing protein | 0.0086 | 0.008 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.213 | 0.3272 | 0.3268 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.067 | 0.0992 | 0.0992 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0107 | 0.0113 | 0.0108 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.2146 | 0.3297 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.001 | 0.0004 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0038 | 0.0006 | 0.0006 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0041 | 0.001 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0131 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0066 | 0.0049 | 0.1022 | |
Schistosoma mansoni | hypothetical protein | 0.0212 | 0.0277 | 0.0271 |
Brugia malayi | hypothetical protein | 0.0054 | 0.003 | 0.003 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.4309 | 0.6674 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0131 | 0.015 | 1 |
Schistosoma mansoni | Smad4 | 0.0086 | 0.008 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2146 | 0.3297 | 0.3293 |
Echinococcus granulosus | GPCR family 2 | 0.0212 | 0.0277 | 0.0407 |
Loa Loa (eye worm) | nuclear factor I | 0.0048 | 0.002 | 0.0014 |
Echinococcus granulosus | lamin dm0 | 0.0162 | 0.0198 | 0.0289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.025 | 0.0244 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0212 | 0.0277 | 0.0407 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2146 | 0.3297 | 0.3293 |
Trichomonas vaginalis | set domain proteins, putative | 0.0239 | 0.0319 | 0.0208 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0086 | 0.008 | 0.0111 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0009 | 0.0004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.025 | 0.0244 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0086 | 0.008 | 0.0074 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0107 | 0.0113 | 0.0161 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.025 | 0.0244 |
Trichomonas vaginalis | CAMK family protein kinase | 0.4309 | 0.6674 | 0.6636 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0131 | 0.015 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0162 | 0.0198 | 0.0193 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0212 | 0.0277 | 0.0277 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0131 | 0.015 | 1 |
Brugia malayi | MH2 domain containing protein | 0.1262 | 0.1916 | 0.1916 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0086 | 0.008 | 0.0074 |
Echinococcus multilocularis | lamin | 0.0162 | 0.0198 | 0.0289 |
Brugia malayi | Kinase associated domain 1 family protein | 0.213 | 0.3272 | 0.3272 |
Brugia malayi | hypothetical protein | 0.004 | 0.0009 | 0.0009 |
Brugia malayi | MH1 domain containing protein | 0.0048 | 0.002 | 0.002 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0041 | 0.001 | 0.0004 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.2146 | 0.3297 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0194 | 0.0188 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0107 | 0.0113 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.003 | 0.1427 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0041 | 0.001 | 0.0006 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0041 | 0.001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0068 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0212 | 0.0277 | 0.0271 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0107 | 0.0113 | 0.7393 |
Echinococcus granulosus | lamin | 0.0162 | 0.0198 | 0.0289 |
Echinococcus multilocularis | musashi | 0.0162 | 0.0198 | 0.0289 |
Schistosoma mansoni | smad1 5 8 and | 0.0086 | 0.008 | 0.0074 |
Echinococcus granulosus | smad | 0.0086 | 0.008 | 0.0111 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0216 |
Echinococcus multilocularis | calcium activated potassium channel | 0.2146 | 0.3297 | 0.4936 |
Schistosoma mansoni | smad1 5 8 and | 0.0086 | 0.008 | 0.0074 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0041 | 0.001 | 0.0006 |
Brugia malayi | RNA binding protein | 0.0195 | 0.025 | 0.025 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.001 | 0.0004 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0078 | 0.0068 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0063 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.213 | 0.3272 | 0.3268 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2146 | 0.3297 | 0.3293 |
Brugia malayi | MH2 domain containing protein | 0.0086 | 0.008 | 0.008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0195 | 0.025 | 0.0244 |
Onchocerca volvulus | 0.0239 | 0.0319 | 0.7341 | |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0066 | 0.0049 | 0.0044 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0212 | 0.0277 | 0.0407 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0107 | 0.0113 | 0.0108 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2146 | 0.3297 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0198 | 0.0193 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0087 | 0.0081 | 0.0075 |
Echinococcus granulosus | tumor protein p63 | 0.2128 | 0.3269 | 0.4894 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0107 | 0.0113 | 0.0161 |
Echinococcus granulosus | tar DNA binding protein | 0.0195 | 0.025 | 0.0366 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0131 | 0.015 | 1 |
Schistosoma mansoni | lamin | 0.0162 | 0.0198 | 0.0193 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0162 | 0.0198 | 0.0198 |
Schistosoma mansoni | hypothetical protein | 0.0212 | 0.0277 | 0.0271 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0041 | 0.001 | 0.0006 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0131 | 0.015 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.021 | 0.0274 | 0.0268 |
Brugia malayi | Smad1 | 0.0086 | 0.008 | 0.008 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2146 | 0.3297 | 0.3293 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0078 | 0.0068 | 0.0093 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.067 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.0661 | 0.0656 |
Echinococcus multilocularis | tumor protein p63 | 0.2128 | 0.3269 | 0.4894 |
Trichomonas vaginalis | CAMK family protein kinase | 0.6439 | 1 | 1 |
Onchocerca volvulus | 0.0162 | 0.0198 | 0.4518 | |
Schistosoma mansoni | serine/threonine kinase | 0.6439 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0162 | 0.0198 | 0.0193 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0086 | 0.008 | 0.0111 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0107 | 0.0113 | 0.6959 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0041 | 0.001 | 1 |
Brugia malayi | protein ZK524.3 | 0.0041 | 0.001 | 0.001 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2146 | 0.3297 | 0.4936 |
Schistosoma mansoni | hypothetical protein | 0.213 | 0.3272 | 0.3268 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.002 | 0.0014 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0086 | 0.008 | 0.0074 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.133 | 0.2023 | 0.3025 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0277 | 0.0271 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0131 | 0.015 | 0.2209 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0086 | 0.008 | 0.0111 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0458 | 0.0661 | 0.0661 |
Schistosoma mansoni | smad | 0.0086 | 0.008 | 0.0074 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0107 | 0.0113 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0009 | 0.0003 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0086 | 0.008 | 0.0111 |
Trichomonas vaginalis | CAMK family protein kinase | 0.4309 | 0.6674 | 0.6636 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.6439 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0086 | 0.008 | 0.008 |
Echinococcus multilocularis | hypothetical protein | 0.213 | 0.3272 | 0.4898 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0107 | 0.0113 | 0.7393 |
Echinococcus granulosus | Smad4 | 0.0086 | 0.008 | 0.0111 |
Loa Loa (eye worm) | intermediate filament protein | 0.0162 | 0.0198 | 0.0193 |
Loa Loa (eye worm) | Smad1 | 0.0086 | 0.008 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0063 | 0.0057 |
Loa Loa (eye worm) | RNA binding protein | 0.0195 | 0.025 | 0.0244 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0009 | 0.0003 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0009 | 0.0004 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0087 | 0.0081 | 0.0081 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0212 | 0.0277 | 0.0271 |
Schistosoma mansoni | hypothetical protein | 0.0458 | 0.0661 | 0.0656 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0054 | 0.003 | 0.1427 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0054 | 0.003 | 0.1427 |
Schistosoma mansoni | microtubule-associated protein tau | 0.133 | 0.2023 | 0.2018 |
Brugia malayi | MH1 domain containing protein | 0.0048 | 0.002 | 0.002 |
Schistosoma mansoni | lamin | 0.0162 | 0.0198 | 0.0193 |
Echinococcus granulosus | intermediate filament protein | 0.0162 | 0.0198 | 0.0289 |
Brugia malayi | Isocitrate dehydrogenase | 0.0131 | 0.015 | 0.015 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0212 | 0.0277 | 0.0407 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0107 | 0.0113 | 0.7393 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0107 | 0.0113 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.067 | 0.0992 | 0.0987 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0131 | 0.015 | 0.0216 |
Onchocerca volvulus | 0.0162 | 0.0198 | 0.4518 | |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0107 | 0.0113 | 0.6959 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0195 | 0.025 | 0.025 |
Echinococcus granulosus | microtubule associated protein 2 | 0.133 | 0.2023 | 0.3025 |
Brugia malayi | methionyl-tRNA synthetase | 0.0041 | 0.001 | 0.001 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.1262 | 0.1916 | 0.1912 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0131 | 0.015 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0312 | 0.0432 | 0.0427 |
Echinococcus multilocularis | GPCR, family 2 | 0.0212 | 0.0277 | 0.0407 |
Brugia malayi | MH2 domain containing protein | 0.0038 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 0.0432 | 0.0427 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0054 | 0.003 | 0.1427 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0131 | 0.015 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0195 | 0.025 | 0.0244 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0213 | 0.0279 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0131 | 0.015 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0195 | 0.025 | 0.0244 |
Schistosoma mansoni | smad1 5 8 and | 0.0086 | 0.008 | 0.0074 |
Brugia malayi | intermediate filament protein | 0.0162 | 0.0198 | 0.0198 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0131 | 0.015 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0216 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0041 | 0.001 | 0.0004 |
Leishmania major | hypothetical protein, conserved | 0.0054 | 0.003 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.003 | 0.0024 |
Brugia malayi | methionyl-tRNA synthetase | 0.0107 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0212 | 0.0277 | 0.0271 |
Echinococcus granulosus | calcium activated potassium channel | 0.2146 | 0.3297 | 0.4936 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.001 | 0.0004 |
Echinococcus multilocularis | Smad4 | 0.0086 | 0.008 | 0.0111 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0107 | 0.0113 | 0.7393 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0041 | 0.001 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0212 | 0.0277 | 0.0407 |
Onchocerca volvulus | 0.0312 | 0.0432 | 1 | |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0107 | 0.0113 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.1262 | 0.1916 | 0.1912 |
Brugia malayi | TAR-binding protein | 0.0195 | 0.025 | 0.025 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0131 | 0.015 | 0.0216 |
Echinococcus multilocularis | tar DNA binding protein | 0.0195 | 0.025 | 0.0366 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0212 | 0.0277 | 0.0277 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.067 | 0.0992 | 0.0987 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2146 | 0.3297 | 0.3293 |
Echinococcus multilocularis | lamin dm0 | 0.0162 | 0.0198 | 0.0289 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of bovine brain MAOA | ChEMBL. | 18834112 | |
Activity (binding) | Inhibition of bovine brain MAOB | ChEMBL. | 18834112 | |
ED100 (functional) | = 0.21 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 17336532 |
ED50 (functional) | = 0.56 umol/L | Cytotoxicity against human KB cells | ChEMBL. | 18329753 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.