Detailed information for compound 1015083

Basic information

Technical information
  • TDR Targets ID: 1015083
  • Name: 1-(4-fluorophenyl)sulfonyl-N-(5-propan-2-yl-1 ,3,4-thiadiazol-2-yl)pyrrolidine-2-carboxamid e
  • MW: 398.475 | Formula: C16H19FN4O3S2
  • H donors: 1 H acceptors: 5 LogP: 2.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCN1S(=O)(=O)c1ccc(cc1)F)Nc1nnc(s1)C(C)C
  • InChi: 1S/C16H19FN4O3S2/c1-10(2)15-19-20-16(25-15)18-14(22)13-4-3-9-21(13)26(23,24)12-7-5-11(17)6-8-12/h5-8,10,13H,3-4,9H2,1-2H3,(H,18,20,22)
  • InChiKey: ATXSQAJQXNRCIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-fluorophenyl)sulfonyl-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2-carboxamide
  • 1-(4-fluorophenyl)sulfonyl-N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-2-pyrrolidinecarboxamide
  • ASN 06350454

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0369 0.1732
Echinococcus granulosus intermediate filament protein 0.0062 0.0043 0.02
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0374 1
Trypanosoma brucei Polypeptide deformylase 1 0.2618 0.3786 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0051 0.0237
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0051 0.0036
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0001 0.0002
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0015 0.0069
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.2618 0.3786 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0182 0.3764
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Echinococcus granulosus lamin dm0 0.0062 0.0043 0.02
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0001 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0043 0.0015 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0015 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Echinococcus multilocularis musashi 0.0062 0.0043 0.02
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0015 0.0069
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0001 0.0002
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.2618 0.3786 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0031 0.0147
Brugia malayi Matrixin family protein 0.0045 0.0018 0.0468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0001 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0276 0.0355 0.7337
Onchocerca volvulus 0.0062 0.0043 0.1256
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0847
Loa Loa (eye worm) hypothetical protein 0.0045 0.0018 0.0362
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0015 0.0069
Onchocerca volvulus 0.0062 0.0043 0.1256
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0001 0.0013
Entamoeba histolytica hypothetical protein 0.0043 0.0015 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0036 0.0972
Leishmania major polypeptide deformylase-like protein, putative 0.2618 0.3786 1
Onchocerca volvulus 0.0043 0.0015 0.0435
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0292 0.6042
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0051 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0001 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0051 0.0051
Loa Loa (eye worm) matrix metalloproteinase 0.0045 0.0018 0.0362
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0055 0.0257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0001 0.0002
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0045 0.0018 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0001 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.0244 0.6368
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0001 0.0002
Brugia malayi nuclear receptor NHR-88 0.0034 0.0001 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0073 0.0058 0.1199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0031 0.0147
Brugia malayi hypothetical protein 0.0043 0.0015 0.0393
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0305
Brugia malayi beta-lactamase 0.0043 0.0015 0.0394
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0031 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0001 0.0013
Onchocerca volvulus 0.0064 0.0045 0.1334
Brugia malayi Latrophilin receptor protein 2 0.0073 0.0058 0.1549
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0001 0.0013
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.0229 0.6743
Brugia malayi steroid hormone receptor 0.0034 0.0001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0305
Schistosoma mansoni hypothetical protein 0.0073 0.0058 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Echinococcus multilocularis lamin 0.0062 0.0043 0.02
Echinococcus granulosus lamin 0.0062 0.0043 0.02
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.0374 1
Brugia malayi beta-lactamase family protein 0.0043 0.0015 0.0394
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0001 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0001 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0073 0.0058 0.1549
Schistosoma mansoni hypothetical protein 0.0073 0.0058 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0001 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0015 0.0069
Schistosoma mansoni lamin 0.0062 0.0043 0.02
Mycobacterium ulcerans hydrolase 0.0055 0.0032 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0062 0.0043 0.0881
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0043 0.1139
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0001 0.001
Echinococcus multilocularis lamin dm0 0.0062 0.0043 0.02
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0055 0.1135
Loa Loa (eye worm) hypothetical protein 0.0231 0.0289 0.5974
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0001 0.0013
Echinococcus granulosus GPCR family 2 0.0073 0.0058 0.0272
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0374 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0073 0.0058 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.0244 0.6368
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0001 0.0013
Plasmodium falciparum peptide deformylase 0.686 1 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0015 0.0015
Echinococcus granulosus importin subunit beta 1 0.0034 0.0001 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0364 0.0484 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0036 0.0171
Mycobacterium leprae PROBABLE HYDROLASE 0.0055 0.0032 0.0017
Onchocerca volvulus 0.0043 0.0015 0.0435
Entamoeba histolytica hypothetical protein 0.0043 0.0015 0.5
Loa Loa (eye worm) matrixin family protein 0.0101 0.0098 0.2035
Brugia malayi ecdysteroid receptor 0.0034 0.0001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0305
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0305
Brugia malayi Importin beta-1 subunit 0.0034 0.0001 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0001 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0374 1
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0055 0.1466
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0001 0.0013
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0001 0.0004
Loa Loa (eye worm) beta-lactamase 0.0043 0.0015 0.0305
Schistosoma mansoni hypothetical protein 0.0364 0.0484 0.2268
Loa Loa (eye worm) hypothetical protein 0.0055 0.0032 0.0662
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0001 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0031 0.0147
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0001 0.0002
Trypanosoma cruzi Peptide deformylase 2, putative 0.2618 0.3786 1
Echinococcus granulosus microtubule associated protein 2 0.1489 0.2132 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0001 0.0002
Loa Loa (eye worm) matrixin family protein 0.011 0.0112 0.231
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0051 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0158 0.0182 0.4862
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0055 0.0257
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0015 0.0394
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0055 0.0257
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0001 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0015 0.0036
Schistosoma mansoni lamin 0.0062 0.0043 0.02
Onchocerca volvulus 0.0045 0.0018 0.0516
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0043 0.0881
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0001 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0001 0.0015
Onchocerca volvulus 0.0058 0.0036 0.1073
Loa Loa (eye worm) hypothetical protein 0.0073 0.0058 0.1199
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0055 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0001 0.0013
Brugia malayi RNA binding protein 0.0071 0.0055 0.1466
Brugia malayi Matrixin family protein 0.0045 0.0018 0.0468
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0001 0.0015
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0015 0.0069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0073 0.0058 0.0272
Onchocerca volvulus Matrilysin homolog 0.0045 0.0018 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0001 0.0013
Brugia malayi Hemopexin family protein 0.0064 0.0045 0.1209
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0043 0.0881
Loa Loa (eye worm) hypothetical protein 0.0045 0.0018 0.0362
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0048 0.0021 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0055 0.0257
Onchocerca volvulus 0.0034 0.0001 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0374 1
Echinococcus multilocularis GPCR, family 2 0.0073 0.0058 0.0272
Echinococcus granulosus tar DNA binding protein 0.0071 0.0055 0.0257
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0001 0.0002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0051 0.0095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0001 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.1489 0.2132 1
Plasmodium vivax peptide deformylase, putative 0.686 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Schistosoma mansoni hypothetical protein 0.0043 0.0015 0.0069
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0369 0.1732
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0064 0.0045 0.0212
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0 0.0003
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0055 0.0032 0.0017
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0073 0.0058 0.0272
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0229 0.5952
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0001 0.001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0001 0.0002
Onchocerca volvulus 0.0265 0.0339 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0073 0.0058 0.0272
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0051 0.0237
Brugia malayi Matrixin family protein 0.0045 0.0018 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0055 0.0257
Brugia malayi TAR-binding protein 0.0071 0.0055 0.1466
Loa Loa (eye worm) MH2 domain-containing protein 0.0276 0.0355 0.7337
Schistosoma mansoni hypothetical protein 0.0073 0.0058 0.0272
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0031 0.0649
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0001 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0031 0.0147
Entamoeba histolytica hypothetical protein 0.0043 0.0015 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0018 0.0362
Trypanosoma brucei Peptide deformylase 2 0.2618 0.3786 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0055 0.0032 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0001 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0001 0.0013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0051 0.0237
Loa Loa (eye worm) hypothetical protein 0.0286 0.0369 0.7638
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0001 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0001 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0015 0.0069
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.0374 0.7741
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0051 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0001 0.0002
Onchocerca volvulus Matrix metalloproteinase homolog 0.0101 0.0098 0.2901
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0001 0.0002
Brugia malayi Matrixin family protein 0.0045 0.0018 0.0468
Echinococcus granulosus snurportin 1 0.0364 0.0484 0.2268
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0015 0.0305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0231 0.0289 0.5974
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0165 0.0193 0.0903
Brugia malayi RNA, U transporter 1 0.0097 0.0093 0.2482
Trichomonas vaginalis set domain proteins, putative 0.0265 0.0339 0.9026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0001 0.0002
Brugia malayi Pre-SET motif family protein 0.0233 0.0292 0.7805
Echinococcus multilocularis snurportin 1 0.0364 0.0484 0.2268
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0031 0.0839
Toxoplasma gondii hypothetical protein 0.686 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Schistosoma mansoni importin beta-1 0.0034 0.0001 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0031 0.0147
Schistosoma mansoni intermediate filament proteins 0.0062 0.0043 0.02
Onchocerca volvulus Matrilysin homolog 0.0101 0.0098 0.2901
Schistosoma mansoni hypothetical protein 0.0158 0.0182 0.0854
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0165 0.0193 0.0903
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0001 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0001 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0001 0.0002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0 0.0002
Schistosoma mansoni hypothetical protein 0.0058 0.0036 0.0171
Brugia malayi beta-lactamase family protein 0.0043 0.0015 0.0394
Brugia malayi intermediate filament protein 0.0062 0.0043 0.1139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0001 0.0002
Loa Loa (eye worm) RNA binding protein 0.0071 0.0055 0.1135
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0305
Brugia malayi nuclear hormone receptor 0.0034 0.0001 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0073 0.0058 0.0272
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0001 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0374 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0001 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0231 0.0289 0.7718
Brugia malayi MH2 domain containing protein 0.0276 0.0355 0.9479
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.686 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0055 0.1135
Plasmodium vivax importin-beta 2, putative 0.0034 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0305
Brugia malayi hypothetical protein 0.0286 0.0369 0.9868
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0358 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.0374 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.686 1 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0231 0.0289 0.7718
Mycobacterium ulcerans peptide deformylase 0.686 1 1
Schistosoma mansoni coup transcription factor 0.0034 0.0001 0.0002
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.686 1 1
Treponema pallidum polypeptide deformylase (def) 0.686 1 0.5
Brugia malayi Matrixin family protein 0.011 0.0112 0.2984
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0001 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0031 0.0147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0051 0.0237
Trypanosoma cruzi Peptide deformylase 2, putative 0.2618 0.3786 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0001 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.1489 0.2132 1
Onchocerca volvulus 0.0043 0.0015 0.0435

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100 uM Inhibition of purified human recombinant APE1 expressed in Escherichia coli M15 cells ChEMBL. 19072053

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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