Detailed information for compound 1017516

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.378 | Formula: C18H23NO6
  • H donors: 5 H acceptors: 4 LogP: -1.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1=C2[C@H]3NCC[C@]2(C[C@@H]([C@@H]1O)O)c1c([C@@H]3O)ccc(c1O)OC
  • InChi: 1S/C18H23NO6/c1-24-10-4-3-8-11(16(10)23)18-5-6-19-13(14(8)21)12(18)17(25-2)15(22)9(20)7-18/h3-4,9,13-15,19-23H,5-7H2,1-2H3/t9-,13+,14-,15-,18-/m0/s1
  • InChiKey: CQFMGBHPLGTYRE-ANUCULNSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0045 0.0144 0.0192
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0644 0.0595
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.035 0.0475
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0064 0.0299 0.0507
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0209
Echinococcus multilocularis g protein coupled receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis integrin alpha ps 0.0069 0.0335 0.0291
Brugia malayi serine/threonine kinase 12 0.0115 0.0704 0.1387
Echinococcus granulosus potassium voltage gated channel protein 0.0064 0.0299 0.0255
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0064 0.0299 0.0526
Onchocerca volvulus Putative nachr subunit 0.0157 0.1046 0.2022
Onchocerca volvulus 0.0066 0.031 0.0529
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Echinococcus multilocularis shaker cognate 0.0064 0.0299 0.0255
Schistosoma mansoni jumonji domain containing protein 0.0215 0.1517 0.2421
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0704 0.1124
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0115 0.0704 0.2354
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Echinococcus multilocularis glycine receptor subunit beta 0.0084 0.0455 0.0412
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni neuropeptide F-like receptor 0.0239 0.1706 0.2724
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.0455 0.0885
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0455 0.0885
Loa Loa (eye worm) transcription factor SMAD2 0.0484 0.3681 0.7366
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Echinococcus multilocularis ryanodine receptor 44f 0.0064 0.0299 0.0255
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0452
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.1706 0.1669
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0299 0.0255
Echinococcus multilocularis voltage dependent calcium channel 0.0178 0.1213 0.1173
Toxoplasma gondii hypothetical protein 0.0107 0.0644 0.0595
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0064 0.0299 0.0477
Loa Loa (eye worm) TYRA-2 protein 0.0239 0.1706 0.3365
Echinococcus multilocularis potassium large conductance calcium activated 0.0064 0.0299 0.0255
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0064 0.0299 0.0526
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0115 0.0704 0.2354
Schistosoma mansoni Smad4 0.0033 0.0045 0.0071
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.1706 0.2724
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0704 0.2251
Onchocerca volvulus Neuropeptide F receptor homolog 0.0239 0.1706 0.336
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0084 0.0455 0.0831
Schistosoma mansoni neuropeptide receptor 0.0239 0.1706 0.2724
Loa Loa (eye worm) calcium channel 0.0178 0.1213 0.2366
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0178 0.1213 0.1173
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0084 0.0455 0.0885
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0455 0.0885
Loa Loa (eye worm) GABA receptor subunit 0.0045 0.0144 0.02
Echinococcus multilocularis dnaJ subfamily B 0.0476 0.3623 0.3594
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0644 0.0595
Loa Loa (eye worm) G-protein coupled receptor 0.0239 0.1706 0.3365
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0064 0.0299 0.0571
Schistosoma mansoni hypothetical protein 0.0239 0.1706 0.2724
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0299 0.0255
Echinococcus multilocularis two pore calcium channel protein 1 0.0064 0.0299 0.0255
Onchocerca volvulus 0.0099 0.0579 0.1076
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Brugia malayi Dopamine receptor protein 2 0.0239 0.1706 0.3405
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0064 0.0299 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.009 0.0151
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Toxoplasma gondii subtilisin SUB12 0.0107 0.0644 0.0595
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0178 0.1213 0.1173
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Onchocerca volvulus 0.0239 0.1706 0.336
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0084 0.0455 0.0726
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0283 0.0239
Schistosoma mansoni jumonji/arid domain-containing protein 0.0136 0.0876 0.1399
Loa Loa (eye worm) acetylcholine receptor protein 0.0039 0.009 0.0092
Brugia malayi hypothetical protein 0.0039 0.009 0.0151
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0239 0.1706 0.1669
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0452
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus multilocularis sodium leak channel non selective protein 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.1083
Onchocerca volvulus 0.0039 0.009 0.0084
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0239 0.1706 0.2724
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus hyperpolarization activated cyclic 0.0064 0.0299 0.0255
Toxoplasma gondii microneme protein MIC4 0.0107 0.0644 0.0595
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0178 0.1213 0.1936
Brugia malayi sulfakinin receptor protein 0.0239 0.1706 0.3405
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.1083
Trypanosoma brucei aurora B kinase 0.0115 0.0704 0.45
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0178 0.1213 0.2412
Echinococcus granulosus G protein coupled receptor 139 0.0239 0.1706 0.1669
Toxoplasma gondii microneme protein MIC17C 0.0107 0.0644 0.0595
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0111 0.0675 0.1276
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0239 0.1706 0.3405
Echinococcus granulosus transient receptor potential cation channel 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni smad1 5 8 and 0.0033 0.0045 0.0071
Echinococcus multilocularis neuropeptide FF receptor 2 0.0239 0.1706 0.1669
Loa Loa (eye worm) ACC-1 protein 0.0084 0.0455 0.0831
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0064 0.0299 0.0255
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0064 0.0299 0.0515
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0266 0.1924 0.3807
Brugia malayi Protein kinase domain containing protein 0.0346 0.2574 0.5152
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0239 0.1706 0.2724
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0115 0.0704 0.0662
Echinococcus granulosus sodium leak channel non selective protein 0.0064 0.0299 0.0255
Onchocerca volvulus 0.0065 0.0304 0.0518
Brugia malayi AKH receptor 0.0239 0.1706 0.3405
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.1083
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0049 0.0008
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0084 0.0455 0.0831
Brugia malayi Protein kinase domain containing protein 0.0049 0.0175 0.0322
Echinococcus granulosus g protein coupled receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.2225 0.4417
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Loa Loa (eye worm) hypothetical protein 0.0207 0.1451 0.2849
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0115 0.0704 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0115 0.0704 0.0662
Leishmania major hypothetical protein, conserved 0.0064 0.0299 0.039
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0064 0.0299 0.0477
Echinococcus multilocularis G-protein coupled receptor, putative 0.0239 0.1706 0.1669
Brugia malayi Trypsin-like protease protein 5 0.0099 0.0579 0.1136
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) melatonin receptor type 1A 0.0239 0.1706 0.3365
Loa Loa (eye worm) hypothetical protein 0.0036 0.0068 0.0047
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0704 0.2354
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0058 0.025 0.287
Schistosoma mansoni calcium-activated potassium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.009 0.0144
Loa Loa (eye worm) hypothetical protein 0.0085 0.0463 0.0846
Loa Loa (eye worm) neuropeptide F receptor 0.0239 0.1706 0.3365
Treponema pallidum fructose-bisphosphate aldolase 0.034 0.2526 0.5
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Echinococcus multilocularis sex peptide receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0266 0.1924 0.3807
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0083 0.0038
Schistosoma mansoni histamine h1 receptor 0.0239 0.1706 0.2724
Echinococcus granulosus hyperpolarization activated cyclic 0.0064 0.0299 0.0255
Brugia malayi putative neuropeptide receptor NPR1 0.0239 0.1706 0.3405
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0039 0.009 0.0046
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0064 0.0299 0.0255
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Brugia malayi bZIP transcription factor family protein 0.0084 0.0455 0.0885
Onchocerca volvulus 0.0107 0.0644 0.1207
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Brugia malayi hypothetical protein 0.0039 0.009 0.0151
Schistosoma mansoni jun-related protein 0.0068 0.0328 0.0524
Echinococcus multilocularis nAChR subunit 0.0045 0.0144 0.0099
Echinococcus granulosus somatostatin receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0064 0.0299 0.0477
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0157 0.1046 0.1006
Schistosoma mansoni amine GPCR 0.0239 0.1706 0.2724
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0064 0.0299 0.0571
Onchocerca volvulus 0.0239 0.1706 0.336
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0039 0.009 0.0151
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0067 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0064 0.0299 0.0255
Onchocerca volvulus 0.0099 0.0579 0.1076
Schistosoma mansoni amine GPCR 0.0239 0.1706 0.2724
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0064 0.0299 0.0571
Echinococcus granulosus calcium activated potassium channel 0.0066 0.0313 0.0269
Brugia malayi Bromodomain containing protein 0.0058 0.025 0.0473
Schistosoma mansoni alpha-1 adrenergic receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0045 0.0144 0.0192
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.025 0.0206
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Onchocerca volvulus 0.0107 0.0644 0.1207
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Brugia malayi Melatonin receptor type 1A 0.0239 0.1706 0.3405
Loa Loa (eye worm) ryanodine receptor 0.0064 0.0299 0.0515
Leishmania major hypothetical protein, unknown function 0.0064 0.0299 0.039
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0067 0.0023
Schistosoma mansoni hypothetical protein 0.0505 0.3854 0.6153
Schistosoma mansoni amine GPCR 0.0239 0.1706 0.2724
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0084 0.0455 0.0885
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0553 0.0511
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0283 0.0483
Onchocerca volvulus 0.0084 0.0455 0.0824
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0452
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi RNA binding protein 0.0062 0.0283 0.0539
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0455 0.0412
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Brugia malayi RE15519p 0.0239 0.1706 0.3405
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Onchocerca volvulus 0.0239 0.1706 0.336
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0455 0.0885
Brugia malayi jmjC domain containing protein 0.0036 0.0067 0.0105
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0067 0.0046
Loa Loa (eye worm) hypothetical protein 0.0645 0.4981 1
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0299 0.0255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0064 0.0299 0.0255
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0178 0.1213 0.1173
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0084 0.0455 0.0412
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0178 0.1213 0.1173
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.1706 0.2724
Echinococcus multilocularis potassium voltage gated channel protein 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0239 0.1706 0.1669
Brugia malayi serine/threonine-protein kinase 6 0.0115 0.0704 0.1387
Echinococcus multilocularis calcium activated potassium channel 0.0066 0.0313 0.0269
Echinococcus multilocularis neuropeptide Y receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0299 0.0255
Onchocerca volvulus 0.0163 0.1093 0.2117
Schistosoma mansoni protein kinase 0.0128 0.081 0.1293
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Schistosoma mansoni acetylcholine receptor subunit beta 0.0039 0.009 0.0144
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Mycobacterium ulcerans hypothetical protein 0.0099 0.0579 0.298
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0644 0.0595
Toxoplasma gondii aurora kinase 0.0115 0.0704 0.0657
Loa Loa (eye worm) hypothetical protein 0.0058 0.025 0.0416
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0084 0.0455 0.0412
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0771 0.6003 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0064 0.0299 0.0507
Echinococcus granulosus glycine receptor subunit alpha 1 0.0084 0.0455 0.0412
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0166 0.1121 1
Schistosoma mansoni voltage-gated cation channel 0.0178 0.1213 0.1936
Onchocerca volvulus 0.0107 0.0644 0.1207
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0175 0.028
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Echinococcus multilocularis transfer RNA-Gly 0.0064 0.0299 0.0255
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.1706 0.2724
Loa Loa (eye worm) voltage-gated potassium channel 0.0064 0.0299 0.0515
Schistosoma mansoni ephrin receptor 0.0066 0.031 0.0495
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0067 0.0023
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Schistosoma mansoni acetylcholine receptor-related 0.0039 0.009 0.0144
Toxoplasma gondii microneme protein, putative 0.0107 0.0644 0.0595
Toxoplasma gondii transporter, cation channel family protein 0.0178 0.1213 0.1182
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0064 0.0299 0.0255
Echinococcus granulosus sodium channel protein 0.0771 0.6003 0.5985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0064 0.0299 0.0571
Brugia malayi Cation transporter family protein 0.0084 0.0455 0.0885
Schistosoma mansoni hypothetical protein 0.0099 0.0579 0.0925
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0299 0.0239
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus transmembrane protease serine 3 0.0099 0.0579 0.0537
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0178 0.1213 0.1173
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0644 0.1214
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Leishmania major protein kinase, putative 0.0115 0.0704 0.1073
Echinococcus granulosus ryanodine receptor 44f 0.0064 0.0299 0.0255
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0644 0.1214
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0064 0.0299 0.0571
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0239 0.1706 0.1669
Onchocerca volvulus 0.0046 0.0148 0.0201
Loa Loa (eye worm) AUR protein kinase 0.0115 0.0704 0.1336
Trypanosoma brucei RNA helicase, putative 0.0102 0.0603 0.3784
Echinococcus multilocularis G protein coupled receptor 139 0.0239 0.1706 0.1669
Plasmodium falciparum serine/threonine protein kinase, putative 0.0115 0.0704 1
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0049 0.0175 0.0131
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0455 0.0885
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0064 0.0299 0.0477
Trypanosoma brucei hypothetical protein, conserved 0.0211 0.1482 1
Brugia malayi hypothetical protein 0.0163 0.1093 0.217
Echinococcus granulosus g protein coupled receptor 0.0239 0.1706 0.1669
Schistosoma mansoni smad1 5 8 and 0.0033 0.0045 0.0071
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Echinococcus granulosus potassium large conductance calcium activated 0.0064 0.0299 0.0255
Echinococcus multilocularis jun protein 0.0084 0.0455 0.0412
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Brugia malayi Trypsin family protein 0.0099 0.0579 0.1136
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0084 0.0455 0.0412
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0107 0.0644 0.1207
Schistosoma mansoni nAChR subunit 0.0039 0.009 0.0144
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Brugia malayi ephrin receptor 1 precursor 0.0031 0.0032 0.0034
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0266 0.1924 0.3072
Schistosoma mansoni serine-type protease inhibitor 0.0456 0.3458 0.5521
Toxoplasma gondii PAN domain-containing protein 0.1236 0.9755 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0239 0.1706 0.3405
Echinococcus multilocularis potassium voltage gated channel protein 0.0064 0.0299 0.0255
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0435 0.0392
Brugia malayi Tachykinin-like peptides receptor 99D 0.0239 0.1706 0.3405
Brugia malayi follicle stimulating hormone receptor 0.0239 0.1706 0.3405
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0083 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.2225 0.4451
Loa Loa (eye worm) hypothetical protein 0.0345 0.256 0.5096
Echinococcus multilocularis neuropeptides capa receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis g protein coupled receptor 0.0239 0.1706 0.1669
Schistosoma mansoni neuropeptide receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0064 0.0299 0.0507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0435 0.0392
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0049 0.0175 0.0264
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus granulosus neuropeptide receptor 0.0239 0.1706 0.1669
Schistosoma mansoni biogenic amine receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0266 0.1924 0.3802
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Onchocerca volvulus 0.0266 0.1924 0.3802
Loa Loa (eye worm) jmjC domain-containing protein 0.0136 0.0876 0.1684
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Schistosoma mansoni neurotransmitter gated ion channel 0.0045 0.0144 0.0229
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0064 0.0299 0.0571
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0084 0.0455 0.0885
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0239 0.1706 0.1669
Schistosoma mansoni hypothetical protein 0.0033 0.0045 0.0072
Brugia malayi Trypsin family protein 0.0099 0.0579 0.1136
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0064 0.0299 0.0255
Echinococcus multilocularis hyperpolarization activated cyclic 0.0064 0.0299 0.0255
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0255 0.1834 0.1797
Loa Loa (eye worm) voltage-gated potassium channel 0.0064 0.0299 0.0515
Loa Loa (eye worm) neuropeptide F receptor 0.0239 0.1706 0.3365
Echinococcus multilocularis two pore calcium channel protein 2 0.0064 0.0299 0.0255
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0553 0.0511
Toxoplasma gondii microneme protein MIC17B 0.0107 0.0644 0.0595
Echinococcus multilocularis conserved hypothetical protein 0.0064 0.0299 0.0255
Schistosoma mansoni smad1 5 8 and 0.0033 0.0045 0.0071
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Onchocerca volvulus Alhambra homolog 0.0058 0.025 0.0408
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0064 0.0299 0.0477
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0067 0.0023
Schistosoma mansoni transient receptor potential channel 0.0064 0.0299 0.0477
Echinococcus granulosus glycine receptor subunit beta 0.0084 0.0455 0.0412
Onchocerca volvulus 0.0239 0.1706 0.336
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0067 0.0023
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0579 0.0925
Echinococcus granulosus neuropeptide Y receptor 0.0239 0.1706 0.1669
Echinococcus granulosus two pore calcium channel protein 2 0.0064 0.0299 0.0255
Echinococcus multilocularis potassium voltage gated channel protein 0.0064 0.0299 0.0255
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0084 0.0455 0.0885
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0084 0.0455 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0064 0.0299 0.0255
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0704 0.2251
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Brugia malayi PHD-finger family protein 0.0058 0.025 0.0473
Schistosoma mansoni neuropeptide f receptor 76f 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0084 0.0455 0.0824
Echinococcus granulosus neuropeptides capa receptor 0.0239 0.1706 0.1669
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0067 0.0108
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.1451 0.2892
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Echinococcus granulosus microtubule associated protein 2 0.0804 0.6264 0.6247
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0064 0.0299 0.0477
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0166 0.1121 0.5
Echinococcus multilocularis cpg binding protein 0.0035 0.0064 0.002
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0067 0.0023
Entamoeba histolytica protein kinase , putative 0.0115 0.0704 0.2354
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) AUR protein kinase 0.0115 0.0704 0.1336
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0084 0.0455 0.0412
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus enteropeptidase 0.0099 0.0579 0.0537
Onchocerca volvulus 0.0107 0.0644 0.1207
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0239 0.1706 0.3365
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus granulosus potassium voltage gated channel protein 0.0064 0.0299 0.0255
Echinococcus multilocularis potassium voltage gated channel protein 0.0064 0.0299 0.0255
Echinococcus multilocularis lysine specific demethylase 5A 0.0134 0.0861 0.082
Schistosoma mansoni protein kinase 0.0128 0.081 0.1293
Onchocerca volvulus 0.0645 0.4981 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0644 0.1214
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0115 0.0704 0.2354
Schistosoma mansoni biogenic amine (5HT) receptor 0.0239 0.1706 0.2724
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.1706 0.3365
Echinococcus multilocularis peregrin 0.0058 0.025 0.0206
Schistosoma mansoni transient receptor potential channel 0.0064 0.0299 0.0477
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0178 0.1213 0.1173
Loa Loa (eye worm) hypothetical protein 0.0036 0.0067 0.0046
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Brugia malayi jmjC domain containing protein 0.0036 0.0067 0.0105
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0064 0.0299 0.0255
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.009 0.0046
Echinococcus multilocularis enteropeptidase 0.0099 0.0579 0.0537
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Brugia malayi ORL1-like opioid receptor 0.0239 0.1706 0.3405
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0049 0.0175 0.0131
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0144 0.0258
Brugia malayi Protein kinase domain containing protein 0.0046 0.0154 0.0278
Schistosoma mansoni hypothetical protein 0.0102 0.0603 0.0962
Brugia malayi cation channel family protein 0.0064 0.0299 0.0571
Echinococcus granulosus potassium voltage gated channel protein 0.0064 0.0299 0.0255
Giardia lamblia Aurora kinase 0.0115 0.0704 0.1996
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Echinococcus granulosus GPCR family 2 0.0096 0.0553 0.0511
Loa Loa (eye worm) TK/ROR protein kinase 0.0046 0.0154 0.022
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0239 0.1706 0.2724
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0084 0.0455 0.0831
Echinococcus granulosus potassium voltage gated channel protein 0.0064 0.0299 0.0255
Echinococcus multilocularis neuropeptide Y receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0064 0.0299 0.0255
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0064 0.0299 0.0477
Brugia malayi excitatory GABA receptor EXP-1A 0.0084 0.0455 0.0885
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus hypothetical protein 0.0239 0.1706 0.1669
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0178 0.1213 0.1173
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0645 0.4981 0.7952
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0157 0.1046 0.2076
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0579 0.0537
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus Mastin 0.0099 0.0579 0.0537
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0239 0.1706 0.1669
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.1482 1
Brugia malayi hypothetical protein 0.0066 0.031 0.0593
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.031 0.0267
Schistosoma mansoni hypothetical protein 0.0046 0.0148 0.0236
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Trypanosoma cruzi hypothetical protein, conserved 0.0046 0.0148 0.0568
Echinococcus multilocularis somatostatin receptor 0.0239 0.1706 0.1669
Echinococcus granulosus transient receptor potential gamma protein 0.0064 0.0299 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0283 0.0483
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0579 0.0925
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0084 0.0455 0.0412
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0099 0.0579 0.0925
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0166 0.1121 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0045 0.0144 0.0258
Brugia malayi Dopamine receptor protein 1 0.0239 0.1706 0.3405
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi MH2 domain containing protein 0.0033 0.0045 0.0059
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0178 0.1213 0.8096
Echinococcus multilocularis serotonin receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0299 0.0255
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Toxoplasma gondii hypothetical protein 0.0064 0.0299 0.0239
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni transient receptor potential channel 4 0.0064 0.0299 0.0477
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0644 0.1214
Leishmania major hypothetical protein, conserved 0.0046 0.0148 0.0135
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0704 0.2251
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0064 0.0299 0.0477
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.035 0.0558
Echinococcus multilocularis nAChR subunit 0.0084 0.0455 0.0412
Echinococcus granulosus glycine receptor subunit alpha 1 0.0084 0.0455 0.0412
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0239 0.1706 0.1669
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Echinococcus granulosus jun protein 0.0084 0.0455 0.0412
Schistosoma mansoni neurotransmitter gated ion channel 0.0039 0.009 0.0144
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Schistosoma mansoni neuropeptide receptor 0.0239 0.1706 0.2724
Brugia malayi serine/threonine protein kinase 6 0.0115 0.0704 0.1387
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi Kringle domain containing protein 0.0046 0.0148 0.0267
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0084 0.0455 0.0412
Schistosoma mansoni opsin-like receptor 0.0239 0.1706 0.2724
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0039 0.009 0.0151
Schistosoma mansoni ryanodine receptor related 0.0064 0.0299 0.0477
Brugia malayi cation channel family protein 0.0064 0.0299 0.0571
Schistosoma mansoni hypothetical protein 0.0239 0.1706 0.2724
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Brugia malayi putative neuropeptide receptor 0.0239 0.1706 0.3405
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0239 0.1706 0.3405
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0239 0.1706 0.3405
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.0455 0.0726
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.1083
Schistosoma mansoni neuropeptide receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus multilocularis neuropeptide receptor 0.0239 0.1706 0.1669
Brugia malayi Cation transporter family protein 0.0266 0.1924 0.3844
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Loa Loa (eye worm) RNA binding protein 0.0062 0.0283 0.0483
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0255 0.1834 0.1797
Onchocerca volvulus 0.0084 0.0455 0.0824
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Schistosoma mansoni biogenic amine receptor 0.0239 0.1706 0.2724
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0553 0.103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Echinococcus granulosus glycoprotein Antigen 5 0.0099 0.0579 0.0537
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0116 0.0716 0.1412
Echinococcus granulosus neuropeptide receptor 0.0239 0.1706 0.1669
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0553 0.1083
Onchocerca volvulus 0.0039 0.009 0.0084
Schistosoma mansoni protein kinase 0.0115 0.0704 0.1124
Schistosoma mansoni 60S ribosomal protein L21 0.0064 0.0299 0.0477
Schistosoma mansoni integrin alpha 0.0154 0.1018 0.1626
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0099 0.0579 0.0537
Loa Loa (eye worm) hypothetical protein 0.0227 0.1613 0.3176
Schistosoma mansoni cpg binding protein 0.0035 0.0064 0.0102
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0064 0.0299 0.0477
Echinococcus granulosus g-protein coupled receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0067 0.0046
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0064 0.0299 0.0571
Onchocerca volvulus 0.0099 0.0579 0.1076
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0579 0.0925
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Echinococcus multilocularis tissue type plasminogen activator 0.0046 0.0148 0.0103
Schistosoma mansoni biogenic amine receptor 0.0239 0.1706 0.2724
Onchocerca volvulus 0.0107 0.0644 0.1207
Schistosoma mansoni microtubule-associated protein tau 0.0804 0.6264 1
Onchocerca volvulus 0.0107 0.0644 0.1207
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0128 0.081 0.0769
Echinococcus granulosus nAChR subunit 0.0084 0.0455 0.0412
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0452
Entamoeba histolytica protein kinase, putative 0.0115 0.0704 0.2354
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus multilocularis neuropeptide s receptor 0.0687 0.5325 0.5303
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0045 0.0144 0.0229
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0064 0.0299 0.0255
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Loa Loa (eye worm) LGC-31 protein 0.0084 0.0455 0.0831
Toxoplasma gondii hypothetical protein 0.0064 0.0299 0.0239
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0064 0.0299 0.0255
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.025 0.0416
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0553 0.0511
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0064 0.0299 0.0255
Echinococcus multilocularis hyperpolarization activated cyclic 0.0064 0.0299 0.0255
Brugia malayi MH1 domain containing protein 0.0033 0.0045 0.0059
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.009 0.0092
Onchocerca volvulus 0.0239 0.1706 0.336
Loa Loa (eye worm) hypothetical protein 0.0065 0.0304 0.0526
Brugia malayi G-protein coupled receptor 0.0239 0.1706 0.3405
Brugia malayi MH1 domain containing protein 0.0033 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Brugia malayi GnHR receptor homolog 0.0239 0.1706 0.3405
Echinococcus granulosus 7tm_1 domain containing protein 0.0239 0.1706 0.1669
Brugia malayi CXXC zinc finger family protein 0.0033 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0084 0.0455 0.0885
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.035 0.0306
Brugia malayi Cyclic-nucleotide gated cation channel 0.0064 0.0299 0.0571
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.1706 0.1669
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0299 0.0255
Echinococcus granulosus voltage gated hydrogen channel 1 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0067 0.0046
Echinococcus multilocularis integrin alpha ps 0.0069 0.0335 0.0291
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0064 0.0299 0.0571
Brugia malayi Smad1 0.0033 0.0045 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Leishmania major hypothetical protein, conserved 0.0211 0.1482 0.2384
Echinococcus multilocularis transient receptor potential gamma protein 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Echinococcus multilocularis allatostatin A receptor 0.0239 0.1706 0.1669
Echinococcus granulosus geminin 0.0505 0.3854 0.3827
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Echinococcus multilocularis g-protein coupled receptor 0.0239 0.1706 0.1669
Echinococcus granulosus tachykinin peptides receptor 99D 0.0239 0.1706 0.1669
Echinococcus granulosus tissue type plasminogen activator 0.0046 0.0148 0.0103
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0239 0.1706 0.1669
Echinococcus granulosus shaker cognate 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0163 0.1093 0.2123
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0283 0.0452
Echinococcus multilocularis voltage dependent calcium channel 0.0178 0.1213 0.1173
Echinococcus multilocularis neuropeptide receptor A26 0.0687 0.5325 0.5303
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Onchocerca volvulus 0.0107 0.0644 0.1207
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0239 0.1706 0.3365
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0064 0.0299 0.0255
Schistosoma mansoni myosin xvIII 0.0239 0.1706 0.2724
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0239 0.1706 0.2724
Brugia malayi Dopamine receptor 0.0239 0.1706 0.3405
Onchocerca volvulus 0.0039 0.009 0.0084
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0239 0.1706 0.1669
Echinococcus granulosus alpha 1A adrenergic receptor 0.0239 0.1706 0.1669
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.1018 0.2019
Echinococcus granulosus neuropeptide Y receptor 0.0239 0.1706 0.1669
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.1482 1
Schistosoma mansoni hypothetical protein 0.0239 0.1706 0.2724
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0064 0.0299 0.0571
Echinococcus multilocularis transient receptor potential cation channel 0.0064 0.0299 0.0255
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.034 0.2526 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Echinococcus granulosus transient receptor potential cation channel 0.0064 0.0299 0.0255
Echinococcus granulosus integrin alpha ps 0.0069 0.0335 0.0291
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Toxoplasma gondii microneme protein MIC17A 0.0107 0.0644 0.0595
Brugia malayi Transient-receptor-potential like protein 0.0064 0.0299 0.0571
Loa Loa (eye worm) hypothetical protein 0.0099 0.0579 0.1083
Brugia malayi hypothetical protein 0.0039 0.009 0.0151
Schistosoma mansoni hypothetical protein 0.0476 0.3623 0.5784
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0455 0.0412
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Schistosoma mansoni jumonji/arid domain-containing protein 0.0136 0.0876 0.1399
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0064 0.0299 0.0571
Loa Loa (eye worm) hypothetical protein 0.0303 0.2225 0.4417
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0064 0.0299 0.0515
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus granulosus tm gpcr rhodopsin 0.0239 0.1706 0.1669
Loa Loa (eye worm) PAN domain-containing protein 0.0107 0.0644 0.1214
Loa Loa (eye worm) hypothetical protein 0.0113 0.0693 0.1313
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0067 0.0108
Onchocerca volvulus 0.0239 0.1706 0.336
Schistosoma mansoni protein kinase 0.0128 0.081 0.1293
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Onchocerca volvulus 0.0239 0.1706 0.336
Schistosoma mansoni hypothetical protein 0.0099 0.0579 0.0925
Echinococcus granulosus voltage dependent calcium channel 0.0178 0.1213 0.1173
Loa Loa (eye worm) voltage-gated calcium channel 0.0064 0.0299 0.0515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0455 0.0885
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Schistosoma mansoni opsin-like receptor 0.0239 0.1706 0.2724
Brugia malayi hypothetical protein 0.0064 0.0299 0.0571
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0064 0.0299 0.0515
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0084 0.0455 0.0412
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0064 0.0299 0.0255
Echinococcus multilocularis transmembrane protease serine 3 0.0099 0.0579 0.0537
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0239 0.1706 0.3365
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0064 0.0299 0.1636
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.065 0.5022 0.8017
Echinococcus multilocularis voltage gated potassium channel 0.0064 0.0299 0.0255
Toxoplasma gondii transporter, cation channel family protein 0.0064 0.0299 0.0239
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0064 0.0299 0.0255
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.025 0.0399
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0283 0.0539
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0704 0.2251
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0099 0.0579 0.0537
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.0455 0.0726
Schistosoma mansoni adenoreceptor 0.0239 0.1706 0.2724
Schistosoma mansoni integrin alpha-ps 0.0069 0.0335 0.0534
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0553 0.0511
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Brugia malayi MH2 domain containing protein 0.0484 0.3681 0.7381
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0064 0.0299 0.0477
Brugia malayi ion channel NompC 0.0064 0.0299 0.0571
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0239 0.1706 0.1669
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.035 0.0558
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Brugia malayi hypothetical protein 0.0039 0.009 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Onchocerca volvulus 0.0545 0.4181 0.8377
Onchocerca volvulus 0.0107 0.0644 0.1207
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0239 0.1706 0.1669
Echinococcus multilocularis fmrfamide receptor 0.0239 0.1706 0.1669
Schistosoma mansoni hypothetical protein 0.0505 0.3854 0.6153
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Loa Loa (eye worm) hypothetical protein 0.0157 0.1046 0.2029
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0266 0.1924 0.3072
Echinococcus multilocularis Mastin 0.0099 0.0579 0.0537
Echinococcus granulosus integrin alpha 3 0.0118 0.0729 0.0687
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0239 0.1706 0.2724
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Schistosoma mansoni amine GPCR 0.0239 0.1706 0.2724
Schistosoma mansoni hypothetical protein 0.0096 0.0553 0.0883
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0299 0.0255
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0039 0.009 0.0151
Entamoeba histolytica protein kinase, putative 0.0049 0.0175 0.0133
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0084 0.0455 0.0726
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.0455 0.0885
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0157 0.1046 0.1006
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0178 0.1213 0.1936
Echinococcus multilocularis microtubule associated protein 2 0.0804 0.6264 0.6247
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0084 0.0455 0.0412
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Loa Loa (eye worm) hypothetical protein 0.0033 0.0046 0.0003
Loa Loa (eye worm) trypsin family protein 0.0099 0.0579 0.1083
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.025 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0874 0.683 0.6816
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Schistosoma mansoni smad 0.0033 0.0045 0.0071
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0064 0.0299 0.1636
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0178 0.1213 0.8096
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0157 0.1046 0.1006
Onchocerca volvulus 0.0266 0.1924 0.3802
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.035 0.0306
Toxoplasma gondii PAN domain-containing protein 0.0107 0.0644 0.0595
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0084 0.0455 0.0885
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0064 0.0299 0.0571
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0099 0.0579 0.1136
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0064 0.0299 0.0477
Schistosoma mansoni serine-type protease inhibitor 0.0456 0.3458 0.5521
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0107 0.0644 0.0595
Schistosoma mansoni voltage-dependent calcium channel 0.0064 0.0299 0.0477
Toxoplasma gondii hypothetical protein 0.0113 0.0693 0.0646
Brugia malayi TAR-binding protein 0.0062 0.0283 0.0539
Echinococcus granulosus nAChR subunit 0.0045 0.0144 0.0099
Echinococcus granulosus voltage dependent calcium channel 0.0178 0.1213 0.1173
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Echinococcus granulosus dnaJ subfamily B 0.0476 0.3623 0.3594
Onchocerca volvulus 0.0107 0.0644 0.1207
Onchocerca volvulus 0.0099 0.0579 0.1076
Brugia malayi larval opioid receptor 0.0239 0.1706 0.3405
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0351 0.0561
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0579 0.0925
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0239 0.1706 0.2724
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0045 0.0144 0.0258
Schistosoma mansoni neuropeptide F-like receptor 0.0239 0.1706 0.2724
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus fmrfamide receptor 0.0239 0.1706 0.1669
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0064 0.0299 0.0255
Echinococcus multilocularis aurora kinase A 0.0115 0.0704 0.0662
Schistosoma mansoni opsin-like receptor 0.0239 0.1706 0.2724
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0084 0.0455 0.0412
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Echinococcus granulosus potassium voltage gated channel protein 0.0064 0.0299 0.0255
Schistosoma mansoni hypothetical protein 0.0096 0.0553 0.0883
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0039 0.009 0.0092
Schistosoma mansoni nAChR subunit 0.0084 0.0455 0.0726
Echinococcus granulosus hypothetical protein 0.0064 0.0299 0.0255
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0064 0.0299 0.0255
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0128 0.081 0.0769
Plasmodium falciparum cysteine repeat modular protein 1 0.0046 0.0148 0.1263
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.035 0.0291
Trypanosoma cruzi aurora B kinase, putative 0.0115 0.0704 0.45
Schistosoma mansoni integrin alpha-ps 0.0036 0.0068 0.0109
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Schistosoma mansoni hypothetical protein 0.0058 0.025 0.0399
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni cpg binding protein 0.0033 0.0049 0.0078
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0553 0.1083
Echinococcus multilocularis orexin receptor type 2 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0096 0.0553 0.103
Onchocerca volvulus 0.0239 0.1706 0.336
Brugia malayi Cation transporter family protein 0.0084 0.0455 0.0885
Plasmodium falciparum phd finger protein, putative 0.0058 0.025 0.287
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0046 0.0148 0.1263
Echinococcus multilocularis glycine receptor subunit beta 0.0084 0.0455 0.0412
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Schistosoma mansoni hypothetical protein 0.0096 0.0553 0.0883
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0064 0.0299 0.0477
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.009 0.0151
Loa Loa (eye worm) ACC-1 protein 0.0084 0.0455 0.0831
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0064 0.0299 0.0255
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0064 0.0299 0.0255
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) hypothetical protein 0.0116 0.0716 0.136
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0064 0.0299 0.0571
Brugia malayi Serotonin receptor 0.0239 0.1706 0.3405
Echinococcus granulosus neuropeptide FF receptor 2 0.0239 0.1706 0.1669
Loa Loa (eye worm) voltage-dependent calcium channel 0.0178 0.1213 0.2366
Echinococcus granulosus two pore calcium channel protein 1 0.0064 0.0299 0.0255
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0157 0.1046 0.1006
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Echinococcus granulosus aurora kinase A 0.0115 0.0704 0.0662
Echinococcus granulosus voltage gated potassium channel 0.0064 0.0299 0.0255
Echinococcus granulosus glycine receptor subunit alpha 1 0.0084 0.0455 0.0412
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0045 0.0144 0.0258
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0752 0.1433
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0045 0.0144 0.0229
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Brugia malayi voltage-dependent calcium channel 0.0064 0.0299 0.0571
Echinococcus granulosus neuropeptide s receptor 0.0687 0.5325 0.5303
Onchocerca volvulus 0.0107 0.0644 0.1207
Brugia malayi hypothetical protein 0.0099 0.0579 0.1136
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0064 0.0299 0.0571
Brugia malayi Trypsin family protein 0.0099 0.0579 0.1136
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0039 0.009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0645 0.4981 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus granulosus lysine specific demethylase 5A 0.0136 0.0876 0.0835
Loa Loa (eye worm) hypothetical protein 0.0178 0.1213 0.2366
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0064 0.0299 0.0239
Schistosoma mansoni hypothetical protein 0.0207 0.1451 0.2317
Echinococcus granulosus biogenic amine 5HT receptor 0.0239 0.1706 0.1669
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0084 0.0455 0.0885
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.029 0.023
Echinococcus granulosus phd:f box containing protein 0.0036 0.0067 0.0023
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0239 0.1706 0.2724
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Echinococcus multilocularis neuropeptides capa receptor 0.0239 0.1706 0.1669
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0067 0.0108
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0067 0.0023
Toxoplasma gondii PAN domain-containing protein 0.1236 0.9755 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.2225 0.4451
Schistosoma mansoni hypothetical protein 0.0064 0.0299 0.0477
Brugia malayi jmjC domain containing protein 0.0136 0.0876 0.1733
Toxoplasma gondii hypothetical protein 0.0107 0.0644 0.0595
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) hypothetical protein 0.0081 0.0436 0.0793
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0239 0.1706 0.2724
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.009 0.0046
Echinococcus multilocularis serotonin receptor 0.0239 0.1706 0.1669
Brugia malayi neuropeptide F receptor 0.0239 0.1706 0.3405
Echinococcus granulosus neuropeptide receptor A26 0.0687 0.5325 0.5303
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus sex peptide receptor 0.0239 0.1706 0.1669
Brugia malayi hypothetical protein 0.0239 0.1706 0.3405
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0157 0.1046 0.1006
Brugia malayi Serotonin receptor 0.0239 0.1706 0.3405
Echinococcus multilocularis GPCR, family 2 0.0096 0.0553 0.0511
Loa Loa (eye worm) ion channel NompC 0.0064 0.0299 0.0515
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0111 0.0675 0.1328
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0064 0.0299 0.0477
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0067 0.0108
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Loa Loa (eye worm) hypothetical protein 0.0113 0.0693 0.1313
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0067 0.0108
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0064 0.0299 0.0477
Echinococcus granulosus transient receptor potential cation channel 0.0064 0.0299 0.0255
Echinococcus granulosus peregrin 0.0058 0.025 0.0206
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0084 0.0455 0.0885
Echinococcus granulosus g protein coupled receptor 0.0239 0.1706 0.1669
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0239 0.1706 0.2724
Brugia malayi phosphoinositide-dependent protein kinase I 0.0049 0.0175 0.0322
Brugia malayi PAN domain containing protein 0.0107 0.0644 0.1266
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0771 0.6003 0.5985
Brugia malayi Trypsin family protein 0.0645 0.4981 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.025 0.0189
Echinococcus granulosus orexin receptor type 2 0.0239 0.1706 0.1669
Brugia malayi jmjC domain containing protein 0.0036 0.0067 0.0105
Schistosoma mansoni growth hormone secretagogue receptor 0.0239 0.1706 0.2724
Schistosoma mansoni voltage-gated ion channel 0.0064 0.0299 0.0477
Echinococcus granulosus neuropeptides capa receptor 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0117 0.0723 0.1374
Echinococcus granulosus serotonin receptor 0.0239 0.1706 0.1669
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.1213 0.2366
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0064 0.0299 0.0255
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0084 0.0455 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus granulosus dro:myosuppressin receptor 0.0239 0.1706 0.1669
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0099 0.0579 0.0537
Schistosoma mansoni amine GPCR 0.0239 0.1706 0.2724
Echinococcus granulosus transient receptor potential cation channel 0.0064 0.0299 0.0255
Echinococcus granulosus allatostatin A receptor 0.0239 0.1706 0.1669
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0239 0.1706 0.3405
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0239 0.1706 0.3365
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.034 0.2526 1
Loa Loa (eye worm) G-protein coupled receptor 0.0239 0.1706 0.3365
Schistosoma mansoni hypothetical protein 0.0096 0.0553 0.0883
Loa Loa (eye worm) hypothetical protein 0.0039 0.009 0.0092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0239 0.1706 0.1669
Onchocerca volvulus 0.0239 0.1706 0.336
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.025 0.0206
Echinococcus granulosus 7TM GPCR rhodopsin 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0107 0.0644 0.1214
Loa Loa (eye worm) hypothetical protein 0.0045 0.0144 0.02
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0157 0.1046 0.1006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Schistosoma mansoni hypothetical protein 0.0239 0.1706 0.2724
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0239 0.1706 0.3405
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis voltage gated potassium channel 0.0064 0.0299 0.0255
Brugia malayi jmjC domain containing protein 0.0255 0.1834 0.3662
Echinococcus granulosus cpg binding protein 0.0035 0.0064 0.002
Schistosoma mansoni transient receptor potential channel 0.0064 0.0299 0.0477
Giardia lamblia Fructose-bisphosphate aldolase 0.034 0.2526 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus granulosus voltage gated potassium channel 0.0064 0.0299 0.0255
Brugia malayi G-protein coupled receptor 0.0239 0.1706 0.3405
Brugia malayi hypothetical protein 0.0039 0.009 0.0151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0239 0.1706 0.1669
Toxoplasma gondii transporter, cation channel family protein 0.0064 0.0299 0.0239
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0239 0.1706 0.1669
Schistosoma mansoni nAChR subunit 0.0039 0.009 0.0144
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0099 0.0579 0.0925
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Schistosoma mansoni vesicular amine transporter 0.0064 0.0299 0.0477
Schistosoma mansoni two-pore calcium channel 0.0064 0.0299 0.0477
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0049 0.0175 0.0264
Toxoplasma gondii PAN/Apple domain-containing protein 0.0107 0.0644 0.0595
Loa Loa (eye worm) hypothetical protein 0.0084 0.0455 0.0831
Brugia malayi neuropeptide F receptor 0.0239 0.1706 0.3405
Loa Loa (eye worm) integrin alpha pat-2 0.0237 0.1689 0.3331
Echinococcus granulosus transient receptor potential cation channel 0.0064 0.0299 0.0255
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.031 0.0267
Schistosoma mansoni hypothetical protein 0.0068 0.0328 0.0524
Loa Loa (eye worm) MH2 domain-containing protein 0.0484 0.3681 0.7366
Schistosoma mansoni cercarial elastase (S01 family) 0.0099 0.0579 0.0925
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0064 0.0299 0.0255
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus granulosus transient receptor potential cation channel 0.0064 0.0299 0.0255
Schistosoma mansoni cpg binding protein 0.0035 0.0064 0.0102
Echinococcus multilocularis sodium channel protein 0.0771 0.6003 0.5985
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0064 0.0299 0.0571
Loa Loa (eye worm) TK/EPH protein kinase 0.0084 0.0454 0.083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Echinococcus granulosus tar DNA binding protein 0.0062 0.0283 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.034 0.2526 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0157 0.1046 0.2029
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0039 0.009 0.0046
Echinococcus granulosus glycine receptor subunit beta 0.0084 0.0455 0.0412
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0084 0.0455 0.0831
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0084 0.0455 0.0831
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1267 1 1
Brugia malayi olfactory channel protein osm-9 0.0064 0.0299 0.0571
Loa Loa (eye worm) hypothetical protein 0.0033 0.0045 0.0001
Loa Loa (eye worm) AUR protein kinase 0.0115 0.0704 0.1336
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0239 0.1706 0.2724
Schistosoma mansoni voltage-gated potassium channel 0.0064 0.0299 0.0477
Entamoeba histolytica protein kinase, putative 0.0115 0.0704 0.2354
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0064 0.0299 0.0255
Echinococcus multilocularis glycoprotein Antigen 5 0.0099 0.0579 0.0537
Echinococcus granulosus peptide allatostatin:somatostatin 0.0239 0.1706 0.1669
Brugia malayi MH2 domain containing protein 0.0033 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0121 0.0752 0.1432
Echinococcus multilocularis neuropeptide receptor 0.0239 0.1706 0.1669
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0064 0.0299 0.0255
Echinococcus multilocularis integrin alpha 3 0.0118 0.0729 0.0687
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0045 0.0071
Loa Loa (eye worm) hypothetical protein 0.0239 0.1706 0.3365
Echinococcus multilocularis rhodopsin orphan GPCR 0.0239 0.1706 0.1669
Loa Loa (eye worm) hypothetical protein 0.0064 0.0299 0.0515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.009 0.0151
Echinococcus granulosus TRP transient receptor potential channel 0.0064 0.0299 0.0255
Echinococcus multilocularis fmrfamide receptor 0.0239 0.1706 0.1669
Brugia malayi G protein-coupled receptor 0.0239 0.1706 0.3405
Brugia malayi jmjC domain containing protein 0.0036 0.0067 0.0105
Toxoplasma gondii kringle domain-containing protein 0.0046 0.0148 0.0083
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0239 0.1706 0.336
Onchocerca volvulus 0.0099 0.0579 0.1076
Echinococcus multilocularis geminin 0.0505 0.3854 0.3827
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0084 0.0455 0.0412

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 16.1 uM Antimalarial activity against Plasmodium yoelii 265 sporozoites in primary mice (Mus musculus) hepatocytes after 48 hrs ChEMBL. 18456502

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium yoelii 18456502

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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