Detailed information for compound 1018875

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 460.454 | Formula: C26H21FN2O5
  • H donors: 1 H acceptors: 3 LogP: 3.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC1(Oc2ccccc2C(=O)C1(O)OC)c1cn(nc1c1ccc(cc1)F)c1ccccc1
  • InChi: 1S/C26H21FN2O5/c1-32-25(31)24(30)20-10-6-7-11-22(20)34-26(25,33-2)21-16-29(19-8-4-3-5-9-19)28-23(21)17-12-14-18(27)15-13-17/h3-16,31H,1-2H3
  • InChiKey: UHCVHJHATKRASV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0515 0.048
Schistosoma mansoni kinase 0.005 0.0621 0.0597
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.046 0.1123
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0507 0.157
Brugia malayi SEA domain containing protein 0.0016 0.0138 0.0427
Loa Loa (eye worm) hypothetical protein 0.0016 0.0138 0.0427
Loa Loa (eye worm) hypothetical protein 0.0035 0.0402 0.1244
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0603 0.148
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.1549 0.2909
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0884 0.5396
Onchocerca volvulus 0.0042 0.0507 0.104
Trypanosoma brucei unspecified product 0.003 0.033 0.1563
Echinococcus granulosus dna polymerase eta 0.007 0.0897 0.0863
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222
Loa Loa (eye worm) hypothetical protein 0.0042 0.0507 0.157
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1549 1
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0515 0.2843
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1549 0.3845
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Brugia malayi Muscle positioning protein 4 0.0016 0.0138 0.0427
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.4011 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.036 0.0873
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.03 0.4088 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.046 0.246
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Loa Loa (eye worm) hypothetical protein 0.007 0.0897 0.2776
Loa Loa (eye worm) hypothetical protein 0.0016 0.0138 0.0427
Onchocerca volvulus 0.0042 0.0507 0.104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0507 0.157
Mycobacterium ulcerans hypothetical protein 0.0042 0.0507 0.1012
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.046 0.0274
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.1549 0.1518
Brugia malayi beta-lactamase family protein 0.0042 0.0507 0.157
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.046 0.246
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.046 0.0424
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0061 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0037 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0507 0.157
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.046 0.091
Brugia malayi 6-phosphofructokinase 0.0117 0.1549 0.4795
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1299 0.8273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Brugia malayi phosphofructokinase 0.0117 0.1549 0.4795
Loa Loa (eye worm) hypothetical protein 0.0013 0.0104 0.0323
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.036 0.0873
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0155 0.0479
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0402 0.0366
Echinococcus multilocularis microtubule associated protein 2 0.0725 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0507 0.157
Brugia malayi CXXC zinc finger family protein 0.0029 0.0321 0.0995
Trypanosoma brucei polo-like protein kinase 0.0099 0.1299 0.8273
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.079 0.0766
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0376 0.034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0699 0.8193
Leishmania major DNA polymerase eta, putative 0.0041 0.0486 0.2643
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222
Loa Loa (eye worm) hypothetical protein 0.0129 0.1709 0.5291
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0515 0.1594
Onchocerca volvulus 0.0035 0.0402 0.0743
Loa Loa (eye worm) hypothetical protein 0.0039 0.046 0.1423
Mycobacterium ulcerans beta-lactamase 0.0042 0.0507 0.1012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0515 0.0021
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.036 0.0654
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.036 0.0873
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222
Trypanosoma brucei unspecified product 0.0043 0.0515 0.2843
Loa Loa (eye worm) histone methyltransferase 0.001 0.0061 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1299 0.1277
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0507 0.1012
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.033 0.1563
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1549 0.3257
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0507 0.157
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.046 0.0424
Onchocerca volvulus 0.0271 0.3686 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.083 0.1821
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.1549 0.2909
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.083 0.0806
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0507 0.279
Brugia malayi beta-lactamase family protein 0.0042 0.0507 0.157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0155 0.0479
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.083 0.0796
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1299 0.4022
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.033 0.1563
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0402 0.0366
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0515 0.1261
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0515 0.048
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0507 0.0472
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1299 0.1267
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0507 0.1242
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Loa Loa (eye worm) hypothetical protein 0.0017 0.0155 0.0479
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0884 0.2736
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.036 0.0641
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0884 0.085
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.046 0.0424
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.046 0.246
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1549 0.3845
Brugia malayi Pre-SET motif family protein 0.0035 0.0402 0.1244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0402 0.0377
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0515 0.1031
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0104 0.0079
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.083 1
Onchocerca volvulus Huntingtin homolog 0.0129 0.1709 0.4427
Loa Loa (eye worm) hypothetical protein 0.0042 0.0507 0.157
Onchocerca volvulus 0.0042 0.0507 0.104
Treponema pallidum hypothetical protein 0.03 0.4088 1
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0515 0.2843
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0507 0.0483
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0515 0.0021
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.036 0.5
Echinococcus multilocularis MAM 0.0017 0.0155 0.0118
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0515 0.1261
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.03 0.4088 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0507 0.1242
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.083 0.09
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0515 0.2843
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0507 0.1012
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1918 0.394
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.083 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0507 0.1242
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.083 0.5021
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1549 0.3257
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.046 0.0435
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0507 0.1012
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0507 0.279
Schistosoma mansoni cpg binding protein 0.0031 0.0344 0.032
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0884 0.5396
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.4011 0.9794
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.03 0.4088 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0884 0.085
Brugia malayi Pre-SET motif family protein 0.0238 0.323 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.083 0.0806
Onchocerca volvulus 0.0029 0.0321 0.0517
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1549 0.4795
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.03 0.4088 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0478 0.0442
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0507 0.1242
Schistosoma mansoni hypothetical protein 0.0016 0.0138 0.0113
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.046 0.0435
Onchocerca volvulus 0.0017 0.0155 0.0047
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.1549 0.3626
Schistosoma mansoni hypothetical protein 0.0554 0.7623 0.7617
Schistosoma mansoni microtubule-associated protein tau 0.0725 1 1
Trypanosoma brucei unspecified product 0.003 0.033 0.1563
Echinococcus granulosus dnaJ subfamily B 0.0412 0.5645 0.5629
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Leishmania major hypothetical protein, conserved 0.0042 0.0507 0.279
Schistosoma mansoni cpg binding protein 0.0031 0.0344 0.032
Schistosoma mansoni hypothetical protein 0.0412 0.5645 0.5634
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0884 0.086
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.036 0.0873
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0515 0.2843
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.036 0.0641
Echinococcus multilocularis dna polymerase eta 0.007 0.0897 0.0863
Echinococcus multilocularis geminin 0.0554 0.7623 0.7614
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1918 0.4553
Brugia malayi 6-phosphofructokinase 0.0117 0.1549 0.4795
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1549 0.1527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Onchocerca volvulus 0.0177 0.2386 0.6336
Echinococcus granulosus geminin 0.0554 0.7623 0.7614
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.323 1
Brugia malayi beta-lactamase 0.0042 0.0507 0.157
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1299 0.3273
Schistosoma mansoni cpg binding protein 0.0029 0.0321 0.0297
Mycobacterium ulcerans lipase LipD 0.0042 0.0507 0.1012
Leishmania major DNA polymerase eta, putative 0.007 0.0897 0.5486
Trichomonas vaginalis esterase, putative 0.0042 0.0507 0.1242
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.036 0.5
Trichomonas vaginalis set domain proteins, putative 0.0271 0.3686 0.9189
Echinococcus granulosus MAM 0.0017 0.0155 0.0118
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.036 0.3521
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.046 0.0424
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0486 0.2643
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0321 0.0995
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.036 0.3521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0402 0.0377
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0515 0.1031
Loa Loa (eye worm) beta-lactamase 0.0042 0.0507 0.157
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0603 0.148
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0138 0.0427
Schistosoma mansoni hypothetical protein 0.0017 0.0155 0.0129
Giardia lamblia DINP protein human, muc B family 0.0043 0.0515 0.1051
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.036 0.0641
Schistosoma mansoni hypothetical protein 0.0554 0.7623 0.7617
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.036 0.0641
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1549 0.4795
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1549 0.3845
Loa Loa (eye worm) phosphofructokinase 0.0117 0.1549 0.4795
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0515 0.048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0402 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1549 0.3257
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0507 0.279
Brugia malayi hypothetical protein 0.0017 0.0155 0.0479
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1549 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.046 0.1423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.4011 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1709 0.5291
Leishmania major DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.1549 0.1518
Onchocerca volvulus Huntingtin homolog 0.0129 0.1709 0.4427
Brugia malayi polk-prov protein 0.0013 0.0104 0.0323
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.1549 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0507 0.157
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.3675 0.8847
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0402 0.0366
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0507 0.0472
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0884 0.2736
Echinococcus granulosus cpg binding protein 0.0031 0.0344 0.0309
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0402 0.4102
Loa Loa (eye worm) TK/ALK protein kinase 0.0017 0.0155 0.0479
Brugia malayi hypothetical protein 0.0177 0.2386 0.7388
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.006 0.0185
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0884 0.5396
Echinococcus granulosus dna polymerase kappa 0.0043 0.0515 0.048
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0486 0.5264
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.03 0.4088 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0061 0.0025
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1918 0.394
Schistosoma mansoni DNA polymerase eta 0.007 0.0897 0.0873
Toxoplasma gondii ABC1 family protein 0.0042 0.0507 0.5556
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0515 0.0491
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.033 0.1563
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Giardia lamblia Kinase, PLK 0.0099 0.1299 0.3059
Brugia malayi hypothetical protein 0.0129 0.1709 0.5291
Brugia malayi Protein kinase domain containing protein 0.0017 0.0155 0.0479
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0897 0.5486
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1299 0.8273
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0884 0.5396
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0402 0.0377
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.1549 0.319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0507 0.0483
Plasmodium vivax SET domain protein, putative 0.0035 0.0402 0.0747
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.5645 0.5629
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.046 0.1123
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.046 0.0424
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.4011 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.036 0.0873
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1549 0.1527
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1299 0.1267
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.083 0.1821
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Schistosoma mansoni hypothetical protein 0.0017 0.0155 0.0129
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.036 0.0873
Loa Loa (eye worm) hypothetical protein 0.0177 0.2386 0.7388
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0884 0.1435
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.036 0.0873
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0515 0.1594
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.083 0.1821
Echinococcus granulosus transcription factor Dp 1 0.004 0.0478 0.0442
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1299 0.4022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.4011 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.046 0.246
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1549 0.3845
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1299 0.8273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0507 0.1242
Onchocerca volvulus 0.0017 0.0155 0.0047
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.036 0.3521
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.046 0.0424
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0515 0.0425
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0515 0.0491
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1299 0.2573
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0515 0.2843
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.046 0.1123
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0897 0.2776
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0897 0.5486
Echinococcus multilocularis cpg binding protein 0.0031 0.0344 0.0309
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1299 0.3222

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

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