TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.451 | Formula: C20H21NO3S
H donors: 1 H acceptors: 2 LogP: 3.03 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: SCC1(Cc2c(C1)cccc2)C(=O)NCC(=O)OCc1ccccc1
InChi: 1S/C20H21NO3S/c22-18(24-13-15-6-2-1-3-7-15)12-21-19(23)20(14-25)10-16-8-4-5-9-17(16)11-20/h1-9,25H,10-14H2,(H,21,23)
InChiKey: HKSBHRQLLDXSMP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Neprilysin	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus multilocularis	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Onchocerca volvulus		Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium leprae	probable zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Neospora caninum	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus granulosus	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Toxoplasma gondii	peptidase family M13 protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	IPR000718,Peptidase M13, neprilysin,domain-containing	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium ulcerans	zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Neprilysin	750 aa	713 aa	34.1 %
Onchocerca volvulus		Neprilysin	750 aa	682 aa	31.1 %
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	Neprilysin	750 aa	778 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0421	0.285
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Onchocerca volvulus		0.0034	0.0258	0.348
Echinococcus multilocularis	endothelin converting enzyme 1	0.0114	0.1284	0.1284
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Loa Loa (eye worm)	TK/ROR protein kinase	0.0052	0.0494	0.3343
Loa Loa (eye worm)	casein kinase II	0.0021	0.0094	0.0635
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0028	0.0182	0.1229
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0058	0.0562	0.4377
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0014	0.0005	0.0037
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0034	0.0258	0.0672
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0019	0.0066	0.0447
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0421	0.285
Leishmania major	phospholipase c-like protein	0.0019	0.0066	0.0876
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0018	0.0052	0.0355
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0246	0.1913
Echinococcus multilocularis	enteropeptidase	0.0014	0.0005	0.0005
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0014	0.0005	0.0037
Toxoplasma gondii	microneme protein MIC17B	0.0034	0.0258	0.0672
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0072	0.0741	1
Echinococcus granulosus	enteropeptidase	0.0014	0.0005	0.0037
Onchocerca volvulus		0.0014	0.0001	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1284	0.8693
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0421	0.5671
Onchocerca volvulus		0.0034	0.0258	0.348
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Toxoplasma gondii	PAN domain-containing protein	0.0314	0.3842	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0001	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Onchocerca volvulus		0.0014	0.0005	0.0064
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0072	0.0741	1
Toxoplasma gondii	hypothetical protein	0.0034	0.0258	0.0672
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0929	0.629
Leishmania major	phosphatidylinositol-specific phospholipase-like protein	0.0018	0.0052	0.0693
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0014	0.0005	0.0032
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0421	0.3273
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0494	0.3343
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0421	0.3273
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0258	0.1747
Brugia malayi	Peptidase family M13 containing protein	0.0114	0.1284	0.8693
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0246	0.1913
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0258	0.0672
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Schistosoma mansoni	casein kinase II beta subunit	0.0072	0.0741	0.5775
Onchocerca volvulus		0.0034	0.0258	0.348
Echinococcus multilocularis	transmembrane protease serine 3	0.0014	0.0005	0.0005
Onchocerca volvulus		0.0014	0.0005	0.0064
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0421	0.3273
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0021	0.0094	0.1253
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0018	0.0052	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0929	0.629
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.0904	0.6118
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Mycobacterium ulcerans	zinc metalloprotease	0.0114	0.1284	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0258	0.1747
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0271	0.3642
Brugia malayi	Trypsin family protein	0.0014	0.0005	0.0032
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.003	0.0207	0.1612
Loa Loa (eye worm)	Plcb4 protein	0.0018	0.0052	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1284	0.8693
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0271	0.2102
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0421	0.285
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0421	0.3273
Giardia lamblia	Casein kinase II beta chain	0.0072	0.0741	1
Onchocerca volvulus		0.0047	0.0421	0.5678
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0271	0.1833
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0019	0.0066	0.0447
Brugia malayi	Trypsin family protein	0.0014	0.0005	0.0032
Loa Loa (eye worm)	Csnk2b protein	0.0072	0.0741	0.502
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.1612
Toxoplasma gondii	hypothetical protein	0.0034	0.0258	0.0672
Plasmodium vivax	casein kinase II beta chain, putative	0.0072	0.0741	1
Onchocerca volvulus		0.0014	0.0001	0.0015
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0019	0.0066	0.0066
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0114	0.1284	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0421	0.5671
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0421	0.3273
Schistosoma mansoni	hypothetical protein	0.0014	0.0005	0.0037
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0005
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.0021	0.0094	0.1253
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0258	0.1747
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0421	0.3273
Toxoplasma gondii	propionate-CoA ligase	0.0014	0.0001	0.0003
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0028	0.0182	0.1414
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0421	0.5671
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.1612
Schistosoma mansoni	hypothetical protein	0.0052	0.0494	0.3846
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0028	0.0182	0.1414
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0001	0.0008
Onchocerca volvulus		0.0052	0.0494	0.6659
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0129	0.1477	1
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0001	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0052	0.0494	0.6654
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0072	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0058	0.0562	0.4377
Brugia malayi	Trypsin family protein	0.0014	0.0005	0.0032
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0066	0.0447
Toxoplasma gondii	microneme protein MIC17A	0.0034	0.0258	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0008
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0001	0.0008
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Loa Loa (eye worm)	trypsin family protein	0.0014	0.0005	0.0032
Leishmania major	hypothetical protein, conserved	0.0052	0.0494	0.6654
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0271	0.5
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0019	0.0066	0.0876
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0421	0.3273
Onchocerca volvulus		0.0014	0.0005	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0549	0.3715
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0421	0.5671
Brugia malayi	Trypsin-like protease protein 5	0.0014	0.0005	0.0032
Plasmodium vivax	phospholipase C-like, putative	0.0018	0.0052	0.0693
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.0562	0.4377
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0421	0.5671
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0929	0.629
Onchocerca volvulus		0.0034	0.0258	0.348
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0072	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0904	0.6118
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0421	0.285
Echinococcus granulosus	tissue type plasminogen activator	0.0052	0.0494	0.3846
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0246	0.1913
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0271	0.2102
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0258	0.0672
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0014	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Toxoplasma gondii	microneme protein, putative	0.0034	0.0258	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0929	0.629
Plasmodium falciparum	casein kinase II beta chain	0.0072	0.0741	1
Toxoplasma gondii	microneme protein MIC4	0.0034	0.0258	0.0672
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0114	0.1284	1
Toxoplasma gondii	microneme protein MIC17C	0.0034	0.0258	0.0672
Leishmania major	phosphoinositide-specific phospholipase C, putative	0.0018	0.0052	0.0693
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0904	0.6118
Schistosoma mansoni	endothelin-converting enzyme-related	0.0028	0.0182	0.1414
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.1612
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0052	0.0494	0.6654
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0072	0.0741	1
Onchocerca volvulus		0.0034	0.0258	0.348
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0421	0.285
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0421	0.3273
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0072	0.0741	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0258	0.1747
Onchocerca volvulus		0.0014	0.0001	0.0015
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0052	0.0355
Plasmodium falciparum	cysteine repeat modular protein 1	0.0052	0.0494	0.6654
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0005	0.0032
Schistosoma mansoni	hypothetical protein	0.0014	0.0005	0.0037
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0001	0.0008
Onchocerca volvulus		0.0034	0.0258	0.348
Onchocerca volvulus		0.0014	0.0005	0.0064
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0001	0.0008
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Onchocerca volvulus		0.0056	0.0549	0.7399
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0421	0.285
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0271	0.1833
Echinococcus multilocularis	Mastin	0.0014	0.0005	0.0005
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0058	0.0562	0.4377
Mycobacterium leprae	probable zinc metalloprotease	0.0114	0.1284	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0066	0.0447
Echinococcus multilocularis	glycoprotein Antigen 5	0.0014	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0271	0.1833
Onchocerca volvulus		0.0014	0.0005	0.0064
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0421	0.3273
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Brugia malayi	hypothetical protein	0.0014	0.0005	0.0032
Onchocerca volvulus		0.0034	0.0258	0.348
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.0904	0.6118
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0258	0.0672
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0034	0.0258	0.0672
Brugia malayi	casein kinase II, putaitve	0.0021	0.0094	0.0635
Schistosoma mansoni	acetyl-CoA synthetase	0.0014	0.0001	0.0009
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0072	0.0741	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0028	0.0182	0.1414
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0072	0.0741	1
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0019	0.0066	0.0514
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.0021	0.0094	0.1253
Echinococcus granulosus	casein kinase ii subunit beta	0.0072	0.0741	0.5775
Toxoplasma gondii	ck2 beta subunit	0.0072	0.0741	0.193
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0421	0.5671
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Echinococcus granulosus	endothelin converting enzyme 1	0.0114	0.1284	1
Schistosoma mansoni	phospholipase C beta	0.0018	0.0052	0.0408
Brugia malayi	Kringle domain containing protein	0.0052	0.0494	0.3343
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0421	0.3273
Schistosoma mansoni	neprilysin	0.003	0.0207	0.1612
Brugia malayi	peptidase family M13 containing protein	0.0028	0.0182	0.1229
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0421	0.3273
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.0562	0.4377
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0929	0.629
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0001	0.0001
Onchocerca volvulus		0.0034	0.0258	0.348
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0019	0.0066	0.0876
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0021	0.0094	0.1253
Echinococcus granulosus	transmembrane protease serine 3	0.0014	0.0005	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0271	0.1833
Plasmodium falciparum	phosphoinositide-specific phospholipase C	0.0018	0.0052	0.0693
Toxoplasma gondii	subtilisin SUB12	0.0034	0.0258	0.0672
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0929	0.629
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0028	0.0182	0.1414
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0421	0.3273
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0028	0.0182	0.1414
Toxoplasma gondii	kringle domain-containing protein	0.0052	0.0494	0.1285
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0014	0.0005	0.0037
Brugia malayi	Trypsin family protein	0.0014	0.0005	0.0032
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Toxoplasma gondii	PAN domain-containing protein	0.0034	0.0258	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0904	0.6118
Plasmodium falciparum	casein kinase II beta chain	0.0072	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0114	0.1284	0.8693
Loa Loa (eye worm)	PAN domain-containing protein	0.0034	0.0258	0.1747
Plasmodium vivax	casein kinase II beta chain, putative	0.0072	0.0741	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Onchocerca volvulus		0.0019	0.0066	0.089
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0001	0.0008
Mycobacterium ulcerans	hypothetical protein	0.0014	0.0005	0.0028
Onchocerca volvulus		0.0019	0.0066	0.089
Toxoplasma gondii	PAN domain-containing protein	0.0314	0.3842	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Brugia malayi	AMP-binding enzyme family protein	0.0014	0.0001	0.0008
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0271	0.3642
Onchocerca volvulus		0.0014	0.0001	0.0015
Brugia malayi	Variant SH3 domain containing protein	0.0129	0.1477	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1284	0.8693
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0001	0.0008
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0014	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Echinococcus multilocularis	casein kinase ii subunit beta	0.0072	0.0741	0.0741
Echinococcus granulosus	glycoprotein Antigen 5	0.0014	0.0005	0.0037
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0072	0.0741	1
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0019	0.0066	0.0172
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0246	0.1913
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0258	0.1747
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0014	0.0001	0.0008
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0072	0.0741	0.193
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Onchocerca volvulus		0.0034	0.0258	0.348
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0494	0.3343
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0014	0.0005	0.0037
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0021	0.0094	0.1253
Schistosoma mansoni	cercarial elastase (S01 family)	0.0014	0.0005	0.0037
Brugia malayi	Csnk2b protein	0.0072	0.0741	0.502
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Onchocerca volvulus		0.0034	0.0258	0.348
Toxoplasma gondii	peptidase family M13 protein	0.0114	0.1284	0.3342
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Brugia malayi	PAN domain containing protein	0.0034	0.0258	0.1747
Echinococcus multilocularis	tissue type plasminogen activator	0.0052	0.0494	0.0494
Schistosoma mansoni	hypothetical protein	0.003	0.0207	0.1612
Onchocerca volvulus		0.0014	0.0005	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0271	0.1833
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0014	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0904	0.6118
Onchocerca volvulus		0.0034	0.0258	0.348
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0072	0.0741	1
Echinococcus granulosus	Mastin	0.0014	0.0005	0.0037

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 10 nM	Inhibition of neutral endopeptidase(NEP).	ChEMBL.	No reference
Ki (binding)	= 10 nM	Inhibition of neutral endopeptidase(NEP).	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 102849