Detailed information for compound 1028895

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 298.835 | Formula: C13H19ClN4S
  • H donors: 1 H acceptors: 2 LogP: 4.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(c1nnc(s1)c1ccccc1C)N.Cl
  • InChi: 1S/C13H18N4S.ClH/c1-3-4-9-17(14)13-16-15-12(18-13)11-8-6-5-7-10(11)2;/h5-8H,3-4,9,14H2,1-2H3;1H
  • InChiKey: HYOMULTZVKDHRD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0876 0.3163
Onchocerca volvulus 0.005 0.0275 0.0286
Echinococcus granulosus glycogen phosphorylase 0.0105 0.1003 0.2792
Brugia malayi hypothetical protein 0.0049 0.0267 0.0317
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0625 0.766
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0615 0.0731
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0387 0.0283
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0275 0.0747
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0615 0.0847
Echinococcus granulosus transcription factor Dp 1 0.0039 0.013 0.0363
Brugia malayi hypothetical protein 0.0076 0.0625 0.0743
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.009 0.0813 1
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0275 0.0747
Trypanosoma brucei Polypeptide deformylase 1 0.009 0.0813 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0876 0.238
Brugia malayi PHD-finger family protein 0.003 0.0012 0.0014
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0012 0.0061
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1556 0.5351
Loa Loa (eye worm) hypothetical protein 0.0095 0.0876 0.1042
Echinococcus granulosus phd:f box containing protein 0.003 0.0007 0.0019
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0506 0.6185
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0275 0.0327
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0157 0.004
Echinococcus multilocularis jumonji domain containing protein 0.0128 0.1305 0.1305
Echinococcus multilocularis glycogen phosphorylase 0.0105 0.1003 0.1003
Mycobacterium ulcerans peptide deformylase 0.0237 0.2756 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0045 0.0215 0.0159
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0731
Onchocerca volvulus 0.0755 0.9626 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0366 0.0366
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0175 0.0487
Schistosoma mansoni jumonji domain containing protein 0.0238 0.2775 0.7537
Brugia malayi jmjC domain containing protein 0.003 0.0007 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0615 0.0522
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0625 0.2247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0615 0.167
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0513 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.0141
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0119 0.0123
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0012 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1013 0.1204
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0387 0.472
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.1085 0.129
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0387 0.1385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0615 0.167
Mycobacterium leprae Probable lipase LipE 0.0075 0.0615 0.1889
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0237 0.2756 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0506 0.1407
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.016 0.0435
Echinococcus granulosus PHD finger protein rhinoceros 0.0092 0.0829 0.2308
Trypanosoma brucei protein kinase, putative 0.0058 0.0387 0.472
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0387 0.0387
Echinococcus multilocularis chromobox protein 1 0.0068 0.0513 0.0513
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0175 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Echinococcus multilocularis lysine specific demethylase 5A 0.0111 0.1085 0.1085
Onchocerca volvulus 0.0075 0.0615 0.0639
Brugia malayi jmjC domain containing protein 0.003 0.0007 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0615 0.7538
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0387 0.472
Brugia malayi jmjC domain containing protein 0.03 0.3593 0.4272
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0275 0.0275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0092 0.0829 0.0986
Schistosoma mansoni hypothetical protein 0.0105 0.1013 0.275
Entamoeba histolytica glycogen phosphorylase, putative 0.0105 0.1003 0.2458
Brugia malayi beta-lactamase family protein 0.0075 0.0615 0.0731
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.085 0.2308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.085 0.2308
Entamoeba histolytica glycogen phosphorylase, putative 0.0045 0.0215 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0058 0.0158
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0615 0.0731
Brugia malayi MAP kinase sur-1 0.0058 0.0387 0.0461
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0008
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0615 0.1704
Trypanosoma cruzi Peptide deformylase 2, putative 0.009 0.0813 1
Leishmania major hypothetical protein, conserved 0.0076 0.0625 0.766
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0366 0.1019
Brugia malayi hypothetical protein 0.0041 0.016 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0157 0.004
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0058 0.0069
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.2271 0.6319
Leishmania major polypeptide deformylase-like protein, putative 0.009 0.0813 1
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0007 0.0008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0092 0.0829 0.2252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Toxoplasma gondii hypothetical protein 0.0237 0.2756 1
Echinococcus granulosus peregrin 0.0092 0.0829 0.2308
Schistosoma mansoni phd/f-box containing protein 0.003 0.0007 0.0018
Echinococcus multilocularis chromobox protein 1 0.0068 0.0513 0.0513
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0506 0.6185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Giardia lamblia Glycogen phosphorylase 0.0105 0.1003 0.1923
Schistosoma mansoni jumonji domain containing protein 0.003 0.0007 0.0018
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0175 0.0611
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0007 0.0008
Brugia malayi PHD-finger family protein 0.0092 0.0829 0.0986
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0506 0.1373
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0007 0.0018
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0262 0.0311
Echinococcus granulosus chromobox protein 1 0.0068 0.0513 0.1429
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0387 0.472
Schistosoma mansoni chromobox protein 0.0068 0.0513 0.1394
Echinococcus multilocularis Glycosyl transferase, family 35 0.0105 0.1003 0.1003
Onchocerca volvulus 0.003 0.001 0.001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0068 0.0188
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.009 0.0813 1
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0513 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0615 0.7538
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.03 0.3593 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0175 0.2084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0262 0.0262
Toxoplasma gondii ABC1 family protein 0.0075 0.0615 0.2211
Loa Loa (eye worm) hypothetical protein 0.0076 0.0625 0.0743
Loa Loa (eye worm) hypothetical protein 0.0157 0.1697 0.2018
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0829 0.2992
Mycobacterium tuberculosis Conserved protein 0.0075 0.0615 0.0847
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0007 0.0019
Mycobacterium ulcerans beta-lactamase 0.0075 0.0615 0.1704
Trypanosoma brucei Peptide deformylase 2 0.009 0.0813 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.016 0.0446
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0506 0.6185
Mycobacterium tuberculosis Conserved protein 0.0075 0.0615 0.0847
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Schistosoma mansoni chromobox protein 0.0068 0.0513 0.1394
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0012 0.0061
Mycobacterium ulcerans lipase LipD 0.0075 0.0615 0.1704
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.166 0.1973
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0275 0.0747
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.083 0.231
Giardia lamblia PHD finger protein 15 0.0092 0.0829 0.138
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0175 0.0059
Leishmania major hypothetical protein, conserved 0.0075 0.0615 0.7538
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0615 0.0847
Loa Loa (eye worm) hypothetical protein 0.0057 0.0366 0.0436
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0876 0.2439
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0366 0.0436
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0387 0.0461
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.1085 0.2946
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0387 0.0283
Echinococcus granulosus glycogen phosphorylase 0.0105 0.1003 0.2792
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0506 0.0601
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0615 0.7538
Mycobacterium ulcerans hypothetical protein 0.0075 0.0615 0.1704
Schistosoma mansoni inositol monophosphatase 0.0042 0.0175 0.0475
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0007 0.0007
Brugia malayi beta-lactamase family protein 0.0075 0.0615 0.0731
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0731
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0007 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0615 0.0847
Loa Loa (eye worm) MBCTL1 0.0057 0.0366 0.0436
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0262 0.0311
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0876 0.0876
Onchocerca volvulus Alhambra homolog 0.0092 0.0829 0.0862
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0106 0.1023 0.2779
Echinococcus multilocularis GPCR, family 2 0.0049 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0731
Brugia malayi carbohydrate phosphorylase 0.0105 0.1003 0.1193
Trypanosoma cruzi Peptide deformylase 2, putative 0.009 0.0813 1
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.1085 0.302
Plasmodium falciparum phd finger protein, putative 0.0092 0.0829 0.2992
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0387 0.1078
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0014
Chlamydia trachomatis peptide deformylase 0.0237 0.2756 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0615 0.1711
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0275 0.0275
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0262 0.0311
Brugia malayi Bromodomain containing protein 0.0092 0.0829 0.0986
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.013 0.013
Echinococcus multilocularis geminin 0.0194 0.2185 0.2185
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0175 0.2084
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0275 0.0765
Brugia malayi beta-lactamase 0.0075 0.0615 0.0731
Plasmodium vivax peptide deformylase, putative 0.0237 0.2756 1
Schistosoma mansoni protein phosphatase 2C 0.003 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0092 0.0829 0.2252
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0506 0.6185
Echinococcus granulosus Glycosyl transferase family 35 0.0105 0.1003 0.2792
Echinococcus granulosus jumonji domain containing protein 0.0128 0.1305 0.3632
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0175 0.0059
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0731
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3589 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0615 0.1889
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0366 0.0995
Loa Loa (eye worm) hypothetical protein 0.0105 0.1013 0.1204
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.016 0.016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.166 0.1973
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0012
Schistosoma mansoni glycogen phosphorylase 0.0105 0.1003 0.2724
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.3589 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.166 0.1973
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0387 0.0283
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0615 0.0522
Brugia malayi AF-10 protein 0.003 0.0012 0.0014
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0068 0.0068
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0275 0.0765
Schistosoma mansoni hypothetical protein 0.0307 0.3682 1
Schistosoma mansoni hypothetical protein 0.0049 0.0262 0.0711
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0615 0.0847
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0625 0.2247
Trichomonas vaginalis glycogen phosphorylase, putative 0.0105 0.1003 0.093
Trichomonas vaginalis glycogen phosphorylase, putative 0.0105 0.1003 0.093
Echinococcus multilocularis glycogen phosphorylase 0.0105 0.1003 0.1003
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0262 0.0311
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0506 0.0601
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0387 0.0283
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0045 0.0215 0.0168
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0275 0.0286
Loa Loa (eye worm) inositol-1 0.0042 0.0175 0.0208
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0175 0.0059
Brugia malayi chromobox protein homolog 3 0.0038 0.0119 0.0141
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0625 0.766
Loa Loa (eye worm) beta-lactamase 0.0075 0.0615 0.0731
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0625 0.2247
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.003 0.0012 0.0018
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0366 0.1019
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.085 0.085
Entamoeba histolytica glycogen phosphorylase, putative 0.0045 0.0215 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0876 0.238
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0175 0.2084
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0237 0.2756 1
Schistosoma mansoni hypothetical protein 0.0049 0.0262 0.0711
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0615 0.2211
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.0012 0.0018
Echinococcus granulosus geminin 0.0194 0.2185 0.608
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.6004 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1556 0.2446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.085 0.2308
Loa Loa (eye worm) hypothetical protein 0.005 0.0275 0.0327
Loa Loa (eye worm) hypothetical protein 0.0075 0.0615 0.0731
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.2271 0.2271
Brugia malayi Pre-SET motif family protein 0.0663 0.8411 1
Schistosoma mansoni hypothetical protein 0.0194 0.2185 0.5933
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0237 0.2756 0.4484
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1556 0.5455
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0045 0.0215 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Trichomonas vaginalis set domain proteins, putative 0.0755 0.9626 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0663 0.8411 1
Schistosoma mansoni inositol monophosphatase 0.0042 0.0175 0.0475
Entamoeba histolytica glycogen phosphorylase, putative 0.0105 0.1003 0.2458
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0387 0.472
Schistosoma mansoni hypothetical protein 0.0041 0.016 0.0435
Brugia malayi jmjC domain containing protein 0.003 0.0007 0.0008
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0007 0.0019
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0007 0.0018
Onchocerca volvulus 0.0075 0.0615 0.0639
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0262 0.0729
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0262 0.0729
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0829 0.2992
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.03 0.3593 0.3593
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3589 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0615 0.1704
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0387 0.472
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0625 0.2247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0876 0.238
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.003 0.0012 0.0018
Schistosoma mansoni hypothetical protein 0.0049 0.0262 0.0711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.085 0.2365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.085 0.2365
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0615 0.0522
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0387 0.472
Echinococcus granulosus GPCR family 2 0.0049 0.0262 0.0729
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0175 0.2084
Echinococcus granulosus chromobox protein 1 0.0068 0.0513 0.1429
Brugia malayi jmjC domain containing protein 0.003 0.0007 0.0008
Schistosoma mansoni glycogen phosphorylase 0.0105 0.1003 0.2724
Schistosoma mansoni hypothetical protein 0.003 0.0012 0.0032
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0615 0.0522
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0387 0.0387
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0007 0.0019
Toxoplasma gondii PHD-finger domain-containing protein 0.0092 0.0829 0.2992
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0625 0.766
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0615 0.0615
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0615 0.0847
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0387 0.1052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.085 0.1011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.1085 0.2946
Plasmodium falciparum peptide deformylase 0.0237 0.2756 1
Plasmodium vivax SET domain protein, putative 0.0095 0.0876 0.3163
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0876 0.0876
Brugia malayi mbt repeat family protein 0.005 0.0275 0.0327
Loa Loa (eye worm) PHD-finger family protein 0.0092 0.0829 0.0986
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.3589 1
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0387 0.1078
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0387 0.472
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Brugia malayi mbt repeat family protein 0.005 0.0275 0.0327
Brugia malayi jmjC domain containing protein 0.0111 0.1085 0.129
Brugia malayi Heterochromatin protein 1 0.0068 0.0513 0.0611
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0366 0.0366
Schistosoma mansoni hypothetical protein 0.0194 0.2185 0.5933
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0262 0.0262
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0175 0.0175
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0615 0.0847
Echinococcus multilocularis peregrin 0.0092 0.0829 0.0829
Loa Loa (eye worm) glycogen phosphorylase 0.0105 0.1003 0.1193
Onchocerca volvulus 0.0106 0.1023 0.1063
Echinococcus multilocularis phd:f box containing protein 0.003 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0049 0.0262 0.0711
Brugia malayi Inositol-1 0.0042 0.0175 0.0208
Loa Loa (eye worm) hypothetical protein 0.0154 0.166 0.1973
Schistosoma mansoni hypothetical protein 0.0034 0.0068 0.0184
Echinococcus multilocularis PHD finger protein rhinoceros 0.0092 0.0829 0.0829
Brugia malayi Pre-SET motif family protein 0.0095 0.0876 0.1042
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0007 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.085 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0615 0.0522
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.085 0.085
Loa Loa (eye worm) jmjC domain-containing protein 0.0189 0.2123 0.2524
Onchocerca volvulus Glycogen phosphorylase homolog 0.0105 0.1003 0.1042
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0615 0.0847
Schistosoma mansoni glycogen phosphorylase 0.0045 0.0215 0.0584
Onchocerca volvulus 0.0075 0.0615 0.0639
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0513 0.0415
Mycobacterium tuberculosis Conserved protein 0.0075 0.0615 0.0847
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0008
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0157 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3589 0.3651
Trichomonas vaginalis esterase, putative 0.0075 0.0615 0.0522
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0506 0.1007

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 60 mg kg-1 Anticonvulsant activity tested by maximal metrazole seizure (MMS) test in mouse after 1 hr of administration ChEMBL. 3783589
ED50 (functional) = 119 mg kg-1 Anticonvulsant activity tested by maximal electroshock test (MES) in mouse after 1 hr of administration ChEMBL. 3783589

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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