Detailed information for compound 1029615

Basic information

Technical information
  • TDR Targets ID: 1029615
  • Name: 3-hydrazinyl-2,6-dihydro-1H-1,2,4-triazin-4-i um-5-one chloride
  • MW: 165.582 | Formula: C3H8ClN5O
  • H donors: 4 H acceptors: 1 LogP: -1.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC1=NC(=O)CNN1.Cl
  • InChi: 1S/C3H7N5O.ClH/c4-7-3-6-2(9)1-5-8-3;/h5H,1,4H2,(H2,6,7,8,9);1H
  • InChiKey: BOXFSDZZMNMMEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydrazino-2,6-dihydro-1H-1,2,4-triazin-4-ium-5-one chloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0508 0.0674
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0508 0.0674
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Echinococcus multilocularis cpg binding protein 0.0031 0.0593 0.0579
Brugia malayi MH2 domain containing protein 0.0008 0.004 0.0036
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0013 0.0149 0.0306
Echinococcus granulosus Smad4 0.0008 0.004 0.0026
Loa Loa (eye worm) Smad1 0.0008 0.004 0.0036
Schistosoma mansoni lamin 0.0028 0.0508 0.0495
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0149 1
Echinococcus multilocularis geminin 0.0173 0.4048 0.404
Plasmodium falciparum enoyl-acyl carrier reductase 0.0189 0.4429 1
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0149 0.0135
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0149 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Brugia malayi MH2 domain containing protein 0.0008 0.004 0.0036
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0149 0.0306
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.004 0.0026
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0149 0.0306
Brugia malayi CXXC zinc finger family protein 0.0029 0.0552 0.0733
Brugia malayi MH1 domain containing protein 0.0008 0.004 0.0036
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0013 0.0149 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Loa Loa (eye worm) oxidoreductase 0.0013 0.0149 0.0184
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0149 0.0135
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.004 0.0026
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0016 0.0001
Schistosoma mansoni cpg binding protein 0.0029 0.0552 0.0538
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0013 0.0149 0.0306
Schistosoma mansoni hypothetical protein 0.0054 0.1153 0.114
Echinococcus multilocularis smad 0.0008 0.004 0.0026
Schistosoma mansoni hypothetical protein 0.0173 0.4048 0.404
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0013 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0508 0.0674
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Brugia malayi MH1 domain containing protein 0.0008 0.004 0.0036
Onchocerca volvulus 0.0028 0.0508 0.0499
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0162 0.0148
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0189 0.4429 1
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Mycobacterium ulcerans oxidoreductase 0.0013 0.0149 0.0306
Loa Loa (eye worm) spectraplakin 0.0054 0.1153 0.1553
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0189 0.4429 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0149 0.0306
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0149 0.0135
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0149 0.1187
Echinococcus multilocularis Spectrin alpha actinin 0.0054 0.1153 0.114
Brugia malayi Smad1 0.0008 0.004 0.0036
Schistosoma mansoni intermediate filament proteins 0.0028 0.0508 0.0495
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0149 0.0306
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.004 0.0036
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0149 0.1187
Echinococcus multilocularis musashi 0.0028 0.0508 0.0495
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.004 0.0026
Brugia malayi Growth-Arrest-Specific Protein 2 Domain containing protein 0.0054 0.1153 0.1553
Schistosoma mansoni Smad4 0.0008 0.004 0.0026
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.004 0.0036
Onchocerca volvulus 0.0029 0.0552 0.0559
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0149 0.0184
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0149 0.0184
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0013 0.0149 0.0306
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0045
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0189 0.4429 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Schistosoma mansoni smad1 5 8 and 0.0008 0.004 0.0026
Leishmania major pteridine reductase 1 0.0013 0.0149 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0149 0.0306
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0508 0.0674
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0189 0.4429 1
Trypanosoma brucei pteridine reductase 1 0.0013 0.0149 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0013 0.0149 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0149 0.0306
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0013 0.0149 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0001
Echinococcus multilocularis lamin 0.0028 0.0508 0.0495
Loa Loa (eye worm) hypothetical protein 0.0054 0.1153 0.1553
Echinococcus granulosus geminin 0.0173 0.4048 0.404
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.004 0.0026
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0189 0.4429 1
Brugia malayi VAB-10A protein 0.0054 0.1153 0.1553
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0059 0.0061
Echinococcus granulosus lamin 0.0028 0.0508 0.0495
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0013 0.0149 0.0306
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2804 0.3805
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0001
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0013 0.0149 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Schistosoma mansoni cpg binding protein 0.0031 0.0593 0.0579
Trypanosoma cruzi kinetoplast DNA-associated protein, putative 0.0054 0.1153 1
Brugia malayi hypothetical protein 0.0309 0.7346 1
Brugia malayi intermediate filament protein 0.0028 0.0508 0.0674
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0197 0.025
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0016 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Schistosoma mansoni hypothetical protein 0.0054 0.1153 0.114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0149 0.0184
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0013 0.0149 1
Echinococcus granulosus cpg binding protein 0.0031 0.0593 0.0579
Onchocerca volvulus 0.0028 0.0508 0.0499
Onchocerca volvulus 0.0309 0.7346 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Schistosoma mansoni hypothetical protein 0.0173 0.4048 0.404
Mycobacterium tuberculosis Possible oxidoreductase 0.0013 0.0149 0.0306
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0056 0.0057
Leishmania major oxidoreductase-like protein 0.0013 0.0149 1
Trichomonas vaginalis hypothetical protein 0.0189 0.4429 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0013 0.0149 0.0306
Schistosoma mansoni smad1 5 8 and 0.0008 0.004 0.0026
Schistosoma mansoni hypothetical protein 0.0418 1 1
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0189 0.4429 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.7346 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Schistosoma mansoni cpg binding protein 0.0031 0.0593 0.0579
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0013 0.0149 0.1187
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0013 0.0149 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0149 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0149 0.0184
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0016 0.0001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0162 0.0148
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0013 0.0149 0.0306
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0013 0.0149 0.0306
Echinococcus granulosus lamin dm0 0.0028 0.0508 0.0495
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0149 0.0184
Echinococcus granulosus Spectrin alpha actinin 0.0054 0.1153 0.114
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Loa Loa (eye worm) hypothetical protein 0.0013 0.0162 0.0201
Loa Loa (eye worm) hypothetical protein 0.0013 0.0149 0.0184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0552 0.0733
Echinococcus granulosus smad 0.0008 0.004 0.0026
Echinococcus granulosus intermediate filament protein 0.0028 0.0508 0.0495
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2804 0.3805
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1352 0.1339
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0197 0.025
Echinococcus multilocularis dnaJ subfamily B 0.0418 1 1
Schistosoma mansoni smad 0.0008 0.004 0.0026
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.119 0.2663
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0149 0.0184
Echinococcus multilocularis lamin dm0 0.0028 0.0508 0.0495
Brugia malayi MH2 domain containing protein 0.0122 0.2804 0.3805
Schistosoma mansoni smad1 5 8 and 0.0008 0.004 0.0026
Schistosoma mansoni lamin 0.0028 0.0508 0.0495
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0149 0.0306
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0149 0.0306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0496 0.0657
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0013 0.0149 0.0306
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0149 0.0135
Echinococcus multilocularis Smad4 0.0008 0.004 0.0026
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.004 0.0026
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0149 0.0306
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0045
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0189 0.4429 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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