TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 427.452 | Formula: C25H21N3O4
H donors: 2 H acceptors: 2 LogP: 5.38 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O/N=C(/c1ccc(nc1Oc1ccc2c(c1)c1ccccc1o2)C)\NCc1ccc(o1)C
InChi: 1S/C25H21N3O4/c1-15-7-11-20(24(28-29)26-14-18-9-8-16(2)30-18)25(27-15)31-17-10-12-23-21(13-17)19-5-3-4-6-22(19)32-23/h3-13,29H,14H2,1-2H3,(H,26,28)
InChiKey: MFPMGTWFTOJYJK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cyclin d	0.0028	0.0558	0.0558
Onchocerca volvulus		0.0028	0.0558	0.056
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0134	0.0134
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0121	0.014
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0558	0.0462
Echinococcus granulosus	lamin dm0	0.0028	0.0571	0.0571
Onchocerca volvulus	Protein CNPPD1 homolog	0.0028	0.0558	0.056
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0134	0.0134
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0282	0.0093
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Trypanosoma brucei	mitotic cyclin 6	0.022	0.5369	0.6877
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0583	0.0673
Trichomonas vaginalis	cyclin D, putative	0.0114	0.2716	0.3495
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.3362	0.3362
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0134	0.0155
Echinococcus granulosus	cpg binding protein	0.003	0.0623	0.0623
Plasmodium falciparum	protein kinase 5	0.014	0.3362	0.4201
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0558	0.0684
Trichomonas vaginalis	cyclins, putative	0.0114	0.2716	0.3495
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0866	0.0866
Brugia malayi	hypothetical protein	0.0006	0.001	0.0012
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0048	0.0048
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0314	0.7711	0.8904
Echinococcus granulosus	cyclin y	0.0028	0.0558	0.0558
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0314	0.7711	1
Schistosoma mansoni	g1/s-specific cyclin C	0.0028	0.0558	0.0558
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.5727	0.5727
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0927	0.0927
Echinococcus granulosus	GPCR family 2	0.0033	0.0706	0.0706
Echinococcus granulosus	cyclin B3 1	0.0114	0.2716	0.2716
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.5727	0.5727
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1675	0.1934
Leishmania major	mitotic cyclin, putative	0.0028	0.0558	0.0462
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0134	0.0134
Echinococcus multilocularis	G1:S specific cyclin D1	0.0028	0.0558	0.0558
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.022	0.5369	0.6877
Brugia malayi	steroid hormone receptor	0.0011	0.0134	0.0155
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.014	0.3362	0.4201
Entamoeba histolytica	hypothetical protein	0.0036	0.0762	0.0286
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.138	0.138
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.014	0.3362	0.4201
Brugia malayi	intracellular kinase	0.0314	0.7711	0.8904
Trichomonas vaginalis	CMGC family protein kinase	0.014	0.3362	0.4336
Echinococcus multilocularis	cyclin G2	0.0028	0.0558	0.0558
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Echinococcus multilocularis	cyclin y	0.0028	0.0558	0.0558
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0571	0.066
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.001	0.0012
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0282	0.0093
Mycobacterium tuberculosis	Probable reductase	0.009	0.2111	0.8837
Entamoeba histolytica	hypothetical protein	0.0036	0.0762	0.0286
Echinococcus multilocularis	musashi	0.0028	0.0571	0.0571
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0762	0.0762
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0134	0.0134
Entamoeba histolytica	cyclin family protein	0.0114	0.2716	0.3017
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.3461	0.3461
Trichomonas vaginalis	cyclin B, putative	0.022	0.5369	0.695
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0706	0.0706
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0028	0.0558	0.0644
Echinococcus granulosus	intermediate filament protein	0.0028	0.0571	0.0571
Trichomonas vaginalis	CMGC family protein kinase	0.014	0.3362	0.4336
Brugia malayi	RNA recognition motif domain containing protein	0.0134	0.3223	0.3722
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0134	0.0134
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0028	0.0558	0.0462
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0134	0.0155
Mycobacterium tuberculosis	Probable oxidoreductase	0.01	0.2361	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0134	0.0155
Brugia malayi	hypothetical protein	0.0028	0.0558	0.0644
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0028	0.0558	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0197	0.0227
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Loa Loa (eye worm)	hypothetical protein	0.022	0.5369	0.62
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0134	0.0155
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0134	0.0155
Onchocerca volvulus		0.0314	0.7711	1
Loa Loa (eye worm)	cyclin C	0.0028	0.0558	0.0644
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0927	0.0954
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.2509	0.2897
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0134	0.0134
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0209	0.0209
Schistosoma mansoni	hypothetical protein	0.0406	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0583	0.0673
Trypanosoma brucei	protein kinase, putative	0.0314	0.7711	1
Schistosoma mansoni	lamin	0.0028	0.0571	0.0571
Echinococcus multilocularis	cpg binding protein	0.003	0.0623	0.0623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0134	0.0155
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.001	0.001
Giardia lamblia	Cyclin fold protein 1, putative	0.0028	0.0558	0.0462
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0246	0.0285
Trichomonas vaginalis	glutathione reductase, putative	0.0014	0.0212	0.0233
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0571	0.066
Entamoeba histolytica	cell division protein kinase 2, putative	0.014	0.3362	0.392
Entamoeba histolytica	cell division protein kinase 2, putative	0.014	0.3362	0.392
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.3223	0.3223
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0134	0.0155
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0134	0.0134
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0209	0.0209
Leishmania major	cyclin 9, putative	0.0028	0.0558	0.0462
Schistosoma mansoni	cyclin B	0.022	0.5369	0.5369
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.001	0.001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0134	0.0134
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0028	0.0558	0.0462
Schistosoma mansoni	hypothetical protein	0.0033	0.0706	0.0706
Trichomonas vaginalis	cyclin B, putative	0.0114	0.2716	0.3495
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0314	0.7711	0.7711
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0134	0.0134
Loa Loa (eye worm)	cyclin domain-containing protein	0.0028	0.0558	0.0644
Brugia malayi	nuclear receptor RXR	0.0006	0.001	0.0012
Brugia malayi	hypothetical protein	0.0036	0.0762	0.088
Trypanosoma cruzi	hypothetical protein, conserved	0.0028	0.0558	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0558	0.0684
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0927	0.1165
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0092	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0558	0.0684
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0762	0.0762
Echinococcus granulosus	cyclin G2	0.0028	0.0558	0.0558
Echinococcus multilocularis	protein kinase shaggy	0.0314	0.7711	0.7711
Schistosoma mansoni	hypothetical protein	0.0036	0.0762	0.0762
Schistosoma mansoni	hypothetical protein	0.0033	0.0706	0.0706
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0282	0.0325
Schistosoma mansoni	cyclin B3	0.0352	0.866	0.866
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0571	0.066
Loa Loa (eye worm)	hypothetical protein	0.0006	0.001	0.0012
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0853	0.0856
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0089	0.0102
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.009	0.2111	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0558	0.0684
Echinococcus multilocularis	cyclin dependent kinase 1	0.014	0.3362	0.3362
Echinococcus multilocularis	cyclin dependent kinase	0.014	0.3362	0.3362
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0134	0.0155
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0282	0.0093
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0134	0.0134
Schistosoma mansoni	hypothetical protein	0.0048	0.1066	0.1066
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0135	0.3251	0.3754
Giardia lamblia	Hypothetical protein	0.0028	0.0558	0.0462
Trypanosoma cruzi	cyclin 6, putative	0.022	0.5369	0.6877
Plasmodium falciparum	cyclin 1	0.0028	0.0558	0.0462
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0706	0.0706
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0134	0.0134
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0853	0.2985
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0134	0.0155
Trypanosoma cruzi	cdc2-related kinase 1	0.014	0.3362	0.4201
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0282	0.0282
Echinococcus multilocularis	Cyclin L1	0.0028	0.0558	0.0558
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0927	0.0954
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Schistosoma mansoni	survival motor neuron protein	0.0048	0.1066	0.1066
Echinococcus granulosus	cyclin A3 4	0.0028	0.0558	0.0558
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.014	0.3362	0.3883
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2509	0.2897
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0028	0.0558	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0209	0.0242
Schistosoma mansoni	cpg binding protein	0.003	0.0623	0.0623
Trypanosoma brucei	trypanothione reductase	0.0039	0.0853	0.0856
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0028	0.0558	0.0558
Loa Loa (eye worm)	CYL-1 protein	0.0028	0.0558	0.0644
Brugia malayi	Cyclin, N-terminal domain containing protein	0.022	0.5369	0.62
Loa Loa (eye worm)	acetyltransferase	0.0144	0.3461	0.3996
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Loa Loa (eye worm)	cyclin domain-containing protein	0.0028	0.0558	0.0644
Trichomonas vaginalis	cyclin B3, putative	0.0028	0.0558	0.0684
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.1675	0.1934
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0246	0.0285
Trichomonas vaginalis	CMGC family protein kinase	0.0314	0.7711	1
Echinococcus granulosus	cyclin dependent kinase	0.014	0.3362	0.3362
Giardia lamblia	Cyclin B-like protein	0.0028	0.0558	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0134	0.0155
Trichomonas vaginalis	cyclins, putative	0.0134	0.3211	0.4139
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0706	0.0706
Entamoeba histolytica	protein kinase, putative	0.0314	0.7711	1
Trypanosoma cruzi	cdc2-related kinase 1	0.014	0.3362	0.4201
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0134	0.0134
Echinococcus multilocularis	cyclin dependent kinase 1	0.014	0.3362	0.3362
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0134	0.0155
Schistosoma mansoni	lamin	0.0028	0.0571	0.0571
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0706	0.0706
Trichomonas vaginalis	CMGC family protein kinase	0.0314	0.7711	1
Onchocerca volvulus		0.022	0.5369	0.6909
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0352	0.866	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0212	0.5
Echinococcus granulosus	G1:S specific cyclin D1	0.0028	0.0558	0.0558
Brugia malayi	Cyclin, N-terminal domain containing protein	0.022	0.5369	0.62
Echinococcus multilocularis	cyclin dependent kinase 5	0.014	0.3362	0.3362
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.009	0.2111	0.8837
Schistosoma mansoni	coup transcription factor	0.0011	0.0134	0.0134
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0134	0.0155
Trichomonas vaginalis	cyclin B3, putative	0.0114	0.2716	0.3495
Onchocerca volvulus		0.0028	0.0571	0.0578
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0853	0.0985
Echinococcus granulosus	cyclins	0.0114	0.2716	0.2716
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0028	0.0558	0.0462
Entamoeba histolytica	cyclin family protein	0.0114	0.2716	0.3017
Loa Loa (eye worm)	cyclin domain-containing protein	0.0352	0.866	1
Schistosoma mansoni	hypothetical protein	0.0028	0.0558	0.0558
Echinococcus granulosus	protein kinase shaggy	0.0314	0.7711	0.7711
Schistosoma mansoni	hypothetical protein	0.0033	0.0706	0.0706
Echinococcus multilocularis	lamin	0.0028	0.0571	0.0571
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0706	0.0706
Trypanosoma cruzi	cdc2-related kinase 3	0.014	0.3362	0.4201
Trichomonas vaginalis	cyclin D, putative	0.0028	0.0558	0.0684
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0028	0.0558	0.0462
Toxoplasma gondii	cyclin 4, putative	0.0028	0.0558	0.0462
Trichomonas vaginalis	cyclins, putative	0.022	0.5369	0.695
Brugia malayi	ecdysteroid receptor	0.0011	0.0134	0.0155
Brugia malayi	Cyclin C	0.0028	0.0558	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0558	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0559	0.0645
Trichomonas vaginalis	mercuric reductase, putative	0.0014	0.0212	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0006	0.001	0.0012
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0134	0.0155
Giardia lamblia	Kinase, CMGC CDK	0.014	0.3362	0.4201
Echinococcus granulosus	lamin	0.0028	0.0571	0.0571
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0121	0.014
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0014	0.0212	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.014	0.3362	0.3883
Trypanosoma brucei	cyclin 3	0.0028	0.0558	0.0462
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0282	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0197	0.0227
Echinococcus granulosus	cyclin y	0.0028	0.0558	0.0558
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0134	0.0134
Trichomonas vaginalis	CMGC family protein kinase	0.014	0.3362	0.4336
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0134	0.0134
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0314	0.7711	0.7711
Trichomonas vaginalis	cyclin A, putative	0.0028	0.0558	0.0684
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.01	0.2361	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0282	0.0093
Loa Loa (eye worm)	cyclin domain-containing protein	0.0028	0.0558	0.0644
Echinococcus granulosus	geminin	0.0345	0.8466	0.8466
Onchocerca volvulus		0.0028	0.0571	0.0578
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.3461	0.3461
Trypanosoma brucei	cyclin 9	0.0028	0.0558	0.0462
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.3223	0.3223
Echinococcus multilocularis	cyclin G2	0.0028	0.0558	0.0558
Brugia malayi	Thioredoxin reductase	0.0039	0.0853	0.0985
Echinococcus multilocularis	tar DNA binding protein	0.0134	0.3223	0.3223
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0134	0.0134
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0134	0.0134
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Echinococcus granulosus	cyclin dependent kinase 5	0.014	0.3362	0.3362
Trypanosoma brucei	cdc2-related kinase 1	0.014	0.3362	0.4201
Echinococcus granulosus	cyclin dependent kinase 1	0.014	0.3362	0.3362
Leishmania major	cyclin	0.022	0.5369	0.6877
Brugia malayi	RNA binding protein	0.0134	0.3223	0.3722
Brugia malayi	hypothetical protein	0.0028	0.0558	0.0644
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.3223	0.3223
Trypanosoma brucei	mitotic cyclin	0.0028	0.0558	0.0462
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.3223	0.3223
Trypanosoma cruzi	cdc2-related kinase 3	0.014	0.3362	0.4201
Plasmodium vivax	protein kinase Crk2	0.014	0.3362	0.4201
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0352	0.866	0.866
Echinococcus multilocularis	cyclin A3 4	0.0028	0.0558	0.0558
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.014	0.3362	0.4201
Echinococcus granulosus	cyclins	0.0114	0.2716	0.2716
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0134	0.0134
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0134	0.0155
Plasmodium falciparum	cyclin	0.0114	0.2716	0.334
Onchocerca volvulus		0.0029	0.0583	0.0592
Giardia lamblia	Kinase, CMGC CDK	0.014	0.3362	0.4201
Loa Loa (eye worm)	cyclin domain-containing protein	0.0028	0.0558	0.0644
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0134	0.0134
Echinococcus multilocularis	cyclin B	0.022	0.5369	0.5369
Echinococcus multilocularis	lamin dm0	0.0028	0.0571	0.0571
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.3461	0.3996
Loa Loa (eye worm)	hypothetical protein	0.022	0.5369	0.62
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0352	0.866	0.866
Loa Loa (eye worm)	RNA binding protein	0.0134	0.3223	0.3722
Entamoeba histolytica	hypothetical protein	0.0036	0.0762	0.0286
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0134	0.0134
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0028	0.0558	0.0462
Trichomonas vaginalis	cyclin B3, putative	0.0028	0.0558	0.0684
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0014	0.0212	0.5
Schistosoma mansoni	cyclins	0.0114	0.2716	0.2716
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2524	0.2915
Echinococcus granulosus	cyclin b3	0.0114	0.2716	0.2716
Brugia malayi	glutathione reductase	0.0039	0.0853	0.0985
Echinococcus multilocularis	cyclin t1	0.0028	0.0558	0.0558
Trypanosoma cruzi	cyclin, putative	0.022	0.5369	0.6877
Giardia lamblia	Hypothetical protein	0.0028	0.0558	0.0462
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.001	0.0012
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0282	0.0093
Schistosoma mansoni	tar DNA-binding protein	0.0134	0.3223	0.3223
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0235	0.5727	0.6613
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.01	0.2361	1
Trichomonas vaginalis	cyclin B, putative	0.022	0.5369	0.695
Leishmania major	trypanothione reductase	0.0039	0.0853	0.0856
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0134	0.0155
Echinococcus granulosus	cyclin G2	0.0028	0.0558	0.0558
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0048	0.0048
Schistosoma mansoni	hypothetical protein	0.0028	0.0558	0.0558
Trichomonas vaginalis	cyclins, putative	0.022	0.5369	0.695
Echinococcus granulosus	cyclins	0.0114	0.2716	0.2716
Trichomonas vaginalis	cyclin B, putative	0.022	0.5369	0.695
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.014	0.3362	0.3883
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.3362	0.3362
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0571	0.0571
Plasmodium falciparum	glutathione reductase	0.0039	0.0853	0.0856
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.009	0.2111	0.8837
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0282	0.0282
Giardia lamblia	Hypothetical protein	0.0114	0.2716	0.334
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0.0212	0.5
Trichomonas vaginalis	cyclin B, putative	0.0028	0.0558	0.0684
Echinococcus multilocularis	cyclin y	0.0028	0.0558	0.0558
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0282	0.0282
Echinococcus granulosus	cyclins	0.0028	0.0558	0.0558
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0134	0.0134
Echinococcus granulosus	Cyclin L1	0.0028	0.0558	0.0558
Schistosoma mansoni	hypothetical protein	0.0072	0.1675	0.1675
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0134	0.3223	0.3722
Brugia malayi	Protein kinase domain containing protein	0.014	0.3362	0.3883
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0282	0.0282
Leishmania major	mitotic cyclin, putative	0.0028	0.0558	0.0462
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0282	0.0325
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0706	0.0815
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0314	0.7711	0.7711
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0028	0.0558	0.0558
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0282	0.0282
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0134	0.0155
Brugia malayi	cell division control protein 2 homolog	0.014	0.3362	0.3883
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0134	0.0155
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0706	0.0815
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0314	0.7711	0.8904
Echinococcus granulosus	cyclin t1	0.0028	0.0558	0.0558
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0028	0.0558	0.0462
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.2509	0.2897
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0282	0.0093
Plasmodium falciparum	glycogen synthase kinase 3	0.0314	0.7711	1
Echinococcus multilocularis	cyclin k	0.0028	0.0558	0.0558
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0.0212	0.5
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.014	0.3362	0.3362
Giardia lamblia	Kinase, CMGC GSK	0.0314	0.7711	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0134	0.0155
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0314	0.7711	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.001	0.0012
Trichomonas vaginalis	cyclin D, putative	0.0114	0.2716	0.3495
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0282	0.0282
Brugia malayi	TAR-binding protein	0.0134	0.3223	0.3722
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0839	0.0837
Giardia lamblia	Kinase, CMGC GSK	0.0314	0.7711	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.336	0.336
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0048	0.0048
Trypanosoma cruzi	cyclin 9, putative	0.0028	0.0558	0.0462
Schistosoma mansoni	hypothetical protein	0.0033	0.0706	0.0706
Echinococcus granulosus	cyclin k	0.0028	0.0558	0.0558
Echinococcus multilocularis	cyclin b3	0.0114	0.2716	0.2716
Trichomonas vaginalis	cyclins, putative	0.022	0.5369	0.695
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0014	0.0212	0.0212
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0282	0.0325
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0134	0.0155
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0314	0.7711	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0028	0.0558	0.0644
Schistosoma mansoni	cyclin G2	0.0028	0.0558	0.0558
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0048	0.0048
Trypanosoma brucei	cdc2-related kinase 3	0.014	0.3362	0.4201
Toxoplasma gondii	hypothetical protein	0.0028	0.0558	0.0462
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0134	0.0134
Brugia malayi	hypothetical protein	0.0235	0.5727	0.6613
Echinococcus granulosus	cyclins	0.0114	0.2716	0.2716
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0014	0.0212	0.0212
Brugia malayi	cyclin fold protein 1 variant b	0.0028	0.0558	0.0644
Schistosoma mansoni	cpg binding protein	0.0029	0.0583	0.0583
Schistosoma mansoni	cyclin G	0.0028	0.0558	0.0558
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0134	0.0155
Trypanosoma cruzi	cyclin, putative	0.022	0.5369	0.6877
Brugia malayi	intermediate filament protein	0.0028	0.0571	0.066
Trichomonas vaginalis	cyclin A, putative	0.022	0.5369	0.695
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0853	0.0985
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0282	0.0325
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0853	0.0856
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0762	0.0762
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0706	0.0815
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0134	0.0155
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0853	0.0856
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.1307	0.146
Echinococcus multilocularis	cyclin	0.0028	0.0558	0.0558
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.001	0.001
Trichomonas vaginalis	cyclin B, putative	0.0028	0.0558	0.0684
Entamoeba histolytica	hypothetical protein	0.0036	0.0762	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0558	0.0644
Schistosoma mansoni	cyclin k	0.0028	0.0558	0.0558
Entamoeba histolytica	protein kinase domain containing protein	0.0314	0.7711	1
Schistosoma mansoni	Cyclin fold protein	0.0028	0.0558	0.0558
Brugia malayi	hypothetical protein	0.0006	0.001	0.0012
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0282	0.0282
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0014	0.0212	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Giardia lamblia	Cyclin A	0.0114	0.2716	0.334
Schistosoma mansoni	cyclin l	0.0028	0.0558	0.0558
Echinococcus granulosus	cyclin	0.0028	0.0558	0.0558
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0927	0.0954
Trypanosoma cruzi	mitotic cyclin, putative	0.0028	0.0558	0.0462
Onchocerca volvulus	Cyclin L homolog	0.0028	0.0558	0.056
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0014	0.0212	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0028	0.0558	0.0558
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0134	0.0155
Onchocerca volvulus	Cyclin L homolog	0.0028	0.0558	0.056
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0134	0.0134
Plasmodium vivax	cyclin 4, putative	0.0028	0.0558	0.0462
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0706	0.0815
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0927	0.1165
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.001	0.0012
Trypanosoma cruzi	CYC2-like cyclin, putative	0.022	0.5369	0.6877
Echinococcus multilocularis	geminin	0.0345	0.8466	0.8466
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0134	0.0155
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0134	0.0155
Loa Loa (eye worm)	cyclin domain-containing protein	0.0028	0.0558	0.0644
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0028	0.0558	0.0644
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0134	0.0155
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0092	0.0106
Trichomonas vaginalis	cyclins, putative	0.0028	0.0558	0.0684
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0839	0.0837
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Entamoeba histolytica	protein kinase domain containing protein	0.0314	0.7711	1
Trichomonas vaginalis	cyclins, putative	0.0028	0.0558	0.0684
Echinococcus multilocularis	dnaJ subfamily B	0.0406	1	1
Trypanosoma cruzi	mitotic cyclin, putative	0.0028	0.0558	0.0462
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.1066	0.1231
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0571	0.066
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0866	0.0866
Schistosoma mansoni	hypothetical protein	0.0345	0.8466	0.8466
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.009	0.2111	0.8837
Treponema pallidum	NADH oxidase	0.0014	0.0212	0.5
Echinococcus multilocularis	cyclin B3 1	0.0114	0.2716	0.2716
Giardia lamblia	G2/mitotic-specific cyclin B	0.022	0.5369	0.6877
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.2716	0.3495
Echinococcus multilocularis	cyclins	0.0114	0.2716	0.2716
Mycobacterium tuberculosis	Probable dehydrogenase	0.009	0.2111	0.8837
Schistosoma mansoni	cpg binding protein	0.003	0.0623	0.0623
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0282	0.0093
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.01	0.2361	1
Schistosoma mansoni	hypothetical protein	0.0345	0.8466	0.8466
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0028	0.0558	0.0558
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0006	0.001	0.0012
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0853	0.0856
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0134	0.0134
Brugia malayi	nuclear hormone receptor	0.0011	0.0134	0.0155
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0014	0.0212	0.0212
Entamoeba histolytica	cyclin, putative	0.022	0.5369	0.6726
Echinococcus granulosus	tar DNA binding protein	0.0134	0.3223	0.3223
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0134	0.0134
Trichomonas vaginalis	cyclins, putative	0.022	0.5369	0.695
Plasmodium vivax	cyclin homologue, putative	0.0028	0.0558	0.0462
Loa Loa (eye worm)	TAR-binding protein	0.0134	0.3223	0.3722
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0314	0.7711	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0134	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0006	0.001	0.0012
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0134	0.0134
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0134	0.0134
Toxoplasma gondii	hypothetical protein	0.0087	0.203	0.2424
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0839	0.0393
Onchocerca volvulus		0.0048	0.1066	0.123
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.2509	0.2897
Entamoeba histolytica	cyclin, putative	0.0114	0.2716	0.3017
Echinococcus granulosus	cyclin B	0.022	0.5369	0.5369
Trichomonas vaginalis	cyclin B, putative	0.022	0.5369	0.695
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0282	0.0093
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0853	0.0856
Echinococcus granulosus	cyclins	0.0114	0.2716	0.2716

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 9 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1862486

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1042816