Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 96 nM | Inhibition of reuptake of [3H]-5-HT at serotonin transporter | ChEMBL. | 10821718 |
Ki (binding) | = 96 nM | Inhibition of reuptake of [3H]-5-HT at serotonin transporter | ChEMBL. | 10821718 |
Ki (binding) | = 10500 nM | Inhibition of reuptake of [3H]-NE at Norepinephrin transpoter | ChEMBL. | 10821718 |
Ki (binding) | = 10500 nM | Inhibition of reuptake of [3H]-NE at Norepinephrin transpoter | ChEMBL. | 10821718 |
Ki (binding) | = 21300 nM | Inhibition of reuptake of [3H]-DA at Dopamine transporter (DAT) | ChEMBL. | 10821718 |
Ki (binding) | = 21300 nM | Inhibition of reuptake of [3H]-DA at Dopamine transporter (DAT) | ChEMBL. | 10821718 |
Ratio (binding) | = 0.005 | Ratio of inhibition of reuptake of 5-hydroxytryptamine to Dopamine | ChEMBL. | 10821718 |
Ratio (binding) | = 0.49 | Ratio of inhibition of reuptake of norepinephrine to dopamine | ChEMBL. | 10821718 |
Ratio (binding) | = 109 | Ratio of inhibition of reuptake of norepinephrine to 5-hydroxytryptamine | ChEMBL. | 10821718 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.