Detailed information for compound 1053026

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.445 | Formula: C18H21F3N4O2S
  • H donors: 1 H acceptors: 4 LogP: 1.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CS(=O)(=O)N1CCC(CC1)NC(c1cnccn1)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C18H21F3N4O2S/c1-28(26,27)25-10-6-15(7-11-25)24-17(16-12-22-8-9-23-16)13-2-4-14(5-3-13)18(19,20)21/h2-5,8-9,12,15,17,24H,6-7,10-11H2,1H3
  • InChiKey: QWMJKMZWDSYHEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0321 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0029 0.0123
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0063 0.0171
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0029 0.0037
Brugia malayi hypothetical protein 0.0446 0.4125 0.4796
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Echinococcus granulosus protein phosphatase 5 0.0022 0.0084 0.0063
Brugia malayi MBOAT family protein 0.0031 0.0167 0.0171
Echinococcus granulosus geminin 0.0168 0.1479 0.1462
Brugia malayi hypothetical protein 0.0025 0.0112 0.0107
Plasmodium vivax serine/threonine protein phosphatase 5, putative 0.0022 0.0084 0.1982
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0025 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.2942
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0029 0.0123
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0167 0.0171
Brugia malayi hypothetical protein 0.0016 0.0028 0.0008
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0031 0.0167 0.4779
Brugia malayi glutaminase DH11.1 0.0275 0.2497 0.2894
Echinococcus multilocularis dna polymerase kappa 0.002 0.0063 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0063 0.0043
Brugia malayi glutathione reductase 0.0047 0.0321 0.0352
Loa Loa (eye worm) hypothetical protein 0.0049 0.0338 0.0372
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0031 0.0167 0.4779
Brugia malayi isocitrate dehydrogenase 0.0016 0.0025 0.0005
Loa Loa (eye worm) serine/threonine protein phosphatase 5 0.0022 0.0084 0.0074
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0031 0.0167 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0338 0.0372
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0896 0.8842
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0063 0.0034
Brugia malayi MBOAT family protein 0.0031 0.0167 0.0171
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0025 0.0005
Leishmania major glycerol uptake protein, putative 0.0031 0.0167 0.4779
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0063 0.005
Trichomonas vaginalis transmembrane protein nessy, putative 0.0031 0.0167 0.0451
Loa Loa (eye worm) hypothetical protein 0.0284 0.2583 0.2995
Schistosoma mansoni hypothetical protein 0.0168 0.1479 0.1705
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0023 0.0095 0.236
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0029 0.0078
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0029 0.0123
Brugia malayi Hhat protein 0.0031 0.0167 0.0171
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0167 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.1855
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.101 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.04 0.3692 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0315 0.2876 0.2862
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Entamoeba histolytica hypothetical protein 0.004 0.0259 1
Trypanosoma brucei glycerol uptake protein, putative 0.0031 0.0167 0.5122
Leishmania major hypothetical protein, conserved 0.0031 0.0167 0.4779
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Loa Loa (eye worm) runx1 0.0056 0.0407 0.0451
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0025 0.0004
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0167 0.0146
Loa Loa (eye worm) hypothetical protein 0.0046 0.0313 0.0342
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0031 0.0167 0.0146
Schistosoma mansoni lozenge 0.0056 0.0407 0.0451
Leishmania major glycerol uptake protein, putative 0.0031 0.0167 0.4779
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0029 0.0123
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0171
Echinococcus multilocularis protein phosphatase 5 0.0022 0.0084 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0029 0.0123
Mycobacterium ulcerans glutaminase 0.0275 0.2497 0.2476
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0031 0.0167 0.4779
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0167 0.0451
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.2942
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0031 0.0167 0.0171
Trypanosoma cruzi GUP1, putative 0.0031 0.0167 0.4779
Onchocerca volvulus 0.0446 0.4125 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0031 0.0167 0.0171
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0029 0.0123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0025 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.101 1
Entamoeba histolytica vacuolar protein sorting 26 0.0031 0.0167 0.6426
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0321 0.0302
Brugia malayi MBOAT family protein 0.0031 0.0167 0.0171
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.1855
Echinococcus multilocularis dna polymerase eta 0.0046 0.0313 0.0293
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0031 0.0167 0.0146
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0167 0.4779
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0029 0.0771
Leishmania major DNA polymerase eta, putative 0.0046 0.0313 0.9728
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.1283
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0167 0.0146
Leishmania major glycerol uptake protein, putative 0.0031 0.0167 0.4779
Schistosoma mansoni hypothetical protein 0.0031 0.0167 0.0171
Mycobacterium tuberculosis Probable reductase 0.0107 0.0896 0.8842
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0063 0.0386
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Loa Loa (eye worm) hypothetical protein 0.0315 0.2876 0.3337
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0063 0.005
Brugia malayi MBOAT family protein 0.0031 0.0167 0.0171
Leishmania major DNA polymerase kappa, putative 0.002 0.0063 0.1283
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0063 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0896 0.8842
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0896 0.8842
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0338 0.0372
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0771
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.101 1
Brugia malayi Alpha-L-fucosidase family protein 0.0913 0.8577 1
Loa Loa (eye worm) alpha-L-fucosidase 0.0913 0.8577 1
Entamoeba histolytica hypothetical protein 0.004 0.0259 1
Brugia malayi serine/threonine protein phosphatase 5 0.0022 0.0084 0.0074
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0031 0.0167 0.0171
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0063 0.0043
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0029 0.0078
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0167 0.0171
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0025 0.0004
Brugia malayi Thioredoxin reductase 0.0047 0.0321 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0771
Loa Loa (eye worm) hhat protein 0.0031 0.0167 0.0171
Loa Loa (eye worm) glutaminase 0.0275 0.2497 0.2894
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.7657 0.7652
Trichomonas vaginalis porcupine, putative 0.0031 0.0167 0.0451
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0167 0.0171
Trypanosoma cruzi GUP1, putative 0.0031 0.0167 0.4779
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0029 0.0771
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0112 0.2942
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0313 0.9746
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0029 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0167 0.6426
Schistosoma mansoni protein phosphatase-5 0.0023 0.0095 0.0087
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0031 0.0167 0.0146
Brugia malayi hypothetical protein 0.004 0.0259 0.0279
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0259 0.0279
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0029 0.0123
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0167 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.1283
Schistosoma mansoni hypothetical protein 0.004 0.0259 0.0279
Plasmodium falciparum glutathione reductase 0.0047 0.0321 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0167 0.6426
Leishmania major glycerol uptake protein, putative 0.0031 0.0167 0.4779
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0313 0.9728
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0191 0.02
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Leishmania major trypanothione reductase 0.0047 0.0321 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0063 0.005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0171
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0183 0.5316
Loa Loa (eye worm) hypothetical protein 0.0446 0.4125 0.4796
Echinococcus granulosus dna polymerase kappa 0.002 0.0063 0.0043
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0029 0.0123
Leishmania major hypothetical protein, conserved 0.0025 0.0112 0.2942
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0063 0.0386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0338 0.0372
Schistosoma mansoni DNA polymerase eta 0.0046 0.0313 0.0342
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0031 0.0167 0.0171
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0029 0.0009
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0008
Echinococcus multilocularis Protein lozenge 0.0056 0.0407 0.0387
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0029 0.5
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0321 0.3011
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.2942
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0025 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0029 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0167 0.0171
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0025 0.0004
Schistosoma mansoni sterol O-acyltransferase 1 0.0315 0.2876 0.3337
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0029 0.0123
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0031 0.0167 0.0171
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0167 0.0451
Trichomonas vaginalis glutaminase, putative 0.0275 0.2497 0.6764
Schistosoma mansoni zinc finger protein 0.0031 0.0167 0.0171
Trichomonas vaginalis alpha-L-fucosidase, putative 0.04 0.3692 1
Schistosoma mansoni alpha-l-fucosidase 0.0913 0.8577 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.1283
Toxoplasma gondii serine/threonine protein phosphatase 0.0022 0.0084 0.1982
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0321 0.0302
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0167 0.0171
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0031 0.0167 0.0146
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0063 0.243
Trypanosoma brucei unspecified product 0.002 0.0063 0.1855
Trypanosoma brucei trypanothione reductase 0.0047 0.0321 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0031 0.0167 1
Loa Loa (eye worm) glutaminase 2 0.0275 0.2497 0.2894
Leishmania major glycerol uptake protein, putative 0.0031 0.0167 0.4779
Entamoeba histolytica hypothetical protein 0.004 0.0259 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0259 0.0239
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0167 0.6426
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0063 0.1283
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0167 0.4779
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.2942
Trypanosoma brucei glycerol uptake protein, putative 0.0031 0.0167 0.5122
Schistosoma mansoni glutaminase 0.0275 0.2497 0.2894
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0112 0.3406
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0167 0.0171
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0896 0.8842
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0031 0.0167 0.0146
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0063 0.005
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0313 0.0342
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0167 0.6426
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0029 0.5
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0025 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0063 0.1855
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0031 0.0167 0.0146
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0029 0.0123
Plasmodium falciparum thioredoxin reductase 0.0047 0.0321 1
Plasmodium falciparum serine/threonine protein phosphatase 5 0.0022 0.0084 0.1982
Loa Loa (eye worm) glutathione reductase 0.0047 0.0321 0.0352
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0025 0.0004
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0063 0.1855
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0031 0.0167 0.0146
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.101 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0029 0.0123
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0031 0.0167 0.0146
Plasmodium vivax glutathione reductase, putative 0.0047 0.0321 1
Loa Loa (eye worm) protein phosphatase 5 0.0021 0.0077 0.0066
Brugia malayi diacylglycerol acyltransferase 0.0031 0.0167 0.0171
Schistosoma mansoni hypothetical protein 0.0033 0.0191 0.02
Mycobacterium ulcerans alpha-L-fucosidase 0.1062 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0896 0.8842
Toxoplasma gondii hypothetical protein 0.0031 0.0167 0.4779
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0259 0.0239
Entamoeba histolytica hypothetical protein 0.004 0.0259 1
Echinococcus granulosus dna polymerase eta 0.0046 0.0313 0.0293
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0029 0.0008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0063 0.0171
Brugia malayi MBOAT family protein 0.0031 0.0167 0.0171
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0112 0.2942
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0167 0.0451
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0029 0.0123
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0167 0.0171
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.1062 1 1
Echinococcus granulosus sterol O acyltransferase 1 0.0315 0.2876 0.2862
Schistosoma mansoni hypothetical protein 0.0168 0.1479 0.1705
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0025 0.0005
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0183 0.5316
Leishmania major serine/threonine protein phosphatase type 5, putative 0.0022 0.0084 0.1982
Plasmodium falciparum glutathione reductase 0.0016 0.0029 0.0123
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0063 0.1283
Entamoeba histolytica hypothetical protein 0.0031 0.0167 0.6426
Loa Loa (eye worm) hhat protein 0.0031 0.0167 0.0171
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0031 0.0167 0.0146
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0321 0.0352
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0023 0.0095 0.2862
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0107
Loa Loa (eye worm) hypothetical protein 0.0033 0.0191 0.02
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0167 0.0146
Loa Loa (eye worm) hypothetical protein 0.0446 0.4125 0.4796
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0321 1
Leishmania major DNA polymerase eta, putative 0.0032 0.0183 0.5316
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0025 0.0657
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0167 0.4779
Echinococcus multilocularis geminin 0.0168 0.1479 0.1462
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0167 0.0146
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0023 0.0095 0.236
Toxoplasma gondii thioredoxin reductase 0.0047 0.0321 1
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0031 0.0167 0.4779
Giardia lamblia DINP protein human, muc B family 0.002 0.0063 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.97 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference
IC90 (functional) = 2.76 uM DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma cruzi ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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