Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 5 | 0.0328 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.0328 | 1 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0328 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0 | 0.5 |
Schistosoma mansoni | inositol transporter | 0.0328 | 1 | 1 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0328 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0328 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0328 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 5 | 0.0328 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 3000 nM | Displacement of [3H]-WIN- 35248 from dopamine transporter (DAT) of rat striatal membrane | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Inhibition of high affinity uptake of [3H]-DA using rat nerve endings obtained from brain regions enriched in DAT. | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Displacement of [3H]-5-HT from serotonin transporter of rat brain | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Displacement of [3H]-NE from Norepinephrine transporter of rat brain | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Displacement of [3H]-WIN- 35248 from dopamine transporter (DAT) of rat striatal membrane | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Inhibition of high affinity uptake of [3H]-DA using rat nerve endings obtained from brain regions enriched in DAT. | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Displacement of [3H]-5-HT from serotonin transporter of rat brain | ChEMBL. | 11514143 |
Ki (binding) | > 3000 nM | Displacement of [3H]-NE from Norepinephrine transporter of rat brain | ChEMBL. | 11514143 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.