TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 548.625 | Formula: C35H32O6
H donors: 0 H acceptors: 2 LogP: 7.4 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: COc1cccc(c1)/C=C/C(=O)c1ccc(cc1)OCCCOc1ccc(cc1)C(=O)/C=C/c1cccc(c1)OC
InChi: 1S/C35H32O6/c1-38-32-8-3-6-26(24-32)10-20-34(36)28-12-16-30(17-13-28)40-22-5-23-41-31-18-14-29(15-19-31)35(37)21-11-27-7-4-9-33(25-27)39-2/h3-4,6-21,24-25H,5,22-23H2,1-2H3/b20-10+,21-11+
InChiKey: IQHKTFJVLDRBPT-CLVAPQHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0811	0.0811
Onchocerca volvulus		0.0036	0.0078	0.0263
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Echinococcus granulosus	histone deacetylase	0.0365	0.2005	0.1997
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0646	0.3653	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.254	0.254
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0078	0.0189
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0401	0.0392
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0078	0.0078
Plasmodium vivax	histone deacetylase, putative	0.0365	0.2005	0.7507
Entamoeba histolytica	cysteine proteinase, putative	0.0183	0.0942	0.3507
Brugia malayi	cathepsin F-like cysteine proteinase	0.0161	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0169	0.086	0.086
Toxoplasma gondii	histone deacetylase HDAC1	0.0365	0.2005	0.5476
Echinococcus multilocularis	cathepsin b	0.173	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0183	0.0942	0.3507
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.173	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0161	0.0811	0.3038
Giardia lamblia	Cathepsin L-like protease	0.0161	0.0811	0.22
Brugia malayi	beta-lactamase	0.0036	0.0078	0.0078
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0024	0.001	0.001
Brugia malayi	histone deacetylase 11	0.0328	0.1792	0.1792
Mycobacterium ulcerans	hydrolase	0.0052	0.0171	1
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0811	0.3016
Giardia lamblia	Cysteine protease	0.0161	0.0811	0.22
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.254	0.6944
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0456	0.254	0.254
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Echinococcus granulosus	glutamate receptor 2	0.0062	0.0231	0.0222
Echinococcus granulosus	integrin beta 2	0.1073	0.6153	0.615
Schistosoma mansoni	cathepsin F (C01 family)	0.0478	0.2671	0.2671
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0078	0.0585
Echinococcus multilocularis	cysteine protease	0.0478	0.2671	0.2664
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0113	0.0113
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0078	0.0078
Loa Loa (eye worm)	histone deacetylase	0.0365	0.2005	0.2005
Onchocerca volvulus	Cathepsin F homolog	0.0478	0.2671	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0183	0.0942	0.3504
Entamoeba histolytica	cysteine proteinase, putative	0.0183	0.0942	0.3507
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0811	0.0811
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0292	0.1579	0.4306
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0161	0.0811	0.22
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Onchocerca volvulus	Cathepsin L homolog	0.0478	0.2671	1
Plasmodium vivax	vivapain-2	0.0478	0.2671	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0078	0.0069
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0024	0.001	0.0005
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0094	0.0419	0.1542
Brugia malayi	Cathepsin L-like precursor	0.0456	0.254	0.254
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0161	0.0811	0.22
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0024	0.001	0.0005
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0017	0.0021
Onchocerca volvulus		0.0161	0.0811	0.3016
Plasmodium falciparum	serine repeat antigen 2	0.0161	0.0811	0.3013
Trypanosoma cruzi	cysteine proteinase, putative	0.0183	0.0942	0.0942
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0161	0.0811	0.22
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0078	0.0078
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Toxoplasma gondii	cathepsin CPC1	0.0161	0.0811	0.22
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0154	0.077	0.0761
Echinococcus multilocularis	cathepsin L cysteine protease	0.0478	0.2671	0.2664
Plasmodium vivax	serine-repeat antigen (SERA)	0.0161	0.0811	0.3038
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0811	0.3016
Giardia lamblia	Cathepsin L-like protease	0.0161	0.0811	0.22
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.173	1	1
Loa Loa (eye worm)	glutamate receptor 1	0.0066	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0008	0.0008
Plasmodium falciparum	histone deacetylase 2	0.0365	0.2005	0.7498
Plasmodium vivax	vivapain-2	0.0478	0.2671	1
Schistosoma mansoni	cathepsin C	0.0161	0.0811	0.0811
Leishmania major	eukaryotic initiation factor 4a, putative	0.0024	0.001	0.0003
Echinococcus multilocularis	calpain A	0.0044	0.0129	0.012
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Loa Loa (eye worm)	matrixin family protein	0.0094	0.0419	0.0419
Echinococcus granulosus	glutamate receptor 1	0.0042	0.0113	0.0103
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.0811	0.0811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Loa Loa (eye worm)	ctsf protein	0.0478	0.2671	0.2671
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0183	0.0942	0.0942
Brugia malayi	Papain family cysteine protease containing protein	0.0183	0.0942	0.0942
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0161	0.0811	0.3013
Trichomonas vaginalis	esterase, putative	0.0036	0.0078	0.0189
Plasmodium vivax	vivapain-1	0.0183	0.0942	0.3528
Onchocerca volvulus	Cathepsin L homolog	0.0161	0.0811	0.3016
Schistosoma mansoni	hypothetical protein	0.0336	0.1839	0.1839
Plasmodium falciparum	serine repeat antigen 9	0.0161	0.0811	0.3013
Giardia lamblia	Histone deacetylase	0.0292	0.1579	0.4306
Trichomonas vaginalis	histone deacetylase, putative	0.0292	0.1579	0.4306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0183	0.0942	0.2559
Loa Loa (eye worm)	hypothetical protein	0.173	1	1
Schistosoma mansoni	glutamate receptor kainate	0.0025	0.0014	0.0014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0401	0.0392
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.0811	0.0811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0811	0.22
Loa Loa (eye worm)	histone deacetylase 7A	0.0365	0.2005	0.2005
Brugia malayi	cathepsin L-like precursor	0.0456	0.254	0.254
Echinococcus granulosus	cathepsin b	0.173	1	1
Echinococcus granulosus	cysteine protease	0.0183	0.0942	0.0933
Giardia lamblia	Cysteine protease	0.0161	0.0811	0.22
Echinococcus multilocularis	cathepsin L cysteine protease	0.0478	0.2671	0.2664
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.0811	0.0811
Plasmodium vivax	histone deacetylase 2, putative	0.0365	0.2005	0.7507
Echinococcus multilocularis	histone deacetylase 8	0.0159	0.0801	0.0792
Brugia malayi	Cathepsin L-like precursor	0.0478	0.2671	0.2671
Trypanosoma cruzi	cysteine proteinase, putative	0.0183	0.0942	0.0942
Trypanosoma cruzi	major cysteine proteinase, putative	0.0161	0.0811	0.0811
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0024	0.001	0.001
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0078	0.0585
Brugia malayi	Cathepsin L-like precursor	0.0478	0.2671	0.2671
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0811	0.22
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0052	0.0052
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0017	0.0021
Trypanosoma cruzi	histone deacetylase, putative	0.0365	0.2005	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0078	0.0078
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0478	0.2671	0.2664
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0078	0.4308
Trypanosoma cruzi	cysteine peptidase, putative	0.0183	0.0942	0.0942
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0161	0.0811	0.3013
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0811	0.3016
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Brugia malayi	Kelch motif family protein	0.023	0.1217	0.1217
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0044	0.0129	0.012
Schistosoma mansoni	hypothetical protein	0.0034	0.0069	0.0069
Giardia lamblia	Cathepsin L precursor	0.0161	0.0811	0.22
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0161	0.0811	0.3016
Trypanosoma cruzi	histone deacetylase 1, putative	0.0292	0.1579	0.1579
Schistosoma mansoni	cathepsin B (C01 family)	0.0161	0.0811	0.0811
Echinococcus granulosus	cathepsin l1	0.0478	0.2671	0.2664
Echinococcus multilocularis	cathepsin L	0.0183	0.0942	0.0933
Echinococcus multilocularis	tumor protein p63	0.0339	0.1853	0.1845
Brugia malayi	calpain family protein 1	0.0042	0.0118	0.0118
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0161	0.0811	0.22
Giardia lamblia	Cathepsin B precursor	0.0646	0.3653	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0017	0.0017
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Echinococcus granulosus	histone deacetylase 1	0.0292	0.1579	0.1571
Leishmania major	histone deacetylase, putative	0.0365	0.2005	0.5477
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0161	0.0811	0.3038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0078	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0078	0.0078
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0042	0.0117	0.0117
Giardia lamblia	Encystation-specific protease	0.0161	0.0811	0.22
Trypanosoma cruzi	histone deacetylase, putative	0.0365	0.2005	0.2005
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0456	0.254	0.254
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0078	0.0189
Schistosoma mansoni	glutamate receptor kainate	0.0025	0.0014	0.0014
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0078	0.0078
Trypanosoma cruzi	cruzipain precursor, putative	0.0478	0.2671	0.2671
Onchocerca volvulus		0.0478	0.2671	1
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0811	0.0811
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0161	0.0811	0.0811
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0078	0.0585
Echinococcus granulosus	histone deacetylase 3	0.0292	0.1579	0.1571
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0161	0.0811	0.22
Onchocerca volvulus		0.0478	0.2671	1
Echinococcus granulosus	tm gpcr rhodopsin	0.053	0.2976	0.2969
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.2671	0.2671
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.0563	0.0563
Leishmania major	cysteine peptidase A (CPA)	0.0478	0.2671	0.7304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.173	1	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0129	0.0129
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0052	0.0171	0.1358
Leishmania major	histone deacetylase, putative	0.0292	0.1579	0.4308
Echinococcus granulosus	histone deacetylase 6	0.0365	0.2005	0.1997
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0161	0.0811	0.22
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0183	0.0942	0.2559
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0017
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0161	0.0811	0.3038
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0042	0.0118	0.0118
Plasmodium vivax	histone deacetylase, putative	0.0328	0.1792	0.671
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0161	0.0811	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0161	0.0811	0.22
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0161	0.0811	0.3013
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0078	0.0585
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0017	0.0028
Brugia malayi	Histone deacetylase family protein	0.0365	0.2005	0.2005
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0008	0.0008
Trypanosoma brucei	histone deacetylase 1	0.0292	0.1579	0.4306
Trichomonas vaginalis	histone deacetylase, putative	0.0292	0.1579	0.4306
Giardia lamblia	Cathepsin B precursor	0.0646	0.3653	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0017	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0811	0.22
Loa Loa (eye worm)	matrix metalloproteinase	0.0042	0.0117	0.0117
Giardia lamblia	Cathepsin L precursor	0.0161	0.0811	0.22
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0078	0.0078
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0078	0.0585
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0051	0.0166	0.0157
Trypanosoma cruzi	major cysteine proteinase, putative	0.0161	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0117	0.0117
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0811	0.3016
Onchocerca volvulus		0.0478	0.2671	1
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0024	0.001	0.001
Brugia malayi	Papain family cysteine protease containing protein	0.0183	0.0942	0.0942
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.0811	0.0811
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0401	0.0401
Toxoplasma gondii	cathepsin CPC2	0.0161	0.0811	0.22
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0161	0.0811	0.0811
Entamoeba histolytica	hypothetical protein	0.0161	0.0811	0.3016
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0161	0.0811	0.22
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0078	0.0078
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0078	0.0585
Plasmodium falciparum	histone deacetylase 1	0.0292	0.1579	0.5897
Echinococcus granulosus	glutamate receptor 2	0.0071	0.0285	0.0275
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0811	0.3016
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Loa Loa (eye worm)	calpain family protein 1	0.0042	0.0118	0.0118
Giardia lamblia	Cathepsin B precursor	0.0161	0.0811	0.22
Giardia lamblia	Cathepsin B precursor	0.0161	0.0811	0.22
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0811	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0811	0.0811
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.2671	0.2671
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0401	0.0392
Giardia lamblia	Cysteine protease	0.0161	0.0811	0.22
Entamoeba histolytica	cysteine proteinase, putative	0.0183	0.0942	0.3507
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0078	0.4308
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Leishmania major	eukaryotic initiation factor 4a, putative	0.0024	0.001	0.0003
Plasmodium falciparum	serine repeat antigen 1	0.0161	0.0811	0.3013
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0051	0.0166	0.0157
Echinococcus multilocularis	histone deacetylase 6	0.0365	0.2005	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0024	0.001	0.001
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0161	0.0811	0.0811
Schistosoma mansoni	ATP-binding cassette transporter	0.0025	0.0014	0.0014
Onchocerca volvulus		0.006	0.0221	0.0797
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0811	0.0811
Toxoplasma gondii	ABC1 family protein	0.0036	0.0078	0.0189
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0078	0.0078
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Echinococcus granulosus	calpain A	0.0044	0.0129	0.012
Plasmodium falciparum	serine repeat antigen 3	0.0161	0.0811	0.3013
Brugia malayi	fibroinase precursor	0.0161	0.0811	0.0811
Brugia malayi	Glutamate receptor 1 precursor	0.0066	0.0257	0.0257
Plasmodium falciparum	serine repeat antigen 7	0.0161	0.0811	0.3013
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Schistosoma mansoni	histone deacetylase hda2	0.0159	0.0801	0.0801
Schistosoma mansoni	histone deacetylase 1 2 3	0.0159	0.0801	0.0801
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0017	0.0028
Plasmodium falciparum	histone deacetylase, putative	0.0365	0.2005	0.7498
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0161	0.0811	0.0811
Toxoplasma gondii	cathepsin B	0.0646	0.3653	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0161	0.0811	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1073	0.1073
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Entamoeba histolytica	cysteine proteinase, putative	0.0456	0.254	0.9509
Giardia lamblia	Hypothetical protein	0.0161	0.0811	0.22
Brugia malayi	Matrixin family protein	0.0042	0.0117	0.0117
Brugia malayi	Integrin beta pat-3 precursor	0.1465	0.8452	0.8452
Onchocerca volvulus		0.0478	0.2671	1
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Schistosoma mansoni	histone deacetylase 4 5	0.0365	0.2005	0.2005
Schistosoma mansoni	cathepsin F (C01 family)	0.0456	0.254	0.254
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Brugia malayi	Matrixin family protein	0.0042	0.0117	0.0117
Brugia malayi	calpain family protein 1	0.0042	0.0118	0.0118
Giardia lamblia	Cysteine protease	0.0161	0.0811	0.22
Leishmania major	hypothetical protein, conserved	0.0036	0.0078	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0024	0.0024
Echinococcus multilocularis	histone deacetylase 1	0.0292	0.1579	0.1571
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0078	0.4308
Plasmodium falciparum	serine repeat antigen 5	0.0161	0.0811	0.3013
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0071	0.0285	0.0275
Brugia malayi	histone deacetylase 1 (HD1)	0.0292	0.1579	0.1579
Giardia lamblia	Cathepsin B precursor	0.0161	0.0811	0.22
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0162	0.0162
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0161	0.0811	0.3038
Echinococcus multilocularis	histone deacetylase 7	0.0365	0.2005	0.1997
Loa Loa (eye worm)	histone deacetylase 11	0.0328	0.1792	0.1792
Schistosoma mansoni	glutamate receptor AMPA	0.0025	0.0014	0.0014
Leishmania major	histone deacetylase, putative	0.0365	0.2005	0.5477
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0161	0.0811	0.22
Toxoplasma gondii	histone deacetylase HDAC3	0.0292	0.1579	0.4306
Brugia malayi	Cathepsin L-like precursor	0.0478	0.2671	0.2671
Loa Loa (eye worm)	hypothetical protein	0.005	0.016	0.016
Schistosoma mansoni	glutamate receptor kainate	0.0025	0.0014	0.0014
Schistosoma mansoni	glutamate receptor NMDA	0.0025	0.0014	0.0014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Toxoplasma gondii	histone deacetylase HDAC5	0.0159	0.0801	0.2171
Trypanosoma cruzi	histone deacetylase 1, putative	0.0292	0.1579	0.1579
Echinococcus granulosus	histone deacetylase 6	0.0365	0.2005	0.1997
Echinococcus multilocularis	glutamate receptor 2	0.0062	0.0231	0.0222
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0078	0.0189
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0161	0.0811	0.22
Brugia malayi	Glutamate receptor 2 precursor	0.0066	0.0257	0.0257
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.254	0.6944
Echinococcus granulosus	histone deacetylase 7	0.0365	0.2005	0.1997
Trypanosoma cruzi	histone deacetylase, putative	0.0159	0.0801	0.0801
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0078	0.0585
Echinococcus multilocularis	histone deacetylase	0.0365	0.2005	0.1997
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0161	0.0811	0.0811
Brugia malayi	beta-lactamase family protein	0.0036	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Entamoeba histolytica	cysteine proteinase, putative	0.0478	0.2671	1
Brugia malayi	MH2 domain containing protein	0.0118	0.0563	0.0563
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0292	0.1579	0.4306
Onchocerca volvulus		0.0036	0.0078	0.0263
Brugia malayi	Cathepsin L-like precursor	0.0478	0.2671	0.2671
Echinococcus multilocularis	cysteine protease	0.0478	0.2671	0.2664
Trichomonas vaginalis	histone deacetylase, putative	0.0292	0.1579	0.4306
Onchocerca volvulus	Matrilysin homolog	0.0094	0.0419	0.1542
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0041	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0811	0.0811
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0078	0.0294
Brugia malayi	histone deacetylase 3 (HD3)	0.0292	0.1579	0.1579
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0078	0.0189
Loa Loa (eye worm)	cysteine protease	0.0478	0.2671	0.2671
Loa Loa (eye worm)	fibroinase	0.0478	0.2671	0.2671
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0078	0.0585
Echinococcus granulosus	cathepsin L	0.0161	0.0811	0.0802
Echinococcus multilocularis	geminin	0.0336	0.1839	0.1831
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0161	0.0811	0.3038
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0078	0.0069
Echinococcus multilocularis	glutamate receptor 4	0.0042	0.0113	0.0103
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Toxoplasma gondii	histone deacetylase HDAC2	0.0292	0.1579	0.4306
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0478	0.2671	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0478	0.2671	1
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.023	0.1217	0.1217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0161	0.0811	0.22
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0478	0.2671	0.2664
Entamoeba histolytica	cysteine proteinase 2	0.0183	0.0942	0.3507
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0161	0.0811	0.0811
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0183	0.0942	0.0942
Onchocerca volvulus		0.0478	0.2671	1
Echinococcus granulosus	cathepsin L	0.0183	0.0942	0.0933
Plasmodium falciparum	serine repeat antigen 6	0.0161	0.0811	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0171	0.0171
Giardia lamblia	Cathepsin L precursor	0.0161	0.0811	0.22
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Leishmania major	histone deacetylase, putative	0.0292	0.1579	0.4308
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.2671	0.2671
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0811	0.22
Onchocerca volvulus	Matrilysin homolog	0.0042	0.0117	0.0408
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0183	0.0942	0.0942
Onchocerca volvulus		0.0026	0.0024	0.0059
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0161	0.0811	0.0811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0113	0.0113
Onchocerca volvulus		0.0042	0.0117	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0038	0.009	0.009
Onchocerca volvulus	Cathepsin L homolog	0.0478	0.2671	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0161	0.0811	0.0811
Brugia malayi	eukaryotic initiation factor 4A	0.0024	0.001	0.001
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.1206	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Echinococcus granulosus	tumor protein p63	0.0339	0.1853	0.1845
Treponema pallidum	ATP-dependent RNA helicase	0.0024	0.001	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.0017
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0161	0.0811	0.0811
Schistosoma mansoni	histone deacetylase 4 5	0.0365	0.2005	0.2005
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Mycobacterium leprae	PROBABLE HYDROLASE	0.0052	0.0171	1
Echinococcus multilocularis	histone deacetylase 3	0.0292	0.1579	0.1571
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0646	0.3653	1
Echinococcus multilocularis	nuclear receptor co repressor related (ncor)	0.0268	0.144	0.1431
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0478	0.2671	0.2671
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0024	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0161	0.0811	0.22
Schistosoma mansoni	glutamate receptor AMPA	0.0025	0.0014	0.0014
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0017	0.0064
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0078	0.0078
Schistosoma mansoni	histone deacetylase hda2	0.0371	0.204	0.204
Onchocerca volvulus		0.0478	0.2671	1
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0811	0.22
Trichomonas vaginalis	conserved hypothetical protein	0.0161	0.0811	0.22
Trypanosoma cruzi	histone deacetylase, putative	0.0365	0.2005	0.2005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0478	0.2671	0.7303
Schistosoma mansoni	glutamate receptor NMDA	0.0029	0.0041	0.0041
Echinococcus multilocularis	calpain family protein 1, d	0.0031	0.0052	0.0043
Toxoplasma gondii	histone deacetylase HDAC4	0.0328	0.1792	0.4892
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0646	0.3653	0.3653
Loa Loa (eye worm)	calpain family protein 1	0.0031	0.0052	0.0052
Entamoeba histolytica	cysteine protease, putative	0.0183	0.0942	0.3507
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0161	0.0811	0.22
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0478	0.2671	0.7303
Echinococcus granulosus	geminin	0.0336	0.1839	0.1831
Entamoeba histolytica	cysteine proteinase, putative	0.0478	0.2671	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Onchocerca volvulus		0.005	0.016	0.0568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0478	0.2671	0.2664
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0078	0.0189
Echinococcus granulosus	nuclear receptor co repressor related ncor	0.0268	0.144	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0811	0.0811
Brugia malayi	Papain family cysteine protease containing protein	0.0478	0.2671	0.2671
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0071	0.0285	0.0275
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.173	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0162	0.0162
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0069	0.0069
Echinococcus granulosus	histone deacetylase 8	0.0159	0.0801	0.0792
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Echinococcus granulosus	cathepsin l1	0.0456	0.254	0.2533
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0078	0.4308
Giardia lamblia	Cathepsin B precursor	0.0646	0.3653	1
Brugia malayi	hypothetical protein	0.023	0.1217	0.1217
Echinococcus multilocularis	histone deacetylase 6	0.0365	0.2005	0.1997
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0456	0.254	0.254
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0078	0.4308
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0117	0.0117
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.0563	0.0563
Schistosoma mansoni	cathepsin F (C01 family)	0.0478	0.2671	0.2671
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0161	0.0811	0.0811
Brugia malayi	Cathepsin L-like precursor	0.0478	0.2671	0.2671
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0183	0.0942	0.2559
Plasmodium vivax	vivapain-3	0.0183	0.0942	0.3528
Giardia lamblia	Cathepsin B precursor	0.0161	0.0811	0.22
Loa Loa (eye worm)	integrin beta-2	0.1465	0.8452	0.8452
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0478	0.2671	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Loa Loa (eye worm)	hypothetical protein	0.023	0.1217	0.1217
Brugia malayi	Cathepsin L-like precursor	0.0478	0.2671	0.2671
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0041	0.0032
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0025	0.0014	0.0004
Schistosoma mansoni	hypothetical protein	0.0336	0.1839	0.1839
Loa Loa (eye worm)	hypothetical protein	0.005	0.0162	0.0162
Trypanosoma brucei	histone deacetylase 3	0.0365	0.2005	0.5476
Giardia lamblia	Cathepsin B precursor	0.0161	0.0811	0.22
Mycobacterium ulcerans	lipase LipD	0.0036	0.0078	0.4308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0811	0.22
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0008	0.0008
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0183	0.0942	0.0942
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0129	0.0129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Echinococcus multilocularis	cathepsin L	0.0161	0.0811	0.0802
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0078	0.0078
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0161	0.0811	0.3038
Entamoeba histolytica	histone deacetylase, putative	0.0292	0.1579	0.5899
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Brugia malayi	Histone deacetylase 1	0.0292	0.1579	0.1579
Toxoplasma gondii	cathepsin CPL	0.0478	0.2671	0.7303
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0811	0.22
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0118	0.0118
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0161	0.0811	0.3038
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0646	0.3653	0.3653
Schistosoma mansoni	hypothetical protein	0.006	0.0221	0.0221
Trypanosoma cruzi	cysteine protease, putative	0.0183	0.0942	0.0942
Echinococcus multilocularis	histone deacetylase 6	0.0371	0.204	0.2032
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0024	0.001	0.001
Echinococcus multilocularis	cathepsin b	0.173	1	1
Loa Loa (eye worm)	glutamate receptor 2	0.0025	0.0014	0.0014
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0811	0.0811
Plasmodium vivax	histone deacetylase 1, putative	0.0292	0.1579	0.5911
Brugia malayi	Matrixin family protein	0.0042	0.0117	0.0117
Loa Loa (eye worm)	cathepsin B	0.0646	0.3653	0.3653
Schistosoma mansoni	integrin beta subunit	0.0843	0.4806	0.4806
Loa Loa (eye worm)	hypothetical protein	0.0212	0.1108	0.1108
Onchocerca volvulus		0.0456	0.254	0.9509
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Giardia lamblia	Cathepsin L precursor	0.0161	0.0811	0.22
Brugia malayi	Matrixin family protein	0.0042	0.0117	0.0117
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0401	0.0401
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0162	0.0162
Entamoeba histolytica	cysteine protease, putative	0.0478	0.2671	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0078	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0183	0.0942	0.2559
Brugia malayi	cathepsin L precursor	0.0161	0.0811	0.0811
Schistosoma mansoni	cathepsin S (C01 family)	0.0161	0.0811	0.0811
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0078	0.0585
Echinococcus granulosus	glutamate receptor 4	0.0042	0.0113	0.0103
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0161	0.0811	0.3016
Schistosoma mansoni	histone deacetylase	0.0292	0.1579	0.1579
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0478	0.2671	0.2671
Plasmodium vivax	unspecified product	0.0183	0.0942	0.3528
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Brugia malayi	Matrixin family protein	0.0102	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0456	0.254	0.254
Trichomonas vaginalis	histone deacetylase, putative	0.0292	0.1579	0.4306
Trypanosoma brucei	histone deacetylase, putative	0.0365	0.2005	0.5476
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0154	0.077	0.0761
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0478	0.2671	0.7303
Echinococcus granulosus	cathepsin L cysteine protease	0.0183	0.0942	0.0933
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0401	0.0392
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0078	0.4308
Loa Loa (eye worm)	hypothetical protein	0.0292	0.1579	0.1579
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.053	0.2976	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0456	0.254	0.254
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0078	0.0189
Trichomonas vaginalis	histone deacetylase, putative	0.0292	0.1579	0.4306
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0041	0.0032
Plasmodium falciparum	serine repeat antigen 8	0.0161	0.0811	0.3013
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0025	0.0014	0.0004
Trichomonas vaginalis	histone deacetylase, putative	0.0292	0.1579	0.4306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0161	0.0811	0.22
Onchocerca volvulus		0.0036	0.0078	0.0263
Giardia lamblia	Cathepsin L precursor	0.0161	0.0811	0.22
Trypanosoma cruzi	histone deacetylase, putative	0.0159	0.0801	0.0801
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0478	0.2671	0.7303
Echinococcus multilocularis	glutamate receptor 2	0.0066	0.0257	0.0248
Brugia malayi	Hemopexin family protein	0.006	0.0221	0.0221
Loa Loa (eye worm)	histone deacetylase 3	0.0292	0.1579	0.1579
Trypanosoma cruzi	cysteine peptidase, putative	0.0478	0.2671	0.2671
Echinococcus granulosus	histone deacetylase 6	0.0371	0.204	0.2032
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0161	0.0811	0.0811
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0401	0.0401
Onchocerca volvulus		0.0478	0.2671	1
Plasmodium vivax	unspecified product	0.0161	0.0811	0.3038
Echinococcus granulosus	cathepsin b	0.173	1	1
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0161	0.0811	0.3038
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0029	0.0041	0.0032
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0159	0.0801	0.2976
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0161	0.0811	0.3038
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0041	0.0032
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0029	0.0041	0.0032
Entamoeba histolytica	cysteine proteinase, putative	0.0183	0.0942	0.3507
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303
Echinococcus multilocularis	glutamate receptor 2	0.0071	0.0285	0.0275
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0292	0.1579	0.4306
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0008	0.0008
Brugia malayi	Histone deacetylase family protein	0.0365	0.2005	0.2005
Trypanosoma brucei	histone deacetylase 2	0.0159	0.0801	0.2171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0401	0.0401
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0161	0.0811	0.22
Loa Loa (eye worm)	matrixin family protein	0.0102	0.0468	0.0468
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0161	0.0811	0.22
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0044	0.0129	0.012
Trypanosoma brucei	histone deacetylase 4	0.0365	0.2005	0.5476
Giardia lamblia	Cathepsin L precursor	0.0161	0.0811	0.22
Plasmodium falciparum	serine repeat antigen 4	0.0161	0.0811	0.3013
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0646	0.3653	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0401	0.0401
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0811	0.3016
Loa Loa (eye worm)	hypothetical protein	0.0478	0.2671	0.2671
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0161	0.0811	0.0811
Echinococcus multilocularis	integrin beta 2	0.1073	0.6153	0.615
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0478	0.2671	0.2664
Leishmania major	cathepsin L-like protease	0.0478	0.2671	0.7304
Plasmodium vivax	RNA helicase-1, putative	0.0024	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0801	0.0801
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0052	0.0171	0.0171
Brugia malayi	beta-lactamase family protein	0.0036	0.0078	0.0078
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.016	0.016
Loa Loa (eye worm)	histone deacetylase 1	0.0292	0.1579	0.1579
Schistosoma mansoni	histone deacetylase	0.0292	0.1579	0.1579
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0078	0.0078
Giardia lamblia	Hypothetical protein	0.0161	0.0811	0.22
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0478	0.2671	0.7303

Activities

Activity type	Activity value	Assay description	Source	Reference
Parasitaemia (functional)	= 0 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 5	ChEMBL.	11012019
Parasitaemia (functional)	= 0 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 19;death of animal	ChEMBL.	11012019
Parasitaemia (functional)	= 0 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 5	ChEMBL.	11012019
Parasitaemia (functional)	= 0.08 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 5	ChEMBL.	11012019
Parasitaemia (functional)	= 0.08 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 5	ChEMBL.	11012019
Parasitaemia (functional)	= 0.52 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 7	ChEMBL.	11012019
Parasitaemia (functional)	= 0.52 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 7	ChEMBL.	11012019
Parasitaemia (functional)	= 1 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 9	ChEMBL.	11012019
Parasitaemia (functional)	= 1 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 9	ChEMBL.	11012019
Parasitaemia (functional)	= 1.1 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 7	ChEMBL.	11012019
Parasitaemia (functional)	= 1.1 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 7	ChEMBL.	11012019
Parasitaemia (functional)	= 1.7 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 15	ChEMBL.	11012019
Parasitaemia (functional)	= 1.7 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 15	ChEMBL.	11012019
Parasitaemia (functional)	= 1.75 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 5	ChEMBL.	11012019
Parasitaemia (functional)	= 1.75 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 5	ChEMBL.	11012019
Parasitaemia (functional)	= 1.8 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 11	ChEMBL.	11012019
Parasitaemia (functional)	= 1.8 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 11	ChEMBL.	11012019
Parasitaemia (functional)	= 1.81 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 13	ChEMBL.	11012019
Parasitaemia (functional)	= 1.81 %	In vivo activity of compound against chloroquine sensitive strain of Plasmodium berghei infection in mice at 100 mg/kg dose x4 days(ip) and evaluated on day 13	ChEMBL.	11012019
Parasitaemia (functional)	= 1.9 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 7	ChEMBL.	11012019
Parasitaemia (functional)	= 1.9 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 7	ChEMBL.	11012019
Parasitaemia (functional)	= 3 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 9	ChEMBL.	11012019
Parasitaemia (functional)	= 3 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 11	ChEMBL.	11012019
Parasitaemia (functional)	= 3 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 9	ChEMBL.	11012019
Parasitaemia (functional)	= 3 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 11	ChEMBL.	11012019
Parasitaemia (functional)	= 4.2 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 9	ChEMBL.	11012019
Parasitaemia (functional)	= 4.2 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 11	ChEMBL.	11012019
Parasitaemia (functional)	= 4.2 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 9	ChEMBL.	11012019
Parasitaemia (functional)	= 4.2 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 11	ChEMBL.	11012019
Parasitaemia (functional)	= 4.6 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 13	ChEMBL.	11012019
Parasitaemia (functional)	= 4.6 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 13	ChEMBL.	11012019
Parasitaemia (functional)	= 5.4 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 13	ChEMBL.	11012019
Parasitaemia (functional)	= 5.4 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 13	ChEMBL.	11012019
Parasitaemia (functional)	= 7 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 15	ChEMBL.	11012019
Parasitaemia (functional)	= 7 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 15	ChEMBL.	11012019
Parasitaemia (functional)	= 9.5 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 17	ChEMBL.	11012019
Parasitaemia (functional)	= 9.5 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 17	ChEMBL.	11012019
Parasitaemia (functional)	= 13 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 15	ChEMBL.	11012019
Parasitaemia (functional)	= 13 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 19	ChEMBL.	11012019
Parasitaemia (functional)	= 13 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 15	ChEMBL.	11012019
Parasitaemia (functional)	= 13 %	Effect of test compound (50 mg/kg/day) and chloroquinone (15 mg/kg/day) for 4 days on parasitaemia and evaluated on day 19	ChEMBL.	11012019
Parasitaemia (functional)	= 19 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 17	ChEMBL.	11012019
Parasitaemia (functional)	= 19 %	Effect of test compound (50 mg/kg/day) for 4 days on parasitaemia and evaluated on day 17	ChEMBL.	11012019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL67062

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 108159