Detailed information for compound 108437

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.369 | Formula: C19H16N6O2
  • H donors: 2 H acceptors: 4 LogP: 3.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1ncc2c1ncnc2N/N=C/c1ccc(cc1)O
  • InChi: 1S/C19H16N6O2/c1-27-16-4-2-3-14(9-16)25-19-17(11-23-25)18(20-12-21-19)24-22-10-13-5-7-15(26)8-6-13/h2-12,26H,1H3,(H,20,21,24)/b22-10+
  • InChiKey: MDLZWIWHWMIJAI-LSHDLFTRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0047 0.0418 0.1079
Schistosoma mansoni polycystin 1-related 0.002 0.0108 0.0261
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0176
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0418 0.1126
Trichomonas vaginalis lymphoid specific helicase, putative 0.0012 0.0021 0.0071
Schistosoma mansoni transient receptor potential channel 0.0062 0.0592 0.161
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0062 0.0589 0.0887
Schistosoma mansoni hypothetical protein 0.0035 0.0282 0.0746
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0021 0.0029
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0623 0.0621
Onchocerca volvulus 0.003 0.0222 0.2361
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0148 0.0345
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Entamoeba histolytica protein kinase, putative 0.0062 0.0589 0.1543
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0261 0.1131
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0021 0.0049
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0622 0.2697
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0625 0.274
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3203 1
Schistosoma mansoni hypothetical protein 0.0033 0.0261 0.0688
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1198 0.525
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0589 0.258
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0108 0.0255
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0623 0.0621
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0261 0.1095
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0062 0.0589 0.1826
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0222 0.0566
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0222 0.0566
Schistosoma mansoni lipoxygenase 0.002 0.0108 0.0261
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0622 0.2697
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0021 0.0017
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0093 0.0276
Entamoeba histolytica hypothetical protein 0.0035 0.0282 0.0709
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0418 0.1844
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0093 0.361
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0622 0.193
Loa Loa (eye worm) hypothetical protein 0.0063 0.0601 0.2604
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0148 0.0592
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0093 0.0411
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0566
Echinococcus granulosus pyruvate kinase 0.0033 0.0261 0.0673
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0282 0.073
Echinococcus granulosus global transcription activator snf2l2 0.0065 0.0624 0.1665
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0601 0.1636
Onchocerca volvulus 0.003 0.0222 0.2361
Onchocerca volvulus 0.003 0.0222 0.2361
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0093 0.035
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0021 0.0029
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0108 0.0255
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0601 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0093 0.6126
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0222 0.0677
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Onchocerca volvulus 0.0049 0.0442 0.6936
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0108 0.0255
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0261 0.08
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0578
Brugia malayi Latrophilin receptor protein 2 0.0015 0.006 0.0264
Plasmodium falciparum glycogen synthase kinase 3 0.0062 0.0589 0.0588
Plasmodium vivax glycogen synthase kinase 3, putative 0.0062 0.0589 0.0588
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0625 0.274
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0261 0.1572
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0601 0.1602
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0589 0.255
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0353 0.1088
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.006 0.0124
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.0952 0.2616
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0418 0.1292
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0917 0.2463
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0625 0.1939
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1456 0.4538
Schistosoma mansoni glucose transport protein 0.021 0.2268 0.6285
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0222 0.1329
Brugia malayi hypothetical protein 0.002 0.0108 0.0476
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.006 0.0124
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Mycobacterium ulcerans sugar transporter 0.003 0.0222 0.1329
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0021 0.0029
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0338 0.5587
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0079 0.0117
Echinococcus multilocularis pyruvate kinase 0.0033 0.0261 0.0673
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.072 0.1085
Loa Loa (eye worm) hypothetical protein 0.0051 0.0467 0.2009
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0261 0.08
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0261 0.3182
Loa Loa (eye worm) hypothetical protein 0.0094 0.0952 0.4162
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0601 0.1576
Leishmania major pyruvate kinase 0.0033 0.0261 0.08
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0021 0.0019
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0021 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0455 0.1407
Onchocerca volvulus 0.003 0.0222 0.2361
Trypanosoma brucei sugar transporter, putative 0.003 0.0222 0.0677
Brugia malayi major facilitator superfamily protein 0.003 0.0222 0.0977
Onchocerca volvulus 0.003 0.0222 0.2361
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0625 0.1939
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.006 0.0124
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Onchocerca volvulus 0.003 0.0222 0.2361
Leishmania major glucose transporter, lmgt1 0.0065 0.0625 0.1939
Onchocerca volvulus 0.003 0.0222 0.2361
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0283 0.0733
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0021 0.0017
Onchocerca volvulus 0.003 0.0222 0.2361
Chlamydia trachomatis pyruvate kinase 0.0033 0.0261 0.6045
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0021 0.0019
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0093 0.0092
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0261 0.1572
Toxoplasma gondii sugar transporter ST1 0.003 0.0222 0.0332
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0418 0.1126
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0418 0.1292
Trypanosoma cruzi hexose transporter 0.0065 0.0625 0.1939
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1456 0.4538
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.072 0.2234
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0418 0.0629
Entamoeba histolytica protein kinase, putative 0.0065 0.0622 0.1633
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0625 0.1939
Schistosoma mansoni transient receptor potential channel 0.0062 0.0592 0.161
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0093 0.0276
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0222 0.0332
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0021 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0434 0.1914
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0261 0.1131
Brugia malayi hypothetical protein 0.003 0.0222 0.0977
Trypanosoma cruzi hexose transporter, putative 0.0036 0.029 0.0892
Brugia malayi Sugar transporter family protein 0.021 0.2268 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Schistosoma mansoni protein kinase 0.0065 0.0622 0.1695
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Leishmania major hypothetical protein, conserved 0.003 0.0222 0.0677
Schistosoma mansoni hypothetical protein 0.002 0.0108 0.0261
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0222 0.022
Plasmodium vivax hexose transporter 0.021 0.2268 0.2267
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0625 0.1939
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0108 0.0106
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Schistosoma mansoni helicase 0.0065 0.0624 0.1701
Trypanosoma brucei glucose transporter 2A 0.0065 0.0625 0.1939
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0222 0.0578
Onchocerca volvulus 0.003 0.0222 0.2361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0093 0.0276
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0623 0.0621
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Giardia lamblia Pyruvate kinase 0.0017 0.0079 0.0158
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.021 0.2268 0.6151
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.072 0.2234
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0415
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0506 0.1342
Loa Loa (eye worm) hypothetical protein 0.0033 0.0261 0.1095
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0261 0.1095
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1198 0.525
Giardia lamblia DNA repair protein RAD52 0.0337 0.3704 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0622 0.1659
Brugia malayi Sugar transporter family protein 0.003 0.0222 0.0977
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0021 0.0049
Brugia malayi hypothetical protein 0.003 0.0222 0.0977
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0222 0.0919
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0623 0.0621
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0589 0.1543
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.0952 0.256
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Onchocerca volvulus 0.003 0.0222 0.2361
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Onchocerca volvulus Putative transporter 0.003 0.0222 0.2361
Loa Loa (eye worm) hypothetical protein 0.0048 0.0434 0.1862
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0222 0.0956
Trypanosoma cruzi glucose transporter, putative 0.003 0.0222 0.0677
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Giardia lamblia Pyruvate kinase 0.0033 0.0261 0.0653
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0108 0.0255
Leishmania major glucose transporter, lmgt2 0.0065 0.0625 0.1939
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0623 0.0621
Echinococcus multilocularis pyruvate kinase 0.0026 0.0182 0.0458
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0625 0.274
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0261 0.4294
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0418 0.1292
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0601 0.1576
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0021 0.0262
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3203 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0021 0.0049
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0062 0.0589 0.1603
Echinococcus granulosus RUN 0.002 0.0108 0.0255
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0261 0.08
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Onchocerca volvulus 0.0062 0.0589 1
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0139 1
Plasmodium falciparum proline--tRNA ligase 0.0074 0.072 0.0718
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0093 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0625 0.274
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0176
Schistosoma mansoni loxhd1 0.002 0.0108 0.0261
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0623 0.0938
Schistosoma mansoni hypothetical protein 0.0328 0.36 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0623 0.0938
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0261 0.3182
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0261 0.08
Echinococcus granulosus protein kinase shaggy 0.0062 0.0589 0.1569
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0622 0.2743
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Brugia malayi Doublecortin family protein 0.002 0.0108 0.0476
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0592 0.1576
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0282 0.0746
Schistosoma mansoni glucose transport protein 0.021 0.2268 0.6285
Echinococcus multilocularis tumor protein p63 0.0335 0.3678 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0222 0.0919
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1456 0.4538
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0623 0.0621
Leishmania major pyruvate kinase 0.0033 0.0261 0.08
Echinococcus granulosus General substrate transporter 0.0181 0.1933 0.5238
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0418 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.006 0.0264
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0566
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0566
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0261 0.3182
Trypanosoma cruzi hexose transporter, putative 0.003 0.0222 0.0677
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.0127
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.0973 0.2585
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0337 0.3704 1
Toxoplasma gondii protein kinase, putative 0.0595 0.6621 1
Plasmodium vivax sugar transporter, putative 0.003 0.0222 0.022
Brugia malayi MH2 domain containing protein 0.0116 0.1198 0.528
Echinococcus granulosus GPCR family 2 0.0015 0.006 0.0124
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0917 0.2463
Schistosoma mansoni ap endonuclease 0.0018 0.0093 0.022
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0418 0.2537
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0566
Loa Loa (eye worm) BRM protein 0.0042 0.0358 0.1524
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0222 0.0977
Entamoeba histolytica protein kinase, putative 0.0065 0.0622 0.1633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Schistosoma mansoni hypothetical protein 0.0328 0.36 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0021 0.0049
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0139 0.2978
Loa Loa (eye worm) hypothetical protein 0.0033 0.0261 0.1094
Plasmodium falciparum hexose transporter 0.021 0.2268 0.2267
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0601 0.2651
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.006 0.0124
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Loa Loa (eye worm) BRM protein 0.0034 0.0268 0.1126
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0021 0.0091
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0021 0.0091
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0093 0.0092
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0434 0.1914
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0625 0.1939
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0093 0.0276
Toxoplasma gondii exonuclease III APE 0.0018 0.0093 0.0138
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0623 0.0621
Schistosoma mansoni rab6-interacting 0.002 0.0108 0.0261
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0418 0.0417
Loa Loa (eye worm) hypothetical protein 0.0059 0.0556 0.2404
Entamoeba histolytica hypothetical protein 0.0035 0.0282 0.0709
Echinococcus multilocularis GPCR, family 2 0.0015 0.006 0.0124
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Leishmania major protein kinase, putative 0.0065 0.0622 0.193
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0566
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0261 0.0259
Brugia malayi major facilitator superfamily protein 0.003 0.0222 0.0977
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0418 0.2537
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0601 0.2651
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0139 0.0823
Schistosoma mansoni ap endonuclease 0.0018 0.0093 0.022
Trichomonas vaginalis glucose transporter, putative 0.003 0.0222 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0222 0.0977
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0176
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0571 0.1519
Entamoeba histolytica hypothetical protein 0.0096 0.0973 0.2585
Schistosoma mansoni transient receptor potential channel 0.0094 0.0952 0.2616
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0589 0.258
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.072 0.0718
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0418 0.1079
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0418 0.1102
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0108 0.0255
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0093 0.0541
Loa Loa (eye worm) sugar transporter 0.021 0.2268 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0093 0.0541
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0601 0.2634
Echinococcus multilocularis global transcription activator snf2l2 0.0065 0.0624 0.1665
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0418 0.1826
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0176
Trypanosoma brucei protein kinase, putative 0.0062 0.0589 0.1826
Echinococcus multilocularis pyruvate kinase 0.0033 0.0261 0.0673
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.021 0.2268 1
Entamoeba histolytica hypothetical protein 0.0035 0.0282 0.0709
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0418 0.1102
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Brugia malayi BRM protein 0.0065 0.0624 0.2752
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0625 0.1939
Onchocerca volvulus 0.003 0.0222 0.2361
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0442 0.1192
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0108 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0283 0.1192
Schistosoma mansoni protein kinase 0.0065 0.0622 0.1695
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Loa Loa (eye worm) hypothetical protein 0.0049 0.0442 0.1896
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3203 1
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0261 0.0392
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0589 0.1543
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0625 0.274
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0623 0.0938
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0222 0.0566
Loa Loa (eye worm) sugar transporter 0.003 0.0222 0.0919
Schistosoma mansoni protein kinase 0.0065 0.0622 0.1695
Echinococcus multilocularis RUN 0.002 0.0108 0.0255
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0261 0.1151
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.072 0.2234
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0222 0.1329
Giardia lamblia Hexose transporter 0.003 0.0222 0.0545
Echinococcus granulosus pyruvate kinase 0.0017 0.0079 0.0176
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0283 0.0733
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0341 0.3741 0.5649
Loa Loa (eye worm) hypothetical protein 0.0015 0.006 0.0202
Echinococcus multilocularis pyruvate kinase 0.0017 0.0079 0.0176
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0062 0.0589 0.1569
Schistosoma mansoni rab6-interacting 0.002 0.0108 0.0261
Echinococcus granulosus pyruvate kinase 0.0033 0.0261 0.0673
Trypanosoma cruzi sugar transporter, putative 0.003 0.0222 0.0677
Giardia lamblia Sugar-proton symporter 0.003 0.0222 0.0545
Entamoeba histolytica hypothetical protein 0.0035 0.0282 0.0709
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0578
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0592 0.1576
Echinococcus multilocularis protein kinase shaggy 0.0062 0.0589 0.1569
Onchocerca volvulus 0.003 0.0222 0.2361
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0093 0.0197
Toxoplasma gondii hypothetical protein 0.0047 0.0422 0.0634
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.0127
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0021 0.0096
Leishmania major glucose transporter, lmgt3 0.0065 0.0625 0.1939
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0622 0.1695
Schistosoma mansoni pyruvate kinase 0.0017 0.0079 0.018
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0222 0.0977
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0578
Echinococcus multilocularis geminin 0.0328 0.36 0.9787
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0079 0.0077
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.1035
Toxoplasma gondii sugar transporter ST3 0.003 0.0222 0.0332
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0261 0.1151
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0261 0.1095
Onchocerca volvulus 0.003 0.0222 0.2361
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0353 0.1088
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0021 0.0049
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.072 0.2234
Schistosoma mansoni glucose transport protein 0.021 0.2268 0.6285
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0418 0.6932
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0956
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0028
Echinococcus granulosus geminin 0.0328 0.36 0.9787
Plasmodium falciparum pyruvate kinase 0.0033 0.0261 0.0259
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0108 0.0255
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0261 0.115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0282 0.073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0148 0.0592
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0353 0.1088
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0021 0.0028
Plasmodium vivax CDK-related protein kinase 6, putative 0.0893 1 1
Schistosoma mansoni lipoxygenase 0.0055 0.0506 0.1372
Onchocerca volvulus 0.003 0.0222 0.2361
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0222 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Trypanosoma brucei glucose transporter 1E 0.0065 0.0625 0.1939
Toxoplasma gondii sugar transporter ST2 0.003 0.0222 0.0332
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0589 0.1543
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0093 0.0215
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0338 0.2045
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0956
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0592 0.1576
Onchocerca volvulus 0.003 0.0222 0.2361
Echinococcus multilocularis General substrate transporter 0.0181 0.1933 0.5238
Loa Loa (eye worm) hypothetical protein 0.0063 0.0601 0.2604
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.072 0.2234
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0021 0.0091
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.0005 0.0005
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Loa Loa (eye worm) hypothetical protein 0.002 0.0108 0.0415
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0623 0.0621
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0623 0.0621
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0283 0.1248
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0625 0.274
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0021 0.0028
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.0127
Onchocerca volvulus 0.003 0.0222 0.2361
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0093 0.0389
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0566
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0021 0.0096
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0592 0.1576
Brugia malayi Sugar transporter family protein 0.003 0.0222 0.0977
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3203 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0222 0.0677
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0338 0.2045
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.0952 0.256
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0622 0.1659
Mycobacterium ulcerans hypothetical protein 0.0154 0.1633 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0222 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0341 0.3741 0.374
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0625 0.274
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0222 0.0956
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0571 0.1519
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0601 0.1602
Schistosoma mansoni pyruvate kinase 0.0033 0.0261 0.0688
Schistosoma mansoni sugar transporter 0.003 0.0222 0.0578
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.006 0.0202
Brugia malayi Cam kinase protein 1 0.0065 0.0622 0.2743
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0021 0.0017
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0506 0.1342
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus granulosus solute carrier family 22 0.003 0.0222 0.0566
Echinococcus multilocularis solute carrier family 22 0.003 0.0222 0.0566
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0014 0.0064
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0021 0.0069
Brugia malayi hypothetical protein 0.003 0.0222 0.0977
Plasmodium falciparum protein kinase 7 0.0595 0.6621 0.6621
Schistosoma mansoni glucose transporter 0.003 0.0222 0.0578
Loa Loa (eye worm) hypothetical protein 0.0065 0.0622 0.2697
Schistosoma mansoni pyruvate kinase 0.0033 0.0261 0.0688
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0093 0.0389
Brugia malayi intracellular kinase 0.0062 0.0589 0.2597
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0021 0.0096
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0418 0.0417
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0093 0.0197
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1633 1
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0079 0.0077
Echinococcus granulosus tumor protein p63 0.0335 0.3678 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0434 0.1862
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0062 0.0589 0.1826
Giardia lamblia Kinase, CMGC GSK 0.0062 0.0589 0.1543
Loa Loa (eye worm) hypothetical protein 0.003 0.0222 0.0919
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.2268 0.6151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0418 0.1792
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0222 0.0566
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0622 0.2727
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0341 0.3741 0.374
Toxoplasma gondii facilitative glucose transporter GT1 0.021 0.2268 0.3424
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0222 0.1329
Trypanosoma brucei glucose transporter, putative 0.0065 0.0625 0.1939
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0222 0.1329
Brugia malayi hypothetical protein 0.002 0.0108 0.0476
Brugia malayi hypothetical protein 0.0035 0.0282 0.1242
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0062 0.0589 0.1569
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0353 0.1536
Schistosoma mansoni hypothetical protein 0.021 0.2268 0.6285
Trichomonas vaginalis sugar transporter, putative 0.003 0.0222 0.0956
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0222 0.1329
Loa Loa (eye worm) doublecortin family protein 0.002 0.0108 0.0415
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.018 0.0735
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0353 0.1088
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0625 0.1939
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.0127
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0601 0.1636
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0062 0.0589 0.255

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.9 Ability of the compound to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, expressed as log of concentration ChEMBL. 15080992
Log IC50 (binding) = 7.9 Ability of the compound to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, expressed as log of concentration ChEMBL. 15080992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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