TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 403.351 | Formula: C13H18N5O6PS
H donors: 5 H acceptors: 8 LogP: -2.22 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CSc1nc(N)c2c(n1)n(cn2)C1C(O)C([C@@]2([C@H]1C2)COP(=O)(O)O)O
InChi: 1S/C13H18N5O6PS/c1-26-12-16-10(14)6-11(17-12)18(4-15-6)7-5-2-13(5,9(20)8(7)19)3-24-25(21,22)23/h4-5,7-9,19-20H,2-3H2,1H3,(H2,14,16,17)(H2,21,22,23)/t5-,7?,8?,9?,13+/m1/s1
InChiKey: ZPAWXMIERRIGEE-FLBLKNOPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0012	0.0012
Onchocerca volvulus		0.0017	0.0033	0.0331
Schistosoma mansoni	cpg binding protein	0.0031	0.0085	0.0119
Brugia malayi	Serotonin receptor	0.0095	0.0335	0.0517
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0055	0.0552
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.0988	0.924
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus granulosus	neuropeptide FF receptor 2	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Echinococcus granulosus	g-protein coupled receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0055	0.0479
Onchocerca volvulus		0.0095	0.0335	0.5169
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.0503	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0014	0.0014
Loa Loa (eye worm)	histone deacetylase 1	0.0042	0.013	0.0129
Brugia malayi	hypothetical protein	0.0016	0.0027	0.0042
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Schistosoma mansoni	amine GPCR	0.0095	0.0335	0.0504
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0095	0.0335	0.0504
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0025	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0055	0.2102
Loa Loa (eye worm)	acetyltransferase	0.0141	0.0511	0.0511
Echinococcus granulosus	g protein coupled receptor	0.0095	0.0335	0.0675
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0055	0.0211
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0017	0.0033	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0352	0.1331	0.2045
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0017	0.0033	0.0065
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Onchocerca volvulus		0.0017	0.0033	0.0331
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0095	0.0335	0.0675
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0095	0.0335	0.0675
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Schistosoma mansoni	histone deacetylase hda2	0.0012	0.0012	0.0006
Schistosoma mansoni	integrin alpha-ps	0.0392	0.1485	0.2283
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.1066	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0146	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	G-protein coupled receptor	0.0095	0.0335	0.0334
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0033	0.0038
Schistosoma mansoni	histamine h1 receptor	0.0095	0.0335	0.0504
Brugia malayi	putative neuropeptide receptor	0.0095	0.0335	0.0517
Schistosoma mansoni	opsin-like receptor	0.0095	0.0335	0.0504
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0146	0.0295
Schistosoma mansoni	hypothetical protein	0.0015	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0126	0.09
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Echinococcus granulosus	histone deacetylase 3	0.0042	0.013	0.0261
Brugia malayi	Histone deacetylase 1	0.0042	0.013	0.02
Echinococcus multilocularis	fmrfamide receptor	0.0095	0.0335	0.0675
Onchocerca volvulus		0.0095	0.0335	0.5169
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0017	0.0033	0.0065
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0062	0.4212
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0067	0.009
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0055	0.0211
Echinococcus multilocularis	integrin alpha ps	0.0752	0.2884	0.5819
Brugia malayi	hypothetical protein	0.0017	0.0033	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0153	0.0236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Leishmania major	histone deacetylase, putative	0.0042	0.013	0.5822
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0055	0.2102
Schistosoma mansoni	hypothetical protein	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0025	0.0024
Schistosoma mansoni	hypothetical protein	0.0095	0.0335	0.0504
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0062	0.4212
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0017	0.0033	0.0032
Schistosoma mansoni	biogenic amine receptor	0.0095	0.0335	0.0504
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0109	0.022
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0112	0.8538
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0109	0.022
Echinococcus multilocularis	histone deacetylase 7	0.0012	0.0012	0.0024
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0025	0.0049
Schistosoma mansoni	histone deacetylase	0.0042	0.013	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0017	0.0033	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0055	0.0084
Echinococcus granulosus	7TM GPCR rhodopsin	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Echinococcus granulosus	histone deacetylase 6	0.0012	0.0012	0.0024
Echinococcus multilocularis	lamin dm0	0.0026	0.0067	0.0134
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0194	1
Brugia malayi	hypothetical protein	0.0025	0.0062	0.0095
Brugia malayi	follicle stimulating hormone receptor	0.0095	0.0335	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0153	0.0153
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0033	0.0065
Schistosoma mansoni	lamin	0.0026	0.0067	0.009
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	neuropeptide Y receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0062	0.4212
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Echinococcus granulosus	g protein coupled receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0033	0.0038
Echinococcus multilocularis	fmrfamide receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0025	0.0049
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0214	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Brugia malayi	intermediate filament protein	0.0026	0.0067	0.0103
Echinococcus multilocularis	sex peptide receptor	0.0095	0.0335	0.0675
Trypanosoma cruzi	histone deacetylase 1, putative	0.0042	0.013	0.5822
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0008	0.0016
Echinococcus multilocularis	serotonin receptor	0.0095	0.0335	0.0675
Brugia malayi	hypothetical protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0062	0.0061
Echinococcus multilocularis	dro:myosuppressin receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0095	0.0335	0.0675
Echinococcus granulosus	fmrfamide receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0214	0.0431
Echinococcus multilocularis	g protein coupled receptor	0.0095	0.0335	0.0675
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0146	0.0295
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0055	0.0479
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0033	0.0065
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0062	0.2452
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0032	0.0077
Schistosoma mansoni	cpg binding protein	0.0029	0.0079	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	intermediate filament protein	0.0026	0.0067	0.0134
Echinococcus granulosus	serotonin receptor	0.0095	0.0335	0.0675
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.1066	1
Schistosoma mansoni	neuropeptide receptor	0.0095	0.0335	0.0504
Echinococcus granulosus	biogenic amine 5HT receptor	0.0095	0.0335	0.0675
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0095	0.0335	0.0334
Schistosoma mansoni	histone deacetylase 4 5	0.0012	0.0012	0.0006
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0025	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0033	0.0065
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0095	0.0335	0.0675
Echinococcus granulosus	cpg binding protein	0.0031	0.0085	0.0172
Echinococcus multilocularis	neuropeptide Y receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Onchocerca volvulus		0.0017	0.0033	0.0331
Brugia malayi	AKH receptor	0.0095	0.0335	0.0517
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0079	0.0122
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0112	0.0771
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0095	0.0335	0.0675
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0095	0.0335	0.0517
Echinococcus multilocularis	allatostatin A receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0095	0.0335	0.0675
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0112	0.0771
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0094	0.0145
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0014	0.0028
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0055	0.0084
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis		0.0017	0.0033	0.0065
Echinococcus multilocularis	g protein coupled receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0012	0.0012
Brugia malayi	hypothetical protein	0.0017	0.0033	0.0051
Echinococcus multilocularis	integrin alpha ps	0.0361	0.1364	0.2752
Onchocerca volvulus		0.0017	0.0033	0.0331
Trichomonas vaginalis	histone deacetylase, putative	0.0042	0.013	0.0937
Trichomonas vaginalis	histone deacetylase, putative	0.0042	0.013	0.0937
Onchocerca volvulus		0.0026	0.0067	0.0877
Brugia malayi	neuropeptide F receptor	0.0095	0.0335	0.0517
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0095	0.0335	0.0675
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0214	0.0214
Brugia malayi	Histone deacetylase family protein	0.0012	0.0012	0.0019
Echinococcus multilocularis	lamin	0.0026	0.0067	0.0134
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Echinococcus multilocularis	neuropeptides capa receptor	0.0095	0.0335	0.0675
Onchocerca volvulus		0.0017	0.0033	0.0331
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Onchocerca volvulus		0.0017	0.0033	0.0331
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0017	0.0033	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Brugia malayi	RE15519p	0.0095	0.0335	0.0517
Schistosoma mansoni	histone deacetylase 4 5	0.0012	0.0012	0.0006
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0095	0.0335	0.0517
Brugia malayi	G-protein coupled receptor	0.0095	0.0335	0.0517
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0206	0.0306
Echinococcus multilocularis	orexin receptor type 2	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0095	0.0335	0.0504
Echinococcus granulosus	sex peptide receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	histone deacetylase 1	0.0042	0.013	0.0261
Schistosoma mansoni	hypothetical protein	0.0361	0.1364	0.2096
Onchocerca volvulus		0.0017	0.0033	0.0331
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0055	0.0479
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Echinococcus granulosus	neuropeptides capa receptor	0.0095	0.0335	0.0675
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.0503	1
Onchocerca volvulus		0.0017	0.0033	0.0331
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0025	0.0049
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Loa Loa (eye worm)	neuropeptide F receptor	0.0095	0.0335	0.0334
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0025	0.0049
Schistosoma mansoni	hypothetical protein	0.0095	0.0335	0.0504
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0146	0.0226
Onchocerca volvulus		0.0017	0.0033	0.0331
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0095	0.0335	0.0675
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0095	0.0335	0.0675
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.0988	0.924
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0153	0.0236
Schistosoma mansoni	pcd6 interacting protein-related	0.0017	0.0033	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.002	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0055	0.0054
Schistosoma mansoni	histone deacetylase hda2	0.0012	0.0012	0.0006
Schistosoma mansoni	neuropeptide receptor	0.0095	0.0335	0.0504
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Onchocerca volvulus		0.0029	0.0079	0.1071
Onchocerca volvulus		0.0095	0.0335	0.5169
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0017	0.0033	0.0038
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.0988	0.924
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0095	0.0335	0.0675
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	cpg binding protein	0.0031	0.0085	0.0172
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Echinococcus granulosus	tm gpcr rhodopsin	0.0095	0.0335	0.0675
Echinococcus granulosus	somatostatin receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0017	0.0033	0.0032
Brugia malayi	G-protein coupled receptor	0.0095	0.0335	0.0517
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus granulosus	hypothetical protein	0.0095	0.0335	0.0675
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.002	0.003
Schistosoma mansoni	growth hormone secretagogue receptor	0.0095	0.0335	0.0504
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus multilocularis	neuropeptides capa receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	neuropeptide receptor	0.0095	0.0335	0.0504
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	integrin alpha ps	0.0752	0.2884	0.5819
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0062	0.2452
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0214	0.0318
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.0511	0.0778
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0017	0.0033	0.0038
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Onchocerca volvulus		0.0017	0.0033	0.0331
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0214	0.0431
Onchocerca volvulus		0.0017	0.0033	0.0331
Echinococcus granulosus	lamin	0.0026	0.0067	0.0134
Onchocerca volvulus		0.0017	0.0033	0.0331
Schistosoma mansoni	myosin xvIII	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0017	0.0033	0.1023
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0126	0.9677
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0065	0.0065
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0033	0.0038
Schistosoma mansoni	biogenic amine receptor	0.0095	0.0335	0.0504
Trypanosoma brucei	histone deacetylase 1	0.0042	0.013	0.5822
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0095	0.0335	0.5169
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0033	0.0038
Onchocerca volvulus		0.0017	0.0033	0.0331
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0095	0.0335	0.0504
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0062	0.272
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Schistosoma mansoni	hypothetical protein	0.0165	0.0604	0.092
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0095	0.0335	0.0504
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0033	0.0038
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Loa Loa (eye worm)	hypothetical protein	0.1318	0.5076	0.5076
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0095	0.0335	0.0517
Onchocerca volvulus		0.0095	0.0335	0.5169
Brugia malayi	larval opioid receptor	0.0095	0.0335	0.0517
Schistosoma mansoni	biogenic amine receptor	0.0095	0.0335	0.0504
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.0672	0.6187
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0095	0.0335	0.0504
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0095	0.0335	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	histone deacetylase 3	0.0042	0.013	0.0261
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0095	0.0335	0.0517
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Onchocerca volvulus	Glucosylceramidase homolog	0.0173	0.0636	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0008	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0095	0.0335	0.0504
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	histone deacetylase 7A	0.0012	0.0012	0.0012
Echinococcus granulosus	histone deacetylase 6	0.0012	0.0012	0.0024
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0095	0.0335	0.0675
Schistosoma mansoni	hypothetical protein	0.0165	0.0604	0.092
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0055	0.0479
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus granulosus	G protein coupled receptor 139	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus granulosus	histone deacetylase	0.0012	0.0012	0.0024
Echinococcus multilocularis	neuropeptide receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0095	0.0335	0.0675
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.0496	0.1
Brugia malayi	GnHR receptor homolog	0.0095	0.0335	0.0517
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0032	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0095	0.0335	0.0504
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0067	0.0066
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.127	0.4889	0.7551
Loa Loa (eye worm)	histone deacetylase	0.0012	0.0012	0.0012
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0146	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0214	0.1753
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0032	0.5
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0055	0.0479
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0017	0.0033	0.0065
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Brugia malayi	histone deacetylase 1 (HD1)	0.0042	0.013	0.02
Echinococcus granulosus	lamin dm0	0.0026	0.0067	0.0134
Onchocerca volvulus		0.0017	0.0033	0.0331
Schistosoma mansoni	amine GPCR	0.0095	0.0335	0.0504
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0095	0.0335	0.0517
Plasmodium falciparum	histone deacetylase 1	0.0042	0.013	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0095	0.0335	0.0334
Echinococcus multilocularis	neuropeptide Y receptor	0.0095	0.0335	0.0675
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0017	0.0033	0.0051
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0214	0.033
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0033	0.0065
Brugia malayi	sulfakinin receptor protein	0.0095	0.0335	0.0517
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	neuropeptide s receptor	0.0565	0.2156	0.4351
Echinococcus granulosus	histone deacetylase 7	0.0012	0.0012	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0095	0.0335	0.0334
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0079	0.0079
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0017	0.0033	0.0065
Schistosoma mansoni	opsin-like receptor	0.0095	0.0335	0.0504
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0352	0.1331	0.133
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0055	0.2102
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.0503	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	integrin alpha ps	0.0361	0.1364	0.2752
Echinococcus granulosus	histone deacetylase 6	0.0012	0.0012	0.0024
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Schistosoma mansoni	opsin-like receptor	0.0095	0.0335	0.0504
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0352	0.1331	0.2055
Trichomonas vaginalis	histone deacetylase, putative	0.0042	0.013	0.0937
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Trypanosoma cruzi	histone deacetylase 1, putative	0.0042	0.013	0.5822
Echinococcus multilocularis	geminin	0.0165	0.0604	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0095	0.0335	0.0675
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0055	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0032	0.1689
Schistosoma mansoni	histone deacetylase	0.0042	0.013	0.0187
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0146	0.0295
Loa Loa (eye worm)	hypothetical protein	0.127	0.4889	0.4889
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Onchocerca volvulus		0.0095	0.0335	0.5169
Echinococcus multilocularis	integrin alpha 3	0.1287	0.4955	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0055	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0017	0.0033	0.0065
Echinococcus granulosus	allatostatin A receptor	0.0095	0.0335	0.0675
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0214	1
Toxoplasma gondii	histone deacetylase HDAC2	0.0042	0.013	0.6458
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0062	0.2452
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0033	0.0051
Echinococcus granulosus	histone deacetylase 8	0.0012	0.0012	0.0024
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0055	0.0211
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0017	0.0033	0.0051
Schistosoma mansoni	histone deacetylase 1 2 3	0.0012	0.0012	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0067	0.0066
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0636	0.5838
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0095	0.0335	0.0675
Echinococcus granulosus	geminin	0.0165	0.0604	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0055	0.0054
Echinococcus granulosus	neuropeptide receptor	0.0095	0.0335	0.0675
Brugia malayi	hypothetical protein	0.0017	0.0033	0.0051
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0017	0.0033	0.0065
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0126	0.09
Brugia malayi	hypothetical protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Brugia malayi	histone deacetylase 3 (HD3)	0.0042	0.013	0.02
Echinococcus multilocularis	musashi	0.0026	0.0067	0.0134
Brugia malayi	Histone deacetylase family protein	0.0012	0.0012	0.0019
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0095	0.0335	0.0334
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Schistosoma mansoni	amine GPCR	0.0095	0.0335	0.0504
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0033	0.0065
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0055	0.0479
Echinococcus granulosus	integrin alpha 3	0.1287	0.4955	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Giardia lamblia	Histone deacetylase	0.0042	0.013	0.0937
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0055	0.0084
Schistosoma mansoni	cpg binding protein	0.0031	0.0085	0.0119
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0014	0.0028
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0095	0.0335	0.0675
Schistosoma mansoni	hypothetical protein	0.0015	0.0025	0.0025
Echinococcus granulosus	tm gpcr rhodopsin	0.0095	0.0335	0.0675
Schistosoma mansoni	integrin alpha-ps	0.0752	0.2884	0.4446
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0017	0.0033	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Onchocerca volvulus		0.0017	0.0033	0.0331
Brugia malayi	ORL1-like opioid receptor	0.0095	0.0335	0.0517
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0025	0.0024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0033	0.0038
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Brugia malayi	Dopamine receptor protein 2	0.0095	0.0335	0.0517
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Loa Loa (eye worm)	TYRA-2 protein	0.0095	0.0335	0.0334
Echinococcus granulosus	7tm_1 domain containing protein	0.0095	0.0335	0.0675
Loa Loa (eye worm)	G-protein coupled receptor	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus granulosus	tm gpcr rhodopsin	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Brugia malayi	Serotonin receptor	0.0095	0.0335	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Schistosoma mansoni	adenoreceptor	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1364	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0095	0.0335	0.0675
Leishmania major	histone deacetylase, putative	0.0042	0.013	0.5822
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	integrin alpha ps	0.0752	0.2884	0.5819
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0146	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Loa Loa (eye worm)	histone deacetylase 11	0.0012	0.0012	0.0012
Echinococcus granulosus	neuropeptides capa receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0095	0.0335	0.0504
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0055	0.0479
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0095	0.0335	0.0675
Echinococcus granulosus	dro:myosuppressin receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Brugia malayi	neuropeptide F receptor	0.0095	0.0335	0.0517
Echinococcus granulosus	biogenic amine 5HT receptor	0.0095	0.0335	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0042	0.013	0.0129
Echinococcus multilocularis	somatostatin receptor	0.0095	0.0335	0.0675
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0095	0.0335	0.5169
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0095	0.0335	0.0504
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.0988	0.924
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Echinococcus granulosus	g protein coupled receptor	0.0095	0.0335	0.0675
Onchocerca volvulus		0.0023	0.0055	0.068
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Schistosoma mansoni	hypothetical protein	0.0015	0.0025	0.0025
Echinococcus granulosus	neuropeptide receptor A26	0.0565	0.2156	0.4351
Loa Loa (eye worm)	hypothetical protein	0.0926	0.3557	0.3556
Loa Loa (eye worm)	melatonin receptor type 1A	0.0095	0.0335	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.1066	1
Echinococcus granulosus	neuropeptide Y receptor	0.0095	0.0335	0.0675
Echinococcus granulosus	histone deacetylase 1	0.0042	0.013	0.0261
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0214	1
Echinococcus granulosus	orexin receptor type 2	0.0095	0.0335	0.0675
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0017	0.0033	0.0032
Onchocerca volvulus		0.0095	0.0335	0.5169
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.1066	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0095	0.0335	0.0675
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0095	0.0335	0.0675
Brugia malayi	Dopamine receptor protein 1	0.0095	0.0335	0.0517
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0033	0.0065
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Schistosoma mansoni	hypothetical protein	0.0095	0.0335	0.0504
Echinococcus multilocularis	G protein coupled receptor 139	0.0095	0.0335	0.0675
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0017	0.0033	0.1023
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Toxoplasma gondii	histone deacetylase HDAC3	0.0042	0.013	0.6458
Onchocerca volvulus		0.0017	0.0033	0.0331
Brugia malayi	G protein-coupled receptor	0.0095	0.0335	0.0517
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0095	0.0335	0.0504
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.0511	0.079
Onchocerca volvulus		0.0095	0.0335	0.5169
Echinococcus multilocularis	serotonin receptor	0.0095	0.0335	0.0675
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.0988	0.924
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Leishmania major	tyrosine specific protein phosphatase, putative	0.0017	0.0033	0.1023
Brugia malayi	G protein-coupled receptor F59B2.13	0.0095	0.0335	0.0517
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Echinococcus multilocularis	histone deacetylase 8	0.0012	0.0012	0.0024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0033	0.0038
Onchocerca volvulus		0.0095	0.0335	0.5169
Echinococcus granulosus	GPCR family 2	0.0015	0.0025	0.0049
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0352	0.1331	0.2685
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0025	0.0038
Brugia malayi	putative neuropeptide receptor NPR1	0.0095	0.0335	0.0517
Brugia malayi	Protein-tyrosine phosphatase 1	0.0017	0.0033	0.0051
Echinococcus granulosus	Solute carrier family 22 5	0.1005	0.3865	0.7799
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0017	0.0033	0.0038
Plasmodium vivax	histone deacetylase 1, putative	0.0042	0.013	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0264	0.0988	0.1526
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	hypothetical protein	0.0017	0.0033	0.0065
Schistosoma mansoni	hypothetical protein	0.0033	0.0094	0.0132
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0017	0.0033	0.0038
Brugia malayi	Integrin alpha pat-2 precursor	0.1678	0.6475	1
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0095	0.0335	0.0517
Echinococcus multilocularis	histone deacetylase 6	0.0012	0.0012	0.0024
Schistosoma mansoni	lamin	0.0026	0.0067	0.009
Entamoeba histolytica	histone deacetylase, putative	0.0042	0.013	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0042	0.013	0.0937
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Schistosoma mansoni	amine GPCR	0.0095	0.0335	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0095	0.0335	0.0504
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0017	0.0033	0.0038
Brugia malayi	Protein-tyrosine phosphatase	0.0017	0.0033	0.0051
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0352	0.1331	0.2685
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1066	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0067	0.0066
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0264	0.0988	0.0987
Onchocerca volvulus		0.0095	0.0335	0.5169
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0033	0.0065
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0017	0.0033	0.1023
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	neuropeptide F-like receptor	0.0095	0.0335	0.0504
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0095	0.0335	0.0504
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0095	0.0335	0.0504
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.0511	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0094	0.0093
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0017	0.0033	0.0065
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0042	0.013	0.0937
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0126	0.6249
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0017	0.0033	0.1023
Onchocerca volvulus		0.0095	0.0335	0.5169
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	g protein coupled receptor	0.0095	0.0335	0.0675
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0017	0.0033	0.0038
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0017	0.0033	0.0065
Echinococcus multilocularis	histone deacetylase 6	0.0012	0.0012	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0017	0.0033	0.0032
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0017	0.0033	0.0038
Onchocerca volvulus		0.0017	0.0033	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0032
Loa Loa (eye worm)	neuropeptide F receptor	0.0095	0.0335	0.0334
Schistosoma mansoni	neuropeptide f receptor 76f	0.0095	0.0335	0.0504
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0126	0.6249
Trichomonas vaginalis	histone deacetylase, putative	0.0042	0.013	0.0937
Echinococcus multilocularis	histone deacetylase	0.0012	0.0012	0.0024
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0146	0.0213
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0126	0.0253
Trichomonas vaginalis	histone deacetylase, putative	0.0042	0.013	0.0937
Trichomonas vaginalis	glucosylceramidase, putative	0.0264	0.0988	0.924
Schistosoma mansoni	neuropeptide F-like receptor	0.0095	0.0335	0.0504
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0017	0.0033	0.0065
Echinococcus granulosus	neuropeptide s receptor	0.0565	0.2156	0.4351
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0055	0.0552
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Onchocerca volvulus	4.1 G protein, putative homolog	0.0017	0.0033	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0392	0.1485	0.1484
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0146	0.0213
Loa Loa (eye worm)	histone deacetylase 3	0.0042	0.013	0.0129
Brugia malayi	Melatonin receptor type 1A	0.0095	0.0335	0.0517
Schistosoma mansoni	protein tyrosine phosphatase	0.0017	0.0033	0.0038
Brugia malayi	Dopamine receptor	0.0095	0.0335	0.0517
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0017	0.0033	0.0032
Schistosoma mansoni	amine GPCR	0.0095	0.0335	0.0504
Echinococcus granulosus	neuropeptide receptor	0.0095	0.0335	0.0675
Trichomonas vaginalis	histone deacetylase, putative	0.0042	0.013	0.0937
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.0672	0.6187
Schistosoma mansoni	hypothetical protein	0.0015	0.0025	0.0025
Schistosoma mansoni	integrin alpha	0.1678	0.6475	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0017	0.0033	0.0038
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0095	0.0335	0.0504
Leishmania major	hypothetical protein, conserved	0.0025	0.0062	0.2452
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0033	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0335	0.0334
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0095	0.0335	0.0675
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0042	0.013	0.0937
Onchocerca volvulus		0.0095	0.0335	0.5169
Echinococcus multilocularis	neuropeptide receptor A26	0.0565	0.2156	0.4351
Echinococcus multilocularis	neuropeptide receptor	0.0095	0.0335	0.0675
Onchocerca volvulus		0.0026	0.0067	0.0877
Brugia malayi	hypothetical protein	0.0095	0.0335	0.0517
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0017	0.0033	0.0065
Brugia malayi	histone deacetylase 11	0.0012	0.0012	0.0019
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0067	0.0103
Echinococcus multilocularis	histone deacetylase 6	0.0012	0.0012	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0012	0.0012

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 590 nM	Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor	ChEMBL.	11985476
EC50 (binding)	= 1190 nM	Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes	ChEMBL.	11985476
NE (functional)	0	Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11; No effect as either agonist or antagonist at 10 microM	ChEMBL.	11985476

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 203298

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 108865