Detailed information for compound 1102940

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.533 | Formula: C28H30O8
  • H donors: 0 H acceptors: 1 LogP: 5.12 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C(/C(=O)c1cc(OC)c(c(c1)OC)OC)\c1cc(OC)c(c(c1)OC)OC
  • InChi: 1S/C28H30O8/c1-30-20-10-8-17(9-11-20)12-21(18-13-22(31-2)27(35-6)23(14-18)32-3)26(29)19-15-24(33-4)28(36-7)25(16-19)34-5/h8-16H,1-7H3/b21-12+
  • InChiKey: UUFZIXSXJAXEOK-CIAFOILYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0142 0.0367
Echinococcus granulosus Niemann Pick C1 protein 0.0161 0.1607 0.1618
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0321 0.8562
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0199 0.0184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0465 0.2455
Echinococcus multilocularis expressed conserved protein 0.0106 0.1003 0.1003
Echinococcus granulosus dnaJ subfamily B 0.092 0.9936 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0114 0.1097 0.1089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0321 1
Schistosoma mansoni hypothetical protein 0.0186 0.1888 0.1886
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0321 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0112 0.1078 0.5707
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1005 0.1005
Echinococcus granulosus microtubule associated protein 2 0.0788 0.8487 0.8542
Loa Loa (eye worm) DOMON domain-containing protein 0.0017 0.0033 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0452 0.239
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0142 0.0746
Echinococcus multilocularis 0.0016 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Echinococcus granulosus geminin 0.0381 0.4026 0.4052
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0308 0.0294
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0321 0.0307
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.003
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0326 0.3419 1
Trypanosoma brucei unspecified product 0.003 0.0174 0.5142
Echinococcus multilocularis protein dispatched 1 0.0055 0.0449 0.0449
Echinococcus multilocularis microtubule associated protein 2 0.0788 0.8487 0.8487
Trypanosoma brucei unspecified product 0.003 0.0174 0.5142
Loa Loa (eye worm) histone methyltransferase 0.002 0.0064 0.0334
Echinococcus granulosus tumor protein p63 0.0386 0.4077 0.4103
Schistosoma mansoni hypothetical protein 0.092 0.9936 1
Onchocerca volvulus Alhambra homolog 0.0032 0.0199 0.3199
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0321 0.1696
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0348
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0124 0.3499
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0064 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0055 0.0111
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0142 0.0367
Brugia malayi jmjC domain containing protein 0.0043 0.0314 0.1658
Onchocerca volvulus 0.0027 0.0142 0.2101
Schistosoma mansoni DNA polymerase eta 0.0043 0.0321 0.0307
Schistosoma mansoni hypothetical protein 0.0186 0.1888 0.1886
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0142 0.0367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0055 0.0111
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0576 0.3048
Brugia malayi Bromodomain containing protein 0.0032 0.0199 0.1049
Echinococcus granulosus peregrin 0.0032 0.0199 0.0201
Brugia malayi Cytochrome P450 family protein 0.0025 0.0124 0.0648
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0124 0.3499
Brugia malayi SEA domain containing protein 0.0017 0.0033 0.0166
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0021 0.0021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0321 0.8562
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0166
Schistosoma mansoni hypothetical protein 0.0381 0.4026 0.4041
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0186 0.1888 0.1888
Loa Loa (eye worm) hypothetical protein 0.0042 0.0308 0.1627
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0348
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0021 0.0021
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0326 0.3419 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0174 0.5142
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0321 0.1914
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0199 0.0201
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0186 0.1888 0.19
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0314 0.1658
Schistosoma mansoni cpg binding protein 0.0068 0.0594 0.0582
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0308 0.8209
Plasmodium falciparum phd finger protein, putative 0.0032 0.0199 0.0572
Echinococcus multilocularis dnaJ subfamily B 0.092 0.9936 0.9936
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0481 0.2541
Loa Loa (eye worm) hypothetical protein 0.0186 0.1888 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0064 0.0064
Echinococcus granulosus expressed conserved protein 0.0106 0.1003 0.101
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0186 0.1888 0.19
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0308 0.9573
Echinococcus granulosus MAM 0.0018 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0112 0.1078 0.5707
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0374 1
Schistosoma mansoni patched 1 0.0048 0.0374 0.036
Brugia malayi Protein kinase domain containing protein 0.0018 0.0047 0.0241
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0767 0.0756
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0142 0.4108
Echinococcus multilocularis MAM 0.0018 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0186 0.1888 0.1886
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.1049
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0374 0.0377
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0186 0.1888 0.1886
Schistosoma mansoni cpg binding protein 0.0068 0.0594 0.0582
Loa Loa (eye worm) hypothetical protein 0.0048 0.0374 0.1977
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0321 1
Brugia malayi Cytochrome P450 family protein 0.0058 0.0481 0.2541
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0465 0.0451
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0348
Schistosoma mansoni hypothetical protein 0.0017 0.0033 0.0016
Schistosoma mansoni microtubule-associated protein tau 0.0788 0.8487 0.8539
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0308 0.9573
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0314 0.03
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0308 0.1776
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0142 0.0367
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0199 0.1557
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0021 0.0021
Echinococcus granulosus dna polymerase eta 0.0043 0.0321 0.0323
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.1188 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0314 0.03
Schistosoma mansoni hypothetical protein 0.0032 0.0199 0.0184
Loa Loa (eye worm) hypothetical protein 0.0017 0.0033 0.0166
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0338 0.034
Brugia malayi CHE-14 protein 0.0048 0.0374 0.1977
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0241
Brugia malayi cytochrome P450 0.0016 0.0017 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0124 0.0648
Brugia malayi hypothetical protein 0.0018 0.0047 0.0241
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0308 0.9573
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1005 0.1012
Schistosoma mansoni hypothetical protein 0.0046 0.0355 0.0341
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0124 0.0313
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0142 0.4108
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Onchocerca volvulus 0.0018 0.0047 0.0272
Echinococcus granulosus dna polymerase kappa 0.0043 0.0321 0.0323
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0241
Trypanosoma brucei unspecified product 0.0043 0.0321 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0142 0.0367
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0321 0.0894
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0186 0.1888 0.1888
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0308 0.0294
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0308 0.8934
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0374 0.0377
Schistosoma mansoni hypothetical protein 0.0046 0.0355 0.0341
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0321 0.0321
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0308 0.031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0746
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0055 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0321 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0112 0.1078 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0142 0.0746
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0199 0.0199
Echinococcus multilocularis cpg binding protein 0.0068 0.0594 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0308 0.0308
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0326 0.3419 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0348
Schistosoma mansoni apoptosis regulator bax 0.0186 0.1888 0.1886
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0746
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0124 0.3499
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Brugia malayi CXXC zinc finger family protein 0.0065 0.0554 0.2928
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0308 0.031
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0374 0.1977
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0137 0.0121
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0308 0.0308
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0321 1
Echinococcus multilocularis peregrin 0.0032 0.0199 0.0199
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0017 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0137 0.1348 0.1342
Onchocerca volvulus 0.0018 0.0047 0.0272
Leishmania major DNA polymerase kappa, putative 0.0043 0.0321 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0055 0.0111
Brugia malayi Cytochrome P450 family protein 0.0016 0.0017 0.0084
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0067 0.5
Schistosoma mansoni cpg binding protein 0.0065 0.0554 0.0541
Echinococcus multilocularis protein patched 0.0048 0.0374 0.0374
Echinococcus granulosus cpg binding protein 0.0068 0.0594 0.0598
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0124 0.0648
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0321 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0067 0.0147
Echinococcus multilocularis tumor protein p63 0.0386 0.4077 0.4077
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0326 0.3419 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0124 0.0648
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0142 0.0367
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0554 0.2928
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0241
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0308 0.031
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0047 0.0241
Giardia lamblia DINP protein human, muc B family 0.0043 0.0321 1
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0177 0.0933
Brugia malayi PHD-finger family protein 0.0032 0.0199 0.1049
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Leishmania major DNA polymerase eta, putative 0.0043 0.0321 1
Echinococcus granulosus Niemann Pick C1 protein 0.0112 0.1078 0.1085
Schistosoma mansoni hypothetical protein 0.0046 0.0355 0.0341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0142 0.0746
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0308 0.8209
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0321 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0112 0.1078 0.1078
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0321 0.0321
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0308 0.9573
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0199 0.0572
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0274 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0174 0.5142
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0338 0.0338
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0186 0.1888 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Onchocerca volvulus 0.0065 0.0554 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0067 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0142 0.0746
Brugia malayi Cytochrome P450 family protein 0.0025 0.0124 0.0648
Loa Loa (eye worm) hypothetical protein 0.0043 0.0321 0.1696
Loa Loa (eye worm) cytochrome P450 0.0016 0.0017 0.0084
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0199 0.1049
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0321 0.1696
Echinococcus multilocularis geminin 0.0381 0.4026 0.4026
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0308 0.8209
Echinococcus multilocularis dna polymerase eta 0.0043 0.0321 0.0321
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0308 0.0308
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0326 0.3419 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0142 0.0367
Brugia malayi Muscle positioning protein 4 0.0017 0.0033 0.0166
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0142 0.4108
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0314 0.0316
Brugia malayi jmjC domain containing protein 0.0106 0.1005 0.532
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0174 0.5142
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0321 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0321 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0321 0.0323
Schistosoma mansoni hypothetical protein 0.0381 0.4026 0.4041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0321 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0142 0.0367
Leishmania major cytochrome p450-like protein 0.0025 0.0124 0.3499
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0321 0.1696
Onchocerca volvulus 0.0056 0.0465 0.8289
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0067 0.0184
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0321 0.0894
Echinococcus multilocularis Niemann Pick C1 protein 0.0161 0.1607 0.1607
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0321 0.0307
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0321 0.0894
Treponema pallidum hypothetical protein 0.0326 0.3419 0.5
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0321 1
Loa Loa (eye worm) apoptosis regulator protein 0.0186 0.1888 1
Schistosoma mansoni hypothetical protein 0.0046 0.0355 0.0341
Loa Loa (eye worm) hypothetical protein 0.0059 0.0493 0.2608
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0067 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0142 0.0367
Mycobacterium ulcerans hypothetical protein 0.0027 0.0142 0.0367
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0199 0.1557
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0142 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0348
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0321 0.0894
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0308 0.1627
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0021 0.0021
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0142 0.0367

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2200 uM Antiproliferative activity against human K562 cells after 5 days by MTT assay ChEMBL. 19837594

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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