Detailed information for compound 1105330

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 629.466 | Formula: C20H32N5O16P
  • H donors: 11 H acceptors: 12 LogP: -9.94 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCC(=O)NC1C(O)CC(OC1[C@@H](C(CO)O)O)(OP(=O)(OC[C@H]1OC([C@@H]([C@@H]1O)O)n1ccc(nc1=O)N)O)C(=O)O
  • InChi: 1S/C20H32N5O16P/c21-4-11(29)24-12-7(27)3-20(18(33)34,40-16(12)13(30)8(28)5-26)41-42(36,37)38-6-9-14(31)15(32)17(39-9)25-2-1-10(22)23-19(25)35/h1-2,7-9,12-17,26-28,30-32H,3-6,21H2,(H,24,29)(H,33,34)(H,36,37)(H2,22,23,35)/t7?,8?,9-,12?,13-,14-,15-,16?,17?,20?/m1/s1
  • InChiKey: ADBBPRGEOJTHFJ-ZZKZLDMASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0424 0.228 0.2775
Echinococcus granulosus dna polymerase kappa 0.004 0.0091 0.0095
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0424 0.228 0.227
Brugia malayi Tachykinin-like peptides receptor 99D 0.0655 0.3594 1
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1358 0.4456
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0083 0.0338 1
Schistosoma mansoni hypothetical protein 0.014 0.0661 0.0649
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0035 0.0063 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Schistosoma mansoni neuropeptide F-like receptor 0.0424 0.228 0.227
Loa Loa (eye worm) melatonin receptor type 1A 0.0424 0.228 0.4898
Brugia malayi hypothetical protein 0.0032 0.0046 0.0129
Trypanosoma brucei hypothetical protein 0.0119 0.0539 0.2695
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0026 0.0013 0.0027
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0029 0.0026 0.0065
Trichomonas vaginalis tubulin epsilon chain, putative 0.0313 0.1645 0.543
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0046 0.0039
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.0718 0.0862
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.032 0.0376
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis allatostatin A receptor 0.0841 0.4655 0.5682
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0099 0.0426 0.2529
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Schistosoma mansoni tyrosine kinase 0.015 0.0718 0.0705
Loa Loa (eye worm) brahma associated protein 0.0074 0.0287 0.0616
Echinococcus multilocularis 0.0348 0.1848 0.2245
Schistosoma mansoni furin-1 (S08 family) 0.0188 0.0933 0.0921
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0313 0.1645 0.1997
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0087 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0013 0.0027
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0084 0.0086
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0083 0.0338 0.0988
Trichomonas vaginalis tubulin, putative 0.0313 0.1645 0.543
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0424 0.228 0.2775
Trypanosoma brucei calpain-like protein, putative 0.0119 0.0539 0.2695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0156 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0013 0.0027
Schistosoma mansoni tgf-beta family 0.0032 0.0046 0.0033
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0126 0.0582 0.0695
Brugia malayi endoprotease bli-4 precursor 0.0432 0.2324 0.6466
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Brugia malayi protein-tyrosine kinase 0.0035 0.0063 0.0175
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0156 0.0433
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Brugia malayi hypothetical protein 0.0032 0.0046 0.0129
Echinococcus granulosus beta tubulin 0.0313 0.1645 0.1997
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.032 0.0376
Loa Loa (eye worm) hypothetical protein 0.0221 0.1119 0.2404
Giardia lamblia Beta tubulin 0.0313 0.1645 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0099 0.0426 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Echinococcus granulosus neuropeptide FF receptor 2 0.0655 0.3594 0.4383
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0099 0.0426 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus granulosus biogenic amine 5HT receptor 0.0424 0.228 0.2775
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0424 0.228 0.227
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0026 0.0013 0.0027
Echinococcus granulosus tubulin beta 1 chain 0.0313 0.1645 0.1997
Echinococcus multilocularis neuropeptide Y receptor 0.0424 0.228 0.2775
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0082 0.0332 0.3241
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.0718 0.1542
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Echinococcus granulosus G protein coupled receptor 139 0.0424 0.228 0.2775
Brugia malayi brahma associated protein 60 kDa 0.0074 0.0287 0.0798
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0156 0.0174
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Trypanosoma brucei unspecified product 0.0034 0.0054 0.021
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0424 0.228 0.227
Echinococcus multilocularis tyrosine protein kinase Srms 0.0035 0.0063 0.0061
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.1024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Schistosoma mansoni tyrosine kinase 0.0049 0.014 0.0127
Echinococcus granulosus glutamate receptor 2 0.0049 0.014 0.0154
Loa Loa (eye worm) hypothetical protein 0.0841 0.4655 1
Schistosoma mansoni glutamate receptor NMDA 0.0271 0.1407 0.1395
Schistosoma mansoni neuropeptide F-like receptor 0.0424 0.228 0.227
Echinococcus multilocularis neuropeptide receptor 0.0424 0.228 0.2775
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis tubulin beta 1 chain 0.0313 0.1645 0.1997
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.1119 0.2404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) TK protein kinase 0.0035 0.0063 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Brugia malayi Dopamine receptor 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis tyrosine protein kinase Blk 0.0035 0.0063 0.0061
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus multilocularis g-protein coupled receptor 0.0424 0.228 0.2775
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0332 0.977
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Trichomonas vaginalis tubulin alpha chain, putative 0.0313 0.1645 0.543
Trypanosoma brucei RNA helicase, putative 0.0201 0.1009 0.511
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0026 0.0013 0.0027
Schistosoma mansoni hypothetical protein 0.0074 0.0287 0.0274
Echinococcus multilocularis orexin receptor type 2 0.0424 0.228 0.2775
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0424 0.228 0.4898
Schistosoma mansoni hypothetical protein 0.0143 0.0679 0.0666
Mycobacterium ulcerans chitinase/cellulase 0.0068 0.0251 0.6491
Brugia malayi SWIB/MDM2 domain containing protein 0.0074 0.0287 0.0798
Echinococcus multilocularis g protein coupled receptor 0.0424 0.228 0.2775
Onchocerca volvulus 0.0424 0.228 0.4883
Onchocerca volvulus 0.0424 0.228 0.4883
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0046 0.0039
Brugia malayi endochitinase 0.008 0.0318 0.0885
Echinococcus granulosus sex peptide receptor 0.0424 0.228 0.2775
Echinococcus multilocularis neuropeptide receptor 0.0424 0.228 0.2775
Echinococcus granulosus orexin receptor type 2 0.0424 0.228 0.2775
Brugia malayi YY1-associated factor 2 0.0026 0.0013 0.0038
Echinococcus granulosus alpha 1A adrenergic receptor 0.0424 0.228 0.2775
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1358 0.4456
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0271 0.1407 0.1706
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.2117
Onchocerca volvulus 0.0424 0.228 0.4883
Trypanosoma brucei calpain, putative 0.0119 0.0539 0.2695
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0424 0.228 0.6345
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0057 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.0063 0.0061
Brugia malayi AKH receptor 0.0424 0.228 0.6345
Trichomonas vaginalis tubulin epsilon chain, putative 0.0313 0.1645 0.543
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0424 0.228 0.4898
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0424 0.228 0.4898
Toxoplasma gondii PAN domain-containing protein 0.0585 0.3197 1
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Echinococcus multilocularis g protein coupled receptor 0.0424 0.228 0.2775
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0046 0.0032
Loa Loa (eye worm) hypothetical protein 0.0432 0.2324 0.4991
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0424 0.228 0.227
Schistosoma mansoni opsin-like receptor 0.0424 0.228 0.227
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Echinococcus multilocularis neuroendocrine convertase 2 0.0271 0.1409 0.1708
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.032 0.0892
Trichomonas vaginalis hypothetical protein 0.0084 0.0339 0.0991
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0143 0.0679 0.0815
Echinococcus granulosus neuropeptides capa receptor 0.0424 0.228 0.2775
Plasmodium falciparum tubulin beta chain 0.0313 0.1645 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0046 0.0127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0424 0.228 0.227
Brugia malayi SRC-1 0.0039 0.0084 0.0234
Loa Loa (eye worm) cuticular endochitinase 0.008 0.0318 0.0684
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.003 0.0036 0.0049
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) hypothetical protein 0.008 0.032 0.0688
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0077 0.0077
Entamoeba histolytica tubulin family protein 0.0313 0.1645 1
Echinococcus granulosus fmrfamide receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) growth/differentiation factor 10 0.0032 0.0046 0.01
Schistosoma mansoni hypothetical protein 0.0201 0.1009 0.0997
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Entamoeba histolytica tubulin family protein 0.0313 0.1645 1
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Trypanosoma brucei C-8 sterol isomerase, putative 0.0368 0.1962 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0099 0.0426 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0091 0.015
Entamoeba histolytica chitinase, putative 0.008 0.0318 0.1727
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0424 0.228 0.2775
Echinococcus multilocularis dna polymerase kappa 0.004 0.0091 0.0095
Brugia malayi Dopamine receptor protein 2 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0091 0.015
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.2025 0.6721
Schistosoma mansoni tyrosine kinase 0.0039 0.0084 0.0071
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0099 0.0426 0.2117
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0424 0.228 0.6345
Toxoplasma gondii microneme protein, putative 0.0038 0.0077 0.02
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Schistosoma mansoni hypothetical protein 0.0143 0.0679 0.0666
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0084 0.0086
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0084 0.0339 0.0991
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0046 0.0032
Echinococcus multilocularis fmrfamide receptor 0.0424 0.228 0.2775
Trypanosoma cruzi WLM domain containing protein, putative 0.0026 0.0013 0.0027
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.014 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.01
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.014 0.0154
Trichomonas vaginalis tubulin gamma chain, putative 0.0313 0.1645 0.543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus multilocularis sex peptide receptor 0.0424 0.228 0.2775
Echinococcus granulosus neuropeptide Y receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) neuropeptide F receptor 0.0424 0.228 0.4898
Echinococcus multilocularis tgf beta family 0.0032 0.0046 0.004
Echinococcus granulosus neuropeptides capa receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) BEN-1 protein 0.0313 0.1645 0.3533
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.1119 0.3114
Loa Loa (eye worm) TK protein kinase 0.0031 0.0041 0.0089
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0424 0.228 0.2775
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0029 0.0026 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Echinococcus granulosus tm gpcr rhodopsin 0.0424 0.228 0.2775
Brugia malayi brahma associated protein 60 kDa 0.0074 0.0287 0.0798
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0262 0.1358 0.1646
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0332 0.9814
Echinococcus granulosus GPCR family 2 0.008 0.032 0.0376
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) proprotein convertase 2 0.0102 0.0444 0.0953
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.019 0.0948 0.1144
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0424 0.228 0.2775
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0084 0.0086
Trypanosoma cruzi beta tubulin, putative 0.0313 0.1645 0.8375
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0424 0.228 0.4898
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.1185
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0036 0.0023
Echinococcus granulosus tubulin subunit beta 0.0313 0.1645 0.1997
Echinococcus multilocularis bone morphogenetic protein 2 0.0032 0.0046 0.004
Loa Loa (eye worm) neuropeptide F receptor 0.0424 0.228 0.4898
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus granulosus SWI:SNF matrix associated 0.0074 0.0287 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0156 0.0142
Plasmodium vivax tubulin beta chain, putative 0.0313 0.1645 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0114 0.0515 0.0614
Echinococcus granulosus 7TM GPCR rhodopsin 0.0424 0.228 0.2775
Brugia malayi GnHR receptor homolog 0.0424 0.228 0.6345
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0046 0.0039
Echinococcus granulosus g protein coupled receptor 0.0424 0.228 0.2775
Onchocerca volvulus 0.0038 0.0077 0.0137
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0655 0.3594 0.772
Brugia malayi neuroendocrine convertase 1 precursor 0.0271 0.1409 0.3921
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Echinococcus granulosus hypothetical protein 0.0424 0.228 0.2775
Brugia malayi Endochitinase 0.008 0.0318 0.0885
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0083 0.0338 0.5
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Trichomonas vaginalis tubulin beta chain, putative 0.0313 0.1645 0.543
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi Latrophilin receptor protein 2 0.008 0.032 0.0892
Mycobacterium tuberculosis Possible chitinase 0.0068 0.0251 0.7157
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi hypothetical protein 0.0038 0.0077 0.0213
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Brugia malayi Dopamine receptor protein 1 0.0424 0.228 0.6345
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.1676
Echinococcus granulosus dnaJ subfamily B 0.0399 0.2136 0.2598
Loa Loa (eye worm) hypothetical protein 0.0143 0.0679 0.1458
Echinococcus multilocularis tubulin subunit beta 0.0313 0.1645 0.1997
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0036 0.0023
Echinococcus granulosus glutamate NMDA receptor subunit 0.0271 0.1407 0.1706
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Echinococcus granulosus tachykinin peptides receptor 99D 0.0424 0.228 0.2775
Schistosoma mansoni tyrosine kinase 0.0079 0.0314 0.0301
Echinococcus multilocularis neuropeptide receptor A26 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Schistosoma mansoni serine-type protease inhibitor 0.1779 1 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Schistosoma mansoni alpha-1 adrenergic receptor 0.0424 0.228 0.227
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0119 0.0539 0.2695
Brugia malayi beta-tubulin, identical 0.0313 0.1645 0.4577
Toxoplasma gondii PAN domain-containing protein 0.0585 0.3197 1
Schistosoma mansoni brg-1 associated factor 0.0074 0.0287 0.0274
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Chlamydia trachomatis glutamine binding protein 0.0082 0.0332 0.3241
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Brugia malayi endochitinase 0.008 0.0318 0.0885
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2715
Brugia malayi G protein-coupled receptor 0.0424 0.228 0.6345
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Onchocerca volvulus 0.0424 0.228 0.4883
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.014 0.0126
Echinococcus granulosus insulin receptor 0.0049 0.014 0.0155
Echinococcus granulosus 7tm_1 domain containing protein 0.0424 0.228 0.2775
Mycobacterium ulcerans chitinase/cellulase 0.0068 0.0251 0.6491
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.1676
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Onchocerca volvulus 0.0841 0.4655 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Schistosoma mansoni hypothetical protein 0.0074 0.0287 0.0274
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0424 0.228 0.2775
Schistosoma mansoni biogenic amine receptor 0.0424 0.228 0.227
Trypanosoma cruzi WLM domain containing protein, putative 0.0026 0.0013 0.0027
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.2138
Toxoplasma gondii beta-tubulin, putative 0.0313 0.1645 0.5125
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0083 0.0338 1
Schistosoma mansoni tyrosine kinase 0.0039 0.0084 0.0071
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0143 0.0679 0.0815
Schistosoma mansoni adenoreceptor 0.0424 0.228 0.227
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Echinococcus granulosus g-protein coupled receptor 0.0424 0.228 0.2775
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0034 0.0057 0.0053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0841 0.4655 0.4648
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0143 0.0679 0.1889
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Schistosoma mansoni hypothetical protein 0.0143 0.0679 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.019 0.0948 0.2036
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0084 0.0086
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0102 0.0444 0.0431
Echinococcus granulosus neuropeptide receptor 0.0424 0.228 0.2775
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0074 0.0287 0.0859
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) tubulin beta-2A chain 0.0313 0.1645 0.3533
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0041 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0034 0.0057 0.0122
Loa Loa (eye worm) apoptosis regulator protein 0.0143 0.0679 0.1458
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Echinococcus multilocularis somatostatin receptor 0.0424 0.228 0.2775
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0099 0.0426 0.0505
Echinococcus multilocularis beta tubulin 0.0313 0.1645 0.1997
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Brugia malayi sulfakinin receptor protein 0.0424 0.228 0.6345
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Brugia malayi Serotonin receptor 0.0424 0.228 0.6345
Loa Loa (eye worm) chitinase I 0.008 0.0318 0.0684
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0424 0.228 0.2775
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.014 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0948 0.0936
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Brugia malayi RE15519p 0.0424 0.228 0.6345
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0084 0.0086
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0368 0.1962 0.546
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.146 0.8183 1
Echinococcus granulosus nmda type glutamate receptor 0.0114 0.0515 0.0614
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi putative neuropeptide receptor NPR1 0.0424 0.228 0.6345
Echinococcus multilocularis 0.0046 0.0125 0.0137
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0046 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) G-protein coupled receptor 0.0424 0.228 0.4898
Echinococcus multilocularis glutamate receptor 2 0.0049 0.014 0.0154
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0041 0.0034
Echinococcus granulosus dro:myosuppressin receptor 0.0424 0.228 0.2775
Leishmania major C-8 sterol isomerase-like protein 0.0368 0.1962 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0076
Schistosoma mansoni hypothetical protein 0.019 0.0948 0.0936
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0099 0.0426 0.0413
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Echinococcus granulosus tyrosine protein kinase Blk 0.0035 0.0063 0.0061
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0099 0.0426 0.1296
Schistosoma mansoni opsin-like receptor 0.0424 0.228 0.227
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Loa Loa (eye worm) hypothetical protein 0.0368 0.1962 0.4215
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Onchocerca volvulus 0.0074 0.0287 0.0589
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Loa Loa (eye worm) hypothetical protein 0.0169 0.0828 0.1778
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Toxoplasma gondii beta-1 tubulin, putative 0.0313 0.1645 0.5125
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0077 0.0063
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0549 0.2989 0.8318
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.014 0.0154
Loa Loa (eye worm) bone morphogenic protein 6 0.0126 0.0582 0.1249
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Echinococcus granulosus g protein coupled receptor 0.0424 0.228 0.2775
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2715
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.014 0.0154
Giardia lamblia Beta tubulin 0.0313 0.1645 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0084 0.0086
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0823 0.455 0.5554
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0046 0.0127
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Onchocerca volvulus 0.0032 0.0046 0.0071
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Echinococcus multilocularis neuropeptide Y receptor 0.0424 0.228 0.2775
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Echinococcus granulosus tubulin beta 4A class IVa 0.0313 0.1645 0.1997
Brugia malayi G-protein coupled receptor 0.0424 0.228 0.6345
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0084 0.0339 0.0991
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2715
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0156 0.0174
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Brugia malayi proprotein convertase 2 0.0271 0.1409 0.3921
Brugia malayi polk-prov protein 0.003 0.0036 0.0099
Schistosoma mansoni tyrosine kinase 0.0081 0.0325 0.0312
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) tubulin beta chain 0.0313 0.1645 0.3533
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.0046 0.0129
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0424 0.228 0.227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0156 0.0142
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.032 0.0376
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis neuropeptide FF receptor 2 0.0655 0.3594 0.4383
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Loa Loa (eye worm) tubulin beta-4 chain 0.0313 0.1645 0.3533
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Onchocerca volvulus 0.0038 0.0077 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Onchocerca volvulus 0.0032 0.0046 0.0071
Schistosoma mansoni tyrosine kinase 0.0049 0.014 0.0127
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0325 0.0381
Toxoplasma gondii hypothetical protein 0.0038 0.0077 0.02
Onchocerca volvulus 0.0424 0.228 0.4883
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0287 0.0815
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Toxoplasma gondii microneme protein MIC17B 0.0038 0.0077 0.02
Schistosoma mansoni hypothetical protein 0.019 0.0948 0.0936
Toxoplasma gondii microneme protein MIC17C 0.0038 0.0077 0.02
Echinococcus granulosus tm gpcr rhodopsin 0.0424 0.228 0.2775
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.014 0.0154
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0156 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0036 0.0113
Loa Loa (eye worm) LjBmp2/4b 0.0032 0.0046 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Brugia malayi neuropeptide F receptor 0.0424 0.228 0.6345
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0424 0.228 0.227
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.032 0.0376
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus granulosus neuropeptide receptor A26 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Echinococcus granulosus tgf beta family 0.0032 0.0046 0.004
Echinococcus multilocularis geminin 0.019 0.0948 0.1144
Schistosoma mansoni histamine h1 receptor 0.0424 0.228 0.227
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0026 0.0013 0.0027
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Echinococcus granulosus g protein coupled receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) beta-tubulin 0.0313 0.1645 0.3533
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0083 0.0338 0.5
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Brugia malayi G protein-coupled receptor F59B2.13 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0424 0.228 0.4898
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0424 0.228 0.227
Echinococcus granulosus neuropeptide s receptor 0.0424 0.228 0.2775
Schistosoma mansoni biogenic amine receptor 0.0424 0.228 0.227
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0046 0.0039
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0432 0.2324 0.2313
Loa Loa (eye worm) tubulin beta-1 chain 0.0313 0.1645 0.3533
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0046 0.0098
Echinococcus granulosus epidermal growth factor receptor 0.015 0.0718 0.0862
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0084 0.0086
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus multilocularis SWI:SNF matrix associated 0.0074 0.0287 0.0335
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0057 0.0033
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Onchocerca volvulus 0.0038 0.0077 0.0137
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0424 0.228 0.227
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus granulosus allatostatin A receptor 0.0841 0.4655 0.5682
Echinococcus granulosus bone morphogenetic protein 2 0.0032 0.0046 0.004
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0424 0.228 0.4883
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0077 0.0077
Schistosoma mansoni apoptosis regulator bax 0.0143 0.0679 0.0666
Toxoplasma gondii microneme protein MIC17A 0.0038 0.0077 0.02
Loa Loa (eye worm) hypothetical protein 0.0068 0.0251 0.0539
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0029 0.0026 0.0092
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0661 0.184
Brugia malayi replication factor A 73 kDa subunit 0.0034 0.0057 0.0158
Brugia malayi Transforming growth factor beta like domain containing protein 0.0126 0.0582 0.1618
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0325 0.0381
Echinococcus granulosus Furin 1 0.0102 0.0444 0.0527
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0119 0.0539 0.2715
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Brugia malayi Tubulin beta-1 chain 0.0313 0.1645 0.4577
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0046 0.0039
Echinococcus granulosus MAP kinase activated protein kinase 2 0.019 0.0948 0.1144
Brugia malayi Protein kinase domain containing protein 0.0049 0.014 0.0389
Echinococcus multilocularis neuropeptides capa receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0143 0.0679 0.0666
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Echinococcus granulosus neuroendocrine convertase 2 0.0271 0.1409 0.1708
Brugia malayi celfurPC protein 0.0348 0.1848 0.5141
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0074 0.0287 0.0335
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Loa Loa (eye worm) SRC-1 0.0039 0.0084 0.0181
Echinococcus multilocularis G protein coupled receptor 139 0.0424 0.228 0.2775
Loa Loa (eye worm) TYRA-2 protein 0.0424 0.228 0.4898
Onchocerca volvulus Glucosylceramidase homolog 0.036 0.1914 0.4095
Schistosoma mansoni hypothetical protein 0.0074 0.0287 0.0274
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.0046 0.0129
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0046 0.0032
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0156 0.0174
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0074 0.0287 0.0335
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2715
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0052 0.0047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Brugia malayi map kinase activated protein kinase protein 2 0.019 0.0948 0.2638
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Giardia lamblia High cysteine membrane protein Group 2 0.016 0.0777 0.3357
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus granulosus peptide allatostatin:somatostatin 0.0424 0.228 0.2775
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0084 0.0086
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.0616
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.014 0.0155
Brugia malayi larval opioid receptor 0.0424 0.228 0.6345
Toxoplasma gondii microneme protein MIC4 0.0038 0.0077 0.02
Loa Loa (eye worm) BEN-1 protein 0.0313 0.1645 0.3533
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0046 0.0039
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Echinococcus granulosus beta tubulin 0.0313 0.1645 0.1997
Brugia malayi ORL1-like opioid receptor 0.0424 0.228 0.6345
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0398
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0424 0.228 0.227
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.014 0.0301
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0424 0.228 0.2775
Echinococcus granulosus serotonin receptor 0.0424 0.228 0.2775
Echinococcus multilocularis g protein coupled receptor 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.0032 0.0046 0.0032
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0038 0.0077 0.02
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Echinococcus multilocularis nmda type glutamate receptor 0.0114 0.0515 0.0614
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni neuropeptide f receptor 76f 0.0424 0.228 0.227
Schistosoma mansoni myosin xvIII 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis SWI:SNF matrix associated 0.0074 0.0287 0.0335
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0368 0.1962 1
Giardia lamblia Beta tubulin 0.0313 0.1645 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.0859
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0013 0.0027
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0424 0.228 0.227
Echinococcus multilocularis GPCR, family 2 0.008 0.032 0.0376
Echinococcus multilocularis neuropeptide s receptor 0.0424 0.228 0.2775
Schistosoma mansoni replication factor A 1 rfa1 0.0034 0.0057 0.0043
Brugia malayi G-protein coupled receptor 0.0424 0.228 0.6345
Schistosoma mansoni hypothetical protein 0.0038 0.0077 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.014 0.0154
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0823 0.455 0.5554
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0046 0.0032
Brugia malayi putative neuropeptide receptor 0.0424 0.228 0.6345
Echinococcus multilocularis beta tubulin 0.0313 0.1645 0.1997
Loa Loa (eye worm) G-protein coupled receptor 0.0424 0.228 0.4898
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0084 0.0339 0.0991
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.0718 0.1997
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0054 0.021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0042
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0052 0.0047
Echinococcus granulosus geminin 0.019 0.0948 0.1144
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.032 0.0688
Brugia malayi Melatonin receptor type 1A 0.0424 0.228 0.6345
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0398
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Onchocerca volvulus Neuropeptide F receptor homolog 0.0424 0.228 0.4883
Schistosoma mansoni tgf-beta family 0.0032 0.0046 0.0033
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0046 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus multilocularis SWI:SNF matrix associated 0.0074 0.0287 0.0335
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0424 0.228 0.6345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.1119 0.3114
Echinococcus granulosus somatostatin receptor 0.0424 0.228 0.2775
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0325 0.0381
Schistosoma mansoni biogenic amine (5HT) receptor 0.0424 0.228 0.227
Schistosoma mansoni hypothetical protein 0.0084 0.0339 0.0326
Echinococcus granulosus furin 0.0432 0.2324 0.2828
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0099 0.0426 0.0915
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.014 0.0154
Leishmania major chitinase 0.008 0.0318 0.1564
Loa Loa (eye worm) endoprotease bli-4 0.0432 0.2324 0.4991
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.014 0.0154
Toxoplasma gondii hypothetical protein 0.0038 0.0077 0.02
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0046 0.0032
Brugia malayi Serotonin receptor 0.0424 0.228 0.6345
Schistosoma mansoni tyrosine kinase 0.0081 0.0325 0.0312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0424 0.228 0.227
Echinococcus multilocularis neuropeptides capa receptor 0.0424 0.228 0.2775
Echinococcus granulosus neuropeptide Y receptor 0.0424 0.228 0.2775
Schistosoma mansoni tyrosine kinase 0.0079 0.0314 0.0301
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0084 0.0086
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0424 0.228 0.2775
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0034 0.0057 0.0053
Echinococcus multilocularis NMDA receptor 0.0032 0.0046 0.0039
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0424 0.228 0.6345
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0126 0.0582 0.0695
Schistosoma mansoni tyrosine kinase 0.0079 0.0314 0.0301
Echinococcus multilocularis dro:myosuppressin receptor 0.0424 0.228 0.2775
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis serotonin receptor 0.0424 0.228 0.2775
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0188 0.0936 0.201
Echinococcus multilocularis Furin 1 0.0102 0.0444 0.0527
Echinococcus multilocularis serotonin receptor 0.0424 0.228 0.2775
Schistosoma mansoni biogenic amine (5HT) receptor 0.0424 0.228 0.227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.2025 0.6721
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0156 0.0334
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Onchocerca volvulus 0.0038 0.0077 0.0137
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0549 0.2989 0.6422
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Toxoplasma gondii beta tubulin 0.0313 0.1645 0.5125
Schistosoma mansoni opsin-like receptor 0.0424 0.228 0.227
Echinococcus granulosus neuropeptide receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) microfilarial chitinase 0.0068 0.0251 0.0539
Echinococcus multilocularis fmrfamide receptor 0.0424 0.228 0.2775
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Brugia malayi follicle stimulating hormone receptor 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus tyrosine kinase 0.0035 0.0063 0.0061
Echinococcus multilocularis G-protein coupled receptor, putative 0.0424 0.228 0.2775
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Toxoplasma gondii subtilisin SUB12 0.0056 0.0182 0.053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Echinococcus granulosus biogenic amine 5HT receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0424 0.228 0.2775
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Schistosoma mansoni growth hormone secretagogue receptor 0.0424 0.228 0.227
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0424 0.228 0.6345
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.0399 0.2136 0.2125
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Schistosoma mansoni biogenic amine receptor 0.0424 0.228 0.227
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Onchocerca volvulus 0.0038 0.0077 0.0137
Brugia malayi neuropeptide F receptor 0.0424 0.228 0.6345
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0026 0.0013 0.0027
Toxoplasma gondii PAN/Apple domain-containing protein 0.0038 0.0077 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus multilocularis insulin receptor 0.0049 0.014 0.0155
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0036 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Echinococcus granulosus tm gpcr rhodopsin 0.146 0.8183 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0046 0.0039
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0262 0.1358 0.1646
Loa Loa (eye worm) hypothetical protein 0.014 0.0661 0.1421
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0424 0.228 0.2775
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.2136 0.2598
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0424 0.228 0.2775

Activities

Activity type Activity value Assay description Source Reference
Km (binding) = 45 uM Evaluation of michaelis Menton constant of rat liver GaI-beta-1,4GIcNAc alpha2,6-sialyltransferase in presence of compound ChEMBL. No reference
Relative Vmax (binding) = 1 Evaluation of kinetic constant for rat liver GaI-beta-1,4GIcNAc alpha2,6-sialyltransferase in presence of compound ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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