TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 288.309 | Formula: C14H19F3N2O
H donors: 2 H acceptors: 1 LogP: 2.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H](C(C)(C)C)N)NCc1ccc(cc1)C(F)(F)F
InChi: 1S/C14H19F3N2O/c1-13(2,3)11(18)12(20)19-8-9-4-6-10(7-5-9)14(15,16)17/h4-7,11H,8,18H2,1-3H3,(H,19,20)/t11-/m0/s1
InChiKey: HNMBQIVIWHWABG-NSHDSACASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0437	0.0607
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0031	0.0031
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0055	0.0055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0056	0.0641	0.0641
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0074	0.0904	0.0904
Onchocerca volvulus		0.0153	0.2012	0.2959
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0088	0.0088
Onchocerca volvulus		0.003	0.0285	0.038
Onchocerca volvulus		0.0049	0.0551	0.0776
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.027	0.0356
Brugia malayi	MH2 domain containing protein	0.0122	0.1565	0.2624
Leishmania major	DNA polymerase eta, putative	0.0033	0.0326	0.4775
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0025	0.0207	0.0154
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0147	0.1904
Echinococcus granulosus	chromobox protein 2	0.0012	0.0031	0.0031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0056	0.0641	0.105
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0574	0.0936
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0127	0.0143
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0207	0.0437
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0031	0.0031
Brugia malayi	Pre-SET motif family protein	0.0062	0.0736	0.1213
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0062	0.0736	0.0736
Echinococcus granulosus	histone lysine methyltransferase setb	0.0062	0.0736	0.0736
Entamoeba histolytica	hypothetical protein	0.0025	0.0207	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0694	0.9404
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0147	0.0173
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.0016	0.0088	0.0088
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0025	0.0207	0.0154
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0147	0.0147
Brugia malayi	Pre-SET motif family protein	0.0431	0.5895	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0056	0.0641	0.0641
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0087	0.1085	0.1807
Brugia malayi	Muscleblind-like protein	0.0181	0.2402	0.405
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0181	0.2402	0.4048
Onchocerca volvulus		0.0074	0.0904	0.1304
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0062	0.0736	0.0736
Echinococcus multilocularis	microtubule associated protein 2	0.0724	1	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0127	0.0143
Echinococcus multilocularis	muscleblind protein 1	0.0181	0.2402	0.2402
Echinococcus granulosus	chromobox protein 1	0.0073	0.0887	0.0887
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0056	0.0641	0.0641
Echinococcus multilocularis	survival motor neuron protein 1	0.0241	0.3233	0.3233
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0887	0.1278
Schistosoma mansoni	hypothetical protein	0.0016	0.0088	0.0088
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0695	0.0695
Echinococcus granulosus	survival motor neuron protein 1	0.0241	0.3233	0.3233
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0147	0.1904
Treponema pallidum	hypothetical protein	0.0299	0.4055	1
Schistosoma mansoni	hypothetical protein	0.0178	0.2352	0.2352
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0887	0.0887
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0574	0.0934
Echinococcus granulosus	muscleblind protein	0.0181	0.2402	0.2402
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0127	0.0143
Trypanosoma brucei	DNA polymerase eta, putative	0.0047	0.0521	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0207	0.1604
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0016	0.0082	0.0077
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0025	0.0207	0.0154
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0055	0.0055
Echinococcus multilocularis	Chromo domain	0.0012	0.0031	0.0031
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0031	0.0031
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0481	0.0672
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0031	0.0012
Brugia malayi	Protein cec-1.	0.0012	0.0031	0.0012
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0127	0.0143
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0127	0.0143
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0887	0.0887
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0181	0.2402	0.4048
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0031	0.0012
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0241	0.3233	0.5464
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0025	0.0207	0.5
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0147	0.1904
Schistosoma mansoni	hypothetical protein	0.0429	0.5872	0.5872
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0349	0.0553
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0031	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.027	0.0356
Schistosoma mansoni	microtubule-associated protein tau	0.0724	1	1
Echinococcus multilocularis	dnaJ subfamily B	0.0429	0.5872	0.5872
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0088	0.0106
Brugia malayi	hypothetical protein	0.0012	0.0031	0.0012
Trichomonas vaginalis	set domain proteins, putative	0.049	0.6727	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0062	0.0736	0.0736
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1565	0.2622
Echinococcus multilocularis	muscleblind protein	0.0181	0.2402	0.2402
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.0521	0.0847
Onchocerca volvulus		0.049	0.6727	1
Echinococcus granulosus	chromobox protein 1	0.0073	0.0887	0.0887
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0127	0.0143
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0062	0.0736	0.0736
Leishmania major	DNA polymerase eta, putative	0.0047	0.0521	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.2012	0.3384
Echinococcus granulosus	GPCR family 2	0.0016	0.0088	0.0088
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0031	0.0031
Plasmodium vivax	SET domain protein, putative	0.0062	0.0736	0.1753
Schistosoma mansoni	hypothetical protein	0.0035	0.0349	0.0349
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0431	0.5895	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.1085	0.1804
Schistosoma mansoni	chromobox protein	0.0073	0.0887	0.0887
Schistosoma mansoni	DNA polymerase eta	0.0047	0.0521	0.0521
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Brugia malayi	CHD4 protein	0.0014	0.0055	0.0053
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0088	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0736	0.1211
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0056	0.0641	0.0641
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0075	0.0066
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0147	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0313	0.049
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0031	0.0031
Loa Loa (eye worm)	helicase	0.0012	0.0031	0.0009
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0062	0.0736	1
Onchocerca volvulus		0.0012	0.0031	0.000000054034
Schistosoma mansoni	hypothetical protein	0.0049	0.0551	0.0551
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0088	0.0109
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0481	0.0672
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0299	0.4055	1
Echinococcus multilocularis	dna polymerase eta	0.0047	0.0521	0.0521
Schistosoma mansoni	hypothetical protein	0.0178	0.2352	0.2352
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0299	0.4055	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0437	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0437	0.0701
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0207	0.5
Schistosoma mansoni	cpg binding protein	0.0032	0.0309	0.0309
Brugia malayi	hypothetical protein	0.0153	0.2012	0.3386
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0082	0.0077
Brugia malayi	chromobox protein homolog 3	0.0041	0.0437	0.0704
Onchocerca volvulus		0.0087	0.1085	0.1574
Echinococcus granulosus	Chromo domain	0.0012	0.0031	0.0031
Schistosoma mansoni	hypothetical protein	0.0016	0.0088	0.0088
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0299	0.4055	1
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0207	0.0437
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0285	0.0442
Trypanosoma cruzi	DNA polymerase eta, putative	0.0047	0.0521	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0887	0.1467
Echinococcus granulosus	dna polymerase eta	0.0047	0.0521	0.0521
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0026	0.0026
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0147	0.0147
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0088	0.0088
Echinococcus multilocularis	geminin	0.0178	0.2352	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0574	0.0934
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Echinococcus granulosus	cpg binding protein	0.0032	0.0309	0.0309
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Echinococcus granulosus	L aminoadipate semialdehyde	0.0087	0.1085	0.1085
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0207	0.3202
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0326	0.4176
Trypanosoma brucei	unspecified product	0.002	0.0147	0.1904
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0299	0.4055	1
Echinococcus granulosus	dna polymerase kappa	0.002	0.0147	0.0147
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0207	0.2494
Schistosoma mansoni	cpg binding protein	0.003	0.0285	0.0285
Schistosoma mansoni	hypothetical protein	0.0012	0.0031	0.0031
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0055	0.005
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0326	0.4775
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0551	0.0897
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0147	0.0173
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0481	0.0672
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0127	0.0143
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Schistosoma mansoni	chromobox protein	0.0012	0.0031	0.0031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0056	0.0641	0.0641
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0087	0.1085	0.1085
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0887	0.1278
Schistosoma mansoni	chromobox protein	0.0012	0.0031	0.0031
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.079	0.079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0056	0.0641	0.0641
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0031	0.0012
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0551	0.0551
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1565	0.2622
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Echinococcus multilocularis	cpg binding protein	0.0032	0.0309	0.0309
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0147	0.659
Giardia lamblia	DINP protein human, muc B family	0.002	0.0147	0.5
Brugia malayi	SET domain containing protein	0.0015	0.0072	0.0082
Brugia malayi	Heterochromatin protein 1	0.0073	0.0887	0.1469
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0437	0.0607
Brugia malayi	hypothetical protein	0.0241	0.3233	0.5465
Echinococcus granulosus	dnaJ subfamily B	0.0429	0.5872	0.5872
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0349	0.0551
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0031	0.0031
Schistosoma mansoni	cpg binding protein	0.0032	0.0309	0.0309
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0031	0.0031
Echinococcus granulosus	geminin	0.0178	0.2352	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Schistosoma mansoni	hypothetical protein	0.0016	0.0088	0.0088
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0147	0.0147
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0299	0.4055	1
Schistosoma mansoni	chromobox protein	0.0073	0.0887	0.0887
Brugia malayi	CXXC zinc finger family protein	0.003	0.0285	0.0445
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0088	0.0109
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0056	0.0641	0.1048
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0062	0.0736	0.0736
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0031	0.0009
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0147	0.0206
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0055	0.0055
Onchocerca volvulus		0.0032	0.0313	0.0421
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0574	0.0936
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0056	0.0641	0.0641
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0207	0.2494
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0147	0.1904
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0127	0.0143
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0088	0.0088
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0087	0.1085	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0521	0.0844

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 24 mg kg-1	Anticonvulsant activity in ip dosed albino CF1 mouse assessed as protection against maximal electroshock-induced seizure after 30 mins	ChEMBL.	21861463
TD50 (ADMET)	= 133 mg kg-1	Neurotoxicity in ip dosed albino CF1 mouse assessed as median neurological impairing dose after 30 mins	ChEMBL.	21861463
Time (functional)	= 0.25 hr	Anticonvulsant activity in ip dosed albino CF1 mouse assessed as time of peak effect for protection against maximal electroshock-induced seizure	ChEMBL.	21861463
Time (ADMET)	= 0.25 hr	Neurotoxicity in ip dosed albino CF1 mouse assessed as time of peak effect for median neurological impairing	ChEMBL.	21861463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1829685

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1108134