TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 342.862 | Formula: C20H23ClN2O
H donors: 2 H acceptors: 1 LogP: 4.2 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC1NCCC(C1)CNC(=O)c1ccccc1c1cccc(c1)Cl
InChi: 1S/C20H23ClN2O/c1-14-11-15(9-10-22-14)13-23-20(24)19-8-3-2-7-18(19)16-5-4-6-17(21)12-16/h2-8,12,14-15,22H,9-11,13H2,1H3,(H,23,24)
InChiKey: CUVCFXBDBPAFQU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholinergic receptor, muscarinic 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0044	0.0037
Onchocerca volvulus		0.0028	0.0195	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0448	0.0749
Onchocerca volvulus		0.0073	0.0769	0.2507
Schistosoma mansoni	lamin	0.0028	0.0195	0.1701
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0044	0.0053
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0769	0.2507
Mycobacterium ulcerans	hypothetical protein	0.0073	0.0769	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0295	0.0288
Schistosoma mansoni	lamin	0.0028	0.0195	0.1701
Echinococcus granulosus	Niemann Pick C1 protein	0.0137	0.1595	0.2655
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0048	0.0448	0.5766
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0449	0.406
Mycobacterium tuberculosis	Probable esterase LipL	0.0073	0.0769	0.1302
Entamoeba histolytica	hypothetical protein	0.0035	0.0282	0.2562
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0361	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0292	0.0488
Onchocerca volvulus		0.0249	0.303	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0267	0.0439
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.0769	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0282	0.2562
Mycobacterium tuberculosis	Probable hydrolase	0.0073	0.0769	0.1302
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0234	0.0228
Loa Loa (eye worm)	oxidoreductase	0.0014	0.0012	0.002
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0504	0.0842
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.1066	0.1762
Brugia malayi	hypothetical protein	0.0035	0.0282	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0769	0.1283
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.0769	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0449	0.406
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0295	0.0936
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0282	0.046
Echinococcus multilocularis	Niemann Pick C1 protein	0.0137	0.1595	0.159
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0292	0.0488
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0267	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0292	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0769	0.1283
Echinococcus multilocularis	lamin	0.0028	0.0195	0.0189
Echinococcus granulosus	intermediate filament protein	0.0028	0.0195	0.0315
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0295
Onchocerca volvulus		0.0028	0.0195	0.0606
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.0769	0.0762
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0044	0.0037
Schistosoma mansoni	patched 1	0.0041	0.0361	0.3242
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0467	0.5822	1
Brugia malayi	beta-lactamase family protein	0.0073	0.0769	0.1265
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0295	0.0288
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.0448	0.5766
Mycobacterium tuberculosis	Probable lipase LipE	0.0073	0.0769	0.1302
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.1085	0.9977
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0044	0.0037
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0769	1
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.0769	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0234	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0504	0.0842
Echinococcus multilocularis	lamin dm0	0.0028	0.0195	0.0189
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0769	0.7037
Loa Loa (eye worm)	hypothetical protein	0.0051	0.048	0.0801
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0769	0.2507
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0448	0.5766
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0449	0.0739
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0769	0.1302
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.0769	0.1283
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0504	0.0823
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0448	0.5766
Schistosoma mansoni	hypothetical protein	0.004	0.0342	0.3065
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0295	0.3734
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0295
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0295	0.0288
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0449	0.0739
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0769	0.2507
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0044	0.0053
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0292	0.5
Onchocerca volvulus		0.0031	0.0234	0.0735
Echinococcus multilocularis	survival motor neuron protein 1	0.048	0.599	0.5987
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.0769	0.1274
Echinococcus granulosus	GPCR family 2	0.0017	0.0044	0.0062
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0295	0.5
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0448	0.4141
Onchocerca volvulus		0.0073	0.0769	0.2507
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0449	0.0749
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.0769	0.2535
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.002
Onchocerca volvulus		0.0073	0.0769	0.2507
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0295	0.0473
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0267	0.0439
Brugia malayi	hypothetical protein	0.048	0.599	1
Toxoplasma gondii	60S ribosomal protein L27, putative	0.0247	0.2996	1
Onchocerca volvulus		0.0098	0.1087	0.3562
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0048	0.0448	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0769	0.1283
Entamoeba histolytica	hypothetical protein	0.0035	0.0282	0.2562
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0188	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0448	0.0749
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.0267	0.0439
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.0769	0.2507
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0295	0.0936
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0361	0.0354
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0295	0.2628
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0295	0.0492
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0449	0.0442
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0295	0.2628
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0449	0.406
Mycobacterium ulcerans	lipase LipD	0.0073	0.0769	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0234	0.038
Onchocerca volvulus		0.0048	0.0448	0.1445
Schistosoma mansoni	survival motor neuron protein	0.0098	0.1087	1
Toxoplasma gondii	ABC1 family protein	0.0073	0.0769	0.2535
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0195	0.0326
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0195	0.0326
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0044	0.0073
Mycobacterium tuberculosis	Probable lipase LipD	0.0073	0.0769	0.1302
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0292	0.0488
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0195	0.0306
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0292	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0044	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0769	0.1283
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0044	0.0062
Brugia malayi	CHE-14 protein	0.0041	0.0361	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0011
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0036	0.0292	0.3703
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0073	0.0769	0.1302
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0295	0.3734
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0448	0.073
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0014	0.0012	0.0006
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0295	0.0481
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0295	0.0481
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0295	0.3734
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0361	0.1155
Leishmania major	hypothetical protein, conserved	0.0073	0.0769	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0361	0.0602
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0282	0.2511
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0026	0.0043
Brugia malayi	beta-lactamase	0.0073	0.0769	0.1265
Loa Loa (eye worm)	hypothetical protein	0.048	0.599	1
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0292	0.0939
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0295	0.3734
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0448	0.5766
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1066	0.1779
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0219	0.0355
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0448	0.5766
Echinococcus multilocularis	musashi	0.0028	0.0195	0.0189
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0448	0.5766
Brugia malayi	intermediate filament protein	0.0028	0.0195	0.0306
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0073	0.0769	0.1302
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0361	0.0602
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.303	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0769	0.1283
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0048	0.0448	0.5766
Echinococcus granulosus	survival motor neuron protein 1	0.048	0.599	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0048	0.0448	0.4141
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.1066	0.106
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0234	0.0391
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.0769	0.2507
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0195	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.002
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0448	0.0749
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0044	0.0062
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0769	0.1302
Echinococcus granulosus	expressed conserved protein	0.009	0.0991	0.1645
Echinococcus multilocularis	expressed conserved protein	0.009	0.0991	0.0985
Trichomonas vaginalis	esterase, putative	0.0073	0.0769	0.2507
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0436	0.0429
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0448	0.073
Echinococcus granulosus	lamin dm0	0.0028	0.0195	0.0315
Entamoeba histolytica	acyl-coA synthetase, putative	0.0048	0.0448	0.4141
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0769	0.1283
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0504	0.0823
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0098	0.1087	0.1798
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0014	0.0012	0.0009
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0291	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0291	0.0486
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0026	0.0023
Echinococcus granulosus	lamin	0.0028	0.0195	0.0315
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0295	0.0481
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0012	0.002
Brugia malayi	beta-lactamase family protein	0.0073	0.0769	0.1265
Echinococcus multilocularis	protein patched	0.0041	0.0361	0.0354
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0292	0.0939
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0073	0.0769	0.1302
Brugia malayi	AMP-binding enzyme family protein	0.0048	0.0448	0.073
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0234	0.0743
Mycobacterium tuberculosis	Conserved protein	0.0073	0.0769	0.1302
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.1066	0.177
Plasmodium falciparum	mitochondrial ribosomal protein L41, putative	0.0247	0.2996	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0449	0.0442
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0295	0.2681
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0361	0.0592
Brugia malayi	Pre-SET motif family protein	0.0219	0.2642	0.4399
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0449	0.073
Plasmodium vivax	SET domain protein, putative	0.0031	0.0234	0.0743
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0295
Mycobacterium leprae	Probable lipase LipE	0.0073	0.0769	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.0769	0.7037
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.0769	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0291	0.2595
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.0769	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0044	0.0295
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.2642	0.441
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0234	0.2064
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0234	0.2064
Leishmania major	4-coumarate:coa ligase-like protein	0.0048	0.0448	0.5766
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0048	0.0448	0.0751
Mycobacterium ulcerans	acyl-CoA synthetase	0.0048	0.0448	0.5766
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0448	0.5766
Mycobacterium ulcerans	beta-lactamase	0.0073	0.0769	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0282	0.2562
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0048	0.0448	0.5766
Schistosoma mansoni	hypothetical protein	0.0035	0.0282	0.2511
Schistosoma mansoni	hypothetical protein	0.004	0.0342	0.3065
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0234	0.2064
Plasmodium vivax	mitochondrial ribosomal protein L41, putative	0.0247	0.2996	1
Schistosoma mansoni	hypothetical protein	0.004	0.0342	0.3065
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0234	0.0228
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0295	0.0936
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0048	0.0448	0.5766
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0014	0.0012	0.002
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0195	0.0326
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.1066	1
Schistosoma mansoni	hypothetical protein	0.0098	0.1087	1
Schistosoma mansoni	hypothetical protein	0.004	0.0342	0.3065
Brugia malayi	Pre-SET motif family protein	0.0031	0.0234	0.0371
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0282	0.0276
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.0769	0.1265
Loa Loa (eye worm)	beta-lactamase	0.0073	0.0769	0.1283
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0292	0.0488

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 5	Agonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay	ChEMBL.	20483611
Intrinsic activity (functional)	= 28 %	Intrinsic activity at human muscarinic M1 receptor expressed in CHO cells assessed as effect on acetylcholine-induced intracellular calcium level by FLIPR assay relative to acetylcholine	ChEMBL.	20483611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1085739

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1109047