TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 534.565 | Formula: C30H26N6O4
H donors: 3 H acceptors: 4 LogP: 3.96 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc2c(c1)c(/C=C\1/Oc3c(C1=O)cc(cc3)NC(=O)Nc1cccnc1)c([nH]2)c1c(C)nn(c1C)C
InChi: 1S/C30H26N6O4/c1-16-27(17(2)36(3)35-16)28-22(21-13-20(39-4)8-9-24(21)34-28)14-26-29(37)23-12-18(7-10-25(23)40-26)32-30(38)33-19-6-5-11-31-15-19/h5-15,34H,1-4H3,(H2,32,33,38)/b26-14+
InChiKey: GQKMWAFJWXSCNB-VULFUBBASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0021	0.0013	0.0408
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0071	0.0683	0.177
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0021	0.0013	0.0013
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.0523	0.7664
Plasmodium falciparum	lysophospholipase, putative	0.0071	0.0683	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0021	0.0013	0.0097
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0021	0.0013	0.0013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0154	0.1788	0.1788
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0026	0.0084	0.1228
Plasmodium vivax	pyruvate kinase, putative	0.0035	0.0206	0.3022
Leishmania major	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.1121	0.1737
Schistosoma mansoni	transcription factor LCR-F1	0.0084	0.0852	0.0852
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.0523	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0065	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0358	0.0927
Echinococcus granulosus	geminin	0.019	0.2258	0.2258
Schistosoma mansoni	pyruvate kinase	0.0035	0.0206	0.0206
Trypanosoma brucei	pyruvate kinase 1	0.0035	0.0206	0.3022
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0259	0.0845
Schistosoma mansoni	amidase	0.0104	0.1119	0.1119
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0206	0.032
Brugia malayi	Muscleblind-like protein	0.0506	0.6455	1
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0259	0.1113
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0259	0.0259
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0263	0.323	0.5003
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0259	0.0845
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0471	0.0729
Trichomonas vaginalis	glutaminase, putative	0.031	0.3859	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0026	0.0068
Trypanosoma cruzi	GUP1, putative	0.0021	0.0013	0.0097
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0044	0.032	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0259	0.0402
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.0358	0.2644
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0174	0.045
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0058	0.0505	0.0505
Schistosoma mansoni	hypothetical protein	0.0084	0.0852	0.0852
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0154	0.1788	0.1788
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0021	0.0013	0.0013
Mycobacterium ulcerans	lysophospholipase	0.0071	0.0683	0.177
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Schistosoma mansoni	hypothetical protein	0.0021	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.008	0.0801	0.1242
Trypanosoma cruzi	glycerol uptake protein, putative	0.0021	0.0013	0.0097
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0259	0.0672
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0031	0.0152	0.2798
Plasmodium falciparum	pyruvate kinase	0.0035	0.0206	0.3022
Brugia malayi	beta-lactamase	0.0039	0.0259	0.0402
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.0358	0.5246
Trypanosoma cruzi	GUP1, putative	0.0021	0.0013	0.0097
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0683	0.177
Trypanosoma brucei	monoglyceride lipase, putative	0.0071	0.0683	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0206	0.3786
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0021	0.0013	0.0192
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0071	0.0683	0.5041
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.0505	0.3728
Brugia malayi	MBOAT family protein	0.0021	0.0013	0.002
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0259	0.0845
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0071	0.0683	0.177
Echinococcus granulosus	sterol O acyltransferase 1	0.0021	0.0013	0.0013
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0206	0.0206
Mycobacterium tuberculosis	Possible lysophospholipase	0.0071	0.0683	0.2226
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.2737	0.2737
Leishmania major	monoglyceride lipase, putative	0.0071	0.0683	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0104	0.1119	0.1119
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0683	0.177
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0259	0.0402
Brugia malayi	diacylglycerol acyltransferase	0.0021	0.0013	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0358	0.0927
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Leishmania major	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Giardia lamblia	GTOR	0.0058	0.0505	0.9314
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0021	0.0013	0.002
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0523	0.0523
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0021	0.0013	0.0013
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0259	0.3798
Trichomonas vaginalis	porcupine, putative	0.0021	0.0013	0.0034
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0035	0.0206	0.0672
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0259	0.0845
Echinococcus granulosus	zinc finger protein	0.022	0.2654	0.2654
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.0125	0.1835
Plasmodium falciparum	lysophospholipase, putative	0.0071	0.0683	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0174	0.045
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.031	0.2287
Plasmodium vivax	PST-A protein	0.0071	0.0683	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0217	0.0336
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0021	0.0013	0.0013
Brugia malayi	MBOAT family protein	0.0021	0.0013	0.002
Leishmania major	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.0505	0.7395
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0505	0.1309
Onchocerca volvulus		0.0039	0.0259	0.4824
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0026	0.0384
Schistosoma mansoni	sterol O-acyltransferase 1	0.0021	0.0013	0.0013
Loa Loa (eye worm)	pyruvate kinase-PB	0.0025	0.0065	0.01
Toxoplasma gondii	pyruvate kinase PyK1	0.0035	0.0206	0.644
Trichomonas vaginalis	esterase, putative	0.0039	0.0259	0.0672
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0174	0.045
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0259	0.0845
Leishmania major	pyruvate kinase	0.0035	0.0206	0.3022
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0021	0.0013	0.0097
Brugia malayi	glutaminase DH11.1	0.031	0.3859	0.5978
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0259	0.0672
Echinococcus multilocularis	tumor protein p63	0.0404	0.5105	0.5105
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0523	0.1356
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0206	0.0535
Entamoeba histolytica	hypothetical protein, conserved	0.0021	0.0013	0.0097
Leishmania major	pyruvate kinase	0.0035	0.0206	0.3022
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0479	0.0743
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0021	0.0013	0.0192
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0021	0.0013	0.0013
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0026	0.0384
Leishmania major	hypothetical protein, conserved	0.0021	0.0013	0.0192
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0259	0.0259
Echinococcus multilocularis	muscleblind protein 1	0.0506	0.6455	0.6455
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.1034	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0026	0.0068
Schistosoma mansoni	microtubule-associated protein tau	0.0773	1	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0206	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0506	0.6455	1
Entamoeba histolytica	vacuolar protein sorting 26	0.0021	0.0013	0.0097
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.1355	1
Schistosoma mansoni	zinc finger protein	0.024	0.2929	0.2929
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0154	0.1788	0.277
Echinococcus granulosus	muscleblind protein	0.0506	0.6455	0.6455
Schistosoma mansoni	hypothetical protein	0.019	0.2258	0.2258
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.031	0.2287
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0035	0.0206	0.032
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0021	0.0013	0.0013
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0071	0.0683	0.177
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.1355	0.351
Loa Loa (eye worm)	hypothetical protein	0.0506	0.6455	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0154	0.1788	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0259	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0013	0.002
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0071	0.0683	0.177
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0021	0.0013	0.0013
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0259	0.0845
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.2417	0.3744
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0206	0.032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0173	0.0448
Schistosoma mansoni	hypothetical protein	0.019	0.2258	0.2258
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0026	0.0041
Schistosoma mansoni	cellular tumor antigen P53	0.0059	0.0524	0.0524
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0035	0.0206	0.1523
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0206	0.3786
Brugia malayi	amidase	0.0104	0.1119	0.1733
Entamoeba histolytica	hypothetical protein	0.0098	0.1034	0.7633
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.0863	0.2236
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.0505	0.3728
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0047	0.0358	0.5246
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0206	0.032
Echinococcus multilocularis	muscleblind protein	0.0506	0.6455	0.6455
Echinococcus multilocularis	pyruvate kinase	0.0035	0.0206	0.0206
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0021	0.0013	0.0034
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0021	0.0013	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0358	0.0927
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.024	0.2929	0.2929
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0154	0.1788	0.1788
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0245	0.0379
Entamoeba histolytica	hypothetical protein	0.0084	0.0852	0.6289
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0021	0.0013	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0154	0.1788	0.1788
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0026	0.0068
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0104	0.1119	0.1119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0215	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.3068	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0026	0.0026
Onchocerca volvulus		0.0039	0.0259	0.4824
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.1355	0.351
Entamoeba histolytica	hypothetical protein	0.0084	0.0852	0.6289
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0021	0.0013	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0268	0.0694
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0358	0.0927
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0259	0.0672
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0084	0.0852	0.0852
Toxoplasma gondii	ABC1 family protein	0.0039	0.0259	0.8094
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.1355	0.351
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0259	0.0402
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0215	0.0557
Plasmodium falciparum	esterase, putative	0.0071	0.0683	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0211	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0013	0.002
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0026	0.0384
Leishmania major	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Trypanosoma cruzi	monoglyceride lipase, putative	0.0071	0.0683	0.5041
Trypanosoma brucei	pyruvate kinase 1, putative	0.0035	0.0206	0.3022
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0683	0.177
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0021	0.0013	0.0013
Onchocerca volvulus		0.0039	0.0259	0.4824
Echinococcus multilocularis	zinc finger protein	0.022	0.2654	0.2654
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0259	0.3798
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.0523	0.1706
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.0505	0.3728
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.1355	0.2099
Loa Loa (eye worm)	MBOAT family protein	0.0021	0.0013	0.002
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0084	0.0852	0.0852
Giardia lamblia	Pyruvate kinase	0.0035	0.0206	0.3805
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0252	0.0654
Schistosoma mansoni	fatty-acid amide hydrolase	0.0104	0.1119	0.1119
Onchocerca volvulus		0.0059	0.0524	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0801	0.0801
Trichomonas vaginalis	pyruvate kinase, putative	0.0035	0.0206	0.0535
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0211	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0358	0.0927
Brugia malayi	MBOAT family protein	0.0021	0.0013	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0013	0.0034
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.031	0.2287
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0259	0.0672
Entamoeba histolytica	pyruvate kinase, putative	0.0025	0.0065	0.0477
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0021	0.0013	0.0013
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0021	0.0013	0.0013
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0104	0.1119	0.1119
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0259	0.0672
Brugia malayi	beta-lactamase family protein	0.0039	0.0259	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0259	0.0402
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0035	0.0206	0.032
Leishmania major	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0021	0.0013	0.0013
Leishmania major	hypothetical protein, conserved	0.0039	0.0259	0.3798
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0524	0.0811
Trypanosoma brucei	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Treponema pallidum	alginate O-acetylation protein (algI)	0.0021	0.0013	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0173	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1119	0.1733
Schistosoma mansoni	glutaminase	0.031	0.3859	0.3859
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0259	0.0845
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0259	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0013	0.002
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0071	0.0683	0.177
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.2737	0.2737
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0071	0.0683	0.177
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0021	0.0013	0.0013
Loa Loa (eye worm)	glutaminase	0.031	0.3859	0.5978
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0523	0.1356
Echinococcus multilocularis	geminin	0.019	0.2258	0.2258
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0154	0.1788	0.1788
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0259	0.0845
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0259	0.0259
Echinococcus multilocularis	sterol O acyltransferase 1	0.0021	0.0013	0.0013
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.0505	0.7395
Loa Loa (eye worm)	glutaminase 2	0.031	0.3859	0.5978
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0259	0.0402
Trypanosoma cruzi	glycerol uptake protein, putative	0.0021	0.0013	0.0097
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0021	0.0013	0.0097
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0026	0.0193
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0523	0.0523
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0259	0.0845
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0013	0.0034
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.032	0.083
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.0523	0.0523
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0154	0.1788	0.1788
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.0505	0.0782
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.031	0.0803
Mycobacterium ulcerans	pyruvate kinase	0.0035	0.0206	0.0535
Echinococcus multilocularis	pyruvate kinase	0.0028	0.0108	0.0108
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0479	0.0743
Mycobacterium ulcerans	glutaminase	0.031	0.3859	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0259	0.0672
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0505	0.1309
Brugia malayi	follicle stimulating hormone receptor	0.0263	0.323	0.5003
Echinococcus granulosus	tumor protein p63	0.0404	0.5105	0.5105
Echinococcus granulosus	pyruvate kinase	0.0035	0.0206	0.0206
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0259	0.0259
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.04	0.1036
Loa Loa (eye worm)	hhat protein	0.0021	0.0013	0.002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0479	0.0743
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.1355	1
Entamoeba histolytica	hypothetical protein	0.0021	0.0013	0.0097
Loa Loa (eye worm)	MBOAT family protein	0.024	0.2929	0.4537
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0259	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0259	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0245	0.0379
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0021	0.0013	0.0408
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0071	0.0683	0.5041
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0026	0.0384
Brugia malayi	Hhat protein	0.0021	0.0013	0.002
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.2737	0.2737
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0259	0.0672
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.031	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0291	0.0451
Schistosoma mansoni	hypothetical protein	0.0038	0.0245	0.0245
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.1262	0.9314
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0021	0.0013	0.0013
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0026	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0013	0.002
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0217	0.1601
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0026	0.0026
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.0505	0.1309
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0043	0.031	0.031
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.0505	0.0782
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0259	0.1915
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0021	0.0013	0.0013
Brugia malayi	beta-lactamase family protein	0.0039	0.0259	0.0402
Brugia malayi	MBOAT family protein	0.0021	0.0013	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0173	0.0448
Toxoplasma gondii	hypothetical protein	0.0021	0.0013	0.0408
Trypanosoma brucei	monoglyceride lipase, putative	0.0071	0.0683	1
Plasmodium falciparum	lysophospholipase, putative	0.0071	0.0683	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0259	0.0672
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0104	0.1119	0.1119
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.0863	0.2236
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.0542	1
Mycobacterium ulcerans	lipase LipD	0.0039	0.0259	0.0672
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0259	0.0845
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.0801	0.0801
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0021	0.0013	0.0013
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0154	0.1788	0.277
Trypanosoma brucei	glycerol uptake protein, putative	0.0021	0.0013	0.0192
Loa Loa (eye worm)	hhat protein	0.0021	0.0013	0.002
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0071	0.0683	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.0505	0.3728
Onchocerca volvulus	Pyruvate kinase homolog	0.0035	0.0206	0.3786
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0058	0.0505	0.0505
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0058	0.0505	0.0505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0026	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0479	0.0743
Loa Loa (eye worm)	pyruvate kinase	0.0035	0.0206	0.032
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0259	0.0402
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.031	0.0803
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.0505	0.7395
Echinococcus granulosus	pyruvate kinase	0.0035	0.0206	0.0206
Entamoeba histolytica	hypothetical protein	0.0084	0.0852	0.6289
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.0801	0.1242
Schistosoma mansoni	pyruvate kinase	0.0035	0.0206	0.0206
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0259	0.1113
Entamoeba histolytica	hypothetical protein	0.0084	0.0852	0.6289
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0013	0.0034
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0021	0.0013	0.0013
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0259	0.1915
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0021	0.0013	0.0013
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0043	0.031	0.048
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.0505	0.7395
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.0481	0.3549
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0021	0.0013	0.0097
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.024	0.2929	0.2929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0026	0.0068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0215	0.0557
Echinococcus multilocularis	microtubule associated protein 2	0.0773	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0043	0.031	0.4536
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0174	0.045
Brugia malayi	hypothetical protein	0.0084	0.0852	0.132
Brugia malayi	MBOAT family protein	0.024	0.2929	0.4537
Loa Loa (eye worm)	MBOAT family protein	0.0021	0.0013	0.002
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.1355	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0026	0.0193
Chlamydia trachomatis	pyruvate kinase	0.0035	0.0206	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.5 nM	Inhibition of PI3Kalpha	ChEMBL.	20483602
IC50 (binding)	= 5.2 nM	Inhibition of mTOR	ChEMBL.	20483602
IC50 (functional)	= 76 nM	Cytotoxicity against human MDA-MB-361 cells	ChEMBL.	20483602

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	20483602

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1082986

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1110486