Detailed view for Bm1_37870

Basic information

TDR Targets ID: 237131
Brugia malayi, Phosphatidylcholine:ceramide cholinephosphotransferase 1
Source Database / ID:  GenBank

pI: 9.1289 | Length (AA): 356 | MW (Da): 40302 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14360   PAP2 superfamily C-terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0003824   catalytic activity  

Metabolic Pathways

Sphingolipid metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134392)

Species Accession Gene Product
Brugia malayi Bm1_37870   Phosphatidylcholine:ceramide cholinephosphotransferase 1
Caenorhabditis elegans CELE_H21P03.3   Protein SMS-1, isoform C
Homo sapiens ENSG00000198964   sphingomyelin synthase 1
Loa Loa (eye worm) LOAG_03776   hypothetical protein
Mus musculus ENSMUSG00000040451   sphingomyelin synthase 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sphingomyelin synthase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1981 0.4079 0.4079
0.181865 0.75131 0.75131
0.181865 0.75131 0.75131
0.0461 0.5551 1
0.0451 0.3072 0.9522
0.0471 0.3273 0.9272
0.1369 0.5995 1
0.0471 0.3273 0.9272
0.0453 0.5456 1
0.0923 0.5652 1
0.0463 0.633 1
0.313741 0.820076 1
0.0474 0.2854 0.94
0.0471 0.5286 1
0.313741 0.820076 1
0.0453 0.8461 1
0.313741 0.820076 1
0.0485 0.5891 1
0.142 0.9969 1
0.0926 0.5057 1
0.2364 0.4755 1
0.0469 0.4727 1
0.0456 0.2797 1
0.2449 0.5311 1
0.2449 0.5311 1
0.1981 0.4079 0.4079
0.0453 0.2591 1
0.0907 0.9649 0.9649
0.0453 0.5366 1
0.26 0.9951 1
0.313741 0.820076 1
0.26 0.9951 1
0.0453 0.5366 1
0.0485 0.5891 1
0.0453 0.8461 1
0.313741 0.820076 1
0.313741 0.820076 1
0.2449 0.5311 1
0.0412465 0.356188 0.601867
0.2364 0.4755 1
0.0465 0.281 0.9969
0.181865 0.75131 0.75131

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Bm1_37870 (Brugia malayi), Phosphatidylcholine:ceramide cholinephosphotransferase 1
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