Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0214 | 0.1087 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0021 | 0.0108 |
Onchocerca volvulus | 0.0035 | 0.0214 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0058 | 0.1112 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0041 | 0.0275 | 0.1399 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0021 | 0.0366 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0275 | 0.0202 |
Toxoplasma gondii | exonuclease III APE | 0.0041 | 0.0275 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0195 | 0.1909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0214 | 0.1087 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0041 | 0.0275 | 0.0362 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.2195 | 0.6509 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0041 | 0.0275 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0214 | 0.1087 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0078 | 0.1287 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0214 | 0.0656 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0215 | 0.0194 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0041 | 0.0275 | 0.5 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0021 | 0.0366 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0078 | 0.0057 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0323 | 0.3258 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0214 | 0.4272 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0214 | 0.7767 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.1967 | 1 |
Treponema pallidum | hypothetical protein | 0.0323 | 0.3258 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0.0275 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0275 | 0.5518 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0214 | 0.0656 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0459 | 1 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0201 | 0.1967 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0214 | 0.7767 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.024 | 0.1221 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0003 | 0.0114 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0323 | 0.3258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0264 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0214 | 0.1087 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0047 | 0.0891 |
Onchocerca volvulus | 0.0035 | 0.0214 | 0.5 | |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0323 | 0.3258 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0041 | 0.0275 | 0.1399 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0041 | 0.0275 | 0.0362 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0041 | 0.0275 | 0.0255 |
Trypanosoma cruzi | ISWI complex protein | 0.0015 | 0.0003 | 0.0114 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0078 | 0.151 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0214 | 0.1087 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0027 | 0.014 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0041 | 0.0275 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0047 | 0.0026 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0214 | 0.1087 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0214 | 0.0656 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0058 | 0.0295 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0459 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0284 | 0.1444 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0047 | 0.0592 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0102 | 0.0518 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0041 | 0.0275 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0041 | 0.0275 | 0.0202 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0214 | 0.7767 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0573 | 0.2911 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0021 | 0.0366 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0323 | 0.3258 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0015 | 0.0003 | 0.0114 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0214 | 0.1087 |
Onchocerca volvulus | 0.0035 | 0.0214 | 0.5 | |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0215 | 0.4427 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0214 | 0.4272 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.0496 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0214 | 0.1087 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0214 | 0.1087 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0275 | 0.5518 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.0616 | 0.3134 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0041 | 0.0275 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0214 | 0.1087 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0214 | 0.4395 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0214 | 0.0656 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0041 | 0.0275 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0041 | 0.0275 | 0.5797 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0021 | 0.0366 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0.0275 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0214 | 0.0193 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0214 | 0.0656 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0214 | 0.7767 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0003 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0214 | 0.1087 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0239 | 0.1217 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0323 | 0.3258 | 1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0214 | 0.1087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.