Detailed information for compound 1126390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.321 | Formula: C17H17NO4
  • H donors: 0 H acceptors: 1 LogP: 3.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCC1CN(C(=O)O1)c1ccccc1
  • InChi: 1S/C17H17NO4/c1-20-14-7-9-15(10-8-14)21-12-16-11-18(17(19)22-16)13-5-3-2-4-6-13/h2-10,16H,11-12H2,1H3
  • InChiKey: XQCGHSQBEZHHSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, metabotropic 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0894
Schistosoma mansoni glucose transport protein 0.0213 0.2253 0.7341
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0582 0.1896
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0466 0.2066
Plasmodium vivax CDK-related protein kinase 6, putative 0.0905 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0199 0.0884
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Echinococcus multilocularis General substrate transporter 0.0183 0.1918 0.2173
Schistosoma mansoni glucose transport protein 0.0213 0.2253 0.7341
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0199 0.0649
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0201 0.0656
Loa Loa (eye worm) hypothetical protein 0.0016 0.0041 0.0182
Schistosoma mansoni glucose transport protein 0.0213 0.2253 0.7341
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Leishmania major glucose transporter, lmgt2 0.0066 0.0606 0.8651
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0201 0.0894
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0597 0.2648
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.0676
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0393 0.0445
Toxoplasma gondii sugar transporter ST2 0.003 0.0201 0.0305
Schistosoma mansoni hypothetical protein 0.0213 0.2253 0.7341
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Onchocerca volvulus 0.0047 0.0393 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0393 0.1279
Giardia lamblia Sugar-proton symporter 0.003 0.0201 0.346
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0894
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0345 0.3724 0.5632
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi Cam kinase protein 1 0.0065 0.0597 0.2648
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0201 0.5052
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.016 0.0709
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1943 0.8621
Brugia malayi Sugar transporter family protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0228
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0318 0.5469
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0597 0.0597
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1943 0.2201
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0597 0.0597
Brugia malayi hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0597 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.0676
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0582 0.2583
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0582 0.2583
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0597 0.0597
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0201 0.2874
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0201 0.5052
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0606 0.8651
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0466 0.2066
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0201 0.5052
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0119 0.2978
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.1299
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0606 0.269
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0606 0.8651
Trypanosoma cruzi hexose transporter, putative 0.0036 0.027 0.386
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0399 1
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0656
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0201 0.6328
Loa Loa (eye worm) hypothetical protein 0.0064 0.0582 0.2583
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0597 0.0597
Schistosoma mansoni protein kinase 0.0065 0.0597 0.1944
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0345 0.3724 0.3724
Echinococcus granulosus General substrate transporter 0.0183 0.1918 0.851
Trypanosoma cruzi sugar transporter, putative 0.003 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Plasmodium vivax hexose transporter 0.0213 0.2253 0.2253
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0393 0.1279
Brugia malayi mbt repeat family protein 0.0047 0.0393 0.1743
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2253 0.2553
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0393 0.0445
Loa Loa (eye worm) hypothetical protein 0.0052 0.0448 0.1987
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0466 0.1517
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0228
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2253 0.2553
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Brugia malayi major facilitator superfamily protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Leishmania major hypothetical protein, conserved 0.003 0.0201 0.2874
Schistosoma mansoni protein kinase 0.0065 0.0597 0.1944
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0201 0.6328
Brugia malayi hypothetical protein 0.003 0.0201 0.0894
Entamoeba histolytica hypothetical protein 0.0048 0.0399 0.6679
Entamoeba histolytica protein kinase, putative 0.0065 0.0597 1
Plasmodium falciparum protein kinase 7 0.0603 0.6612 0.6612
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2253 1
Brugia malayi major facilitator superfamily protein 0.003 0.0201 0.0894
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0399 0.0399
Brugia malayi hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.0676
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0399 0.1769
Trypanosoma cruzi hexose transporter, putative 0.003 0.0201 0.2874
Schistosoma mansoni protein kinase 0.0065 0.0597 0.1944
Toxoplasma gondii protein kinase, putative 0.0603 0.6612 1
Plasmodium vivax sugar transporter, putative 0.003 0.0201 0.0201
Entamoeba histolytica protein kinase, putative 0.0065 0.0597 1
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0606 0.269
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0075 0.0708 0.0802
Brugia malayi Sugar transporter family protein 0.003 0.0201 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0318 1
Brugia malayi mbt repeat family protein 0.0047 0.0393 0.1743
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0597 0.0903
Trichomonas vaginalis glucose transporter, putative 0.003 0.0201 0.0894
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0701 0.0701
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0055 0.0486 0.2155
Loa Loa (eye worm) MBCTL1 0.0054 0.0466 0.2066
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0606 0.269
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0075 0.0708 0.3142
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.0439 0.143
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0041 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0075 0.0708 0.3142
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0466 0.0528
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0466 0.0528
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0552 0.0625
Loa Loa (eye worm) sugar transporter 0.003 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0228
Loa Loa (eye worm) glutamate receptor 0.0061 0.055 0.244
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0069 0.0644 0.2097
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0656
Plasmodium falciparum hexose transporter 0.0213 0.2253 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0606 0.269
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0064 0.0582 0.2583
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0201 0.0228
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0597 0.2648
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0399 0.0399
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0399 0.0452
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0333 0.1477
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0393 0.1743
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0051 0.0439 0.0497
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0201 1
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Toxoplasma gondii sugar transporter ST1 0.003 0.0201 0.0305
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0119 1
Mycobacterium ulcerans sugar transporter 0.003 0.0201 0.5052
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0582 0.9752
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0466 0.2066
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0399 0.6849
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0597 0.0597
Trypanosoma cruzi glucose transporter, putative 0.003 0.0201 0.2874
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0582 1
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0041 0.0182
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0582 1
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.2253 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0065 0.0597 0.2648
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0393 0.1743
Schistosoma mansoni glucose transporter 0.003 0.0201 0.0656
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0399 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0399 0.0603
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0201 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0201 0.0201
Giardia lamblia Hexose transporter 0.003 0.0201 0.346
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0597 0.0597
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0399 0.6849
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0606 0.8651
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0318 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Trypanosoma brucei glucose transporter 1E 0.0066 0.0606 0.8651
Trypanosoma brucei glucose transporter 2A 0.0066 0.0606 0.8651
Schistosoma mansoni hypothetical protein 0.0286 0.307 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.8826 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2253 0.2553
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2253 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0701 0.106
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0701 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.1299
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0582 0.1896
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2253 1
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0606 0.8651
Leishmania major protein kinase, putative 0.0065 0.0597 0.8517
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0606 0.269
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0393 1
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0201 0.0894
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0399 0.1769
Loa Loa (eye worm) sugar transporter 0.0213 0.2253 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0201 0.0228
Leishmania major glucose transporter, lmgt3 0.0066 0.0606 0.8651
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0656
Echinococcus granulosus metabotropic glutamate receptor 2 0.0051 0.0439 0.1947
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0201 0.0894
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0393 0.1279
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.2648
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0041 0.0182
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0552 0.2448
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0201 0.0305
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0201 0.0894
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0393 0.1743
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2253 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0597 0.1944
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0606 0.8651
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0597 0.0597
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Plasmodium falciparum mitogen-activated protein kinase 2 0.0345 0.3724 0.3724
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0054 0.0466 0.2066
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0582 0.2583
Toxoplasma gondii sugar transporter ST3 0.003 0.0201 0.0305
Trypanosoma brucei sugar transporter, putative 0.003 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0213 0.2253 0.2553
Loa Loa (eye worm) glutamate receptor 0.0024 0.0135 0.0598
Toxoplasma gondii facilitative glucose transporter GT1 0.0213 0.2253 0.3408
Brugia malayi Metabotropic glutamate receptor precursor. 0.0061 0.055 0.244
Trypanosoma brucei glucose transporter, putative 0.0066 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0047 0.0393 0.1743
Brugia malayi Sugar transporter family protein 0.0213 0.2253 1
Leishmania major glucose transporter, lmgt1 0.0066 0.0606 0.8651
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0597 0.8517
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0597 0.2648
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0701 1
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0119 0.2978
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0656
Loa Loa (eye worm) hypothetical protein 0.0048 0.0399 0.1769
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0701 0.0701
Trypanosoma cruzi hexose transporter 0.0066 0.0606 0.8651
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0597 0.0597
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0597 0.2648
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0582 0.2583
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0597 0.0903
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0582 0.0659
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0597 0.0903

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 2190 nM Allosteric modulation of human mGluR2 expressed in CHO dhfr cells co-expressing G-protein Galpha16 assessed as potentiation of glutamate-induced calcium flux by FLIPR assay ChEMBL. 20409708

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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