TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.169 | Formula: C14H12BrN3
H donors: 0 H acceptors: 3 LogP: 3.8 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCCc1nc(C#N)nc(c1)c1cccc(c1)Br
InChi: 1S/C14H12BrN3/c1-2-4-12-8-13(18-14(9-16)17-12)10-5-3-6-11(15)7-10/h3,5-8H,2,4H2,1H3
InChiKey: DZTHXSGBNCWOBB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	ctsf protein	0.0086	0.2093	0.4219
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Giardia lamblia	Cysteine protease	0.002	0.01	0.0237
Giardia lamblia	Hypothetical protein	0.002	0.01	0.0237
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0064	0.2548
Loa Loa (eye worm)	hypothetical protein	0.0181	0.4959	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.01	0.0202
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2093	0.4219
Plasmodium vivax	unspecified product	0.002	0.01	0.0479
Leishmania major	cysteine peptidase A (CPA)	0.0086	0.2093	1
Giardia lamblia	Cathepsin B precursor	0.002	0.01	0.0237
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0251	0.0921
Loa Loa (eye worm)	hypothetical protein	0.005	0.1008	0.2033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0061	0.5
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0086	0.2093	0.2093
Brugia malayi	cathepsin Z-like cysteine proteinase	0.002	0.01	0.0202
Onchocerca volvulus		0.0086	0.2093	0.4756
Onchocerca volvulus		0.0086	0.2093	0.4756
Leishmania major	DNA polymerase eta, putative	0.0019	0.0064	0.0305
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0251	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0908	0.1831
Brugia malayi	hypothetical protein	0.0159	0.4289	0.8649
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0251	0.0921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.002	0.01	0.0179
Brugia malayi	cathepsin L-like precursor	0.0059	0.1285	0.2591
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0064	0.0129
Plasmodium falciparum	serine repeat antigen 9	0.002	0.01	0.0479
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.01	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0061	0.0122
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.002	0.01	0.0202
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.01	0.0179
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0908	0.1831
Echinococcus granulosus	cathepsin b	0.0181	0.4959	0.4959
Echinococcus multilocularis	cathepsin L	0.0047	0.0908	0.0908
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0251	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.002	0.01	0.0479
Giardia lamblia	Cysteine protease	0.002	0.01	0.0237
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.002	0.01	0.0479
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.01	0.0179
Entamoeba histolytica	cysteine protease, putative	0.002	0.01	0.0179
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1285	0.6019
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.4959	0.4959
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.01	0.0179
Echinococcus multilocularis	cathepsin b	0.0181	0.4959	0.4959
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0908	0.4161
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0251	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1008	0.2033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.1507	0.3039
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2093	0.4219
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1285	0.2591
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.01	0.0202
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.007	0.1603	0.7661
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.002	0.01	0.0479
Toxoplasma gondii	preprocathepsin c precursor, putative	0.002	0.01	0.0479
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0251	0.0506
Loa Loa (eye worm)	cysteine protease	0.0086	0.2093	0.4219
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0251	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.01	0.0179
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.01	0.0202
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0908	0.4161
Giardia lamblia	Cathepsin B precursor	0.002	0.01	0.0237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2093	1
Echinococcus multilocularis	cysteine protease	0.0086	0.2093	0.2093
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.01	0.0202
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.4959	0.4959
Giardia lamblia	Cysteine protease	0.002	0.01	0.0237
Trypanosoma cruzi	cruzipain precursor, putative	0.0086	0.2093	0.4219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0251	0.1198
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0064	0.0129
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.1507	0.3039
Brugia malayi	Papain family cysteine protease containing protein	0.0086	0.2093	0.4219
Loa Loa (eye worm)	hypothetical protein	0.0159	0.4289	0.8649
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0908	0.4339
Loa Loa (eye worm)	hypothetical protein	0.002	0.01	0.0202
Echinococcus granulosus	cysteine protease	0.0047	0.0908	0.0908
Giardia lamblia	Cathepsin B precursor	0.002	0.01	0.0237
Loa Loa (eye worm)	cathepsin B	0.007	0.1603	0.3232
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0251	0.1198
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.01	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0061	0.0122
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.002	0.01	0.0479
Onchocerca volvulus		0.0059	0.1285	0.2828
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.01	0.0179
Entamoeba histolytica	cysteine protease, putative	0.002	0.01	0.0179
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0908	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.002	0.01	0.0179
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0086	0.2093	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0064	0.0129
Onchocerca volvulus		0.0086	0.2093	0.4756
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.01	0.0179
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0251	1
Giardia lamblia	Hypothetical protein	0.002	0.01	0.0237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2093	0.2093
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0251	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.4959	0.4959
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0086	0.2093	0.2093
Plasmodium falciparum	serine repeat antigen 1	0.002	0.01	0.0479
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.01	0.0237
Plasmodium vivax	unspecified product	0.0027	0.0307	0.1466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.01	0.0479
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0251	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2093	0.2093
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2093	0.4219
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0531	0.107
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0059	0.1285	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1285	0.2591
Echinococcus granulosus	tar DNA binding protein	0.0066	0.1507	0.1507
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1285	0.6019
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Brugia malayi	cathepsin F-like cysteine proteinase	0.002	0.01	0.0202
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.002	0.01	0.0479
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0064	0.0064
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.01	0.01
Brugia malayi	RNA binding protein	0.0066	0.1507	0.3039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1285	0.6019
Giardia lamblia	Cathepsin B precursor	0.002	0.01	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1285	0.2591
Giardia lamblia	Cathepsin L precursor	0.002	0.01	0.0237
Echinococcus multilocularis	geminin	0.0348	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0061	0.0122
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.01	0.0237
Echinococcus granulosus	cathepsin L	0.002	0.01	0.01
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Schistosoma mansoni	hypothetical protein	0.0348	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0251	0.0506
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.01	0.0202
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1507	0.1507
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1507	0.1507
Giardia lamblia	Cathepsin L precursor	0.002	0.01	0.0237
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0908	0.0908
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0251	1
Giardia lamblia	Cathepsin B precursor	0.007	0.1603	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0064	0.0129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2093	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0307	0.0619
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.01	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0061	0.0122
Onchocerca volvulus		0.0086	0.2093	0.4756
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0181	0.4959	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2093	0.4219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0908	0.4161
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0908	0.4161
Giardia lamblia	Cysteine protease	0.002	0.01	0.0237
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2093	0.4756
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0064	0.0064
Plasmodium falciparum	serine repeat antigen 4	0.002	0.01	0.0479
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0251	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0251	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.0307	0.0619
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.01	0.0202
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0908	0.1831
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2093	0.4219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Plasmodium vivax	vivapain-2	0.0086	0.2093	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0086	0.2093	1
Onchocerca volvulus	Cathepsin L homolog	0.0086	0.2093	0.4756
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0251	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.002	0.01	0.0479
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0064	0.0305
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0251	1
Giardia lamblia	Cathepsin B precursor	0.007	0.1603	1
Giardia lamblia	Cathepsin L precursor	0.002	0.01	0.0237
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.1507	0.1507
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0064	0.0305
Loa Loa (eye worm)	fibroinase	0.0086	0.2093	0.4219
Entamoeba histolytica	cysteine protease, putative	0.002	0.01	0.0179
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Brugia malayi	fibroinase precursor	0.002	0.01	0.0202
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.002	0.01	0.01
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.01	0.0179
Echinococcus multilocularis	cathepsin L cysteine protease	0.0086	0.2093	0.2093
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0064	0.0064
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0908	0.1831
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.002	0.01	0.0479
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.002	0.01	0.0202
Echinococcus granulosus	dna polymerase eta	0.0019	0.0064	0.0064
Plasmodium falciparum	serine repeat antigen 5	0.002	0.01	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0251	0.0506
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0064	0.0165
Plasmodium falciparum	serine repeat antigen 7	0.002	0.01	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0307	0.0619
Entamoeba histolytica	cysteine protease, putative	0.002	0.01	0.0179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.002	0.01	0.0179
Schistosoma mansoni	hypothetical protein	0.0034	0.0531	0.0531
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.01	0.0202
Schistosoma mansoni	cathepsin s	0.0027	0.0307	0.0307
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.002	0.01	0.0179
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.01	0.01
Schistosoma mansoni	cathepsin C	0.002	0.01	0.01
Entamoeba histolytica	cysteine protease, putative	0.0086	0.2093	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.003	0.1199
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.002	0.01	0.0479
Plasmodium falciparum	serine repeat antigen 3	0.002	0.01	0.0479
Echinococcus granulosus	cathepsin l1	0.0059	0.1285	0.1285
Toxoplasma gondii	cathepsin CPL	0.0086	0.2093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.01	0.0179
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0064	0.0129
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.01	0.01
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0086	0.2093	1
Onchocerca volvulus		0.0086	0.2093	0.4756
Giardia lamblia	Cathepsin B precursor	0.007	0.1603	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0307	0.0619
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Giardia lamblia	Cathepsin B precursor	0.002	0.01	0.0237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.01	0.0179
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.003	0.1199
Echinococcus granulosus	cathepsin L	0.0047	0.0908	0.0908
Giardia lamblia	Encystation-specific protease	0.002	0.01	0.0237
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.01	0.01
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0064	0.0064
Echinococcus multilocularis	cathepsin b	0.0181	0.4959	0.4959
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0061	0.0122
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2093	0.4219
Loa Loa (eye worm)	hypothetical protein	0.002	0.01	0.0202
Giardia lamblia	Cathepsin L precursor	0.002	0.01	0.0237
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0307	0.0619
Echinococcus granulosus	cathepsin l1	0.0086	0.2093	0.2093
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0064	0.0305
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.002	0.01	0.01
Onchocerca volvulus		0.0086	0.2093	0.4756
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0064	0.0064
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1008	0.2033
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0064	0.0305
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1285	0.2591
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0064	0.0129
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0061	0.029
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0251	0.1198
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1008	0.2033
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0064	0.0064
Echinococcus multilocularis	cathepsin L	0.002	0.01	0.01
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.003	0.1199
Entamoeba histolytica	hypothetical protein	0.002	0.01	0.0179
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Schistosoma mansoni	cathepsin B (C01 family)	0.002	0.01	0.01
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Toxoplasma gondii	cathepsin CPC2	0.002	0.01	0.0479
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.007	0.1603	0.7587
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2093	0.2093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.002	0.01	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.002	0.01	0.0179
Loa Loa (eye worm)	RNA binding protein	0.0066	0.1507	0.3039
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0064	0.0129
Echinococcus granulosus	cathepsin b	0.0181	0.4959	0.4959
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.1507	0.3039
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0251	0.0921
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0086	0.2093	0.2093
Toxoplasma gondii	cathepsin B	0.007	0.1603	0.7661
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.002	0.01	0.0237
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0181	0.4959	0.4959
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1285	0.2591
Plasmodium falciparum	serine repeat antigen 8	0.002	0.01	0.0479
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0064	0.0064
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0307	0.0619
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0908	0.1831
Plasmodium falciparum	serine repeat antigen 6	0.002	0.01	0.0479
Plasmodium vivax	vivapain-3	0.0047	0.0908	0.4339
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0064	0.0129
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.007	0.1603	0.3232
Giardia lamblia	Cathepsin L-like protease	0.002	0.01	0.0237
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.002	0.01	0.0479
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0908	0.0908
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.002	0.01	0.0479
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.002	0.01	0.0179
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0061	0.2422
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2093	0.4219
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0908	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0908	0.4161
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.01	0.0202
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.002	0.01	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2093	0.4219
Brugia malayi	cathepsin L precursor	0.002	0.01	0.0202
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1507	0.1507
Toxoplasma gondii	cathepsin CPC1	0.002	0.01	0.0479
Plasmodium vivax	unspecified product	0.0047	0.0908	0.4339
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Plasmodium vivax	vivapain-1	0.0047	0.0908	0.4339
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2093	0.4219
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0908	0.0908
Plasmodium vivax	vivapain-2	0.0086	0.2093	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.002	0.01	0.0202
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0086	0.2093	0.4219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.01	0.0179
Giardia lamblia	Cathepsin L-like protease	0.002	0.01	0.0237
Onchocerca volvulus	Cathepsin F homolog	0.0086	0.2093	0.4756
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0064	0.0129
Brugia malayi	Cathepsin L-like precursor	0.0086	0.2093	0.4219
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.01	0.01
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.007	0.1603	0.1603
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0908	0.1831
Trypanosoma cruzi	cysteine peptidase, putative	0.0086	0.2093	0.4219
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0086	0.2093	0.4219
Loa Loa (eye worm)	hypothetical protein	0.002	0.01	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0086	0.2093	1
Entamoeba histolytica	cysteine proteinase, putative	0.0086	0.2093	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0181	0.4959	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.002	0.01	0.0479
Plasmodium falciparum	serine repeat antigen 2	0.002	0.01	0.0479
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1285	0.1285
Schistosoma mansoni	hypothetical protein	0.0348	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0307	0.0619
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0908	0.1831
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.1285	0.2591
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.002	0.01	0.01
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0251	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0251	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1507	0.1507
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0064	0.0064
Onchocerca volvulus		0.0159	0.4289	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0908	0.4161
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.002	0.01	0.01
Onchocerca volvulus		0.0025	0.0251	0.0359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0086	0.2093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.01	0.0202
Echinococcus multilocularis	cysteine protease	0.0086	0.2093	0.2093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.01	0.0179
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0908	0.4339
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0531	0.107
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0064	0.0165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0908	0.4161
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.002	0.01	0.0179
Giardia lamblia	Cathepsin L precursor	0.002	0.01	0.0237
Trypanosoma brucei	unspecified product	0.0019	0.0064	0.0305
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0908	0.0908
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0086	0.2093	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0086	0.2093	0.2093
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0251	0.0506
Schistosoma mansoni	cathepsin S (C01 family)	0.002	0.01	0.01
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.007	0.1603	0.7661
Giardia lamblia	Cathepsin L precursor	0.002	0.01	0.0237
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.002	0.01	0.0479
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0064	0.0305
Leishmania major	cathepsin L-like protease	0.0086	0.2093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0908	0.4339
Brugia malayi	TAR-binding protein	0.0066	0.1507	0.3039
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0307	0.0619
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.003	0.1199
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.01	0.0179
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0064	0.2548
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.002	0.01	0.0237
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0064	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.01	0.0179
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.01	0.0202
Onchocerca volvulus		0.0086	0.2093	0.4756
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0086	0.2093	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1507	0.1507
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0061	0.029
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.0307	0.0619
Entamoeba histolytica	cysteine protease, putative	0.002	0.01	0.0179

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 44 nM	Inhibition of human recombinant cathepsin K	ChEMBL.	20594841
IC50 (binding)	= 174 nM	Inhibition of human recombinant cathepsin S	ChEMBL.	20594841
IC50 (binding)	> 10000 nM	Inhibition of human recombinant cathepsin B	ChEMBL.	20594841
IC50 (binding)	> 10000 nM	Inhibition of human recombinant cathepsin L	ChEMBL.	20594841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1209246

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1129147