Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Beta-1 adrenergic receptor | Starlite/ChEMBL | References |
Cavia porcellus | Beta-2 adrenergic receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0315 | 0.4016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0362 | 0.501 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0362 | 0.501 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0713 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0713 | 1 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0272 | 0.3367 | 0.7403 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0362 | 0.501 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0272 | 0.3367 | 0.8349 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0713 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0315 | 0.4016 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0096 | 0.0713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0337 | 0.4654 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0272 | 0.3367 | 0.8349 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0337 | 0.4654 |
Mycobacterium ulcerans | hypothetical protein | 0.0166 | 0.1772 | 0.1141 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0096 | 0.0713 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0096 | 0.0713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0337 | 0.4654 |
Plasmodium falciparum | peptide deformylase | 0.0713 | 1 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0149 | 0.1518 | 0.3643 |
Brugia malayi | Peptidase family M13 containing protein | 0.0096 | 0.0713 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0053 | 0.0077 | 0.0945 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0071 | 0.0337 | 0.4654 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0166 | 0.1772 | 0.1141 |
Treponema pallidum | polypeptide deformylase (def) | 0.0713 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0071 | 0.0337 | 0.4654 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0362 | 0.501 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0362 | 0.501 |
Onchocerca volvulus | Matrilysin homolog | 0.0049 | 0.001 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0713 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0049 | 0.001 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0272 | 0.3367 | 0.7403 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0362 | 0.501 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0315 | 0.4016 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0096 | 0.0713 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0272 | 0.3367 | 0.8349 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0315 | 0.4016 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0272 | 0.3367 | 0.8349 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0337 | 0.4654 |
Toxoplasma gondii | peptidase family M13 protein | 0.0096 | 0.0713 | 0.0676 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0272 | 0.3367 | 0.7403 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0713 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0713 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0713 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0713 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 6.3 | The apparent pA2 value was measured for beta-2 adrenergic blocking activity on the trachea of guinea pig | ChEMBL. | 6104730 |
Kd (functional) | = 6.71 | Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig | ChEMBL. | 6104730 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.