Detailed information for compound 1139577

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.401 | Formula: C16H24N6O
  • H donors: 3 H acceptors: 3 LogP: 0.92 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)C)NCC1(N)CCN(C1)c1ncnc2c1c(C)c[nH]2
  • InChi: 1S/C16H24N6O/c1-10(2)15(23)19-7-16(17)4-5-22(8-16)14-12-11(3)6-18-13(12)20-9-21-14/h6,9-10H,4-5,7-8,17H2,1-3H3,(H,19,23)(H,18,20,21)
  • InChiKey: XWOXIQHSCKISQW-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.016 0.1529 0.6992
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.041 0.0787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0484 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Schistosoma mansoni single-minded 0.005 0.0301 0.063
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.041 0.0787
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0084 0.0108
Brugia malayi jmjC domain containing protein 0.0062 0.0439 0.1799
Echinococcus multilocularis cysteine protease 0.0034 0.0125 0.0197
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0469 0.1943
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0484 0.0636
Entamoeba histolytica hypothetical protein 0.0048 0.0283 0.4412
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0493 0.1819
Brugia malayi Cathepsin L-like precursor 0.0034 0.0125 0.0304
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.041 0.0787
Leishmania major cathepsin L-like protease 0.0034 0.0125 0.0371
Loa Loa (eye worm) ctsf protein 0.0034 0.0125 0.0496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Plasmodium vivax vivapain-2 0.0034 0.0125 0.0055
Loa Loa (eye worm) hypothetical protein 0.006 0.041 0.1825
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0156 0.0453
Leishmania major cathepsin L-like protease 0.0034 0.0125 0.0371
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0301 0.063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0125 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2021 0.9351
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0283 0.1795
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Brugia malayi Cam kinase protein 1 0.0066 0.0484 0.2014
Onchocerca volvulus 0.0034 0.0125 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0484 0.0404
Onchocerca volvulus 0.003 0.0084 0.0058
Schistosoma mansoni protein kinase 0.0066 0.0484 0.113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Schistosoma mansoni lamin 0.0053 0.0336 0.0726
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0076 0.0589 0.0797
Onchocerca volvulus 0.003 0.0084 0.0058
Loa Loa (eye worm) cysteine protease 0.0034 0.0125 0.0496
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0484 0.0417
Loa Loa (eye worm) hypothetical protein 0.016 0.1529 0.7051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0336 0.1481
Schistosoma mansoni intermediate filament proteins 0.0053 0.0336 0.0726
Echinococcus granulosus single minded 2 0.0037 0.0156 0.0262
Leishmania major cathepsin L-like protease 0.0034 0.0125 0.0371
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0071 0.0085
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0156 0.0262
Brugia malayi jmjC domain containing protein 0.0062 0.0439 0.1799
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Brugia malayi Sugar transporter family protein 0.0217 0.216 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.0042 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0125 0.0183
Trypanosoma brucei glucose transporter 2A 0.0067 0.0493 0.3684
Echinococcus granulosus lamin 0.0053 0.0336 0.0634
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0469 0.091
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0469 0.091
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0283 0.3046
Echinococcus multilocularis lamin dm0 0.0053 0.0336 0.0634
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0283 0.0201
Mycobacterium ulcerans sugar transporter 0.003 0.0084 0.2954
Echinococcus multilocularis musashi 0.0053 0.0336 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0493 0.1819
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0125 0.024
Brugia malayi Cathepsin L-like precursor 0.0034 0.0125 0.0304
Onchocerca volvulus Huntingtin homolog 0.0126 0.1146 0.4749
Onchocerca volvulus 0.003 0.0084 0.0058
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0112
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0469 0.171
Echinococcus granulosus cathepsin l1 0.0034 0.0125 0.0197
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.1468 0.6765
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.041 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Entamoeba histolytica protein kinase, putative 0.0066 0.0484 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0125 0.0197
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0283 0.1059
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0059 0.006
Onchocerca volvulus 0.003 0.0084 0.0058
Toxoplasma gondii sugar transporter ST3 0.003 0.0084 0.002
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0484 0.0404
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0484 0.2172
Onchocerca volvulus 0.006 0.041 0.1497
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0493 0.3684
Brugia malayi Cathepsin L-like precursor 0.0034 0.0125 0.0304
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0484 0.0417
Plasmodium vivax sugar transporter, putative 0.003 0.0084 0.0013
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0469 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Leishmania major cathepsin L-like protease 0.013 0.1196 1
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0493 0.3684
Loa Loa (eye worm) hypothetical protein 0.0034 0.0125 0.0496
Loa Loa (eye worm) hypothetical protein 0.0029 0.0071 0.0242
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0438 0.0846
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2336 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0469 0.109
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0071 0.0085
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Echinococcus granulosus intermediate filament protein 0.0053 0.0336 0.0634
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0217 0.0591
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0119 0.107 0.8867
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0589 0.4545
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0283 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0439 0.1007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0439 0.0847
Onchocerca volvulus 0.0037 0.0156 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0283 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0484 0.113
Loa Loa (eye worm) hypothetical protein 0.0126 0.1146 0.5266
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0589 0.4545
Schistosoma mansoni lipoxygenase 0.025 0.2528 0.6722
Onchocerca volvulus 0.003 0.0084 0.0058
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0336 0.1309
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0036
Onchocerca volvulus 0.0053 0.0336 0.1171
Plasmodium falciparum protein kinase 7 0.0612 0.6571 0.6542
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0357 0.3726 0.7656
Trypanosoma cruzi cruzipain precursor, putative 0.013 0.1196 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Onchocerca volvulus 0.003 0.0084 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.1196 1
Onchocerca volvulus 0.003 0.0084 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0125 0.0149
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Onchocerca volvulus 0.016 0.1529 0.6437
Brugia malayi hypothetical protein 0.0126 0.1146 0.517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Loa Loa (eye worm) sugar transporter 0.0217 0.216 1
Schistosoma mansoni lipoxygenase 0.0357 0.3726 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0333 0.1294
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0125 0.0496
Echinococcus multilocularis General substrate transporter 0.0186 0.1821 0.3709
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0084 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0125 0.0042
Schistosoma mansoni polycystin 1-related 0.006 0.041 0.0928
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Brugia malayi major facilitator superfamily protein 0.003 0.0084 0.0108
Plasmodium vivax hexose transporter 0.0217 0.216 0.2105
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0283 0.0327
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0125 0.0371
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0051
Toxoplasma gondii cathepsin CPL 0.0034 0.0125 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Onchocerca volvulus Huntingtin homolog 0.0126 0.1146 0.4749
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0484 0.0404
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.035 0.3649 0.5504
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.0885 0.7206
Brugia malayi hypothetical protein 0.003 0.0084 0.0108
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0084 0.2954
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0493 0.1819
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0493 0.3684
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Onchocerca volvulus 0.003 0.0084 0.0058
Schistosoma mansoni glucose transport protein 0.0217 0.216 0.5717
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0469 0.2102
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0156 0.551
Schistosoma mansoni rab6-interacting 0.006 0.041 0.0928
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0493 0.3684
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0484 0.0417
Trypanosoma cruzi hexose transporter 0.0067 0.0493 0.3684
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0084 0.0303
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.4858 1
Brugia malayi hypoxia-induced factor 1 0.0155 0.1468 0.67
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Brugia malayi Sugar transporter family protein 0.003 0.0084 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0493 0.1819
Brugia malayi Cathepsin L-like precursor 0.0034 0.0125 0.0304
Loa Loa (eye worm) fibroinase 0.0034 0.0125 0.0496
Loa Loa (eye worm) hypothetical protein 0.006 0.041 0.1825
Onchocerca volvulus 0.0034 0.0125 0.024
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0484 0.0404
Entamoeba histolytica protein kinase, putative 0.0066 0.0484 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0084 0.5
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0125 0.024
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Brugia malayi hypothetical protein 0.006 0.041 0.1661
Onchocerca volvulus 0.003 0.0084 0.0058
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0146 0.0407
Onchocerca volvulus 0.003 0.0084 0.0058
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Brugia malayi Cathepsin L-like precursor 0.0034 0.0125 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0125 0.0304
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0439 0.0847
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0484 0.0404
Leishmania major cathepsin L-like protease 0.0034 0.0125 0.0371
Leishmania major glucose transporter, lmgt3 0.0067 0.0493 0.3684
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0493 0.1819
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Leishmania major cathepsin L-like protease 0.013 0.1196 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0112
Echinococcus multilocularis cysteine protease 0.0034 0.0125 0.0197
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.041 0.0787
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0589 0.4545
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0125 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0154 0.0628
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0084 0.0036
Schistosoma mansoni loxhd1 0.006 0.041 0.0928
Onchocerca volvulus 0.0232 0.2336 1
Schistosoma mansoni glucose transporter 0.003 0.0084 0.0036
Brugia malayi Cathepsin L-like precursor 0.0034 0.0125 0.0304
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0438 0.0846
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0439 0.1961
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0336 0.1481
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0283 0.0582
Toxoplasma gondii sugar transporter ST1 0.003 0.0084 0.002
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0283 0.0886
Onchocerca volvulus 0.003 0.0084 0.0058
Toxoplasma gondii sugar transporter ST2 0.003 0.0084 0.002
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0469 0.1943
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0112
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.4858 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0283 0.0214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0125 0.0197
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Onchocerca volvulus 0.0034 0.0125 0.024
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0125 0.0371
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0125 0.024
Loa Loa (eye worm) hypothetical protein 0.0052 0.0325 0.143
Brugia malayi hypothetical protein 0.003 0.0084 0.0108
Echinococcus multilocularis solute carrier family 22 0.003 0.0084 0.0112
Plasmodium falciparum mitogen-activated protein kinase 2 0.035 0.3649 0.3595
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0484 0.1777
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0112
Plasmodium falciparum hexose transporter 0.0217 0.216 0.2094
Schistosoma mansoni lamin 0.0053 0.0336 0.0726
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0061 0.0197
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0283 0.1795
Brugia malayi Doublecortin family protein 0.006 0.041 0.1661
Plasmodium vivax CDK-related protein kinase 6, putative 0.092 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0202 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.035 0.3649 0.3604
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0596
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0084 0.0112
Loa Loa (eye worm) hypothetical protein 0.0053 0.0333 0.1467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0217 0.216 0.3215
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Schistosoma mansoni protein kinase 0.0066 0.0484 0.113
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0071 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0283 0.0525
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0333 0.1466
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.041 0.0341
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0484 0.2014
Loa Loa (eye worm) hypothetical protein 0.0126 0.1146 0.5266
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Echinococcus granulosus lamin dm0 0.0053 0.0336 0.0634
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0469 0.9583
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0333 0.1294
Echinococcus granulosus RUN 0.006 0.041 0.0787
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.1196 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.013 0.1196 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0484 0.2172
Treponema pallidum prolyl-tRNA synthetase 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0084 0.0108
Schistosoma mansoni sugar transporter 0.003 0.0084 0.0036
Schistosoma mansoni protein kinase 0.0066 0.0484 0.113
Echinococcus multilocularis lamin 0.0053 0.0336 0.0634
Onchocerca volvulus 0.003 0.0084 0.0058
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0202 1
Schistosoma mansoni hypothetical protein 0.0217 0.216 0.5717
Loa Loa (eye worm) hypothetical protein 0.0048 0.0283 0.1235
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0125 0.0042
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0112
Trypanosoma brucei glucose transporter, putative 0.0067 0.0493 0.3684
Brugia malayi intermediate filament protein 0.0053 0.0336 0.1309
Plasmodium falciparum LCCL domain-containing protein 0.006 0.041 0.0329
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0493 0.3684
Loa Loa (eye worm) doublecortin family protein 0.006 0.041 0.1825
Onchocerca volvulus 0.0034 0.0125 0.024
Schistosoma mansoni hypothetical protein 0.0036 0.0146 0.0208
Schistosoma mansoni glucose transport protein 0.0217 0.216 0.5717
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0484 0.3599
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0493 0.3684
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0283 0.0525
Brugia malayi hypothetical protein 0.006 0.041 0.1661
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0125 0.0183
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0484 0.0941
Leishmania major glucose transporter, lmgt2 0.0067 0.0493 0.3684
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0493 0.3684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Loa Loa (eye worm) sugar transporter 0.003 0.0084 0.0303
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0084 0.2954
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0125 0.0149
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.041 0.0787
Plasmodium falciparum proline--tRNA ligase 0.0076 0.0589 0.051
Onchocerca volvulus Putative transporter 0.003 0.0084 0.0058
Loa Loa (eye worm) hypothetical protein 0.0168 0.1612 0.7441
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0469 0.109
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0125 0.0496
Loa Loa (eye worm) hypothetical protein 0.0053 0.0333 0.1466
Toxoplasma gondii protein kinase, putative 0.0612 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0493 0.1819
Onchocerca volvulus 0.003 0.0084 0.0058
Plasmodium vivax proline--tRNA ligase, putative 0.0076 0.0589 0.0522
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.4858 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0125 0.0183
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Leishmania major glucose transporter, lmgt1 0.0067 0.0493 0.3684
Onchocerca volvulus 0.0034 0.0125 0.024
Onchocerca volvulus 0.006 0.041 0.1497
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0439 0.0847
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0439 0.1007
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.216 0.4413
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0357 0.3726 0.7656
Echinococcus multilocularis RUN 0.006 0.041 0.0787
Leishmania major protein kinase, putative 0.0066 0.0484 0.3599
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0439 0.1007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Loa Loa (eye worm) hypothetical protein 0.0053 0.0336 0.1481
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0484 0.2172
Brugia malayi Pre-SET motif family protein 0.0029 0.0071 0.0045
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0084 0.0303
Loa Loa (eye worm) hypothetical protein 0.0065 0.0469 0.2102
Brugia malayi major facilitator superfamily protein 0.003 0.0084 0.0108
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0217 0.216 0.4413
Onchocerca volvulus 0.0053 0.0336 0.1171
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0084 0.2954
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0125 0.0183
Echinococcus granulosus solute carrier family 22 0.003 0.0084 0.0112
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0283 1
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0084 0.0112
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0283 0.5182
Schistosoma mansoni hypothetical protein 0.006 0.041 0.0928
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0439 0.0847
Brugia malayi Sugar transporter family protein 0.003 0.0084 0.0108
Trypanosoma brucei glucose transporter 1E 0.0067 0.0493 0.3684
Brugia malayi hypothetical protein 0.003 0.0084 0.0108
Onchocerca volvulus 0.0034 0.0125 0.024
Schistosoma mansoni glucose transport protein 0.0217 0.216 0.5717
Onchocerca volvulus 0.0034 0.0125 0.024
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0084 0.0112
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0484 0.0636
Onchocerca volvulus 0.003 0.0084 0.0058
Brugia malayi Pre-SET motif family protein 0.0204 0.2021 0.9338
Leishmania major cathepsin L-like protease 0.013 0.1196 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0125 0.0197
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0484 0.0636
Echinococcus granulosus General substrate transporter 0.0186 0.1821 0.3709
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0084 0.002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0125 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.216 0.922
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0303
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0469 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0125 0.0197
Leishmania major cathepsin L-like protease 0.0034 0.0125 0.0371
Onchocerca volvulus 0.003 0.0084 0.0058
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0283 0.1795
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0589 0.4545
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0484 0.0941
Plasmodium vivax vivapain-2 0.0034 0.0125 0.0055
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0589 0.4545
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0084 0.0112
Schistosoma mansoni rab6-interacting 0.006 0.041 0.0928
Onchocerca volvulus 0.003 0.0084 0.0058
Echinococcus granulosus neuropeptide s receptor 0.0459 0.4858 1
Brugia malayi hypothetical protein 0.0168 0.1612 0.7389
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0493 0.1819
Trypanosoma cruzi cysteine peptidase, putative 0.013 0.1196 1
Brugia malayi PAS domain containing protein 0.005 0.0301 0.1142

Activities

Activity type Activity value Assay description Source Reference
Ratio (binding) = 50 Inhibition of AKT1 after 90 mins by IMAP assay ChEMBL. 20481595

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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