Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Beta-2 adrenergic receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0181 | 0.05 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0181 | 0.05 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0181 | 0.05 | 0.05 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0251 | 0.0788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.05 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.05 | 0.05 |
Echinococcus granulosus | tumor protein p63 | 0.1714 | 0.6872 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2466 | 1 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2466 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.0788 | 0.0788 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.05 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0181 | 0.05 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0181 | 0.05 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0181 | 0.05 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0181 | 0.05 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.05 | 0.05 |
Plasmodium vivax | hypothetical protein, conserved | 0.0181 | 0.05 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0181 | 0.05 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.2466 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2466 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0181 | 0.05 | 0.5 |
Brugia malayi | beta-lactamase | 0.0181 | 0.05 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0181 | 0.05 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0181 | 0.05 | 0.6341 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0231 | 0.0231 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0181 | 0.05 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.05 | 0.05 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0231 | 0.4611 |
Echinococcus multilocularis | tumor protein p63 | 0.1714 | 0.6872 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0231 | 0.0231 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0181 | 0.05 | 0.6341 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0181 | 0.05 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0181 | 0.05 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0181 | 0.05 | 0.5 |
Onchocerca volvulus | 0.0251 | 0.0788 | 1 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0181 | 0.05 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0181 | 0.05 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0181 | 0.05 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0181 | 0.05 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.05 | 0.05 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.05 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0181 | 0.05 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.05 | 0.05 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.1159 | 0.4567 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0181 | 0.05 | 0.05 |
Mycobacterium ulcerans | beta-lactamase | 0.0181 | 0.05 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0181 | 0.05 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log KD (binding) | = 8.05 | Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]-dihydroalprenolol (DHA) | ChEMBL. | 2993621 |
Kd (binding) | = 17.78 nM | Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]-dihydroalprenolol (DHA) | ChEMBL. | 2993621 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.