Detailed information for compound 1157380

Basic information

Technical information
  • TDR Targets ID: 1157380
  • Name: 2-[(furan-2-ylmethylamino)methyl]chroman-7-ol
  • MW: 259.3 | Formula: C15H17NO3
  • H donors: 2 H acceptors: 1 LogP: 2.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)OC(CC2)CNCc1ccco1
  • InChi: 1S/C15H17NO3/c17-12-5-3-11-4-6-14(19-15(11)8-12)10-16-9-13-2-1-7-18-13/h1-3,5,7-8,14,16-17H,4,6,9-10H2
  • InChiKey: VGDCLOXHDNBUQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(2-furylmethylamino)methyl]chroman-7-ol
  • 2-[(2-furylmethylamino)methyl]-7-chromanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0188 0.63
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0255 0.8765
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.0022
Schistosoma mansoni ran 0.0023 0.0074 0.0077
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0255 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0291 0.076
Schistosoma mansoni hypothetical protein 0.0114 0.1348 0.1396
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.0022
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0074 0.0077
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0026
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0188 0.5257
Onchocerca volvulus 0.0151 0.1854 1
Schistosoma mansoni smad1 5 8 and 0.005 0.0454 0.047
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0291 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Echinococcus multilocularis geminin 0.0712 0.9661 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0291 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.027 0.0279
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0047 0.0049
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0291 0.076
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0291 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0047 0.0049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.1348 0.1396
Entamoeba histolytica hypothetical protein 0.0037 0.027 0.9189
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0068 0.0043
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0025 0.0026
Schistosoma mansoni smad 0.005 0.0454 0.047
Schistosoma mansoni hypothetical protein 0.0712 0.9661 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0291 1
Schistosoma mansoni hypothetical protein 0.0114 0.1348 0.1396
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.0022
Loa Loa (eye worm) hypothetical protein 0.0247 0.3196 0.3179
Echinococcus granulosus importin subunit beta 1 0.0031 0.0188 0.0195
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.4372 0.4358
Echinococcus granulosus dna polymerase kappa 0.0038 0.0291 0.0301
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0068 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0255 0.8765
Schistosoma mansoni hypothetical protein 0.0247 0.3196 0.3308
Brugia malayi MH1 domain containing protein 0.005 0.0454 0.043
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.2347 0.2328
Loa Loa (eye worm) hypothetical protein 0.0031 0.0188 0.0164
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0454 0.047
Brugia malayi Smad1 0.005 0.0454 0.043
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0291 1
Echinococcus multilocularis snurportin 1 0.0332 0.4372 0.4525
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.0022
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.0026
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0291 0.076
Schistosoma mansoni DNA polymerase eta 0.0038 0.0291 0.0301
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0074 0.0049
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.0037 0.027 0.0279
Loa Loa (eye worm) nuclear factor I 0.0028 0.0142 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.1348 0.1327
Schistosoma mansoni hypothetical protein 0.0114 0.1348 0.1396
Echinococcus granulosus dna polymerase eta 0.0038 0.0291 0.0301
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0101 0.0072
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0291 0.0301
Brugia malayi nuclear receptor NHR-88 0.0021 0.0047 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0047 0.0022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.2347 0.2328
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0293 0.3831 1
Giardia lamblia DINP protein human, muc B family 0.0038 0.0291 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0025 0.0026
Brugia malayi latrophilin 2 splice variant baaae 0.0247 0.3196 0.3179
Leishmania major hypothetical protein, conserved 0.0025 0.0101 0.1251
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0047 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0025 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0291 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0025 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0255 0.8765
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0047 0.0049
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.0026
Brugia malayi hypothetical protein 0.0151 0.1854 0.1833
Entamoeba histolytica hypothetical protein 0.0036 0.0255 0.865
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0255 0.0482
Loa Loa (eye worm) Smad1 0.005 0.0454 0.043
Echinococcus multilocularis smad 0.005 0.0454 0.047
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0101 0.1251
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0855
Schistosoma mansoni ran 0.0023 0.0074 0.0077
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0049
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0106 0.1491
Schistosoma mansoni smad 0.0022 0.0068 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0068 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0047 0.0022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0047 0.0049
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0068 0.007
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0068 0.0043
Schistosoma mansoni importin beta-1 0.0031 0.0188 0.0195
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0026
Echinococcus multilocularis expressed protein 0.0376 0.4996 0.5171
Schistosoma mansoni hypothetical protein 0.0114 0.1348 0.1396
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0026
Treponema pallidum hypothetical protein 0.0293 0.3831 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0291 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0291 1
Echinococcus multilocularis GPCR, family 2 0.0114 0.1348 0.1396
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0125 0.2348
Schistosoma mansoni Smad4 0.0022 0.0068 0.007
Brugia malayi hypothetical protein 0.0025 0.0101 0.0076
Plasmodium falciparum importin beta, putative 0.0031 0.0188 0.0304
Entamoeba histolytica hypothetical protein 0.0037 0.027 0.9189
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0068 0.0115
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0454 0.043
Schistosoma mansoni transcription factor btf3 0.0036 0.0255 0.0264
Schistosoma mansoni smad1 5 8 and 0.005 0.0454 0.047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0101 0.0076
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.1348 0.1396
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0047 0.0049
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0026
Brugia malayi steroid hormone receptor 0.0021 0.0047 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0855
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0362 0.4788 0.4775
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2347 0.243
Loa Loa (eye worm) transcription factor SMAD2 0.0736 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0026
Entamoeba histolytica hypothetical protein 0.0025 0.0106 0.3061
Leishmania major importin beta-1 subunit, putative 0.0025 0.0106 0.1491
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0026
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0362 0.4788 0.4775
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0047 0.0049
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0074 0.0077
Entamoeba histolytica hypothetical protein 0.0037 0.027 0.9189
Echinococcus granulosus transcription factor btf3 0.0036 0.0255 0.0264
Leishmania major basic transcription factor 3a, putative 0.0036 0.0255 0.8344
Brugia malayi MH1 domain containing protein 0.0028 0.0142 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0142 0.0117
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0454 0.047
Brugia malayi beta-NAC-like protein 0.0036 0.0255 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0125 0.2348
Brugia malayi hypothetical protein 0.0037 0.027 0.0245
Loa Loa (eye worm) hypothetical protein 0.0151 0.1854 0.1833
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0101 0.0072
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0291 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0047 0.0049
Brugia malayi MH2 domain containing protein 0.005 0.0454 0.043
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0267
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0025 0.0855
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0047 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2347 0.243
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0255 0.0482
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0047 0.0049
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.027 0.0279
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0 0.5
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0068 0.007
Trypanosoma brucei unspecified product 0.0027 0.0125 0.2348
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0047 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0454 0.043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0047 0.0049
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0255 0.8344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0049
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0291 0.0301
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0255 0.865
Echinococcus multilocularis Smad4 0.005 0.0454 0.047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2347 0.243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2347 0.243
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0106 0.3655
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0047 0.0049
Echinococcus multilocularis transcription factor btf3 0.0036 0.0255 0.0264
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0101 0.1251
Loa Loa (eye worm) hypothetical protein 0.0362 0.4788 0.4775
Brugia malayi ecdysteroid receptor 0.0021 0.0047 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2347 0.243
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0855
Loa Loa (eye worm) MH2 domain-containing protein 0.0736 1 1
Echinococcus multilocularis dna polymerase eta 0.0038 0.0291 0.0301
Schistosoma mansoni Smad4 0.005 0.0454 0.047
Leishmania major DNA polymerase eta, putative 0.0038 0.0291 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0047 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0047 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0255 0.0231
Echinococcus granulosus snurportin 1 0.0332 0.4372 0.4525
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0025 0.0026
Brugia malayi MH2 domain containing protein 0.0022 0.0068 0.0043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.1348 0.1396
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0293 0.3831 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0047 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0047 0.0022
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0026
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0101 0.1251
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0047 0.0022
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0068 0.0043
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0291 0.0301
Leishmania major DNA polymerase kappa, putative 0.0038 0.0291 1
Echinococcus granulosus smad 0.005 0.0454 0.047
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.1327
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0047 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0047 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0047 0.0049
Echinococcus granulosus GPCR family 2 0.0114 0.1348 0.1396
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0255 0.8344
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0026
Brugia malayi Importin beta-1 subunit 0.0031 0.0188 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2347 0.243
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0855
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0101 0.15
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0188 0.5257
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0454 0.047
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0188 0.0195
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0026
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0106 0.3655
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0047 0.0049
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0025 0.0026
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0106 0.3655
Brugia malayi nuclear hormone receptor 0.0021 0.0047 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0114 0.1348 0.1327
Schistosoma mansoni smad1 5 8 and 0.005 0.0454 0.047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0047 0.0049
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0068 0.007
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0293 0.3831 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0291 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.0022
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0125 0.2348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0047 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2347 0.243
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0291 0.076
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0047 0.0049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0291 1
Schistosoma mansoni Smad4 0.0022 0.0068 0.007
Trypanosoma brucei unspecified product 0.0027 0.0125 0.2348
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.0712 0.9661 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0101 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Schistosoma mansoni coup transcription factor 0.0021 0.0047 0.0049
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.1348 0.1327
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0291 0.0301
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0047 0.0022
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0074 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0291 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0047 0.0049
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0047 0.0049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0454 0.047
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0047 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0293 0.3831 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0047 0.0022
Echinococcus granulosus Smad4 0.005 0.0454 0.047
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0047 0.0049
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0454 0.047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0047 0.0022
Plasmodium vivax importin-beta 2, putative 0.0031 0.0188 0.0304
Brugia malayi Calcitonin receptor-like protein seb-1 0.0362 0.4788 0.4775
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0025 0.0026
Trypanosoma brucei unspecified product 0.0038 0.0291 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0291 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0025 0.0026
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0291 0.0267
Brugia malayi MH1 domain containing protein 0.005 0.0454 0.043
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0025 0.0026
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0291 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0291 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0047 0.0049
Entamoeba histolytica Ran family GTPase 0.0023 0.0074 0.1845
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0047 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.1348 0.1396
Schistosoma mansoni hypothetical protein 0.0332 0.4372 0.4525
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0291 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0026
Brugia malayi RNA, U transporter 1 0.0088 0.0985 0.0963
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Brugia malayi MH1 domain containing protein 0.0028 0.0142 0.0117
Echinococcus granulosus expressed protein 0.0376 0.4996 0.5171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0047 0.0049
Trichomonas vaginalis ran, putative 0.0023 0.0074 0.2543
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0255 0.8344
Entamoeba histolytica hypothetical protein 0.0037 0.027 0.9189
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.027 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0047 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0291 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0025 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0855
Brugia malayi MH2 domain containing protein 0.005 0.0454 0.043
Echinococcus granulosus geminin 0.0712 0.9661 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0293 0.3831 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0047 0.0022
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0047 0.0022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.