TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 141.131 | Formula: C4H7N5O
H donors: 2 H acceptors: 3 LogP: -0.74 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: N1CC(C1)Oc1nnn[nH]1
InChi: 1S/C4H7N5O/c1-3(2-5-1)10-4-6-8-9-7-4/h3,5H,1-2H2,(H,6,7,8,9)
InChiKey: QFIJNFFDXFVYNN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0036	0.0263	0.0537
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0177	0.3593	0.7185
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.1072	0.219
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0165	0.3297	0.9176
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0457	0.0934
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0076	0.1201	0.3344
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0036	0.0263	0.0732
Onchocerca volvulus		0.0177	0.3593	1
Echinococcus granulosus	cysteine protease	0.0093	0.1613	0.2913
Plasmodium falciparum	serine repeat antigen 9	0.0036	0.0263	0.0732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.2243	0.5946
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.1072	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0093	0.1613	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0177	0.3593	0.7337
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0036	0.0263	0.0732
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0457	0.0584
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0534	0.0813
Loa Loa (eye worm)	hypothetical protein	0.007	0.1072	0.219
Onchocerca volvulus		0.012	0.2243	0.5946
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.1072	0.2984
Brugia malayi	cathepsin B-like cysteine proteinase	0.0165	0.3297	0.6732
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0036	0.0263	0.0732
Trypanosoma cruzi	cysteine protease, putative	0.0093	0.1613	0.4489
Loa Loa (eye worm)	hypothetical protein	0.007	0.1072	0.219
Onchocerca volvulus	Cathepsin F homolog	0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0263	0.0537
Brugia malayi	Papain family cysteine protease containing protein	0.0177	0.3593	0.7337
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.0766	0.2131
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0036	0.0263	0.0537
Giardia lamblia	Cathepsin B precursor	0.0076	0.1201	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0177	0.3593	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Plasmodium vivax	unspecified product	0.0057	0.0766	0.2131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.1613	0.4489
Schistosoma mansoni	cathepsin F (C01 family)	0.0177	0.3593	1
Entamoeba histolytica	cysteine proteinase, putative	0.0177	0.3593	1
Echinococcus multilocularis	cathepsin b	0.0165	0.3297	0.6546
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.3593	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.1072	0.243
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0457	0.0584
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.1072	0.219
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0457	0.0584
Trypanosoma cruzi	major cysteine proteinase, putative	0.0036	0.0263	0.0732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1613	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0177	0.3593	0.7337
Giardia lamblia	Cathepsin B precursor	0.0076	0.1201	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0177	0.3593	0.7185
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.3593	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0036	0.0263	0.0732
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0263	0.0537
Plasmodium vivax	vivapain-3	0.0093	0.1613	0.4489
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.1613	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0165	0.3297	0.9111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1072	0.219
Onchocerca volvulus		0.0047	0.0534	0.0813
Toxoplasma gondii	ABC1 family protein	0.007	0.1072	0.2984
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0076	0.1201	0.3344
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0036	0.0263	0.0732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0036	0.0263	0.0732
Brugia malayi	Papain family cysteine protease containing protein	0.0093	0.1613	0.3294
Plasmodium falciparum	serine repeat antigen 6	0.0036	0.0263	0.0732
Loa Loa (eye worm)	cysteine protease	0.0177	0.3593	0.7337
Brugia malayi	Cathepsin L-like precursor	0.0177	0.3593	0.7337
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0457	0.0934
Schistosoma mansoni	cathepsin F (C01 family)	0.012	0.2243	0.5946
Loa Loa (eye worm)	hypothetical protein	0.007	0.1072	0.219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0457	0.0419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0165	0.3297	0.6732
Brugia malayi	Cathepsin L-like precursor	0.0177	0.3593	0.7337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0177	0.3593	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Entamoeba histolytica	cysteine proteinase, putative	0.0177	0.3593	1
Plasmodium vivax	hypothetical protein, conserved	0.007	0.1072	0.2984
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0766	0.1563
Entamoeba histolytica	cysteine proteinase 2	0.0093	0.1613	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0263	0.0537
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.1072	0.1746
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.012	0.2243	0.6243
Onchocerca volvulus		0.0177	0.3593	1
Brugia malayi	cathepsin L precursor	0.0036	0.0263	0.0537
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0766	0.1563
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0534	0.0813
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0177	0.3593	1
Plasmodium vivax	vivapain-1	0.0093	0.1613	0.4489
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0076	0.1201	0.3344
Onchocerca volvulus		0.0177	0.3593	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	0.3297	0.9111
Brugia malayi	Cathepsin L-like precursor	0.0177	0.3593	0.7337
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.1072	0.2984
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0263	0.0537
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0177	0.3593	0.7337
Echinococcus granulosus	cathepsin b	0.0165	0.3297	0.6546
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Brugia malayi	beta-lactamase family protein	0.007	0.1072	0.219
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0177	0.3593	0.7185
Onchocerca volvulus		0.007	0.1072	0.243
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0036	0.0263	0.0732
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0177	0.3593	0.7185
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Leishmania major	cysteine peptidase A (CPA)	0.0177	0.3593	1
Plasmodium falciparum	serine repeat antigen 7	0.0036	0.0263	0.0732
Trypanosoma cruzi	cruzipain precursor, putative	0.0057	0.0766	0.2131
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0036	0.0263	0.0732
Loa Loa (eye worm)	fibroinase	0.0177	0.3593	0.7337
Loa Loa (eye worm)	beta-lactamase	0.007	0.1072	0.219
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0036	0.0263	0.0732
Brugia malayi	Cathepsin L-like precursor	0.012	0.2243	0.458
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0057	0.0766	0.1563
Plasmodium falciparum	serine repeat antigen 8	0.0036	0.0263	0.0732
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	0.3297	0.9111
Brugia malayi	Cathepsin L-like precursor	0.0177	0.3593	0.7337
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0457	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0766	0.1563
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.3593	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Mycobacterium leprae	Probable lipase LipE	0.007	0.1072	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0177	0.3593	1
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0177	0.3593	0.7337
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0093	0.1613	0.4489
Echinococcus multilocularis	cathepsin L	0.0093	0.1613	0.2913
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.1072	0.2984
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1613	0.4489
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0263	0.0537
Plasmodium falciparum	serine repeat antigen 5	0.0036	0.0263	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0263	0.0537
Trypanosoma cruzi	cysteine proteinase, putative	0.0093	0.1613	0.4489
Loa Loa (eye worm)	cathepsin B	0.0076	0.1201	0.2453
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.1613	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0093	0.1613	0.4489
Plasmodium vivax	serine-repeat antigen (SERA)	0.0036	0.0263	0.0732
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0076	0.1201	0.2818
Onchocerca volvulus		0.007	0.1072	0.243
Toxoplasma gondii	cathepsin CPC2	0.0036	0.0263	0.0732
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.4898	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0766	0.1563
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Brugia malayi	hypothetical protein	0.0233	0.4898	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0177	0.3593	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.1613	0.4489
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Onchocerca volvulus		0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1072	0.219
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0177	0.3593	1
Onchocerca volvulus		0.0177	0.3593	1
Loa Loa (eye worm)	ctsf protein	0.0177	0.3593	0.7337
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.012	0.2243	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0036	0.0263	0.0732
Echinococcus granulosus	cathepsin l1	0.0177	0.3593	0.7185
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.1613	0.4054
Brugia malayi	fibroinase precursor	0.0036	0.0263	0.0537
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0036	0.0263	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0766	0.1563
Toxoplasma gondii	cathepsin CPL	0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1072	0.219
Brugia malayi	cathepsin L-like precursor	0.012	0.2243	0.458
Trypanosoma cruzi	cruzipain precursor, putative	0.0177	0.3593	1
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0534	0.109
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.1613	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0093	0.1613	0.2913
Echinococcus granulosus	cathepsin l1	0.012	0.2243	0.4272
Brugia malayi	cathepsin L-like cysteine proteinase	0.0036	0.0263	0.0537
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0093	0.1613	0.4489
Giardia lamblia	Cathepsin B precursor	0.0076	0.1201	1
Mycobacterium ulcerans	beta-lactamase	0.007	0.1072	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.007	0.1072	0.5
Toxoplasma gondii	cathepsin CPC1	0.0036	0.0263	0.0732
Trichomonas vaginalis	esterase, putative	0.007	0.1072	0.243
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0036	0.0263	0.0732
Trypanosoma cruzi	major cysteine proteinase, putative	0.0036	0.0263	0.0732
Mycobacterium ulcerans	hypothetical protein	0.007	0.1072	0.5
Plasmodium falciparum	serine repeat antigen 2	0.0036	0.0263	0.0732
Mycobacterium leprae	conserved hypothetical protein	0.007	0.1072	0.5
Entamoeba histolytica	cysteine proteinase 1, putative	0.0093	0.1613	0.4054
Onchocerca volvulus		0.0177	0.3593	1
Brugia malayi	Cathepsin L-like precursor	0.012	0.2243	0.458
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Mycobacterium ulcerans	lipase LipD	0.007	0.1072	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0165	0.3297	0.9111
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0036	0.0263	0.0537
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.007	0.1072	0.5
Plasmodium vivax	unspecified product	0.0036	0.0263	0.0732
Onchocerca volvulus	Cathepsin L homolog	0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0263	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0233	0.4898	1
Echinococcus granulosus	cathepsin b	0.0165	0.3297	0.6546
Brugia malayi	Papain family cysteine protease containing protein	0.0093	0.1613	0.3294
Plasmodium falciparum	serine repeat antigen 1	0.0036	0.0263	0.0732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0177	0.3593	0.7185
Leishmania major	cathepsin L-like protease	0.0177	0.3593	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0036	0.0263	0.0732
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Toxoplasma gondii	cathepsin B	0.0076	0.1201	0.3344
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0457	0.0419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.012	0.2243	0.458
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0057	0.0766	0.1563
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Brugia malayi	beta-lactamase family protein	0.007	0.1072	0.219
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Onchocerca volvulus		0.007	0.1072	0.243
Brugia malayi	beta-lactamase	0.007	0.1072	0.219
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0036	0.0263	0.0732
Echinococcus granulosus	cathepsin L	0.0093	0.1613	0.2913
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0093	0.1613	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.1072	0.243
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0177	0.3593	1
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.1072	0.243
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0263	0.0537
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0036	0.0263	0.0732
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0177	0.3593	0.7185
Plasmodium falciparum	serine repeat antigen 3	0.0036	0.0263	0.0732
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0177	0.3593	1
Plasmodium falciparum	serine repeat antigen 4	0.0036	0.0263	0.0732
Loa Loa (eye worm)	hypothetical protein	0.012	0.2243	0.458
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0263	0.0537
Echinococcus multilocularis	cysteine protease	0.0177	0.3593	0.7185
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0093	0.1613	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0076	0.1201	0.2818
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.1072	0.243
Leishmania major	hypothetical protein, conserved	0.007	0.1072	0.2984
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0036	0.0263	0.0732
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Onchocerca volvulus		0.0177	0.3593	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2243	0.458
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Plasmodium vivax	unspecified product	0.0093	0.1613	0.4489
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0177	0.3593	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0263	0.0537
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.4898	1
Entamoeba histolytica	cysteine protease, putative	0.0093	0.1613	0.4054
Echinococcus multilocularis	cathepsin b	0.0165	0.3297	0.6546
Brugia malayi	Cathepsin L-like precursor	0.0177	0.3593	0.7337
Echinococcus multilocularis	cysteine protease	0.0177	0.3593	0.7185
Onchocerca volvulus	Cathepsin L homolog	0.0177	0.3593	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0177	0.3593	1
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0263	0.0537
Plasmodium vivax	vivapain-2	0.0177	0.3593	1
Entamoeba histolytica	cysteine proteinase, putative	0.012	0.2243	0.5946
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.1072	0.243
Schistosoma mansoni	cathepsin s	0.0057	0.0766	0.1509
Loa Loa (eye worm)	hypothetical protein	0.012	0.2243	0.458
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0177	0.3593	1
Plasmodium vivax	vivapain-2	0.0177	0.3593	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.1072	0.243
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0457	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0263	0.0537
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.1613	0.4054
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.1072	0.1746

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1199876

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1161426