Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0153 | 0.0284 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0008 | 0.0115 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0153 | 0.0284 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.063 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0175 | 0.0408 |
Brugia malayi | MBOAT family protein | 0.0153 | 0.0284 | 0.4009 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0153 | 0.0284 | 0.0663 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0294 | 0.0683 | 0.1595 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0153 | 0.0284 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.063 |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.0153 | 0.0284 | 0.0663 |
Onchocerca volvulus | 0.0294 | 0.0683 | 1 | |
Brugia malayi | hypothetical protein | 0.0272 | 0.0621 | 0.8771 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.3058 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0153 | 0.0284 | 0.5 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.0153 | 0.0284 | 0.0663 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0053 | 0.0001 | 0.0002 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0199 | 0.0413 | 0.6004 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0348 | 0.0834 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0041 | 0.0488 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0303 | 0.0708 | 1 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0008 | 0.0019 |
Plasmodium falciparum | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase | 0.3588 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0167 | 0.0324 | 0.0758 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.0057 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0621 | 0.145 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0303 | 0.0708 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0303 | 0.0708 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0294 | 0.0683 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.063 |
Plasmodium vivax | hydroxymethylpterin pyrophosphokinase-dihydropteroate synthetase, putative | 0.3588 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0057 | 0.0134 |
Brugia malayi | MBOAT family protein | 0.0153 | 0.0284 | 0.4009 |
Brugia malayi | RNA binding protein | 0.0073 | 0.0057 | 0.081 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.006 | 0.002 | 0.0227 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.0153 | 0.0284 | 0.0663 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0153 | 0.0284 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0167 | 0.0324 | 0.4582 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.0153 | 0.0284 | 0.0663 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0164 | 0.0316 | 0.3469 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0303 | 0.0708 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0001 | 0.0002 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0053 | 0.0001 | 0.0012 |
Loa Loa (eye worm) | hhat protein | 0.0153 | 0.0284 | 0.0663 |
Brugia malayi | Hhat protein | 0.0153 | 0.0284 | 0.4009 |
Echinococcus multilocularis | GPCR, family 2 | 0.0053 | 0.0001 | 0.0002 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0153 | 0.0284 | 0.0663 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0008 | 0.0019 |
Trypanosoma cruzi | GUP1, putative | 0.0153 | 0.0284 | 0.3397 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0348 | 0.0834 | 1 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0057 | 0.0134 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.1566 | 0.4281 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0303 | 0.0708 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.0057 | 0.0134 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0348 | 0.0834 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0153 | 0.0284 | 0.0663 |
Mycobacterium tuberculosis | Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1) | 0.3588 | 1 | 1 |
Onchocerca volvulus | 0.0294 | 0.0683 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0209 | 0.0444 | 0.3766 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0153 | 0.0284 | 0.0274 |
Leishmania major | hypothetical protein, conserved | 0.0153 | 0.0284 | 0.063 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0294 | 0.0683 | 0.1595 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0284 | 0.0663 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0167 | 0.0324 | 0.4582 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0001 | 0.0002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0209 | 0.0444 | 0.3766 |
Mycobacterium leprae | Probable dihydropteroate synthase 1 FolP1 (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate dipyrophosphorylase 1) | 0.3588 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0303 | 0.0708 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.0153 | 0.0284 | 0.0663 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0294 | 0.0683 | 0.1595 |
Toxoplasma gondii | dihydropteroate synthase | 0.3588 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0164 | 0.0316 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0001 | 0.0002 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.1566 | 0.4281 | 1 |
Mycobacterium ulcerans | dihydropteroate synthase 1 FolP1 | 0.3588 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0067 | 0.0041 | 0.0488 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0153 | 0.0284 | 0.0663 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.0153 | 0.0284 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.1566 | 0.4281 | 1 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0153 | 0.0284 | 0.0663 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0057 | 0.0134 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0933 | 0.2491 | 0.5818 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0001 | 0.0002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0294 | 0.0683 | 0.1595 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0153 | 0.0284 | 0.0663 |
Brugia malayi | MBOAT family protein | 0.0153 | 0.0284 | 0.4009 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0153 | 0.0284 | 0.5 |
Leishmania major | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.063 |
Mycobacterium tuberculosis | Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2) | 0.1429 | 0.3893 | 0.3863 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0303 | 0.0708 | 1 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0153 | 0.0284 | 0.0663 |
Mycobacterium ulcerans | dihydropteroate synthase 2 FolP2 | 0.1429 | 0.3893 | 0.3863 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.3397 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0153 | 0.0284 | 0.0663 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0164 | 0.0316 | 0.3788 |
Toxoplasma gondii | hypothetical protein | 0.0153 | 0.0284 | 0.0274 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.0049 | 0.0039 |
Leishmania major | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.063 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0324 | 0.0758 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.0049 | 0.0114 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0153 | 0.0284 | 0.0663 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.0153 | 0.0284 | 0.0663 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.0025 | 0.029 |
Mycobacterium ulcerans | B12-dependent methionine synthase | 0.1429 | 0.3893 | 0.3863 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.0057 | 0.081 |
Brugia malayi | MBOAT family protein | 0.0153 | 0.0284 | 0.4009 |
Brugia malayi | MBOAT family protein | 0.0153 | 0.0284 | 0.4009 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0057 | 0.0134 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0294 | 0.0683 | 0.9412 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0041 | 0.0488 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0303 | 0.0708 | 0.1653 |
Entamoeba histolytica | hypothetical protein | 0.0153 | 0.0284 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0049 | 0.0114 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0053 | 0.0001 | 0.0002 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0284 | 0.0663 |
Trypanosoma cruzi | GUP1, putative | 0.0153 | 0.0284 | 0.3397 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.0284 | 0.0663 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0114 | 0.0175 | 0.2466 |
Leishmania major | methionine synthase, putative | 0.1429 | 0.3893 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.3397 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0272 | 0.0621 | 0.145 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0001 | 0.0002 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0153 | 0.0284 | 0.0274 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.1566 | 0.4281 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0348 | 0.0834 | 0.2059 |
Schistosoma mansoni | zinc finger protein | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.0049 | 0.0019 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.0057 | 0.081 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0153 | 0.0284 | 0.0663 |
Brugia malayi | Protein kinase domain containing protein | 0.0294 | 0.0683 | 0.9648 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0067 | 0.0041 | 0.0488 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0153 | 0.0284 | 0.0663 |
Mycobacterium ulcerans | hypothetical protein | 0.0183 | 0.0369 | 0.0322 |
Loa Loa (eye worm) | hhat protein | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0272 | 0.0621 | 0.145 |
Loa Loa (eye worm) | MBOAT family protein | 0.0153 | 0.0284 | 0.0663 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.0057 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0284 | 0.0663 |
Echinococcus granulosus | GPCR family 2 | 0.0053 | 0.0001 | 0.0002 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.0049 | 0.0114 |
Brugia malayi | diacylglycerol acyltransferase | 0.0153 | 0.0284 | 0.4009 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.3058 |
Loa Loa (eye worm) | MBOAT family protein | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0294 | 0.0683 | 0.9412 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0053 | 0.0001 | 0.0002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.0057 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0175 | 0.0408 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0153 | 0.0284 | 0.0663 |
Onchocerca volvulus | 0.0153 | 0.0284 | 0.4086 | |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0153 | 0.0284 | 0.0663 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.0057 | 0.0134 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0049 | 0.0114 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0183 | 0.0369 | 0.0322 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0153 | 0.0284 | 0.3397 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0153 | 0.0284 | 0.0663 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0199 | 0.0413 | 0.3052 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.0057 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.1413 | 0.3849 | 0.8989 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0294 | 0.0683 | 0.9412 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0053 | 0.0001 | 0.0012 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0153 | 0.0284 | 0.0663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.