Detailed information for compound 1169775

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 625.392 | Formula: C19H34NO16P3
  • H donors: 9 H acceptors: 12 LogP: -4.56 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@H]1[C@@H](OCCNC(=O)C23CC4CC(C3)CC(C2)C4)[C@@H](OP(=O)(O)O)[C@@H]([C@H]([C@@H]1OP(=O)(O)O)OP(=O)(O)O)O
  • InChi: 1S/C19H34NO16P3/c21-12-14(33-2-1-20-18(23)19-6-9-3-10(7-19)5-11(4-9)8-19)15(34-37(24,25)26)13(22)17(36-39(30,31)32)16(12)35-38(27,28)29/h9-17,21-22H,1-8H2,(H,20,23)(H2,24,25,26)(H2,27,28,29)(H2,30,31,32)/t9?,10?,11?,12-,13-,14+,15-,16+,17+,19?/m0/s1
  • InChiKey: CHOSAADDMFDSAS-PNRLNZIISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol 1,4,5-trisphosphate receptor type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni inositol 145-trisphosphate receptor Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma japonicum Inositol 1,4,5-trisphosphate receptor type 1, putative Get druggable targets OG5_129492 All targets in OG5_129492
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma mansoni inositol 145-trisphosphate receptor Get druggable targets OG5_129492 All targets in OG5_129492
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma japonicum ko:K04959 inositol 1,4,5-triphosphate receptor, type 2, putative Get druggable targets OG5_129492 All targets in OG5_129492
Schistosoma japonicum ko:K04958 inositol 1,4,5-triphosphate receptor, type 1, putative Get druggable targets OG5_129492 All targets in OG5_129492
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129492 All targets in OG5_129492
Brugia malayi cation channel family protein Get druggable targets OG5_129492 All targets in OG5_129492
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.0609 0.0596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Mycobacterium ulcerans hypothetical protein 0.0042 0.0148 0.1202
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0148 0.0784
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.243 0.5294
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0107 0.0609 0.0609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.0606 0.0606
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0148 0.0323
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0107 0.0609 0.0609
Echinococcus granulosus cathepsin b 0.144 1 1
Echinococcus multilocularis GA binding protein alpha chain 0.0083 0.0441 0.0441
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0196 0.0183
Giardia lamblia Encystation-specific protease 0.0156 0.0957 0.2522
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0128 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Plasmodium falciparum serine repeat antigen 5 0.0156 0.0957 0.2061
Echinococcus multilocularis ryanodine receptor 44f 0.0073 0.0369 0.0369
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.0957 0.2522
Loa Loa (eye worm) hypothetical protein 0.0033 0.009 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0148 0.0135
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.1004 0.1726
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0018 0.004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0957 0.0957
Plasmodium falciparum serine repeat antigen 6 0.0156 0.0957 0.2061
Echinococcus multilocularis geminin 0.0166 0.1022 0.1022
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.0957 0.2522
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0014 0.003
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0957 0.0957
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0018 0.004
Schistosoma mansoni hypothetical protein 0.0166 0.1022 0.1022
Giardia lamblia Cysteine protease 0.0156 0.0957 0.2522
Trypanosoma cruzi cysteine peptidase, putative 0.0672 0.4591 0.4584
Entamoeba histolytica cysteine protease, putative 0.0156 0.0957 0.2085
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0156 0.0957 0.2061
Plasmodium falciparum serine repeat antigen 1 0.0156 0.0957 0.2061
Mycobacterium ulcerans beta-lactamase 0.0042 0.0148 0.1202
Loa Loa (eye worm) hypothetical protein 0.0125 0.0739 0.0739
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0366 0.243 0.243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0672 0.4591 0.4591
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0148 0.0323
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0553 0.3754 0.3754
Onchocerca volvulus 0.0042 0.0148 0.0323
Schistosoma mansoni hypothetical protein 0.0166 0.1022 0.1022
Echinococcus multilocularis cathepsin L 0.0156 0.0957 0.0957
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0196 0.0183
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0627 0.4274 0.4266
Onchocerca volvulus 0.0672 0.4591 1
Giardia lamblia Cathepsin B precursor 0.0553 0.3754 1
Plasmodium falciparum serine repeat antigen 8 0.0156 0.0957 0.2061
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0068 0.0054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0366 0.243 0.243
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Leishmania major cathepsin L-like protease 0.0836 0.5748 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.173 1
Brugia malayi fibroinase precursor 0.0156 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0068
Onchocerca volvulus 0.0042 0.0148 0.0323
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0148
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0148 0.0784
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0068 0.0118
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0148 0.0323
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0018 0.004
Loa Loa (eye worm) hypothetical protein 0.0209 0.1328 0.1328
Echinococcus granulosus geminin 0.0166 0.1022 0.1022
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0156 0.0957 0.2061
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0018 0.004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0148 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0228 0.0497
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0209 0.1328 0.1328
Plasmodium falciparum cysteine proteinase falcipain 1 0.0366 0.243 0.5279
Schistosoma mansoni cathepsin F (C01 family) 0.0463 0.3118 0.3118
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0156 0.0957 0.0957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0366 0.243 0.4215
Entamoeba histolytica cysteine proteinase 2 0.0366 0.243 0.5294
Toxoplasma gondii preprocathepsin c precursor, putative 0.0156 0.0957 0.2061
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0148 0.1202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0156 0.0957 0.2085
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0148 1
Onchocerca volvulus 0.0672 0.4591 1
Echinococcus multilocularis ryanodine receptor 44f 0.0094 0.0517 0.0517
Schistosoma mansoni gabp alpha 0.0083 0.0441 0.0441
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Trypanosoma cruzi cysteine protease, putative 0.0366 0.243 0.242
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0196 0.0183
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0198 0.0198
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.243 0.5294
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0148 0.0148
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Giardia lamblia Cysteine protease 0.0156 0.0957 0.2522
Entamoeba histolytica serine/threonine protein kinase, putative 0.0107 0.0609 0.1326
Entamoeba histolytica cysteine protease, putative 0.0156 0.0957 0.2085
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0128 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0083 0.0441 0.0441
Trypanosoma cruzi cruzipain precursor, putative 0.0836 0.5748 0.5742
Schistosoma mansoni ryanodine receptor related 0.0131 0.078 0.078
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0148 0.0784
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0156 0.0957 0.2085
Toxoplasma gondii ABC1 family protein 0.0042 0.0148 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Plasmodium vivax vivapain-2 0.0672 0.4591 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0553 0.3754 0.6523
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0148 0.1202
Brugia malayi Inositol-1 0.0039 0.0128 0.0128
Toxoplasma gondii hypothetical protein 0.0056 0.0246 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Onchocerca volvulus 0.0672 0.4591 1
Giardia lamblia Cathepsin B precursor 0.0156 0.0957 0.2522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Onchocerca volvulus 0.0156 0.0957 0.2085
Loa Loa (eye worm) hypothetical protein 0.0463 0.3118 0.3118
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0148
Leishmania major cathepsin L-like protease 0.0672 0.4591 0.7983
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Plasmodium falciparum serine repeat antigen 4 0.0156 0.0957 0.2061
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0035 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0672 0.4591 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0156 0.0957 0.2061
Leishmania major cysteine peptidase A (CPA) 0.0672 0.4591 0.7983
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Trypanosoma cruzi cysteine peptidase, putative 0.0836 0.5748 0.5742
Brugia malayi cathepsin L precursor 0.0156 0.0957 0.0957
Schistosoma mansoni cathepsin s 0.0209 0.1328 0.1328
Giardia lamblia Cathepsin B precursor 0.0553 0.3754 1
Plasmodium falciparum serine repeat antigen 3 0.0156 0.0957 0.2061
Mycobacterium tuberculosis Conserved protein 0.0042 0.0148 0.0784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.144 1 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0128 0.0128
Brugia malayi beta-lactamase family protein 0.0042 0.0148 0.0148
Echinococcus multilocularis cathepsin L 0.0366 0.243 0.243
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.144 1 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0156 0.0957 0.2522
Trypanosoma cruzi cysteine peptidase, putative 0.0836 0.5748 0.5742
Giardia lamblia Cysteine protease 0.0156 0.0957 0.2522
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0128 0.0279
Loa Loa (eye worm) hypothetical protein 0.0156 0.0957 0.0957
Plasmodium vivax vivapain-3 0.0366 0.243 0.5279
Plasmodium vivax serine-repeat antigen (SERA) 0.0156 0.0957 0.2061
Plasmodium vivax unspecified product 0.0209 0.1328 0.2872
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0957 0.2085
Brugia malayi Cathepsin L-like precursor 0.0463 0.3118 0.3118
Loa Loa (eye worm) inositol-1 0.0039 0.0128 0.0128
Trypanosoma cruzi polo-like protein kinase, putative 0.0107 0.0609 0.0596
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0156 0.0957 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.0606 0.0606
Giardia lamblia Cathepsin L-like protease 0.0156 0.0957 0.2522
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0042 0.0148 0.0235
Echinococcus granulosus cathepsin L cysteine protease 0.0366 0.243 0.243
Trypanosoma cruzi cysteine proteinase, putative 0.0366 0.243 0.242
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0957 0.0957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0128 0.0279
Onchocerca volvulus Cathepsin L homolog 0.0672 0.4591 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.004
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0128 1
Giardia lamblia Cathepsin L precursor 0.0156 0.0957 0.2522
Schistosoma mansoni ap endonuclease 0.0023 0.0014 0.0014
Loa Loa (eye worm) cathepsin B 0.0553 0.3754 0.3754
Echinococcus granulosus cathepsin L 0.0156 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0463 0.3118 0.6791
Toxoplasma gondii cathepsin CPC1 0.0156 0.0957 0.2061
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0018 0.004
Onchocerca volvulus 0.0672 0.4591 1
Brugia malayi Papain family cysteine protease containing protein 0.0366 0.243 0.243
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.1328 0.1316
Entamoeba histolytica cysteine proteinase, putative 0.0672 0.4591 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.009 0.009
Brugia malayi cathepsin F-like cysteine proteinase 0.0209 0.1328 0.1328
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0008
Schistosoma mansoni cathepsin B (C01 family) 0.0156 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0148
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0107 0.0608 0.0608
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0148 0.0135
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0014 0.0014
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0128 0.0128
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0957 0.0957
Entamoeba histolytica cysteine proteinase 1, putative 0.0366 0.243 0.5294
Brugia malayi Ets-domain containing protein 0.0083 0.0441 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0163 0.1006 0.1006
Schistosoma mansoni hypothetical protein 0.0033 0.009 0.009
Brugia malayi Cathepsin L-like precursor 0.0463 0.3118 0.3118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0107 0.0606 0.0606
Mycobacterium ulcerans lipase LipD 0.0042 0.0148 0.1202
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0156 0.0957 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0957 0.2085
Brugia malayi beta-lactamase family protein 0.0042 0.0148 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0107 0.0606 0.0606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0148 0.0784
Giardia lamblia Cathepsin L-like protease 0.0156 0.0957 0.2522
Mycobacterium ulcerans hypothetical protein 0.0023 0.0018 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0836 0.5748 0.5742
Entamoeba histolytica cysteine proteinase, putative 0.0463 0.3118 0.6791
Echinococcus granulosus GA binding protein alpha chain 0.0083 0.0441 0.0441
Brugia malayi hypothetical protein 0.003 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0957 0.2085
Toxoplasma gondii cathepsin CPC2 0.0156 0.0957 0.2061
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0099 0.0498
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0148 0.0148
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0107 0.0606 0.0606
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0344 0.2282 0.3956
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0957 0.2085
Echinococcus granulosus cathepsin l cysteine peptidase 0.0672 0.4591 0.4591
Onchocerca volvulus 0.0023 0.0018 0.004
Echinococcus granulosus microtubule associated protein 2 0.0793 0.5439 0.5439
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0672 0.4591 0.4591
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0111 0.0635 0.0622
Onchocerca volvulus 0.0672 0.4591 1
Mycobacterium leprae Probable lipase LipE 0.0042 0.0148 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0156 0.0957 0.2085
Leishmania major hypothetical protein, conserved 0.0075 0.0386 0.0648
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.1328 0.1316
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0018
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0068 0.0094
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.1133 0.6525
Loa Loa (eye worm) hypothetical protein 0.0156 0.0957 0.0957
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.0609 0.0609
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0198 0.0198
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0014 0.003
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Brugia malayi Cathepsin L-like cysteine proteinase 0.0463 0.3118 0.3118
Brugia malayi cathepsin L-like cysteine proteinase 0.0156 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0156 0.0957 0.0957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Brugia malayi cation channel family protein 0.0201 0.127 0.127
Brugia malayi Cathepsin L-like precursor 0.0672 0.4591 0.4591
Schistosoma mansoni ets-related 0.0253 0.1634 0.1634
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.144 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0156 0.0957 0.2061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0018
Schistosoma mansoni kinase 0.0054 0.0238 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0107 0.0606 0.0606
Giardia lamblia Cathepsin L precursor 0.0156 0.0957 0.2522
Brugia malayi Cathepsin L-like precursor 0.0209 0.1328 0.1328
Brugia malayi Papain family cysteine protease containing protein 0.0366 0.243 0.243
Brugia malayi serine/threonine-protein kinase plk-2 0.0107 0.0609 0.0609
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.0957 0.0957
Echinococcus granulosus cathepsin L cysteine proteinase 0.0672 0.4591 0.4591
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0156 0.0957 0.0957
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Entamoeba histolytica hypothetical protein 0.0156 0.0957 0.2085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0107 0.0606 0.0606
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0156 0.0957 0.0957
Plasmodium vivax unspecified product 0.0366 0.243 0.5279
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.144 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Echinococcus multilocularis cathepsin b 0.144 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.2282 0.2271
Trypanosoma cruzi major cysteine proteinase, putative 0.0156 0.0957 0.0945
Brugia malayi Cathepsin L-like precursor 0.0672 0.4591 0.4591
Echinococcus granulosus cysteine protease 0.0366 0.243 0.243
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Giardia lamblia Cathepsin B precursor 0.0156 0.0957 0.2522
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0366 0.243 0.243
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0196 0.0318
Entamoeba histolytica cysteine proteinase, putative 0.0672 0.4591 1
Leishmania major cathepsin L-like protease 0.0836 0.5748 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0156 0.0957 0.2085
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0553 0.3754 0.8176
Plasmodium falciparum serine repeat antigen 7 0.0156 0.0957 0.2061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0107 0.0606 0.0606
Plasmodium falciparum serine repeat antigen 9 0.0156 0.0957 0.2061
Echinococcus granulosus cathepsin b 0.144 1 1
Echinococcus granulosus ryanodine receptor 44f 0.0094 0.0517 0.0517
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0068 0.0054
Leishmania major cathepsin L-like protease 0.0672 0.4591 0.7983
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0148 0.0323
Loa Loa (eye worm) cysteine protease 0.0672 0.4591 0.4591
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0128 0.0114
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0131 0.078 0.078
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0128 0.0279
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0111 0.0635 0.1084
Schistosoma mansoni cathepsin F (C01 family) 0.0672 0.4591 0.4591
Giardia lamblia Hypothetical protein 0.0156 0.0957 0.2522
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Leishmania major cathepsin L-like protease 0.0672 0.4591 0.7983
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Schistosoma mansoni inositol monophosphatase 0.0039 0.0128 0.0128
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Schistosoma mansoni microtubule-associated protein tau 0.0793 0.5439 0.5439
Onchocerca volvulus 0.0042 0.0148 0.0323
Loa Loa (eye worm) hypothetical protein 0.0049 0.0198 0.0198
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0366 0.243 0.242
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0099 0.6231
Plasmodium vivax vivapain-2 0.0672 0.4591 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0148 0.0784
Plasmodium falciparum cysteine proteinase falcipain 3 0.0672 0.4591 1
Giardia lamblia Cathepsin L precursor 0.0156 0.0957 0.2522
Loa Loa (eye worm) fibroinase 0.0672 0.4591 0.4591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0957 0.2085
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0156 0.0957 0.0957
Loa Loa (eye worm) beta-lactamase 0.0042 0.0148 0.0148
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0209 0.1328 0.1328
Trypanosoma cruzi cysteine peptidase, putative 0.0366 0.243 0.242
Loa Loa (eye worm) hypothetical protein 0.0156 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0071 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0957 0.2085
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0014 0.5
Entamoeba histolytica cysteine protease, putative 0.0156 0.0957 0.2085
Brugia malayi Papain family cysteine protease containing protein 0.0672 0.4591 0.4591
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0271 0.0257
Loa Loa (eye worm) hypothetical protein 0.0672 0.4591 0.4591
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0128 0.0249
Giardia lamblia Cathepsin B precursor 0.0156 0.0957 0.2522
Plasmodium falciparum serine repeat antigen 2 0.0156 0.0957 0.2061
Toxoplasma gondii cathepsin B 0.0553 0.3754 0.8171
Loa Loa (eye worm) ryanodine receptor 0.0035 0.0105 0.0105
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0148 0.0148
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0156 0.0957 0.2061
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0156 0.0957 0.2061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0957 0.2085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0957 0.2085
Echinococcus multilocularis cysteine protease 0.0672 0.4591 0.4591
Loa Loa (eye worm) hypothetical protein 0.0156 0.0957 0.0957
Leishmania major mitochondrial DNA polymerase beta 0.0344 0.2282 0.3956
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0553 0.3754 0.6523
Loa Loa (eye worm) hypothetical protein 0.0128 0.0756 0.0756
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0228 0.0497
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Onchocerca volvulus 0.0672 0.4591 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0957 0.2085
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0068 0.0118
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0366 0.243 0.5294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0672 0.4591 0.4591
Trypanosoma cruzi major cysteine proteinase, putative 0.0321 0.2113 0.2102
Giardia lamblia Cathepsin B precursor 0.0156 0.0957 0.2522
Toxoplasma gondii cathepsin CPL 0.0672 0.4591 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0018 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0156 0.0957 0.2085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0014 0.0014
Onchocerca volvulus 0.0672 0.4591 1
Trypanosoma cruzi cysteine proteinase, putative 0.0366 0.243 0.242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Brugia malayi Cathepsin L-like precursor 0.0672 0.4591 0.4591
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0957 0.0957
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0107 0.0609 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.0957 0.2085
Brugia malayi Cathepsin L-like precursor 0.0672 0.4591 0.4591
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0128 0.1019
Loa Loa (eye worm) hypothetical protein 0.144 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0128 0.0199
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0148 0.0784
Schistosoma mansoni cathepsin S (C01 family) 0.0156 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0156 0.0957 0.2061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0018 0.0026
Giardia lamblia Cathepsin L precursor 0.0156 0.0957 0.2522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0198 0.0198
Entamoeba histolytica cysteine protease, putative 0.0672 0.4591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0463 0.3118 0.6791
Schistosoma mansoni cathepsin C 0.0156 0.0957 0.0957
Giardia lamblia Cathepsin L precursor 0.0156 0.0957 0.2522
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0014 0.003
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0553 0.3754 0.3745
Giardia lamblia Cathepsin L precursor 0.0156 0.0957 0.2522
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0156 0.0957 0.2061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0148 0.0784
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0366 0.243 0.5294
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Brugia malayi cathepsin L-like precursor 0.0463 0.3118 0.3118
Echinococcus granulosus cathepsin L 0.0366 0.243 0.243
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0156 0.0957 0.2061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0018 0.004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0148 0.0784
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0148
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0128 0.0114
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Giardia lamblia Cysteine protease 0.0156 0.0957 0.2522
Giardia lamblia Kinase, PLK 0.0107 0.0609 0.1591
Onchocerca volvulus Serine\/threonine kinase homolog 0.0107 0.0609 0.1326
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0148 0.0294
Echinococcus multilocularis cathepsin b 0.144 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0957 0.0957
Entamoeba histolytica cysteine protease, putative 0.0156 0.0957 0.2085
Onchocerca volvulus Cathepsin L homolog 0.0672 0.4591 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.144 1 1
Onchocerca volvulus Cathepsin F homolog 0.0672 0.4591 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.2282 0.2271
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0148 0.0148
Brugia malayi Fli-1 protein 0.0253 0.1634 0.1634
Onchocerca volvulus Cathepsin L homolog 0.0156 0.0957 0.2085
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0957 0.2085
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0107 0.0608 0.0608
Leishmania major cathepsin L-like protease 0.0836 0.5748 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.0957 0.0957
Mycobacterium tuberculosis Conserved protein 0.0042 0.0148 0.0784
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.0957 0.2085
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0672 0.4591 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0148 0.0323
Echinococcus granulosus cathepsin l1 0.0672 0.4591 0.4591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Entamoeba histolytica cysteine protease, putative 0.0366 0.243 0.5294
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.243 0.5294
Mycobacterium ulcerans hypothetical protein 0.0181 0.1133 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0148
Onchocerca volvulus 0.0463 0.3118 0.6791
Schistosoma mansoni ap endonuclease 0.0023 0.0014 0.0014
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.1004 0.1726
Echinococcus multilocularis cysteine protease 0.0672 0.4591 0.4591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0209 0.1328 0.1328
Brugia malayi Cathepsin L-like precursor 0.0672 0.4591 0.4591
Leishmania major cathepsin L-like protease 0.0672 0.4591 0.7983
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Loa Loa (eye worm) ctsf protein 0.0672 0.4591 0.4591
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0156 0.0957 0.2085
Brugia malayi Cathepsin L-like precursor 0.0672 0.4591 0.4591
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.0957 0.0957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0672 0.4591 0.4591
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0148
Plasmodium vivax serine-repeat antigen (SERA) 0.0156 0.0957 0.2061
Echinococcus granulosus cathepsin l1 0.0463 0.3118 0.3118
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0148 0.0235
Loa Loa (eye worm) hypothetical protein 0.0463 0.3118 0.3118
Entamoeba histolytica cysteine protease, putative 0.0156 0.0957 0.2085
Brugia malayi Ets-domain containing protein 0.0083 0.0441 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0957 0.2085
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0107 0.0606 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0018 0.0008
Echinococcus multilocularis cathepsin L cysteine protease 0.0672 0.4591 0.4591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.0957 0.2085
Trypanosoma brucei polo-like protein kinase 0.0107 0.0609 0.1038
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.0957 0.0957
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0672 0.4591 0.4591
Giardia lamblia Cathepsin B precursor 0.0156 0.0957 0.2522
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0068 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0107 0.0609 0.1326
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.0957 0.0957
Entamoeba histolytica cysteine protease, putative 0.0156 0.0957 0.2085
Loa Loa (eye worm) fli-1 protein 0.0253 0.1634 0.1634
Echinococcus multilocularis microtubule associated protein 2 0.0793 0.5439 0.5439
Plasmodium vivax unspecified product 0.0156 0.0957 0.2061
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0156 0.0957 0.2061
Loa Loa (eye worm) hypothetical protein 0.0209 0.1328 0.1328
Trichomonas vaginalis esterase, putative 0.0042 0.0148 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.0957 0.2085
Entamoeba histolytica cysteine proteinase, putative 0.0366 0.243 0.5294
Loa Loa (eye worm) hypothetical protein 0.0463 0.3118 0.3118
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.0957 0.0957
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.1004 0.0991
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0156 0.0957 0.2061
Brugia malayi beta-lactamase 0.0042 0.0148 0.0148
Echinococcus granulosus ryanodine receptor 44f 0.0073 0.0369 0.0369
Giardia lamblia Cathepsin B precursor 0.0553 0.3754 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0672 0.4591 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0672 0.4591 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0128 0.0279
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0672 0.4591 1
Leishmania major hypothetical protein, conserved 0.003 0.0068 0.0094
Schistosoma mansoni cathepsin F (C01 family) 0.0672 0.4591 0.4591
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0836 0.5748 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0672 0.4591 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0107 0.0609 0.1038
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0018 0.004
Leishmania major cathepsin L-like protease 0.0672 0.4591 0.7983
Plasmodium vivax vivapain-1 0.0366 0.243 0.5279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0366 0.243 0.4215
Loa Loa (eye worm) hypothetical protein 0.0094 0.0517 0.0517
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0068 0.0118
Brugia malayi cathepsin F-like cysteine proteinase 0.0156 0.0957 0.0957
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0156 0.0957 0.2522
Giardia lamblia Hypothetical protein 0.0156 0.0957 0.2522

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 71 % Agonist activity to rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular stores at maximum effective concentration ChEMBL. 19668195
EC50 (functional) = 30 nM Agonist activity at rat recombinant IP3R1 expressed in chicken DT40 cells assessed as calcium release from intracellular stores ChEMBL. 19668195
Kd (binding) = 0.2 nM Displacement of [3H]IP3 from rat recombinant IP3R1 binding core residue (224-604) expressed in chicken DT40 cells by equilibrium competitive binding assay ChEMBL. 19668195
Kd (binding) = 1.63 nM Displacement of [3H]IP3 from rat recombinant N-terminal IP3R1 (1-604) expressed in chicken DT40 cells by equilibrium competitive binding assay ChEMBL. 19668195
Kd (binding) = 7.62 nM Displacement of [3H]IP3 from full-length rat recombinant IP3R1 expressed in chicken DT40 cells by equilibrium competitive binding assay ChEMBL. 19668195

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.