Detailed information for compound 1171595

Basic information

Technical information
  • TDR Targets ID: 1171595
  • Name: 1-[2-(2-pyridin-1-ium-1-ylethoxy)ethyl]pyridi n-1-ium
  • MW: 230.306 | Formula: C14H18N2O++
  • H donors: 0 H acceptors: 0 LogP: 1.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O(CC[n+]1ccccc1)CC[n+]1ccccc1
  • InChi: 1S/C14H18N2O/c1-3-7-15(8-4-1)11-13-17-14-12-16-9-5-2-6-10-16/h1-10H,11-14H2/q+2
  • InChiKey: HMEXVBNLYUWRDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[2-(1-pyridin-1-iumyl)ethoxy]ethyl]pyridin-1-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0155
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0013 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0418 0.065
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0102 0.0099
Onchocerca volvulus 0.0447 0.5122 1
Schistosoma mansoni dishevelled 0.0017 0.0102 0.0102
Brugia malayi RasGEF domain containing protein 0.0012 0.0044 0.0063
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0012 0.0044 0.5
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0044 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0013 0.0013
Brugia malayi RasGEF domain containing protein 0.0012 0.0044 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0074 0.0071
Brugia malayi nuclear hormone receptor 0.001 0.0013 0.0015
Onchocerca volvulus 0.0061 0.0608 0.1164
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0167 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0074 0.0074
Schistosoma mansoni dishevelled 0.0017 0.0102 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0015
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0074 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0013 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.2913 0.457
Schistosoma mansoni cpg binding protein 0.0064 0.0648 0.0648
Echinococcus granulosus Pleckstrin G protein interacting region 0.0017 0.0102 0.0099
Schistosoma mansoni hypothetical protein 0.0082 0.0852 0.0852
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0009
Schistosoma mansoni hypothetical protein 0.0176 0.1959 0.1959
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0167 1
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0553 0.637 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0167 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0059 1
Schistosoma mansoni hypothetical protein 0.069 0.7975 0.7975
Loa Loa (eye worm) hypothetical protein 0.0082 0.0852 0.1333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0015
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0012 0.0044 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0013 0.0013
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0044 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0015
Schistosoma mansoni ras GTP exchange factor 0.0012 0.0044 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0852 0.0849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0015
Echinococcus multilocularis GPCR, family 2 0.0082 0.0852 0.0849
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0017 0.0102 0.0102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0118 0.0114
Schistosoma mansoni lozenge 0.0056 0.0554 0.0554
Echinococcus granulosus segment polarity protein dishevelled 0.0017 0.0102 0.0099
Onchocerca volvulus 0.0012 0.0044 0.006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0059 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0099 0.5
Trypanosoma cruzi hypothetical protein 0.0012 0.0044 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0013 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0013 0.0009
Onchocerca volvulus Huntingtin homolog 0.0124 0.1343 0.2603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.1403 0.1403
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0102 0.0099
Brugia malayi ecdysteroid receptor 0.001 0.0013 0.0015
Brugia malayi TAR-binding protein 0.0063 0.0633 0.0988
Echinococcus multilocularis son of sevenless 1 0.0012 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Loa Loa (eye worm) runx1 0.0056 0.0554 0.0864
Onchocerca volvulus Huntingtin homolog 0.0124 0.1343 0.2603
Onchocerca volvulus 0.0023 0.0167 0.0302
Brugia malayi steroid hormone receptor 0.001 0.0013 0.0015
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0012 0.0044 0.006
Trypanosoma cruzi hypothetical protein 0.0012 0.0044 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0009
Brugia malayi N-terminal motif family protein 0.0354 0.4045 0.6348
Echinococcus granulosus ras GTP exchange factor 0.0012 0.0044 0.004
Echinococcus granulosus tar DNA binding protein 0.0063 0.0633 0.0629
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.2913 0.457
Onchocerca volvulus 0.0017 0.0102 0.0175
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0063
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0852 0.1333
Loa Loa (eye worm) hypothetical protein 0.0176 0.1959 0.3072
Schistosoma mansoni hypothetical protein 0.0082 0.0852 0.0852
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0167 1
Echinococcus granulosus geminin 0.069 0.7975 0.7974
Schistosoma mansoni hypothetical protein 0.069 0.7975 0.7975
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0013 0.0015
Brugia malayi hypothetical protein 0.0017 0.0102 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1959 0.3072
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0099 0.139
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0044 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0447 0.5122 0.804
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.0082 0.0852 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0059 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0102 0.0099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0102 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0059 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0167 0.0257
Echinococcus multilocularis ras GTP exchange factor 0.0012 0.0044 0.004
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0633 0.0633
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0012 0.0044 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0852 0.0849
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0167 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.001 0.0013 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0418 0.0414
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0099 0.5
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0118 0.0179
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0013
Brugia malayi N-terminal motif family protein 0.0012 0.0044 0.0063
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0115 0.0175
Echinococcus multilocularis Protein lozenge 0.0056 0.0554 0.055
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0258 0.2913 0.457
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0167 1
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0553 0.637 0.6369
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0167 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Schistosoma mansoni cpg binding protein 0.0064 0.0648 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0167 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0013 0.0009
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0013 0.0013
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0633 0.0629
Loa Loa (eye worm) hypothetical protein 0.0023 0.0167 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0013 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Echinococcus multilocularis cpg binding protein 0.0064 0.0648 0.0645
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0167 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0553 0.637 0.6369
Echinococcus granulosus GPCR family 2 0.0082 0.0852 0.0849
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0852 0.0849
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0009
Echinococcus multilocularis regulator of G protein signaling 7 0.0017 0.0102 0.0099
Brugia malayi RNA binding protein 0.0063 0.0633 0.0988
Loa Loa (eye worm) hypothetical protein 0.0447 0.5122 0.804
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0074 0.0071
Schistosoma mansoni nuclear hormone receptor 0.001 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0017 0.0102 0.0175
Echinococcus granulosus FTZ F1 alpha 0.001 0.0013 0.0009
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0059 1
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0012 0.0044 0.004
Brugia malayi hypothetical protein 0.0553 0.637 1
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0012 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0015
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0633 0.0988
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0059 1
Brugia malayi Serine/threonine-protein kinase SULU 0.0553 0.637 1
Toxoplasma gondii hypothetical protein 0.0017 0.0102 0.0797
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0167 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.0553 0.637 0.637
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0013 0.0013
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0044 0.0044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0074 0.0071
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0633 0.0988
Schistosoma mansoni dep domain containing protein 0.0017 0.0102 0.0102
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.2913 0.457
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0009
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0102 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0633 0.0633
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0017 0.0102 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0418 0.065
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0167 1
Echinococcus multilocularis geminin 0.069 0.7975 0.7974
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0633 0.0633
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0167 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0013 0.0009
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0102 0.0099
Brugia malayi hypothetical protein 0.0124 0.1343 0.2104
Trichomonas vaginalis helicase, putative 0.0014 0.0059 1
Echinococcus granulosus cpg binding protein 0.0064 0.0648 0.0645
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0418 0.0418
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0418 0.0414
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0012 0.0044 0.0044
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0354 0.4045 0.7892
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0608 0.0949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0015
Schistosoma mansoni regulator of G protein signaling 0.0017 0.0102 0.0102
Echinococcus granulosus son of sevenless 1 0.0012 0.0044 0.004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Schistosoma mansoni hypothetical protein 0.0082 0.0852 0.0852
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0044 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0633 0.0633
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0852 0.0849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0418 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0852 0.1333
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0167 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0167 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0418 0.0418
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0633 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.015
Loa Loa (eye worm) DIX domain-containing protein 0.0017 0.0102 0.0155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0418 0.0414
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0013 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0167 0.0257
Brugia malayi CXXC zinc finger family protein 0.0061 0.0608 0.0949
Schistosoma mansoni coup transcription factor 0.001 0.0013 0.0013
Brugia malayi N-terminal motif family protein 0.0012 0.0044 0.0063
Loa Loa (eye worm) hypothetical protein 0.0124 0.1343 0.2104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0015
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0017 0.0102 0.0155
Brugia malayi DIX domain containing protein 0.0017 0.0102 0.0155
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0044 0.0063
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0013 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0852 0.1333
Echinococcus granulosus regulator of G protein signaling 7 0.0017 0.0102 0.0099
Echinococcus granulosus Protein son of sevenless 0.0012 0.0044 0.004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0013 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0118 0.0114
Schistosoma mansoni cpg binding protein 0.0061 0.0608 0.0608
Brugia malayi hypothetical protein 0.0447 0.5122 0.804
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1242 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.0633 0.0988
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0059 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0059 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0167 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0059 1
Schistosoma mansoni z-protein (S1r protein) 0.0017 0.0102 0.0102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0099 0.015
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0099 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0015
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0017 0.0102 0.0155
Schistosoma mansoni hypothetical protein 0.0864 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0864 1 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.0167 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0418 0.0418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0015
Brugia malayi RasGEF domain containing protein 0.0012 0.0044 0.0063
Echinococcus multilocularis Protein son of sevenless 0.0012 0.0044 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0015
Loa Loa (eye worm) hypothetical protein 0.0124 0.1343 0.2104
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0013 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0633 0.0633
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0167 1
Loa Loa (eye worm) hypothetical protein 0.0354 0.4045 0.6348
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0012 0.0044 0.004
Brugia malayi regulator of G-protein signaling egl-10 0.0017 0.0102 0.0155
Brugia malayi hypothetical protein 0.0017 0.0102 0.0155
Echinococcus multilocularis segment polarity protein dishevelled 0.0017 0.0102 0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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