Detailed information for compound 1173085

Basic information

Technical information
  • TDR Targets ID: 1173085
  • Name: 1-propylsulfinylsulfanylpropane
  • MW: 166.305 | Formula: C6H14OS2
  • H donors: 1 H acceptors: 1 LogP: 2.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCS[S+](CCC)[O-]
  • InChi: 1S/C6H14OS2/c1-3-5-8-9(7)6-4-2/h3-6H2,1-2H3
  • InChiKey: XPRZAEWSYWTDSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(propylsulfinylthio)propane
  • 85085-09-2
  • 1948-52-3
  • 1-Propanesulfinic acid, thio-, S-propyl ester
  • EINECS 217-755-9
  • NSC 23131
  • S-Propyl propane-1-thiosulphinate
  • 1-Propanesulfinothioic acid, S-propyl ester
  • NSC23131

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Starlite/ChEMBL References
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Giardia lamblia Cathepsin L precursor cysteine peptidase, Clan CA, family C1, Cathepsin L-like 450 aa 428 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cysteine protease 0.0048 0.0721 0.0721
Brugia malayi fibroinase precursor 0.002 0.0092 0.0092
Brugia malayi Fli-1 protein 0.0232 0.4891 0.4891
Echinococcus granulosus cathepsin L 0.002 0.0092 0.0092
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0721 0.0721
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0092 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0343 0.034
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.002 0.0092 0.056
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0811 0.0811
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0184 0.0184
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.002 0.0092 0.056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0248 0.151
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0048 0.0291
Giardia lamblia Cysteine protease 0.002 0.0092 0.0752
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0092 0.0092
Plasmodium falciparum serine repeat antigen 4 0.002 0.0092 0.056
Brugia malayi Cathepsin L-like precursor 0.0089 0.1642 0.1642
Echinococcus granulosus GPCR family 2 0.0016 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0811 0.0809
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0092 0.056
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.1428 0.8692
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 1
Plasmodium vivax serine-repeat antigen (SERA) 0.002 0.0092 0.056
Giardia lamblia Cathepsin L precursor 0.002 0.0092 0.0752
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0721 0.4219
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0867 0.5276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1014 0.1914
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.002 0.0092 0.056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.281 0.281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0867 0.0865
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0092 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.281 0.281
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.1222 0.2321
Loa Loa (eye worm) hypothetical protein 0.0028 0.0257 0.0254
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.002 0.0092 0.056
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0092 0.0752
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0003
Toxoplasma gondii cathepsin CPL 0.0089 0.1642 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0701 0.1332
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0048 0.0291
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.2076 0.8837
Schistosoma mansoni ets-related 0.0232 0.4891 0.6439
Leishmania major cathepsin L-like protease 0.0089 0.1642 0.312
Brugia malayi hypothetical protein 0.0035 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0061 0.1014 0.1012
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0048 0.0091
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0808 0.3437
Trypanosoma cruzi cysteine peptidase, putative 0.0248 0.5265 1
Leishmania major cathepsin L-like protease 0.0248 0.5265 1
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.0721 0.1369
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.002 0.0092 0.056
Schistosoma mansoni ap endonuclease 0.0018 0.0048 0.0063
Echinococcus multilocularis cysteine protease 0.0089 0.1642 0.1642
Brugia malayi Cathepsin L-like precursor 0.0061 0.1014 0.1014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0257 0.0487
Echinococcus granulosus cathepsin b 0.0181 0.3746 0.3746
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Trypanosoma cruzi cysteine peptidase, putative 0.0248 0.5265 1
Schistosoma mansoni hypothetical protein 0.0036 0.0445 0.0585
Brugia malayi N-terminal motif family protein 0.0189 0.3911 0.3911
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0002 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0092 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.002 0.0092 0.056
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0089 0.1642 0.1641
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0701 0.1332
Echinococcus multilocularis muscleblind protein 0.0457 1 1
Brugia malayi Cathepsin L-like precursor 0.0089 0.1642 0.1642
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0092 0.0277
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0048 0.0334
Loa Loa (eye worm) hypothetical protein 0.0457 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0092 0.009
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.0277
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.1428 0.8692
Schistosoma mansoni cathepsin F (C01 family) 0.0089 0.1642 0.2162
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0092 0.0121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0092 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Echinococcus granulosus cathepsin b 0.0181 0.3746 0.3746
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0092 0.009
Onchocerca volvulus 0.0089 0.1642 0.2978
Loa Loa (eye worm) hypothetical protein 0.0036 0.0436 0.0434
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.235 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1014 0.1012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1014 0.1914
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.1362 0.136
Brugia malayi Probable ClpP-like protease 0.0079 0.1428 0.1428
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0048 0.0391
Schistosoma mansoni gabp alpha 0.0076 0.1362 0.1792
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0189 0.3911 0.3909
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.002 0.0092 0.056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0445 0.0445
Loa Loa (eye worm) fibroinase 0.0089 0.1642 0.1641
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0701 0.4271
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0048 0.0091
Onchocerca volvulus 0.0089 0.1642 0.2978
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0028 0.0257 0.0257
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0048 0.0334
Brugia malayi Cathepsin L-like cysteine proteinase 0.0061 0.1014 0.1014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0174
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0092 0.0092
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0701 0.2985
Schistosoma mansoni cathepsin F (C01 family) 0.0061 0.1014 0.1335
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0867 0.1646
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0048 0.0334
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0092 0.0121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.1222 0.1609
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.1428 0.1428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0343 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Brugia malayi Ets-domain containing protein 0.0076 0.1362 0.1362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Plasmodium falciparum serine repeat antigen 7 0.002 0.0092 0.056
Brugia malayi Cathepsin L-like precursor 0.0089 0.1642 0.1642
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0002 0.0002
Leishmania major cysteine peptidase A (CPA) 0.0089 0.1642 0.312
Trypanosoma cruzi cysteine proteinase, putative 0.0048 0.0721 0.1369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Echinococcus granulosus cathepsin L cysteine proteinase 0.0089 0.1642 0.1642
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0092 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0048 0.009
Giardia lamblia Hypothetical protein 0.002 0.0092 0.0752
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0092 0.0121
Loa Loa (eye worm) cathepsin B 0.007 0.1222 0.122
Giardia lamblia Cathepsin L precursor 0.002 0.0092 0.0752
Brugia malayi cathepsin F-like cysteine proteinase 0.0028 0.0257 0.0257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0092 0.0174
Leishmania major cathepsin L-like protease 0.0248 0.5265 1
Schistosoma mansoni cathepsin C 0.002 0.0092 0.0121
Plasmodium falciparum serine repeat antigen 5 0.002 0.0092 0.056
Plasmodium falciparum serine repeat antigen 9 0.002 0.0092 0.056
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0721 0.0948
Toxoplasma gondii exonuclease III APE 0.0018 0.0048 0.0291
Plasmodium falciparum serine repeat antigen 2 0.002 0.0092 0.056
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0701 0.0701
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0445 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0721 0.136
Trypanosoma cruzi cysteine peptidase, putative 0.0248 0.5265 1
Trichomonas vaginalis set domain proteins, putative 0.025 0.5298 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.002 0.0092 0.0277
Onchocerca volvulus 0.0089 0.1642 0.2978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0048 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.281 0.3699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Loa Loa (eye worm) hypothetical protein 0.0181 0.3746 0.3744
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.002 0.0092 0.056
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.009
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0092 0.0121
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.0277
Onchocerca volvulus 0.0089 0.1642 0.2978
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.2076 0.87
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0808 0.2663
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0092 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0174
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0174
Leishmania major cathepsin L-like protease 0.0089 0.1642 0.312
Giardia lamblia Cathepsin B precursor 0.002 0.0092 0.0752
Giardia lamblia Cathepsin L precursor 0.002 0.0092 0.0752
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.009
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0048 0.009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.461 0.4609
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0092 0.0175
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.1428 0.5613
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0092 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0092 0.0174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Echinococcus multilocularis cathepsin L 0.002 0.0092 0.0092
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0092 0.0121
Echinococcus multilocularis muscleblind protein 1 0.0457 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0092 0.0092
Plasmodium falciparum serine repeat antigen 6 0.002 0.0092 0.056
Entamoeba histolytica hypothetical protein 0.002 0.0092 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0174
Onchocerca volvulus 0.0031 0.0343 0.0482
Brugia malayi hypothetical protein 0.0036 0.0445 0.0445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.3746 0.4931
Brugia malayi Cathepsin L-like precursor 0.0028 0.0257 0.0257
Plasmodium falciparum glutathione reductase 0.0047 0.0701 0.4271
Leishmania major hypothetical protein, conserved 0.0055 0.0867 0.1646
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.249
Echinococcus multilocularis cysteine protease 0.0089 0.1642 0.1642
Giardia lamblia Cathepsin B precursor 0.002 0.0092 0.0752
Loa Loa (eye worm) hypothetical protein 0.0028 0.0257 0.0254
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0867 0.5276
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0089 0.1642 0.31
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0092 0.0174
Echinococcus granulosus cathepsin l1 0.0089 0.1642 0.1642
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.0277
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0089 0.1642 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.3746 0.4931
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0092 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0867 0.1646
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0721 0.136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0002 0.0002
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0092 0.056
Brugia malayi hypothetical protein 0.0055 0.0867 0.0867
Brugia malayi glutathione reductase 0.0047 0.0701 0.0701
Toxoplasma gondii hypothetical protein 0.0027 0.0248 0.151
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0701 0.0699
Entamoeba histolytica cysteine protease, putative 0.0089 0.1642 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0048 0.0721 0.4219
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.002 0.0092 0.056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0721 0.0721
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0092 0.0121
Echinococcus granulosus cathepsin L cysteine protease 0.0048 0.0721 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0089 0.1642 0.31
Giardia lamblia Cathepsin L-like protease 0.002 0.0092 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0343 0.0451
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.0277
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0436 0.0436
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0248 0.151
Brugia malayi cathepsin L-like precursor 0.0061 0.1014 0.1014
Loa Loa (eye worm) fli-1 protein 0.0232 0.4891 0.489
Plasmodium falciparum thioredoxin reductase 0.0047 0.0701 0.4271
Echinococcus multilocularis cathepsin L 0.0048 0.0721 0.0721
Toxoplasma gondii cathepsin CPC2 0.002 0.0092 0.056
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.2076 0.8837
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Loa Loa (eye worm) hypothetical protein 0.0028 0.0257 0.0254
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.002 0.0092 0.056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.281 0.3699
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0701 0.0701
Loa Loa (eye worm) hypothetical protein 0.0061 0.1014 0.1012
Echinococcus multilocularis cathepsin b 0.0181 0.3746 0.3746
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.3746 0.4931
Onchocerca volvulus Cathepsin L homolog 0.0089 0.1642 0.2978
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0867 0.5276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Entamoeba histolytica cysteine proteinase, putative 0.0089 0.1642 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.2076 0.8837
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.249
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0808 0.0808
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.3746 0.3746
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0092 0.0174
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.1222 0.2321
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 1
Plasmodium vivax vivapain-2 0.0089 0.1642 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.009
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0721 0.4219
Schistosoma mansoni hypothetical protein 0.0036 0.0436 0.0575
Plasmodium vivax serine-repeat antigen (SERA), putative 0.002 0.0092 0.056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.3746 0.4931
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0092 0.0174
Leishmania major trypanothione reductase 0.0047 0.0701 0.1332
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0867 0.5276
Plasmodium vivax SET domain protein, putative 0.0031 0.0343 0.2086
Leishmania major cathepsin L-like protease 0.0089 0.1642 0.312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0721 0.1369
Onchocerca volvulus 0.0061 0.1014 0.1771
Entamoeba histolytica cysteine protease, putative 0.002 0.0092 0.0277
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.022 0.4636 0.8806
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.281 0.3699
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.2076 0.8837
Loa Loa (eye worm) hypothetical protein 0.0089 0.1642 0.1641
Schistosoma mansoni ap endonuclease 0.0018 0.0048 0.0063
Onchocerca volvulus 0.0089 0.1642 0.2978
Onchocerca volvulus Cathepsin L homolog 0.0089 0.1642 0.2978
Loa Loa (eye worm) hypothetical protein 0.0457 1 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0343 0.2086
Echinococcus granulosus muscleblind protein 0.0457 1 1
Giardia lamblia Cysteine protease 0.002 0.0092 0.0752
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0092 0.0092
Plasmodium falciparum cysteine proteinase falcipain 1 0.0048 0.0721 0.4387
Brugia malayi Cathepsin L-like precursor 0.0061 0.1014 0.1014
Giardia lamblia Cathepsin B precursor 0.002 0.0092 0.0752
Giardia lamblia Cathepsin B precursor 0.007 0.1222 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0092 0.0174
Giardia lamblia Encystation-specific protease 0.002 0.0092 0.0752
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0343 0.0451
Leishmania major cathepsin L-like protease 0.0089 0.1642 0.312
Brugia malayi Cathepsin L-like precursor 0.0089 0.1642 0.1642
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 0.8692
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.1362 0.1362
Giardia lamblia Cathepsin L precursor 0.002 0.0092 0.0752
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.249
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Toxoplasma gondii preprocathepsin c precursor, putative 0.002 0.0092 0.056
Loa Loa (eye worm) glutathione reductase 0.0047 0.0701 0.0699
Schistosoma mansoni hypothetical protein 0.0016 0.0002 0.0003
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0089 0.1642 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0867 0.1646
Plasmodium falciparum cysteine proteinase falcipain 3 0.0089 0.1642 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Giardia lamblia Cysteine protease 0.002 0.0092 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Schistosoma mansoni hypothetical protein 0.0024 0.0184 0.0242
Trypanosoma cruzi cruzipain precursor, putative 0.0248 0.5265 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0092 0.0121
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0808 0.0808
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.281 0.2808
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0092 0.0174
Plasmodium vivax vivapain-2 0.0089 0.1642 1
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0174
Schistosoma mansoni cathepsin F (C01 family) 0.0089 0.1642 0.2162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.1362 0.1362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0343 0.0451
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0002 0.0002
Onchocerca volvulus Cathepsin F homolog 0.0089 0.1642 0.2978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0721 0.1369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0701 0.4271
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.3746 0.7115
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.1222 0.2306
Entamoeba histolytica hypothetical protein 0.0036 0.0445 0.249
Brugia malayi Papain family cysteine protease containing protein 0.0089 0.1642 0.1642
Giardia lamblia Cathepsin L-like protease 0.002 0.0092 0.0752
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0002 0.0002
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0089 0.1642 0.1642
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0316 0.0316
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0048 0.0046
Echinococcus multilocularis cathepsin L cysteine protease 0.0089 0.1642 0.1642
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0048 0.0721 0.1369
Toxoplasma gondii cathepsin CPC1 0.002 0.0092 0.056
Echinococcus multilocularis cathepsin L cysteine protease 0.0089 0.1642 0.1642
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.002 0.0092 0.0752
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0092 0.0092
Toxoplasma gondii cathepsin B 0.007 0.1222 0.744
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.2076 0.8837
Trypanosoma cruzi cysteine protease, putative 0.0048 0.0721 0.1369
Plasmodium vivax unspecified product 0.0048 0.0721 0.4387
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.0257 0.0487
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.235 1
Loa Loa (eye worm) ctsf protein 0.0089 0.1642 0.1641
Giardia lamblia Dipeptidyl-peptidase I precursor 0.002 0.0092 0.0752
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.1428 0.1879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0811 0.0811
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Echinococcus granulosus cathepsin L 0.0048 0.0721 0.0721
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.1428 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0343 0.0343
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0048 0.0048
Echinococcus multilocularis cathepsin b 0.0181 0.3746 0.3746
Plasmodium vivax vivapain-1 0.0048 0.0721 0.4387
Plasmodium falciparum serine repeat antigen 3 0.002 0.0092 0.056
Brugia malayi Thioredoxin reductase 0.0047 0.0701 0.0701
Giardia lamblia Cathepsin B precursor 0.007 0.1222 1
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.235 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Onchocerca volvulus 0.0089 0.1642 0.2978
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0089 0.1642 0.1641
Loa Loa (eye worm) hypothetical protein 0.0052 0.0811 0.0809
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0189 0.3911 0.7334
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0343 0.0343
Brugia malayi Pre-SET motif family protein 0.0219 0.461 0.461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0445 0.0445
Giardia lamblia Hypothetical protein 0.002 0.0092 0.0752
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0048 0.0091
Echinococcus granulosus geminin 0.0351 0.7596 0.7596
Loa Loa (eye worm) hypothetical protein 0.0079 0.1428 0.1426
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.1642 0.312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.281 0.281
Giardia lamblia Cathepsin B precursor 0.007 0.1222 1
Echinococcus multilocularis geminin 0.0351 0.7596 0.7596
Entamoeba histolytica cysteine proteinase 2 0.0048 0.0721 0.4219
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0089 0.1642 0.1642
Schistosoma mansoni cathepsin s 0.0028 0.0257 0.0338
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0721 0.4219
Leishmania major cathepsin L-like protease 0.0248 0.5265 1
Giardia lamblia Cathepsin B precursor 0.002 0.0092 0.0752
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.235 1
Plasmodium vivax vivapain-3 0.0048 0.0721 0.4387
Leishmania major cathepsin L-like protease 0.0089 0.1642 0.312
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.281 0.281
Giardia lamblia Cathepsin L precursor 0.002 0.0092 0.0752
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.1222 0.2321
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0092 0.0092
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1014 0.6058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0721 0.0948
Plasmodium falciparum serine repeat antigen 8 0.002 0.0092 0.056
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0721 0.4219
Onchocerca volvulus 0.025 0.5298 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.111 0.1108
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0089 0.1642 0.31
Brugia malayi Cathepsin L-like precursor 0.0089 0.1642 0.1642
Schistosoma mansoni hypothetical protein 0.0351 0.7596 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0248 0.1738
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0257 0.0254
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.1428 0.8692
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0343 0.0343
Entamoeba histolytica cysteine proteinase, putative 0.0089 0.1642 1
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0721 0.1369
Onchocerca volvulus 0.0089 0.1642 0.2978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0092 0.0174
Trypanosoma cruzi major cysteine proteinase, putative 0.018 0.3714 0.7055
Giardia lamblia Cysteine protease 0.002 0.0092 0.0752
Echinococcus multilocularis GPCR, family 2 0.0016 0.0002 0.0002
Brugia malayi Ets-domain containing protein 0.0076 0.1362 0.1362
Mycobacterium tuberculosis Probable reductase 0.0108 0.2076 0.8837
Plasmodium vivax unspecified product 0.0028 0.0257 0.1563
Brugia malayi Cathepsin L-like precursor 0.0089 0.1642 0.1642
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0048 0.0721 0.0948
Plasmodium falciparum serine repeat antigen 1 0.002 0.0092 0.056
Plasmodium vivax glutathione reductase, putative 0.0047 0.0701 0.4271
Giardia lamblia Cathepsin L precursor 0.002 0.0092 0.0752
Echinococcus granulosus cathepsin l1 0.0061 0.1014 0.1014
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0808 0.3437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.281 0.281
Plasmodium vivax unspecified product 0.002 0.0092 0.056
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0048 0.0091
Brugia malayi cathepsin L precursor 0.002 0.0092 0.0092
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0048 0.0048
Loa Loa (eye worm) cysteine protease 0.0089 0.1642 0.1641
Giardia lamblia Cathepsin B precursor 0.002 0.0092 0.0752
Echinococcus granulosus cathepsin l cysteine peptidase 0.0089 0.1642 0.1642
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0351 0.7596 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0343 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0092 0.0174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0248 0.5265 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.1428 0.1428
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.002 0.0092 0.056
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0089 0.1642 0.31
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0092 0.009
Entamoeba histolytica cysteine protease, putative 0.0048 0.0721 0.4219

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 40 uM Antiparasitic activity against Trypanosoma brucei brucei ChEMBL. 20692829
IC50 (functional) = 78.3 uM Antiparasitic activity against Plasmodium falciparum ChEMBL. 20692829
Ki (binding) = 4.44 uM Inhibition of Trypanosoma brucei rhodesiense rhodesain ChEMBL. 20692829
Ki (binding) = 11.3 uM Inhibition of cathepsin L ChEMBL. 20692829
Ki (binding) = 15.6 uM Inhibition of cathepsin B ChEMBL. 20692829
TDI (binding) = 6664 /min/M Time dependent inhibition of cathepsin L by Dixon plot analysis ChEMBL. 20692829
TDI (binding) = 7150 /min/M Time dependent inhibition of Trypanosoma brucei rhodesiense rhodesain by Dixon plot analysis ChEMBL. 20692829

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.