Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Histamine H3 receptor | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H4 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Histamine H4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase | 0.0064 | 0.0932 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0064 | 0.0932 | 0.0932 |
Echinococcus multilocularis | geminin | 0.0186 | 0.3542 | 0.3542 |
Onchocerca volvulus | 0.0064 | 0.0932 | 0.5 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0064 | 0.0932 | 0.0932 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0064 | 0.0932 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0064 | 0.0932 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0064 | 0.0932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0932 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0064 | 0.0932 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0064 | 0.0932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0932 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0186 | 0.3542 | 0.4106 |
Mycobacterium ulcerans | monoamine oxidase | 0.0064 | 0.0932 | 0.0932 |
Mycobacterium ulcerans | oxidoreductase | 0.0064 | 0.0932 | 0.0932 |
Plasmodium vivax | hypothetical protein, conserved | 0.0064 | 0.0932 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0932 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.3542 | 0.3542 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0932 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0064 | 0.0932 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0064 | 0.0932 | 0.108 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0487 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.3542 | 0.3542 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0487 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0423 | 0.8626 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0487 | 1 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0064 | 0.0932 | 1 |
Brugia malayi | hypothetical protein | 0.0064 | 0.0932 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0064 | 0.0932 | 0.0932 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0064 | 0.0932 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0064 | 0.0932 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0487 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0064 | 0.0932 | 0.108 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0064 | 0.0932 | 1 |
Echinococcus multilocularis | 0.0064 | 0.0932 | 0.0932 | |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0064 | 0.0932 | 0.0932 |
Schistosoma mansoni | amine oxidase | 0.0064 | 0.0932 | 0.0932 |
Leishmania major | UDP-galactopyranose mutase | 0.0064 | 0.0932 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0423 | 0.8626 | 1 |
Schistosoma mansoni | amine oxidase | 0.0064 | 0.0932 | 0.0932 |
Mycobacterium ulcerans | dehydrogenase | 0.0064 | 0.0932 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0932 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0064 | 0.0932 | 0.108 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0064 | 0.0932 | 0.108 |
Plasmodium vivax | hypothetical protein, conserved | 0.0064 | 0.0932 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.65 | Displacement of [3H]NAMH from human histamine H3 receptor expressed in C6 cells after 1 hr by liquid scintillation counting | ChEMBL. | 20171098 |
Ki (binding) | = 6.98 | Displacement of [3H]NAMH from rat histamine H3 receptor expressed in C6 cells after 1 hr by liquid scintillation counting | ChEMBL. | 20171098 |
Ki (binding) | = 7.31 | Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting | ChEMBL. | 20171098 |
Ki (binding) | = 8.49 | Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting | ChEMBL. | 20171098 |
pKb (functional) | = 7.15 | Antagonist activity at human histamine H4 receptor expressed in HEK293 cells coexpressing Galphaqi5 assessed as decrease in intracellular calcium by FLIPR | ChEMBL. | 20171098 |
pKb (functional) | = 7.73 | Antagonist activity at rat histamine H4 receptor assessed as decrease in intracellular calcium by FLIPR | ChEMBL. | 20171098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.