Detailed information for compound 1192814

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.835 | Formula: C21H16ClN5O5
  • H donors: 1 H acceptors: 5 LogP: 3.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClC1=C(Nc2cccc(c2)[N+](=O)[O-])C(=O)N(C1=O)c1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C21H16ClN5O5/c1-12-18(21(30)26(24(12)2)14-8-4-3-5-9-14)25-19(28)16(22)17(20(25)29)23-13-7-6-10-15(11-13)27(31)32/h3-11,23H,1-2H3
  • InChiKey: BHAJEDPRGBMELD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.038 0.1062
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0251 0.0872
Echinococcus multilocularis fk506 binding protein 0.0052 0.0375 0.0365
Schistosoma mansoni growth hormone secretagogue receptor 0.0039 0.0245 0.0235
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2181 0.787
Loa Loa (eye worm) hypothetical protein 0.0059 0.0441 0.1248
Brugia malayi G protein-coupled receptor 0.0039 0.0245 0.0743
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0234 0.208 0.2071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0039 0.0245 0.0235
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0039 0.0245 0.0743
Mycobacterium ulcerans beta-lactamase 0.011 0.0916 0.3282
Echinococcus granulosus tachykinin peptides receptor 99D 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.011 0.0916 0.2703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0234 0.208 0.2071
Brugia malayi beta-lactamase family protein 0.011 0.0916 0.2776
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.025 0.0665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0245 0.0235
Plasmodium vivax glutathione reductase, putative 0.0039 0.025 0.2644
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0916 0.0906
Loa Loa (eye worm) hypothetical protein 0.0039 0.0251 0.0668
Echinococcus granulosus chromobox protein 1 0.0069 0.0529 0.0519
Plasmodium vivax importin-beta 2, putative 0.0029 0.0158 0.1628
Echinococcus multilocularis G-protein coupled receptor, putative 0.0039 0.0245 0.0235
Schistosoma mansoni alpha-1 adrenergic receptor 0.0039 0.0245 0.0235
Brugia malayi larval opioid receptor 0.0039 0.0245 0.0743
Echinococcus granulosus 7TM GPCR rhodopsin 0.0039 0.0245 0.0235
Schistosoma mansoni opsin-like receptor 0.0039 0.0245 0.0235
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0245 0.0235
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0245 0.0235
Onchocerca volvulus 0.0039 0.0245 0.0386
Leishmania major peptidylprolyl isomerase-like protein 0.0052 0.0375 0.403
Echinococcus multilocularis ferritin 0.0018 0.005 0.004
Brugia malayi Serine/threonine-protein kinase SULU 0.0365 0.3299 1
Schistosoma mansoni ran 0.0022 0.0086 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Onchocerca volvulus 0.0042 0.0279 0.0554
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0529 0.1878
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1902 0.5723
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus granulosus neuropeptide receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.065
Mycobacterium ulcerans glutaminase 0.0308 0.2768 1
Schistosoma mansoni glutaminase 0.0308 0.2768 0.2761
Echinococcus multilocularis chromobox protein 1 0.0069 0.0529 0.0519
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.025 0.037
Brugia malayi Muscleblind-like protein 0.0303 0.2719 0.8241
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0916 1
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus granulosus g protein coupled receptor 0.0039 0.0245 0.0235
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0086 0.0075
Schistosoma mansoni patched 1 0.0049 0.0338 0.0328
Trichomonas vaginalis fk506-binding protein, putative 0.0052 0.0375 0.1323
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0245 0.0235
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0245 0.0235
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis neuropeptide receptor 0.0039 0.0245 0.0235
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.208 0.2071
Echinococcus granulosus expressed protein 0.0018 0.005 0.004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0279 0.0268
Echinococcus granulosus sex peptide receptor 0.0039 0.0245 0.0235
Toxoplasma gondii ABC1 family protein 0.011 0.0916 1
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0916 0.14
Loa Loa (eye worm) hypothetical protein 0.003 0.0167 0.0411
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0245 0.0235
Onchocerca volvulus 0.0039 0.0245 0.0386
Brugia malayi Dopamine receptor 0.0039 0.0245 0.0743
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.005 0.1084
Echinococcus granulosus serotonin receptor 0.0039 0.0245 0.0235
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0245 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0173 0.0163
Loa Loa (eye worm) hypothetical protein 0.0045 0.0308 0.0841
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0039 0.0245 0.0235
Echinococcus granulosus snurportin 1 0.0313 0.2812 0.2804
Echinococcus multilocularis chromobox protein 1 0.0069 0.0529 0.0519
Leishmania major hypothetical protein, conserved 0.011 0.0916 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus chromobox protein 1 0.0069 0.0529 0.0519
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus neuropeptide s receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0375 0.0365
Brugia malayi hypothetical protein 0.0016 0.0034 0.0102
Brugia malayi Melatonin receptor type 1A 0.0039 0.0245 0.0743
Mycobacterium ulcerans hypothetical protein 0.011 0.0916 0.3282
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0251 0.6594
Leishmania major cytochrome p450-like protein 0.002 0.0067 0.062
Echinococcus granulosus muscleblind protein 0.0303 0.2719 0.2711
Brugia malayi G protein-coupled receptor F59B2.13 0.0039 0.0245 0.0743
Brugia malayi putative neuropeptide receptor NPR1 0.0039 0.0245 0.0743
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0916 0.3282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0245 0.0235
Schistosoma mansoni neuropeptide receptor 0.0039 0.0245 0.0235
Echinococcus granulosus hypothetical protein 0.0039 0.0245 0.0235
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0052 0.0375 0.1138
Schistosoma mansoni neuropeptide receptor 0.0039 0.0245 0.0235
Onchocerca volvulus 0.0039 0.0245 0.0386
Schistosoma mansoni amine GPCR 0.0039 0.0245 0.0235
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0704 0.6477 1
Schistosoma mansoni neuropeptide F-like receptor 0.0039 0.0245 0.0235
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0116 0.1161
Schistosoma mansoni opsin-like receptor 0.0039 0.0245 0.0235
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0813 0.124
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0346
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0245 0.0649
Leishmania major importin beta-1 subunit, putative 0.0024 0.0106 0.1055
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0245 0.0235
Brugia malayi Thioredoxin reductase 0.0039 0.025 0.0758
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Entamoeba histolytica hypothetical protein 0.0024 0.0106 0.024
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0158 0.1628
Brugia malayi Dopamine receptor protein 2 0.0039 0.0245 0.0743
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0039 0.0245 0.0649
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0719 0.1096
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0916 0.14
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0251 0.2657
Echinococcus granulosus peptide allatostatin:somatostatin 0.0039 0.0245 0.0235
Echinococcus granulosus G protein coupled receptor 139 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0113 0.0943 0.2786
Trichomonas vaginalis immunophilin, putative 0.0052 0.0375 0.1323
Echinococcus multilocularis allatostatin A receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0067 0.062
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0245 0.0649
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0039 0.0245 0.0235
Schistosoma mansoni biogenic amine (5HT) receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.011 0.0916 0.2703
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Onchocerca volvulus 0.0039 0.0245 0.0386
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0033 0.0022
Mycobacterium leprae Probable lipase LipE 0.011 0.0916 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0067 0.062
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1398 0.1388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0916 0.3282
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0273 0.095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.208 0.2071
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0245 0.0235
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0245 0.0235
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0039 0.0245 0.0235
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0086 0.0828
Loa Loa (eye worm) hypothetical protein 0.011 0.0916 0.2703
Echinococcus multilocularis g-protein coupled receptor 0.0039 0.0245 0.0235
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0813 0.8807
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0245 0.0235
Schistosoma mansoni opsin-like receptor 0.0039 0.0245 0.0235
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0251 0.0762
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus dro:myosuppressin receptor 0.0039 0.0245 0.0235
Schistosoma mansoni chromobox protein 0.0069 0.0529 0.0519
Schistosoma mansoni ferritin 0.0018 0.005 0.004
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus importin subunit beta 1 0.0029 0.0158 0.0147
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.003
Brugia malayi beta-lactamase 0.011 0.0916 0.2776
Mycobacterium tuberculosis Conserved protein 0.011 0.0916 0.14
Echinococcus granulosus g-protein coupled receptor 0.0039 0.0245 0.0235
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1398 0.1388
Brugia malayi RNA, U transporter 1 0.0083 0.0664 0.2012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0106 0.0346
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0039 0.0245 0.0649
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0273 0.095
Plasmodium falciparum importin beta, putative 0.0029 0.0158 0.404
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0033 0.0022
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0039 0.0245 0.0235
Brugia malayi G-protein coupled receptor 0.0039 0.0245 0.0743
Brugia malayi CHE-14 protein 0.0049 0.0338 0.1026
Schistosoma mansoni hypothetical protein 0.0039 0.0245 0.0235
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0173 0.0163
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0158 0.0147
Echinococcus granulosus neuropeptide FF receptor 2 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0245 0.0235
Schistosoma mansoni ferritin 0.0018 0.005 0.004
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0375 0.403
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0052 0.0375 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0039 0.0245 0.0743
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0338 0.0328
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0308 0.0297
Schistosoma mansoni amine GPCR 0.0039 0.0245 0.0235
Mycobacterium tuberculosis Conserved protein 0.011 0.0916 0.14
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0033 0.0246
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0916 0.0906
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0022
Brugia malayi AKH receptor 0.0039 0.0245 0.0743
Echinococcus granulosus fmrfamide receptor 0.0039 0.0245 0.0235
Mycobacterium leprae conserved hypothetical protein 0.011 0.0916 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.0161
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0086 0.0828
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0916 0.14
Brugia malayi Dopamine receptor protein 1 0.0039 0.0245 0.0743
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0039 0.0245 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0251 0.1931
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0052 0.0375 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0011 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.011 0.0916 0.2703
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0375 0.403
Loa Loa (eye worm) hypothetical protein 0.0029 0.0158 0.0383
Echinococcus granulosus neuropeptides capa receptor 0.0039 0.0245 0.0235
Brugia malayi chromobox protein homolog 3 0.0039 0.0245 0.0744
Onchocerca volvulus 0.011 0.0916 0.3718
Trichomonas vaginalis esterase, putative 0.011 0.0916 0.3282
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0106 0.1055
Loa Loa (eye worm) hypothetical protein 0.011 0.0916 0.2703
Echinococcus multilocularis snurportin 1 0.0313 0.2812 0.2804
Plasmodium vivax hypothetical protein, conserved 0.011 0.0916 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0234 0.208 0.2071
Schistosoma mansoni amine GPCR 0.0039 0.0245 0.0235
Echinococcus granulosus biogenic amine 5HT receptor 0.0039 0.0245 0.0235
Brugia malayi hypothetical protein 0.0365 0.3299 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0116 0.0253
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0338 0.0328
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0916 0.0906
Mycobacterium ulcerans lipase LipD 0.011 0.0916 0.3282
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0251 0.2657
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0916 0.3282
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0916 0.14
Loa Loa (eye worm) hypothetical protein 0.0094 0.0769 0.2253
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Plasmodium vivax SET domain protein, putative 0.0031 0.0173 0.1796
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0052 0.0375 0.338
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0116 0.1161
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.038 0.1062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0916 0.2703
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0116 0.2881
Brugia malayi glutaminase DH11.1 0.0308 0.2768 0.8392
Loa Loa (eye worm) melatonin receptor type 1A 0.0039 0.0245 0.0649
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0052 0.0375 0.1323
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0813 0.124
Echinococcus multilocularis somatostatin receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0916 0.14
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.005 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0086 0.0075
Brugia malayi Serotonin receptor 0.0039 0.0245 0.0743
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0365 0.3299 0.3292
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.026
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0163 0.0152
Echinococcus multilocularis neuropeptides capa receptor 0.0039 0.0245 0.0235
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0116 0.1161
Echinococcus multilocularis muscleblind protein 1 0.0303 0.2719 0.2711
Echinococcus multilocularis neuropeptide s receptor 0.0039 0.0245 0.0235
Schistosoma mansoni immunophilin 0.0052 0.0375 0.0365
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0916 0.2776
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0106 0.0346
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0116 0.1161
Schistosoma mansoni hypothetical protein 0.0047 0.0322 0.0312
Echinococcus multilocularis expressed conserved protein 0.0106 0.0879 0.0869
Brugia malayi neuropeptide F receptor 0.0039 0.0245 0.0743
Trichomonas vaginalis ferritin, putative 0.0018 0.005 0.0143
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.005 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0851
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0916 0.3282
Schistosoma mansoni eyes absent homolog 0.0094 0.0769 0.0759
Trypanosoma brucei trypanothione reductase 0.0039 0.025 0.2644
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Schistosoma mansoni amine GPCR 0.0039 0.0245 0.0235
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0245 0.0235
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0052 0.0375 0.1323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0255 0.0245
Trichomonas vaginalis glutaminase, putative 0.0308 0.2768 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Onchocerca volvulus 0.011 0.0916 0.3718
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0916 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0338 0.0935
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.2054
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.005 0.0061
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Echinococcus granulosus expressed conserved protein 0.0106 0.0879 0.0869
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0039 0.0245 0.0235
Schistosoma mansoni apoferritin-2 0.0018 0.005 0.004
Plasmodium falciparum glutathione reductase 0.0039 0.025 0.6563
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0039 0.0245 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0173 0.0163
Echinococcus granulosus g protein coupled receptor 0.0039 0.0245 0.0235
Echinococcus granulosus neuropeptide receptor 0.0039 0.0245 0.0235
Schistosoma mansoni hypothetical protein 0.0039 0.0245 0.0235
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.003
Schistosoma mansoni biogenic amine receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis dro:myosuppressin receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0173 0.0163
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0251 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.003
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0041 0.0124
Schistosoma mansoni neuropeptide receptor 0.0039 0.0245 0.0235
Brugia malayi ORL1-like opioid receptor 0.0039 0.0245 0.0743
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0024
Loa Loa (eye worm) G-protein coupled receptor 0.0039 0.0245 0.0649
Onchocerca volvulus 0.0039 0.0245 0.0386
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.003
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0039 0.0245 0.0235
Schistosoma mansoni ran 0.0022 0.0086 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Schistosoma mansoni hypothetical protein 0.0047 0.0322 0.0312
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0039 0.0245 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0067 0.0203
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0033 0.0246
Loa Loa (eye worm) glutaminase 0.0308 0.2768 0.8375
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0067 0.0104
Echinococcus multilocularis g protein coupled receptor 0.0039 0.0245 0.0235
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0375 0.0365
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0033 0.01
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.005 0.0061
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0039 0.0245 0.0649
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0033 0.0022
Echinococcus multilocularis geminin 0.108 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus multilocularis GPCR, family 2 0.0017 0.0041 0.003
Loa Loa (eye worm) hypothetical protein 0.0303 0.2719 0.8223
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0916 0.3282
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.0943 1
Brugia malayi glutathione reductase 0.0039 0.025 0.0758
Brugia malayi hypothetical protein 0.0094 0.0769 0.2331
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0039 0.0245 0.0235
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0039 0.0245 0.0743
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0052 0.0375 0.403
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0251 0.0872
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0067 0.0104
Mycobacterium tuberculosis Probable reductase 0.0089 0.0719 0.1096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0581
Echinococcus granulosus somatostatin receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0031 0.0173 0.0429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0033 0.0246
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0033 0.0611
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0338 0.0935
Schistosoma mansoni hypothetical protein 0.0039 0.0245 0.0235
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0086 0.0828
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0173 0.0163
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.0943 0.0933
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0158 0.1628
Loa Loa (eye worm) hypothetical protein 0.011 0.0916 0.2703
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus granulosus alpha 1A adrenergic receptor 0.0039 0.0245 0.0235
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0251 0.0241
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0255 0.0245
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0052 0.0375 0.1138
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0529 0.1518
Echinococcus granulosus g protein coupled receptor 0.0039 0.0245 0.0235
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0251 0.2657
Echinococcus multilocularis serotonin receptor 0.0039 0.0245 0.0235
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0052 0.0375 0.403
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0052 0.0375 0.403
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus 7tm_1 domain containing protein 0.0039 0.0245 0.0235
Echinococcus multilocularis fmrfamide receptor 0.0039 0.0245 0.0235
Brugia malayi Cytochrome P450 family protein 0.0049 0.0345 0.1044
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0052 0.0375 0.1323
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0086 0.2054
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0338 0.1188
Trichomonas vaginalis ran, putative 0.0022 0.0086 0.0272
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0273 0.0524
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0173 0.0163
Brugia malayi Serotonin receptor 0.0039 0.0245 0.0743
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.025 0.2644
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0039 0.0245 0.0649
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0039 0.0245 0.0235
Brugia malayi GnHR receptor homolog 0.0039 0.0245 0.0743
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0086 0.0828
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0052 0.0375 0.403
Schistosoma mansoni neuropeptide receptor 0.0039 0.0245 0.0235
Schistosoma mansoni myosin xvIII 0.0039 0.0245 0.0235
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0039 0.0245 0.0235
Brugia malayi Cytochrome P450 family protein 0.002 0.0067 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0916 0.14
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0041 0.0124
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0251 0.0241
Onchocerca volvulus 0.0039 0.0245 0.0386
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.038 0.1152
Echinococcus granulosus neuropeptide Y receptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.2812 0.8508
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0916 0.3282
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0719 0.1096
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0041 0.0024
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0959 0.095
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Echinococcus multilocularis muscleblind protein 0.0303 0.2719 0.2711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Leishmania major GTP-binding protein, putative 0.0022 0.0086 0.0828
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.0246
Schistosoma mansoni neuropeptide f receptor 76f 0.0039 0.0245 0.0235
Echinococcus granulosus orexin receptor type 2 0.0039 0.0245 0.0235
Schistosoma mansoni biogenic amine receptor 0.0039 0.0245 0.0235
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.025 0.2644
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0052 0.0375 0.0365
Schistosoma mansoni ferritin 0.0018 0.005 0.004
Brugia malayi putative neuropeptide receptor 0.0039 0.0245 0.0743
Brugia malayi Importin beta-1 subunit 0.0029 0.0158 0.0479
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0116 0.2881
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0022
Plasmodium falciparum thioredoxin reductase 0.0039 0.025 0.6563
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0234 0.208 0.6304
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0251 0.2657
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0039 0.0245 0.0235
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0039 0.0245 0.0235
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0719 0.1096
Schistosoma mansoni ferritin light chain 0.0018 0.005 0.004
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.0943 0.2859
Onchocerca volvulus Neuropeptide F receptor homolog 0.0039 0.0245 0.0386
Brugia malayi follicle stimulating hormone receptor 0.0039 0.0245 0.0743
Loa Loa (eye worm) neuropeptide F receptor 0.0039 0.0245 0.0649
Echinococcus multilocularis neuropeptide Y receptor 0.0039 0.0245 0.0235
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0094 0.0769 0.2253
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0916 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0813 0.124
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.0943 0.0933
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0916 0.14
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0251 0.0872
Onchocerca volvulus 0.0039 0.0245 0.0386
Brugia malayi Pre-SET motif family protein 0.0215 0.1902 0.5766
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus granulosus ferritin 0.0018 0.005 0.004
Echinococcus multilocularis neuropeptide FF receptor 2 0.0039 0.0245 0.0235
Brugia malayi G-protein coupled receptor 0.0039 0.0245 0.0743
Brugia malayi Cytochrome P450 family protein 0.002 0.0067 0.0203
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0916 0.0906
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.014 0.0468
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0039 0.0245 0.0235
Schistosoma mansoni histamine h1 receptor 0.0039 0.0245 0.0235
Schistosoma mansoni apoferritin-2 0.0018 0.005 0.004
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0529 0.1878
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Schistosoma mansoni hypothetical protein 0.0313 0.2812 0.2804
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0234 0.208 0.2071
Schistosoma mansoni hypothetical protein 0.0039 0.0245 0.0235
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.0246
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0719 0.1096
Echinococcus granulosus neuropeptide receptor A26 0.0039 0.0245 0.0235
Leishmania major hypothetical protein, conserved 0.0025 0.0116 0.1161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0039 0.0245 0.0386
Leishmania major fk506-binding protein 1-like protein 0.0052 0.0375 0.403
Echinococcus multilocularis protein dispatched 1 0.0055 0.0403 0.0392
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0251 0.0241
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus multilocularis neuropeptide receptor A26 0.0039 0.0245 0.0235
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.003
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0345 0.0954
Loa Loa (eye worm) beta-lactamase 0.011 0.0916 0.2703
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Onchocerca volvulus 0.0039 0.0245 0.0386
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0052 0.0375 0.403
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0039 0.0245 0.0235
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0173 0.1796
Schistosoma mansoni immunophilin 0.0052 0.0375 0.0365
Echinococcus multilocularis G protein coupled receptor 139 0.0039 0.0245 0.0235
Echinococcus multilocularis serotonin receptor 0.0039 0.0245 0.0235
Schistosoma mansoni ferritin 0.0018 0.005 0.004
Schistosoma mansoni hypothetical protein 0.0047 0.0322 0.0312
Leishmania major trypanothione reductase 0.0039 0.025 0.2644
Schistosoma mansoni hypothetical protein 0.108 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.0246
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Schistosoma mansoni hypothetical protein 0.108 1 1
Schistosoma mansoni biogenic amine receptor 0.0039 0.0245 0.0235
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0033 0.0246
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.014 0.0468
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0039 0.0245 0.0649
Onchocerca volvulus 0.0245 0.2181 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0251 0.0241
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0223 0.0676
Brugia malayi isocitrate dehydrogenase 0.0016 0.0033 0.01
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.038 0.1152
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0158 0.1628
Echinococcus granulosus GPCR family 2 0.0017 0.0041 0.003
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0052 0.0375 0.0365
Loa Loa (eye worm) glutaminase 2 0.0308 0.2768 0.8375
Schistosoma mansoni hypothetical protein 0.0047 0.0322 0.0312
Toxoplasma gondii thioredoxin reductase 0.0039 0.025 0.2644
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0719 0.1096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0719 0.7729
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Echinococcus granulosus allatostatin A receptor 0.0039 0.0245 0.0235
Brugia malayi hypothetical protein 0.0025 0.0116 0.0351
Loa Loa (eye worm) glutathione reductase 0.0039 0.025 0.0665
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0245 0.0388
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0308 0.0297
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0338 0.0328
Schistosoma mansoni adenoreceptor 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Loa Loa (eye worm) CYP4Cod1 0.002 0.0067 0.0104
Loa Loa (eye worm) hypothetical protein 0.0303 0.2719 0.8223
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0234 0.208 0.6267
Onchocerca volvulus 0.0039 0.0245 0.0386
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0116 0.1161
Schistosoma mansoni amine GPCR 0.0039 0.0245 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Echinococcus multilocularis expressed protein 0.0018 0.005 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Brugia malayi Heterochromatin protein 1 0.0069 0.0529 0.1603
Schistosoma mansoni hypothetical protein 0.0036 0.0223 0.0212
Echinococcus multilocularis orexin receptor type 2 0.0039 0.0245 0.0235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Trypanosoma brucei cytochrome P450, putative 0.002 0.0067 0.062
Loa Loa (eye worm) FKBP5 protein 0.0052 0.0375 0.1048
Brugia malayi Pre-SET motif family protein 0.0031 0.0173 0.0525
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0365 0.3299 0.3292
Brugia malayi sulfakinin receptor protein 0.0039 0.0245 0.0743
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0086 0.0828
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0033 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0039 0.0245 0.0235
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0039 0.0245 0.0235
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0033 0.0246
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0052 0.0375 0.338
Echinococcus multilocularis sex peptide receptor 0.0039 0.0245 0.0235
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0039 0.0245 0.0235
Echinococcus multilocularis protein patched 0.0049 0.0338 0.0328
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0039 0.0245 0.0743
Schistosoma mansoni immunophilin 0.0045 0.0308 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0245 0.0851
Loa Loa (eye worm) hypothetical protein 0.0039 0.0245 0.0649
Schistosoma mansoni chromobox protein 0.0069 0.0529 0.0519
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0039 0.0245 0.0235
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0052 0.0375 1
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Brugia malayi beta-lactamase family protein 0.011 0.0916 0.2776
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0052 0.0375 1
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0365 0.3299 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0039 0.0245 0.0743
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.005 0.0143
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0052 0.0375 0.1048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0234 0.208 0.2071
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0039 0.0245 0.0235
Schistosoma mansoni ferritin light chain 0.0018 0.005 0.004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0039 0.0245 0.0235
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0011 0.0033
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Onchocerca volvulus 0.011 0.0916 0.3718
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0251 0.0241
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0251 0.0241
Loa Loa (eye worm) TYRA-2 protein 0.0039 0.0245 0.0649
Schistosoma mansoni serine/threonine protein kinase 0.0365 0.3299 0.3292
Mycobacterium tuberculosis Conserved protein 0.011 0.0916 0.14
Brugia malayi hypothetical protein 0.0039 0.0245 0.0743
Onchocerca volvulus 0.0039 0.0245 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0039 0.0245 0.0235
Schistosoma mansoni importin beta-1 0.0029 0.0158 0.0147
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0251 0.0241
Brugia malayi RE15519p 0.0039 0.0245 0.0743
Echinococcus granulosus tm gpcr rhodopsin 0.0039 0.0245 0.0235
Brugia malayi neuropeptide F receptor 0.0039 0.0245 0.0743
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0916 0.3282

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli ATCC 11775 at < 100 ug/mL by agar dilution method ChEMBL. 20708825
Inhibition (functional) = 29.5 % Antinociceptive activity in Swiss mouse assessed as inhibition of acetic acid-induced writhing at 10 mg/kg, ip administered 30 mins before acetic acid challenge measured after 20 mins relative to control ChEMBL. 20708825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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