Detailed information for compound 1197432

Basic information

Technical information
  • TDR Targets ID: 1197432
  • Name: N-(cyclohexylmethyl)-4-(diethylsulfamoyl)benz amide
  • MW: 352.492 | Formula: C18H28N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.45 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(cc1)C(=O)NCC1CCCCC1)CC
  • InChi: 1S/C18H28N2O3S/c1-3-20(4-2)24(22,23)17-12-10-16(11-13-17)18(21)19-14-15-8-6-5-7-9-15/h10-13,15H,3-9,14H2,1-2H3,(H,19,21)
  • InChiKey: CGQXKPURNKOKAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC03559989
  • T5453175

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0171 0.4121
Schistosoma mansoni hypothetical protein 0.0038 0.0567 0.0711
Toxoplasma gondii exonuclease III APE 0.002 0.0171 0.1194
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1878 0.2341
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0707 0.1065
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.6636 1
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0537 0.0613
Schistosoma mansoni DNA polymerase eta 0.0041 0.0623 0.0782
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0171 0.0268
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0707 0.1065
Mycobacterium leprae conserved hypothetical protein 0.0074 0.1343 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0623 0.1032
Onchocerca volvulus 0.0154 0.3086 1
Echinococcus granulosus geminin 0.0371 0.7824 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0319 0.2303
Loa Loa (eye worm) hypothetical protein 0.0074 0.1343 0.2249
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0919 0.1385
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0398 0.0651
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0623 0.0939
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.1343 0.1652
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.007 0.0435
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0171 0.0142
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.1115 0.1358
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0319 0.795
Loa Loa (eye worm) hypothetical protein 0.0041 0.0626 0.1036
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.6636 1
Trichomonas vaginalis esterase, putative 0.0074 0.1343 0.2264
Giardia lamblia PHD finger protein 15 0.003 0.0398 0.2067
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.3002 0.4524
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0012 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.6636 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0171 0.0258
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0012 0.0018
Echinococcus granulosus lamin 0.0031 0.0408 0.0447
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0623 0.0725
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.6636 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0171 0.0288
Loa Loa (eye worm) glutaminase 0.0284 0.5933 1
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2352 0.3952
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0623 0.046
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0029 0.0364 0.0451
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0171 0.091
Loa Loa (eye worm) hypothetical protein 0.0154 0.3086 0.5191
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.1343 0.1193
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0348 0.0525
Leishmania major DNA polymerase kappa, putative 0.0013 0.0012 0.0018
Mycobacterium tuberculosis Conserved protein 0.0074 0.1343 0.1193
Brugia malayi intermediate filament protein 0.0031 0.0408 0.0669
Schistosoma mansoni ap endonuclease 0.002 0.0171 0.0203
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0012 0.0018
Leishmania major hypothetical protein, conserved 0.0074 0.1343 0.2024
Trichomonas vaginalis glutaminase, putative 0.0284 0.5933 1
Brugia malayi beta-lactamase 0.0074 0.1343 0.2249
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.2714 0.4564
Echinococcus granulosus lamin dm0 0.0031 0.0408 0.0447
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.1901 0.2371
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0567 0.0652
Loa Loa (eye worm) hypothetical protein 0.0031 0.0408 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Trypanosoma brucei RNA helicase, putative 0.0137 0.2733 0.4119
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0229 0.0387
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.1343 0.2249
Mycobacterium tuberculosis Conserved protein 0.0074 0.1343 0.1193
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0623 0.105
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Echinococcus granulosus bloom syndrome protein 0.0023 0.0229 0.0217
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0171 0.0268
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0029 0.0364 0.2647
Trypanosoma cruzi UDP-galactopyranose mutase 0.0029 0.0364 0.0549
Mycobacterium ulcerans hypothetical protein 0.0167 0.3371 0.5673
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0623 0.046
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0029 0.0364 0.9135
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0623 0.1032
Onchocerca volvulus 0.0031 0.0408 0.0038
Leishmania major DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Echinococcus multilocularis musashi 0.0031 0.0408 0.0447
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.1115 0.1863
Echinococcus multilocularis protoporphyrinogen oxidase 0.0029 0.0364 0.0391
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0066 0.0405
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1878 0.283
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0171 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0319 0.048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0623 0.1032
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1343 0.1704
Mycobacterium ulcerans dehydrogenase 0.0029 0.0364 0.0595
Plasmodium vivax hypothetical protein, conserved 0.0074 0.1343 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0029 0.0364 0.0391
Loa Loa (eye worm) hypothetical protein 0.0142 0.2825 0.475
Loa Loa (eye worm) hypothetical protein 0.0063 0.1115 0.1863
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.1115 0.1863
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0537 0.0672
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0626 0.1036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0364 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Onchocerca volvulus 0.0074 0.1343 0.3518
Schistosoma mansoni kinase 0.005 0.0825 0.1041
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0537 0.0886
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0029 0.0364 0.2647
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0171 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0012 0.0018
Trypanosoma cruzi UDP-galactopyranose mutase 0.0029 0.0364 0.0549
Leishmania major hypothetical protein, conserved 0.0027 0.0319 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1878 0.2389
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0171 0.0142
Brugia malayi Latrophilin receptor protein 2 0.0063 0.1115 0.1863
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0623 0.1032
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0096 0.0142
Echinococcus multilocularis peregrin 0.003 0.0398 0.0434
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0398 0.0494
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.1115 0.1358
Trypanosoma brucei DNA polymerase eta, putative 0.0041 0.0623 0.0939
Loa Loa (eye worm) glutaminase 2 0.0284 0.5933 1
Schistosoma mansoni hypothetical protein 0.0063 0.1115 0.1412
Loa Loa (eye worm) hypothetical protein 0.0074 0.1343 0.2249
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0537 0.0672
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1878 0.283
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0408 0.0669
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0623 0.0939
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0229 0.0387
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0408 0.0669
Mycobacterium ulcerans oxidoreductase 0.0029 0.0364 0.0595
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.1343 0.1193
Toxoplasma gondii ABC1 family protein 0.0074 0.1343 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1343 0.2264
Schistosoma mansoni ap endonuclease 0.002 0.0171 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Echinococcus multilocularis lamin 0.0031 0.0408 0.0447
Brugia malayi hypothetical protein 0.0038 0.0567 0.0938
Loa Loa (eye worm) hypothetical protein 0.0136 0.2714 0.4564
Brugia malayi glutaminase DH11.1 0.0284 0.5933 1
Onchocerca volvulus 0.0031 0.0408 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0171 0.1194
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Giardia lamblia Kinase, PLK 0.0098 0.1878 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0364 0.2647
Mycobacterium tuberculosis Conserved protein 0.0074 0.1343 0.1193
Loa Loa (eye worm) hypothetical protein 0.0074 0.1343 0.2249
Trypanosoma brucei unspecified product 0.0028 0.0348 0.0525
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0229 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0348 0.0525
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2352 0.3952
Mycobacterium tuberculosis Possible oxidoreductase 0.0029 0.0364 0.0197
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0567 0.0652
Entamoeba histolytica hypothetical protein 0.0038 0.0567 0.302
Trypanosoma brucei unspecified product 0.0041 0.0623 0.0939
Schistosoma mansoni hypothetical protein 0.0371 0.7824 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0623 0.1032
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0029 0.0364 0.2647
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0319 0.048
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0012 0.0018
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1878 0.5507
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.1343 0.1193
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1101 0.184
Plasmodium falciparum phd finger protein, putative 0.003 0.0398 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0171 0.5
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0229 0.0367
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.1343 0.1193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0171 0.0852
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0171 0.0258
Mycobacterium leprae Probable lipase LipE 0.0074 0.1343 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0364 0.2647
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Brugia malayi SWIRM domain containing protein 0.0154 0.3086 0.5191
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0623 0.1032
Leishmania major DNA polymerase eta, putative 0.0041 0.0623 0.0939
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1343 0.2264
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.1343 0.1193
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.1343 0.2249
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0707 0.1065
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1878 0.3151
Loa Loa (eye worm) hypothetical protein 0.0018 0.013 0.0199
Echinococcus multilocularis 0.0029 0.0364 0.0391
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0029 0.0364 0.9135
Loa Loa (eye worm) hypothetical protein 0.0052 0.087 0.1449
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.1115 0.1358
Schistosoma mansoni amine oxidase 0.0029 0.0364 0.0451
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.017 0.4085
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Trypanosoma brucei polo-like protein kinase 0.0098 0.1878 0.283
Loa Loa (eye worm) hypothetical protein 0.0074 0.1343 0.2249
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.3371 0.3256
Entamoeba histolytica hypothetical protein 0.0038 0.0567 0.302
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0623 0.3318
Loa Loa (eye worm) hypothetical protein 0.0142 0.2825 0.475
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0029 0.0364 0.0595
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0012 0.0018
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0012 0.0018
Echinococcus granulosus dna polymerase eta 0.0041 0.0623 0.0725
Echinococcus multilocularis GPCR, family 2 0.0063 0.1115 0.1358
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0623 0.0939
Brugia malayi beta-lactamase family protein 0.0074 0.1343 0.2249
Entamoeba histolytica hypothetical protein 0.0038 0.0567 0.302
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.1343 0.1652
Toxoplasma gondii histone lysine-specific demethylase 0.0029 0.0364 0.2647
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0623 0.0939
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.1115 0.1358
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0623 0.0939
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0012 0.0018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.1343 0.2249
Loa Loa (eye worm) RecQ helicase 0.0023 0.0229 0.0367
Giardia lamblia DINP protein human, muc B family 0.0041 0.0623 0.3275
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0623 0.0725
Brugia malayi MH2 domain containing protein 0.012 0.2352 0.3952
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1343 0.2024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.3002 0.4524
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.3002 0.4524
Loa Loa (eye worm) hypothetical protein 0.0029 0.0364 0.0595
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Brugia malayi Bromodomain containing protein 0.003 0.0398 0.0651
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Plasmodium falciparum protoporphyrinogen oxidase 0.0029 0.0364 0.9135
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0319 0.2303
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0657 0.0768
Brugia malayi hypothetical protein 0.0029 0.0364 0.0595
Loa Loa (eye worm) hypothetical protein 0.003 0.0398 0.0651
Echinococcus granulosus dna polymerase kappa 0.0041 0.0623 0.0725
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0623 0.0782
Leishmania major DNA damage repair protein, putative 0.0013 0.0012 0.0018
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0126 0.0146
Schistosoma mansoni jumonji domain containing protein 0.0079 0.1456 0.1849
Schistosoma mansoni glutaminase 0.0284 0.5933 0.758
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.1343 0.2264
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1343 0.2264
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0142 0.2825 0.356
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.4093 0.6892
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.1343 0.1193
Loa Loa (eye worm) beta-lactamase 0.0074 0.1343 0.2249
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0707 0.1065
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0398 0.0434
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0398 0.2897
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.1343 0.1193
Loa Loa (eye worm) pigment dispersing factor receptor c 0.02 0.4093 0.6892
Schistosoma mansoni intermediate filament proteins 0.0031 0.0408 0.0507
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0319 0.795
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0623 0.0782
Onchocerca volvulus 0.0074 0.1343 0.3518
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0319 0.048
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.1343 0.2264
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0348 0.0525
Echinococcus granulosus GPCR family 2 0.0063 0.1115 0.1358
Loa Loa (eye worm) hypothetical protein 0.0029 0.0364 0.0595
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1878 0.2341
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0657 0.0768
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0012 0.0018
Schistosoma mansoni hypothetical protein 0.0371 0.7824 1
Echinococcus multilocularis lamin dm0 0.0031 0.0408 0.0447
Loa Loa (eye worm) hypothetical protein 0.0027 0.0319 0.0518
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0408 0.0669
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0096 0.0142
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0398 0.0434
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.1343 0.2024
Loa Loa (eye worm) hypothetical protein 0.0074 0.1343 0.2249
Mycobacterium ulcerans monoamine oxidase 0.0029 0.0364 0.0595
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0171 0.0268
Entamoeba histolytica hypothetical protein 0.0038 0.0567 0.302
Plasmodium vivax hypothetical protein, conserved 0.003 0.0398 0.2897
Schistosoma mansoni lamin 0.0031 0.0408 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Echinococcus granulosus peregrin 0.003 0.0398 0.0434
Loa Loa (eye worm) hypothetical protein 0.02 0.4093 0.6892
Schistosoma mansoni amine oxidase 0.0029 0.0364 0.0451
Loa Loa (eye worm) hypothetical protein 0.003 0.0396 0.0648
Echinococcus granulosus intermediate filament protein 0.0031 0.0408 0.0447
Brugia malayi PHD-finger family protein 0.003 0.0398 0.0651
Brugia malayi Calcitonin receptor-like protein seb-1 0.02 0.4093 0.6892
Loa Loa (eye worm) hypothetical protein 0.0015 0.0061 0.0082
Schistosoma mansoni hypothetical protein 0.0063 0.1115 0.1412
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.1343 0.2024
Schistosoma mansoni hypothetical protein 0.0137 0.2733 0.3484
Chlamydia trachomatis protoporphyrinogen oxidase 0.0029 0.0364 0.5
Mycobacterium ulcerans hypothetical protein 0.0074 0.1343 0.2249
Mycobacterium ulcerans lipase LipD 0.0074 0.1343 0.2249
Onchocerca volvulus 0.0074 0.1343 0.3518
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0142 0.2825 0.36
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0623 0.105
Loa Loa (eye worm) hypothetical protein 0.0074 0.1343 0.2249
Brugia malayi jmjC domain containing protein 0.0037 0.0537 0.0886
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0029 0.0364 0.0595
Mycobacterium ulcerans glutaminase 0.0284 0.5933 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1878 0.3151
Schistosoma mansoni hypothetical protein 0.0063 0.1115 0.1412
Brugia malayi jmjC domain containing protein 0.0099 0.1901 0.3191
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0171 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0062
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.1343 0.2249
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0623 0.0725
Schistosoma mansoni hypothetical protein 0.0063 0.1115 0.1412
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.1343 0.1704
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0398 0.2897
Echinococcus multilocularis geminin 0.0371 0.7824 1
Leishmania major DNA polymerase eta, putative 0.0013 0.0012 0.0018
Trypanosoma brucei unspecified product 0.0028 0.0348 0.0525
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0567 0.0711
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0171 0.0288
Echinococcus granulosus lysine specific histone demethylase 1A 0.0142 0.2825 0.356
Schistosoma mansoni lamin 0.0031 0.0408 0.0507
Brugia malayi hypothetical protein 0.0027 0.0319 0.0518
Brugia malayi hypothetical protein 0.0017 0.0112 0.017
Schistosoma mansoni hypothetical protein 0.0136 0.2714 0.3459
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0012 0.0018
Brugia malayi beta-lactamase family protein 0.0074 0.1343 0.2249
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.1901 0.2371
Leishmania major UDP-galactopyranose mutase 0.0029 0.0364 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Schistosoma mansoni hypothetical protein 0.003 0.0398 0.0494
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1878 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0029 0.0364 0.0595
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0797 0.1343
Toxoplasma gondii hypothetical protein 0.0051 0.085 0.6293
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0797 0.1343
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1878 0.283
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1878 0.3165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0062
Echinococcus multilocularis dna polymerase eta 0.0041 0.0623 0.0725
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0012 0.0018
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0537 0.0613
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0623 0.0939
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0012 0.0018
Mycobacterium ulcerans beta-lactamase 0.0074 0.1343 0.2249

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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