TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 492.591 | Formula: C29H24N4O2S
H donors: 1 H acceptors: 4 LogP: 5.77 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Oc1cc2ccccc2cc1c1nnc(n1C)SCC(=O)N1c2ccccc2CCc2c1cccc2
InChi: 1S/C29H24N4O2S/c1-32-28(23-16-21-10-2-3-11-22(21)17-26(23)34)30-31-29(32)36-18-27(35)33-24-12-6-4-8-19(24)14-15-20-9-5-7-13-25(20)33/h2-13,16-17,34H,14-15,18H2,1H3
InChiKey: VMAQYWUMZIJZSM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Staphylococcus aureus (strain N315)	Probable nicotinate-nucleotide adenylyltransferase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	Get druggable targets OG5_131883	All targets in OG5_131883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative	Get druggable targets OG5_131883	All targets in OG5_131883
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Plasmodium yoelii	Predicted nucleotidyltransferase, putative	Get druggable targets OG5_131883	All targets in OG5_131883
Plasmodium berghei	nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative	Get druggable targets OG5_131883	All targets in OG5_131883
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	Get druggable targets OG5_131883	All targets in OG5_131883
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	hypothetical protein, conserved	Get druggable targets OG5_131883	All targets in OG5_131883
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	Get druggable targets OG5_131883	All targets in OG5_131883
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	Get druggable targets OG5_131883	All targets in OG5_131883
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Treponema pallidum	hypothetical protein	Get druggable targets OG5_131883	All targets in OG5_131883
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	Get druggable targets OG5_131883	All targets in OG5_131883
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Babesia bovis	cytidylyltransferase family protein	Get druggable targets OG5_131883	All targets in OG5_131883
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Trypanosoma cruzi	hypothetical protein, conserved	Probable nicotinate-nucleotide adenylyltransferase	189 aa	200 aa	21.0 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %
Trypanosoma brucei	variant surface glycoprotein (VSG, atypical), putative	Probable nicotinate-nucleotide adenylyltransferase	189 aa	171 aa	20.5 %
Plasmodium knowlesi	cytoskeleton associated protein, putative	Probable nicotinate-nucleotide adenylyltransferase	189 aa	170 aa	23.5 %
Trichomonas vaginalis	nicotinamide mononucleotide adenylyltransferase, putative	Probable nicotinate-nucleotide adenylyltransferase	189 aa	210 aa	23.8 %
Entamoeba histolytica	NMN adenylyltransferase, putative	Probable nicotinate-nucleotide adenylyltransferase	189 aa	204 aa	24.5 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Trichomonas vaginalis	nicotinamide mononucleotide adenylyltransferase, putative	Probable nicotinate-nucleotide adenylyltransferase	189 aa	205 aa	19.0 %
Giardia lamblia	Nicotinamide-nucleotide adenylyltransferase	Probable nicotinate-nucleotide adenylyltransferase	189 aa	153 aa	24.2 %
Entamoeba histolytica	nicotinamide nucleotide adenylyltransferase, putative	Probable nicotinate-nucleotide adenylyltransferase	189 aa	204 aa	24.5 %
Giardia lamblia	Nicotinamide-nucleotide adenylyltransferase	Probable nicotinate-nucleotide adenylyltransferase	189 aa	247 aa	20.6 %
Trypanosoma cruzi	hypothetical protein, conserved	Probable nicotinate-nucleotide adenylyltransferase	189 aa	200 aa	20.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0536	0.0536
Leishmania major	cathepsin L-like protease	0.002	0.0105	0.0917
Echinococcus multilocularis	cysteine protease	0.002	0.0105	0.0105
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.1027	0.8931
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0106	0.1682	0.2771
Leishmania major	cathepsin L-like protease	0.002	0.0105	0.0917
Leishmania major	cathepsin L-like protease	0.002	0.0105	0.0917
Loa Loa (eye worm)	hypothetical protein	0.004	0.0465	0.1303
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0105	0.0174
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0465	0.4044
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.3351	0.3351
Mycobacterium ulcerans	lipase LipD	0.004	0.0465	0.0766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Onchocerca volvulus		0.002	0.0105	0.0406
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0502	0.1415
Brugia malayi	Cathepsin L-like precursor	0.002	0.0105	0.0315
Onchocerca volvulus		0.002	0.0105	0.0406
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0465	0.867
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0536	0.4664
Leishmania major	glycosyl hydrolase-like protein	0.0016	0.0033	0.0284
Brugia malayi	beta-lactamase	0.004	0.0465	0.1388
Onchocerca volvulus		0.004	0.0465	0.2411
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0536	1
Loa Loa (eye worm)	cysteine protease	0.002	0.0105	0.0219
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.115	1
Echinococcus granulosus	cathepsin l1	0.002	0.0105	0.0105
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0536	0.4664
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0105	0.0406
Onchocerca volvulus		0.002	0.0105	0.0406
Plasmodium falciparum	thioredoxin reductase	0.0042	0.0502	0.0827
Loa Loa (eye worm)	hypothetical protein	0.004	0.0465	0.1303
Echinococcus granulosus	thioredoxin glutathione reductase	0.0042	0.0512	0.0512
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0033	0.0609
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0105	0.0219
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0105	0.0105
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0033	0.0284
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0345	0.6069	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0465	0.867
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0465	0.0766
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.3351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Leishmania major	cathepsin L-like protease	0.0077	0.115	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.115	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0536	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0465	0.1303
Toxoplasma gondii	ABC1 family protein	0.004	0.0465	0.867
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0016	0.0033	0.0284
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0033	0.0609
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0502	0.1415
Mycobacterium tuberculosis	Probable dehydrogenase	0.0095	0.1486	0.2449
Onchocerca volvulus		0.002	0.0105	0.0406
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0502	0.9361
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0465	0.0766
Leishmania major	cathepsin L-like protease	0.0077	0.115	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0465	0.1303
Entamoeba histolytica	cysteine protease, putative	0.002	0.0105	0.1445
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Schistosoma mansoni	hypothetical protein	0.0205	0.3496	1
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0465	0.0766
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0105	0.0302
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0465	0.0465
Plasmodium vivax	vivapain-2	0.002	0.0105	0.0174
Loa Loa (eye worm)	hypothetical protein	0.004	0.0465	0.1303
Echinococcus multilocularis	geminin	0.0205	0.3496	0.3496
Mycobacterium tuberculosis	Conserved protein	0.004	0.0465	0.0766
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Toxoplasma gondii	cathepsin CPL	0.002	0.0105	0.1967
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0465	0.0766
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0106	0.1682	0.2771
Onchocerca volvulus		0.002	0.0105	0.0406
Loa Loa (eye worm)	fibroinase	0.002	0.0105	0.0219
Trypanosoma brucei	trypanothione reductase	0.0042	0.0502	0.4366
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Brugia malayi	glutathione reductase	0.0042	0.0502	0.1498
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.115	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0105	0.0219
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0465	0.867
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0465	0.133
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0105	0.0406
Brugia malayi	Cathepsin L-like precursor	0.002	0.0105	0.0315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0105	0.0302
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0105	0.0219
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0465	0.1303
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.0847	0.7364
Leishmania major	cathepsin L-like protease	0.002	0.0105	0.0917
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0105	0.0315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trypanosoma brucei	glucosidase, putative	0.0044	0.0536	0.4664
Loa Loa (eye worm)	hypothetical protein	0.004	0.0465	0.1303
Brugia malayi	beta-lactamase family protein	0.004	0.0465	0.1388
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0106	0.1682	0.2172
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0465	0.0766
Schistosoma mansoni	hypothetical protein	0.0205	0.3496	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Leishmania major	hypothetical protein, conserved	0.004	0.0465	0.4044
Mycobacterium tuberculosis	Probable reductase	0.0095	0.1486	0.2449
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0536	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0465	0.867
Echinococcus granulosus	geminin	0.0205	0.3496	0.3496
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0042	0.0512	0.0512
Plasmodium falciparum	glutathione reductase	0.0042	0.0502	0.0827
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Brugia malayi	Cathepsin L-like precursor	0.002	0.0105	0.0315
Trichomonas vaginalis	esterase, putative	0.004	0.0465	0.867
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0105	0.1445
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0345	0.6069	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0105	0.1445
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0536	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0558	1	1
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0345	0.6069	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0033	0.0098
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.3351	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0105	0.0105
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0345	0.6069	1
Mycobacterium ulcerans	hypothetical protein	0.004	0.0465	0.0766
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0465	0.0766
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0465	0.0766
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0536	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0465	0.867
Brugia malayi	Cathepsin L-like precursor	0.002	0.0105	0.0315
Brugia malayi	Thioredoxin reductase	0.0042	0.0502	0.1498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0095	0.1486	0.2449
Treponema pallidum	hypothetical protein	0.0345	0.6069	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Leishmania major	trypanothione reductase	0.0042	0.0502	0.4366
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0095	0.1486	0.2449
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2384	0.7087
Echinococcus multilocularis	neuropeptide s receptor	0.0558	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0502	0.4366
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0095	0.1486	0.2449
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Onchocerca volvulus		0.002	0.0105	0.0406
Schistosoma mansoni	alpha glucosidase	0.0044	0.0536	0.1534
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0465	0.0766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0502	0.0827
Schistosoma mansoni	alpha-glucosidase	0.0169	0.2847	0.8145
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.0502	0.0827
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0105	0.0105
Brugia malayi	Cathepsin L-like precursor	0.002	0.0105	0.0315
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.3351	0.3351
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0254	0.4406	0.726
Mycobacterium tuberculosis	Probable oxidoreductase	0.0106	0.1682	0.2771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0465	0.4044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0105	0.0917
Mycobacterium tuberculosis	Conserved protein	0.004	0.0465	0.0766
Onchocerca volvulus		0.0114	0.1826	1
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0105	0.0917
Onchocerca volvulus		0.002	0.0105	0.0406
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0105	0.0174
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0033	0.0609
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0016	0.0033	0.0609
Brugia malayi	Cathepsin L-like precursor	0.002	0.0105	0.0315
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0465	0.133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0465	0.0465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0105	0.1967
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0105	0.1967
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0105	0.0105
Loa Loa (eye worm)	ctsf protein	0.002	0.0105	0.0219
Echinococcus multilocularis	cysteine protease	0.002	0.0105	0.0105
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0345	0.6069	1
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0465	0.0766
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0465	0.1388
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0536	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0105	0.1967
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0536	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0536	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0536	1
Onchocerca volvulus		0.004	0.0465	0.2411
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0033	0.0609
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.3351	0.3351
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0105	0.0105
Leishmania major	cathepsin L-like protease	0.002	0.0105	0.0917
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Brugia malayi	MH2 domain containing protein	0.0144	0.2384	0.7115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0536	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0536	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0014	0	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2384	0.7087
Leishmania major	cathepsin L-like protease	0.0077	0.115	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0033	0.0609
Schistosoma mansoni	alpha-glucosidase	0.0169	0.2847	0.8145
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0105	0.0406
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0536	0.1518
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.115	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0033	0.0609
Echinococcus granulosus	neuropeptide receptor A26	0.0558	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0105	0.0105
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0536	0.0536
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0502	0.0827
Mycobacterium ulcerans	beta-lactamase	0.004	0.0465	0.0766
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0095	0.1486	0.2449
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0014	0	0.5
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0033	0.0284
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0465	0.4044
Plasmodium vivax	vivapain-2	0.002	0.0105	0.0174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0536	0.1601
Mycobacterium tuberculosis	Conserved protein	0.004	0.0465	0.0766
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.115	1
Onchocerca volvulus		0.004	0.0465	0.2411
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0105	0.1967
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0014	0	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0105	0.0174
Brugia malayi	beta-lactamase family protein	0.004	0.0465	0.1388
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0033	0.0609
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0536	1
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0536	0.4664
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0095	0.1486	0.1823
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0465	0.0766
Loa Loa (eye worm)	beta-lactamase	0.004	0.0465	0.1303

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	7.15 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	24.5 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	> 50 um	PUBCHEM_BIOASSAY: Thrombin 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 1046 (Thrombin 1536 HTS; hits were confirmed in this assay)]	ChEMBL.	No reference
Potency (functional)	1.8526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.9093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	84.9214 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1352979

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1206878