Detailed information for compound 1226287

Basic information

Technical information
  • TDR Targets ID: 1226287
  • Name: 2-(3-methoxyphenyl)-N-[[3-(trifluoromethyl)ph enyl]methyl]ethanamine; oxalic acid
  • MW: 399.361 | Formula: C19H20F3NO5
  • H donors: 3 H acceptors: 4 LogP: 1.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(=O)O.COc1cccc(c1)CCNCc1cccc(c1)C(F)(F)F
  • InChi: 1S/C17H18F3NO.C2H2O4/c1-22-16-7-3-4-13(11-16)8-9-21-12-14-5-2-6-15(10-14)17(18,19)20;3-1(4)2(5)6/h2-7,10-11,21H,8-9,12H2,1H3;(H,3,4)(H,5,6)
  • InChiKey: PUHURAMZQCWACU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3-methoxyphenyl)ethyl-[3-(trifluoromethyl)benzyl]amine; oxalic acid
  • ethanedioic acid; 2-(3-methoxyphenyl)-N-[[3-(trifluoromethyl)phenyl]methyl]ethanamine
  • MLS000692729
  • SMR000285196

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.05 0.3801
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.0196
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Schistosoma mansoni hypothetical protein 0.0019 0.0188 0.0407
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0123 0.006
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0476 0.0862
Onchocerca volvulus 0.0015 0.0091 0.0144
Echinococcus multilocularis lysine specific demethylase 5A 0.0132 0.2757 0.4915
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0553 0.1006
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.029 0.0526
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7817 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0596 0.4688
Brugia malayi hypothetical protein 0.0015 0.0091 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.2508
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0476 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Entamoeba histolytica protein kinase, putative 0.0032 0.0491 0.0627
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3927
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Plasmodium vivax hexose transporter 0.0106 0.2166 0.2094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3927
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Brugia malayi Sugar transporter family protein 0.0015 0.0091 0.0164
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0218 0.0395
Onchocerca volvulus 0.0016 0.0123 0.0195
Loa Loa (eye worm) hypothetical protein 0.0116 0.2412 0.4389
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0491 0.0889
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0209 0.0328
Leishmania major cathepsin L-like protease 0.0016 0.0123 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0252 0.5515 1
Schistosoma mansoni hypothetical protein 0.0106 0.2166 0.4692
Echinococcus multilocularis cysteine protease 0.0016 0.0123 0.006
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.2508
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Brugia malayi jmjC domain containing protein 0.0035 0.0553 0.1002
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0123 0.0224
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0575 0.0893
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.029 0.0368
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0491 0.0893
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0553 0.0713
Plasmodium falciparum protein kinase 7 0.0299 0.6574 0.6542
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1158 0.2107
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1158 0.2099
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0091 0.0165
Brugia malayi hypothetical protein 0.0015 0.0091 0.0164
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.1087 0.1971
Echinococcus granulosus tar DNA binding protein 0.0062 0.1158 0.2099
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.0196
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0553 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.029 0.0233
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0091 0.0116
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0553 0.1002
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.0116
Toxoplasma gondii protein kinase, putative 0.0299 0.6574 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.2508
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0491 0.0404
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0476 0.0862
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0553 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Brugia malayi Pre-SET motif family protein 0.0036 0.0575 0.1043
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0596 0.4688
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.029 0.0258
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0091 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.05 0.064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0188 0.0342
Onchocerca volvulus 0.0015 0.0091 0.0144
Brugia malayi Pre-SET motif family protein 0.0251 0.5495 0.9964
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0123 0.0223
Brugia malayi Cathepsin L-like precursor 0.0016 0.0123 0.0223
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0123 0.006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0252 0.5515 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0575 0.1043
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2166 0.3201
Brugia malayi jmjC domain containing protein 0.0035 0.0553 0.1002
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0123 0.0195
Loa Loa (eye worm) hypothetical protein 0.0058 0.1087 0.1978
Onchocerca volvulus 0.0015 0.0091 0.0144
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0091 0.0227
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2166 0.3826
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0218 0.0472
Entamoeba histolytica hypothetical protein 0.0024 0.029 0.0371
Trypanosoma cruzi hexose transporter, putative 0.0033 0.05 0.3801
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Echinococcus granulosus lysine specific demethylase 5A 0.0132 0.2757 0.4999
Brugia malayi TAR-binding protein 0.0062 0.1158 0.2099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.1087 0.1978
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0596 0.4688
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0123 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Brugia malayi Sugar transporter family protein 0.0015 0.0091 0.0164
Echinococcus granulosus peregrin 0.0058 0.1087 0.1971
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0865 0.7185
Schistosoma mansoni hypothetical protein 0.0058 0.1087 0.2355
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0091 0.0116
Brugia malayi hypothetical protein 0.0015 0.0091 0.0164
Schistosoma mansoni jumonji domain containing protein 0.0213 0.4616 1
Onchocerca volvulus 0.0016 0.0123 0.0195
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1168 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.1087 0.1837
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1158 0.1967
Onchocerca volvulus 0.0015 0.0091 0.0144
Schistosoma mansoni jumonji/arid domain-containing protein 0.0132 0.2757 0.5972
Leishmania major cathepsin L-like protease 0.0016 0.0123 0.03
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0491 0.0404
Leishmania major cathepsin L-like protease 0.0016 0.0123 0.03
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.05 0.3801
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0445 0.0807
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0553 0.1002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Schistosoma mansoni glucose transporter 0.0015 0.0091 0.0196
Plasmodium vivax SET domain protein, putative 0.0036 0.0575 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0737
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.2508
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0491 0.0893
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0491 0.0404
Plasmodium falciparum hexose transporter 0.0106 0.2166 0.2094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0575 0.1246
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.029 0.0629
Onchocerca volvulus 0.0016 0.0123 0.0195
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Brugia malayi Cathepsin L-like precursor 0.0016 0.0123 0.0223
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.029 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0476 0.0608
Brugia malayi jmjC domain containing protein 0.0132 0.2757 0.4999
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0188 0.0901
Onchocerca volvulus 0.0036 0.0575 0.0914
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0048 0.0088
Onchocerca volvulus 0.0015 0.0091 0.0144
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0123 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0575 0.1246
Echinococcus granulosus cathepsin l1 0.0016 0.0123 0.0223
Onchocerca volvulus 0.0016 0.0123 0.0195
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0188 0.015
Plasmodium vivax vivapain-2 0.0016 0.0123 0.0033
Trypanosoma brucei glucose transporter 2A 0.0033 0.05 0.3801
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0553 0.1197
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.029 0.0201
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.029 0.1852
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.029 0.0201
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3927
Echinococcus granulosus General substrate transporter 0.0091 0.1826 0.3312
Trypanosoma cruzi hexose transporter 0.0033 0.05 0.3801
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0445 0.0653
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Schistosoma mansoni protein kinase 0.0032 0.0491 0.1063
Brugia malayi Cathepsin L-like precursor 0.0016 0.0123 0.0223
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0123 0.0157
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3692 1
Onchocerca volvulus 0.0015 0.0091 0.0144
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3826
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3826
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0596 0.4688
Echinococcus multilocularis cysteine protease 0.0016 0.0123 0.006
Schistosoma mansoni glucose transport protein 0.0106 0.2166 0.4692
Leishmania major glucose transporter, lmgt1 0.0033 0.05 0.3801
Entamoeba histolytica protein kinase, putative 0.0032 0.0491 0.0627
Brugia malayi Cam kinase protein 1 0.0032 0.0491 0.0889
Leishmania major cathepsin L-like protease 0.0062 0.1168 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0553 0.4289
Loa Loa (eye worm) hypothetical protein 0.0035 0.0553 0.1006
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0209 0.0328
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0123 0.0195
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.05 0.3801
Plasmodium falciparum phd finger protein, putative 0.0058 0.1087 0.1005
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1045 0.8859
Entamoeba histolytica cysteine protease, putative 0.0016 0.0123 0.0157
Echinococcus granulosus phd:f box containing protein 0.0035 0.0553 0.1002
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0596 0.0779
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0164
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0123 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0553 0.1006
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0476 0.103
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.1087 0.2355
Loa Loa (eye worm) hypothetical protein 0.0024 0.029 0.0528
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0091 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0575 0.1246
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0553 0.0852
Onchocerca volvulus 0.0015 0.0091 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0889
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0491 0.0404
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0019 0.0188 0.0098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Giardia lamblia PHD finger protein 15 0.0058 0.1087 0.1289
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0553 0.1197
Brugia malayi Cathepsin L-like precursor 0.0016 0.0123 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0224 0.0286
Trypanosoma brucei glucose transporter 1E 0.0033 0.05 0.3801
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3826
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.029 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1168 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.6289 0.8044
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0491 0.0617
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Leishmania major cathepsin L-like protease 0.0016 0.0123 0.03
Brugia malayi Bromodomain containing protein 0.0058 0.1087 0.1971
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0123 0.0266
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0889
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0553 0.1197
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0476 0.0766
Plasmodium vivax JmjC domain containing protein 0.0035 0.0553 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.05 0.064
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0164
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0553 0.0466
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0553 0.1197
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0476 0.0498
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0575 0.0747
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0123 0.0157
Onchocerca volvulus 0.0015 0.0091 0.0144
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0476 0.071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.5495 1
Onchocerca volvulus Putative transporter 0.0015 0.0091 0.0144
Onchocerca volvulus 0.0015 0.0091 0.0144
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0553 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0491 0.0404
Onchocerca volvulus 0.0015 0.0091 0.0144
Brugia malayi Cathepsin L-like precursor 0.0016 0.0123 0.0223
Plasmodium vivax hypothetical protein, conserved 0.0058 0.1087 0.1005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Leishmania major cathepsin L-like protease 0.0062 0.1168 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0123 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0132 0.2757 0.5017
Trichomonas vaginalis glucose transporter, putative 0.0033 0.05 0.064
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0188 0.0098
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3692 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0123 0.0033
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0553 0.0852
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.7817 1
Leishmania major glucose transporter, lmgt3 0.0033 0.05 0.3801
Schistosoma mansoni glucose transport protein 0.0106 0.2166 0.4692
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.0116
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0491 0.0617
Loa Loa (eye worm) sugar transporter 0.0015 0.0091 0.0165
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.029 0.1852
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0553 0.1006
Leishmania major cathepsin L-like protease 0.0016 0.0123 0.03
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1168 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0123 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Loa Loa (eye worm) fibroinase 0.0016 0.0123 0.0224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Leishmania major glucose transporter, lmgt2 0.0033 0.05 0.3801
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0188 0.015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Onchocerca volvulus 0.0016 0.0123 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.029 0.1852
Loa Loa (eye worm) hypothetical protein 0.0035 0.0553 0.1006
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Onchocerca volvulus 0.0015 0.0091 0.0144
Loa Loa (eye worm) RNA binding protein 0.0062 0.1158 0.2107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0491 0.0627
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1168 1
Brugia malayi Sugar transporter family protein 0.0106 0.2166 0.3927
Schistosoma mansoni glucose transport protein 0.0106 0.2166 0.4692
Brugia malayi jmjC domain containing protein 0.0252 0.5515 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0123 0.0033
Onchocerca volvulus 0.0015 0.0091 0.0144
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0545 0.0988
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0123 0.0033
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0091 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Onchocerca volvulus 0.0016 0.0123 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0491 0.0404
Loa Loa (eye worm) hypothetical protein 0.0036 0.0575 0.1046
Brugia malayi jmjC domain containing protein 0.0035 0.0553 0.1002
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Onchocerca volvulus 0.0015 0.0091 0.0144
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0123 0.0195
Brugia malayi RNA binding protein 0.0062 0.1158 0.2099
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.2509 0.4566
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2166 0.3927
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0553 0.4289
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0123 0.0224
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0091 0.0164
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.0196
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Schistosoma mansoni protein kinase 0.0032 0.0491 0.1063
Leishmania major hypothetical protein, conserved 0.0035 0.0553 0.4289
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Brugia malayi PHD-finger family protein 0.0058 0.1087 0.1971
Mycobacterium ulcerans sugar transporter 0.0015 0.0091 0.0227
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0123 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.0132 0.2757 0.5972
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0188 0.0901
Plasmodium vivax CDK-related protein kinase 6, putative 0.0448 1 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.05 0.064
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0476 0.0862
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0476 0.0865
Plasmodium falciparum mitogen-activated protein kinase 2 0.0171 0.3653 0.3595
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.029 0.0371
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7817 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0737
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0123 0.006
Echinococcus multilocularis General substrate transporter 0.0091 0.1826 0.32
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3692 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0491 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Brugia malayi AF-10 protein 0.0019 0.0188 0.034
Brugia malayi lysyl-tRNA synthetase 0.0024 0.029 0.0526
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0491 0.3713
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Brugia malayi PHD-finger family protein 0.0019 0.0188 0.034
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0091 0.0196
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.029 0.0768
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.7817 1
Onchocerca volvulus 0.0016 0.0123 0.0195
Onchocerca volvulus 0.0015 0.0091 0.0144
Onchocerca volvulus Alhambra homolog 0.0058 0.1087 0.1728
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0091 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0575 0.0893
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0491 0.1063
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0553 0.0713
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0553 0.0852
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Brugia malayi major facilitator superfamily protein 0.0015 0.0091 0.0164
Schistosoma mansoni protein kinase 0.0032 0.0491 0.1063
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0091 0.0227
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Leishmania major protein kinase, putative 0.0032 0.0491 0.3713
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0553 0.1002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7817 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0737
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0091 0.0227
Brugia malayi major facilitator superfamily protein 0.0015 0.0091 0.0164
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.029 0.0629
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.161 0.2801
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Plasmodium vivax vivapain-2 0.0016 0.0123 0.0033
Echinococcus multilocularis peregrin 0.0058 0.1087 0.1837
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0123 0.03
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0123 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Loa Loa (eye worm) hypothetical protein 0.0026 0.034 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0123 0.0157
Onchocerca volvulus 0.0286 0.6289 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.05 0.3801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0491 0.0737
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.1087 0.1537
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Loa Loa (eye worm) cysteine protease 0.0016 0.0123 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0033 0.05 0.064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1158 0.2107
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0596 0.051
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.1087 0.1537
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0491 0.0404
Onchocerca volvulus 0.0015 0.0091 0.0144
Toxoplasma gondii cathepsin CPL 0.0016 0.0123 0.005
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0171 0.3653 0.5495
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0491 0.0617
Trypanosoma cruzi hexose transporter, putative 0.0018 0.016 0.0648
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.029 0.0768
Trypanosoma brucei glucose transporter, putative 0.0033 0.05 0.3801
Trypanosoma cruzi hexose transporter, putative 0.0033 0.05 0.3801
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1168 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0553 0.4289
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0171 0.3653 0.3595
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.0116
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0476 0.103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Trichomonas vaginalis glucose transporter, putative 0.0033 0.05 0.064
Echinococcus granulosus jumonji domain containing protein 0.0081 0.161 0.2919
Brugia malayi jmjC domain containing protein 0.0035 0.0553 0.1002
Onchocerca volvulus 0.0015 0.0091 0.0144
Loa Loa (eye worm) sugar transporter 0.0106 0.2166 0.3942
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0123 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0033 0.05 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2166 0.2771
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0091 0.0164
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0091 0.0164
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0553 0.1002
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0123 0.0157
Loa Loa (eye worm) hypothetical protein 0.0032 0.0476 0.0865
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0596 0.051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0491 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0123 0.0157
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0596 0.4688
Leishmania major cathepsin L-like protease 0.0062 0.1168 1
Loa Loa (eye worm) ctsf protein 0.0016 0.0123 0.0224
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.0116
Trypanosoma cruzi hexose transporter, putative 0.0033 0.05 0.3801
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0491 0.0889
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0491 0.0404
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0091 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1158 0.2508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0575 0.1246
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0165

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.