Detailed information for compound 1237102

Basic information

Technical information
  • TDR Targets ID: 1237102
  • Name: 2-[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl-N-( 2-methoxyphenyl)-4,6-dimethylpyridine-3-carbo xamide
  • MW: 440.942 | Formula: C23H21ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.31 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)c1c(C)cc(nc1SCC(=O)c1ccc(cc1)Cl)C
  • InChi: 1S/C23H21ClN2O3S/c1-14-12-15(2)25-23(30-13-19(27)16-8-10-17(24)11-9-16)21(14)22(28)26-18-6-4-5-7-20(18)29-3/h4-12H,13H2,1-3H3,(H,26,28)
  • InChiKey: DGQQYPLBGSPCHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(4-chlorophenyl)-2-oxo-ethyl]sulfanyl-N-(2-methoxyphenyl)-4,6-dimethyl-pyridine-3-carboxamide
  • 2-[[2-(4-chlorophenyl)-2-oxoethyl]thio]-N-(2-methoxyphenyl)-4,6-dimethyl-3-pyridinecarboxamide
  • 2-[[2-(4-chlorophenyl)-2-keto-ethyl]thio]-N-(2-methoxyphenyl)-4,6-dimethyl-nicotinamide
  • D276-0402
  • NCGC00117901-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0491
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.001 0.0052
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0125 0.038 0.0369
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0039
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0085 0.0082
Mycobacterium ulcerans integral membrane transporter 0.0097 0.0292 0.0253
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0009 0.0033
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0039
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.001 0.0039
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0003 0.0011
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0014 0.0069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0784 0.388
Loa Loa (eye worm) hypothetical protein 0.0359 0.1125 0.557
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.001 0.0039
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0358 0.1775
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0011
Plasmodium vivax SET domain protein, putative 0.0037 0.01 0.2336
Brugia malayi hypothetical protein 0.0009 0.001 0.005
Loa Loa (eye worm) Smad1 0.001 0.0014 0.0069
Brugia malayi 6-phosphofructokinase 0.0118 0.0358 0.1774
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0014 0.0069
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.01 0.0493
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0039
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0014 0.0058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0041 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0032 0.0148
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0359 0.1125 0.557
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.01 0.0481
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.0537 0.2782
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Schistosoma mansoni cpg binding protein 0.0029 0.0076 0.0378
Echinococcus granulosus smad 0.001 0.0014 0.0058
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0014 0.0058
Brugia malayi Pre-SET motif family protein 0.0037 0.01 0.0491
Echinococcus multilocularis carbonic anhydrase 0.0359 0.1125 0.5565
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0358 0.0356
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0358 0.0356
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0003 0.0013
Schistosoma mansoni 6-phosphofructokinase 0.0118 0.0358 0.1775
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0085 0.0403
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Brugia malayi RasGEF domain containing protein 0.0006 0.0003 0.0011
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0358 0.3098
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0358 0.1774
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0003 0.0013
Schistosoma mansoni regulator of G protein signaling 0.0009 0.001 0.0052
Onchocerca volvulus Putative sulfate transporter 0.0611 0.1924 1
Schistosoma mansoni hypothetical protein 0.0359 0.1125 0.5571
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0069
Echinococcus multilocularis carbonic anhydrase 0.0359 0.1125 0.5565
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.01 0.08
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0097 0.0292 0.232
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0014 0.0058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0032 0.0158
Brugia malayi hypothetical protein 0.0009 0.001 0.005
Echinococcus multilocularis smad 0.001 0.0014 0.0058
Schistosoma mansoni dishevelled 0.0009 0.001 0.0052
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.016
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.001 0.0039
Echinococcus granulosus carbonic anhydrase 0.0359 0.1125 0.5565
Brugia malayi MH2 domain containing protein 0.0144 0.0441 0.2183
Schistosoma mansoni carbonic anhydrase 0.0368 0.1151 0.5702
Brugia malayi CXXC zinc finger family protein 0.0028 0.0071 0.0351
Echinococcus multilocularis cpg binding protein 0.0029 0.0076 0.0366
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0032 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.3153 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0641 0.2019 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0014 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.01 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0085 0.0665
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0009 0.0033
Toxoplasma gondii exonuclease III APE 0.0018 0.0041 0.0273
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0706 0.2225 0.2377
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0071 0.0351
Brugia malayi N-terminal motif family protein 0.0006 0.0003 0.0011
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0359 0.1125 0.557
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0085 0.0082
Mycobacterium leprae Probable transmembrane transport protein 0.0706 0.2225 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.001 0.0052
Brugia malayi N-terminal motif family protein 0.0174 0.0537 0.2659
Brugia malayi phosphofructokinase 0.0118 0.0358 0.1774
Brugia malayi RasGEF domain containing protein 0.0006 0.0003 0.0011
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.001 0.005
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0041 0.0038
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.291 0.9229 1
Mycobacterium ulcerans carbonic anhydrase 0.0368 0.1151 0.1115
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0358 0.1606
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0041 0.0333
Schistosoma mansoni smad 0.001 0.0014 0.0071
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0358 0.3098
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0039
Brugia malayi Pre-SET motif family protein 0.0252 0.0784 0.388
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0685
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0085 0.0403
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0441
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0085 0.0665
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0359 0.1125 0.557
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0003 0.0011
Echinococcus granulosus carbonic anhydrase II 0.0641 0.2019 1
Schistosoma mansoni Smad4 0.001 0.0014 0.0071
Schistosoma mansoni hypothetical protein 0.0033 0.0089 0.0443
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0358 0.0356
Schistosoma mansoni ap endonuclease 0.0018 0.0041 0.0202
Brugia malayi MH2 domain containing protein 0.001 0.0014 0.0069
Loa Loa (eye worm) phosphofructokinase 0.0118 0.0358 0.1774
Echinococcus multilocularis 6 phosphofructokinase 0.0118 0.0358 0.1765
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0359 0.1125 0.557
Brugia malayi 6-phosphofructokinase 0.0118 0.0358 0.1774
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0032 0.0158
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0139 0.0685
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0118 0.0358 1
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0097 0.0292 0.253
Echinococcus multilocularis carbonic anhydrase 0.0359 0.1125 0.5565
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.01 0.0481
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0093 0.0451
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.01 0.0481
Loa Loa (eye worm) hypothetical protein 0.0174 0.0537 0.2659
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0085 0.0713
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0041 0.02
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.01 0.0493
Schistosoma mansoni dishevelled 0.0009 0.001 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0015 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0032 0.0148
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0441 0.2183
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0085 0.0082
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0085 0.0082
Entamoeba histolytica carbonic anhydrase, putative 0.0368 0.1151 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0041 0.019
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0033
Echinococcus multilocularis carbonic anhydrase II 0.0641 0.2019 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0015 0.006
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0641 0.2019 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0003 0.0001
Echinococcus multilocularis GPCR, family 2 0.0015 0.0032 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0085 0.0082
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0085 0.1737
Echinococcus granulosus GPCR family 2 0.0015 0.0032 0.0148
Leishmania major ATP-dependent phosphofructokinase 0.0118 0.0358 0.1606
Schistosoma mansoni carbonic anhydrase 0.0359 0.1125 0.5571
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0071
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0014 0.0058
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0359 0.1125 0.557
Toxoplasma gondii hypothetical protein 0.0359 0.1125 1
Schistosoma mansoni cpg binding protein 0.0029 0.0076 0.0378
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0041 0.019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0009 0.0033
Trypanosoma brucei carbonic anhydrase-like protein 0.0641 0.2019 1
Schistosoma mansoni ap endonuclease 0.0018 0.0041 0.0202
Schistosoma mansoni cpg binding protein 0.0028 0.0071 0.0353
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0071
Schistosoma mansoni carbonic anhydrase-related 0.0359 0.1125 0.5571
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.005
Schistosoma mansoni carbonic anhydrase-related 0.0359 0.1125 0.5571
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0003 0.0001
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.001 0.005
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0368 0.1151 0.4247
Brugia malayi N-terminal motif family protein 0.0006 0.0003 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0085 0.0082
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0641 0.2019 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.01 0.0493
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0641 0.2019 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.001 0.0039
Brugia malayi RasGEF domain containing protein 0.0006 0.0003 0.0011
Echinococcus granulosus carbonic anhydrase 0.0359 0.1125 0.5565
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0139 0.0685
Leishmania major carbonic anhydrase-like protein 0.0641 0.2019 1
Onchocerca volvulus 0.0009 0.001 0.0041
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0032 0.0148
Echinococcus granulosus Smad4 0.001 0.0014 0.0058
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0085 1
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.016
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0118 0.0358 0.0346
Echinococcus granulosus 6 phosphofructokinase 0.0118 0.0358 0.1765
Plasmodium falciparum carbonic anhydrase 0.0359 0.1125 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0003 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0174 0.0863
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.005
Loa Loa (eye worm) hypothetical protein 0.0359 0.1125 0.557
Leishmania major carbonic anhydrase family protein, putative 0.0368 0.1151 0.5613
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0011
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0097 0.0292 0.1271
Echinococcus granulosus cpg binding protein 0.0029 0.0076 0.0366
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.001 0.0039
Loa Loa (eye worm) carbonic anhydrase 3 0.0641 0.2019 1
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0894 0.0892
Onchocerca volvulus 0.0611 0.1924 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0015 0.007
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0359 0.1125 0.557
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0002 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0009 0.0046
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0003 0.0013
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.001 0.005
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0041 0.02
Schistosoma mansoni dep domain containing protein 0.0009 0.001 0.0052
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0948 0.2996 0.3217
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0641 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0032 0.0158
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0641 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0359 0.1125 0.557
Brugia malayi MH1 domain containing protein 0.001 0.0014 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Schistosoma mansoni smad1 5 8 and 0.001 0.0014 0.0071
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.016
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0085 0.0665
Onchocerca volvulus 0.0037 0.01 0.0505
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0441 0.2183
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0118 0.0358 0.1765
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0032 0.0148
Brugia malayi DIX domain containing protein 0.0009 0.001 0.005
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0003 0.0013
Entamoeba histolytica phosphofructokinase, putative 0.0118 0.0358 0.3098
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0003 0.0001
Loa Loa (eye worm) 6-phosphofructokinase 0.0118 0.0358 0.1774
Brugia malayi Smad1 0.001 0.0014 0.0069
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0097 0.0292 0.1437
Schistosoma mansoni carbonic anhydrase-related 0.0359 0.1125 0.5571
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0041 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0003 0.0001
Chlamydia trachomatis sulfate transporter 0.0097 0.0292 1
Echinococcus granulosus carbonic anhydrase 0.0359 0.1125 0.5565
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.001 0.0039
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.001 0.005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0003 0.0001
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0641 0.2019 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0085 0.1375
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0089 0.0441
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0041 0.019
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0097 0.0292 0.1437
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.3153 1 1
Onchocerca volvulus 0.0287 0.0894 0.4638
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.001 0.0041
Trichomonas vaginalis helicase, putative 0.0006 0.0003 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0139 0.0685
Trichomonas vaginalis phosphofructokinase, putative 0.0118 0.0358 0.0356
Schistosoma mansoni hypothetical protein 0.0015 0.0032 0.016
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0085 0.0082
Plasmodium vivax sulfate transporter, putative 0.0097 0.0292 1
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0097 0.0292 0.0253
Onchocerca volvulus 0.0028 0.0071 0.0358
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0097 0.0292 0.0253
Mycobacterium ulcerans 6-phosphofructokinase 0.0118 0.0358 0.0319
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0003 0.0001
Echinococcus multilocularis Smad4 0.001 0.0014 0.0058
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0085 0.1737
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0041 0.019
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0003 0.0013
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0154 0.1292

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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