Detailed information for compound 1240513

Basic information

Technical information
  • TDR Targets ID: 1240513
  • Name: 1-[5-(furan-2-ylmethylamino)-3-(4-methylpheny l)-1,2,4-triazol-1-yl]ethanone
  • MW: 296.324 | Formula: C16H16N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1nn(c(n1)NCc1ccco1)C(=O)C
  • InChi: 1S/C16H16N4O2/c1-11-5-7-13(8-6-11)15-18-16(20(19-15)12(2)21)17-10-14-4-3-9-22-14/h3-9H,10H2,1-2H3,(H,17,18,19)
  • InChiKey: RXSPJQSQIPQCDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[5-(2-furylmethylamino)-3-(4-methylphenyl)-1,2,4-triazol-1-yl]ethanone
  • MLS000719008
  • SMR000291276
  • 1-{5-[(Furan-2-ylmethyl)-amino]-3-p-tolyl-[1,2,4]triazol-1-yl}-ethanone
  • BAS 10421739
  • ZINC04385063

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0525 0.0949
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.023 0.0362
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.1843
Brugia malayi jmjC domain containing protein 0.0114 0.0988 0.1552
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0429 0.0673
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0326 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0239 0.2288 0.2288
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0127 0.1122 0.1763
Brugia malayi PHD-finger family protein 0.0035 0.0164 0.0258
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0019 0.0019
Schistosoma mansoni dopamine-beta-monooxygenase 0.0127 0.1122 0.2098
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0143 0.1294 0.239
Brugia malayi Guanylate kinase family protein 0.0026 0.0076 0.0119
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0143 0.1294 0.2418
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0326 0.0576
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0429 0.0673
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.025 0.2405 0.9182
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0254 0.0254
Echinococcus multilocularis expressed conserved protein 0.0112 0.0965 0.0965
Trypanosoma cruzi aminopeptidase, putative 0.0143 0.1294 0.239
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0164 0.2861
Schistosoma mansoni hypothetical protein 0.0049 0.0314 0.0587
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0525 0.0981
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0019 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0533 0.5351 0.8403
Loa Loa (eye worm) hypothetical protein 0.0436 0.4346 0.6824
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0525 0.0525
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0023 0.0036 0.0057
Echinococcus granulosus Protein patched homolog 1 0.027 0.2617 0.4892
Echinococcus granulosus tissue type plasminogen activator 0.0038 0.0201 0.0376
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0019 0.003
Echinococcus multilocularis peregrin 0.0035 0.0164 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0429 0.0673
Brugia malayi Peptidase family M1 containing protein 0.005 0.0326 0.0512
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0143 0.1294 0.4905
Onchocerca volvulus 0.0487 0.487 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0326 0.0576
Loa Loa (eye worm) hypothetical protein 0.0127 0.1122 0.1763
Echinococcus multilocularis tissue type plasminogen activator 0.0038 0.0201 0.0201
Echinococcus granulosus jumonji domain containing protein 0.0048 0.0306 0.0572
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0143 0.1294 0.239
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.104 0.104
Loa Loa (eye worm) hypothetical protein 0.006 0.0429 0.0673
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0164 0.0306
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0326 0.0576
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0326 0.061
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.005 0.0326 1
Schistosoma mansoni peptidylglycine monooxygenase 0.0127 0.1122 0.2098
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0239 0.2288 0.3594
Loa Loa (eye worm) hypothetical protein 0.0038 0.0201 0.0316
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.024 0.0449
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0525 0.0981
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0143 0.1294 0.1294
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0164 0.0306
Brugia malayi Kringle domain containing protein 0.0038 0.0201 0.0316
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0019 0.0219
Brugia malayi hypothetical protein 0.0043 0.0254 0.0399
Loa Loa (eye worm) hypothetical protein 0.0119 0.104 0.1633
Echinococcus granulosus peregrin 0.0035 0.0164 0.0306
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0164 0.0258
Schistosoma mansoni ap endonuclease 0.0021 0.0019 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0326 0.0512
Schistosoma mansoni hypothetical protein 0.0049 0.0314 0.0587
Trypanosoma cruzi Aminopeptidase M1, putative 0.0143 0.1294 0.239
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0093 0.0769 0.1406
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0525 1
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0533 0.5351 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0038 0.0201 0.0316
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0028 0.0088 0.0088
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0114 0.0988 0.1847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0525 0.0968
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0326 0.061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0525 0.0968
Brugia malayi Peptidase family M1 containing protein 0.0487 0.487 0.7648
Loa Loa (eye worm) hypothetical protein 0.027 0.2617 0.4111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0019 0.0021
Schistosoma mansoni patched 1 0.027 0.2617 0.4892
Loa Loa (eye worm) hypothetical protein 0.005 0.0326 0.0512
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0239 0.2288 0.4277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0525 0.0968
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0038 0.0201 0.5933
Echinococcus granulosus aminopeptidase N 0.0487 0.487 0.9102
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0326 0.0576
Onchocerca volvulus 0.0038 0.0201 0.0079
Brugia malayi Bromodomain containing protein 0.0035 0.0164 0.0258
Loa Loa (eye worm) hypothetical protein 0.0093 0.0769 0.1208
Loa Loa (eye worm) hypothetical protein 0.005 0.0326 0.0512
Echinococcus granulosus sterol regulatory element binding protein 0.027 0.2617 0.4892
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.104 0.1633
Schistosoma mansoni hypothetical protein 0.0041 0.023 0.043
Echinococcus multilocularis jumonji domain containing protein 0.0048 0.0306 0.0306
Trypanosoma brucei Aminopeptidase M1, putative 0.0143 0.1294 0.239
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0093 0.0769 0.1437
Loa Loa (eye worm) guanylate kinase 0.002 0.0008 0.0012
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0326 1
Schistosoma mansoni hypothetical protein 0.0049 0.0314 0.0587
Brugia malayi hypothetical protein 0.005 0.0326 0.0512
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0239 0.2288 0.4277
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.1843
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0254 0.0475
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0326 0.1181
Onchocerca volvulus 0.005 0.0326 0.0345
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0533 0.5351 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0423 0.0664
Schistosoma mansoni hypothetical protein 0.0035 0.0164 0.0306
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.0088 0.0088
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.005 0.0326 0.0576
Plasmodium falciparum cysteine repeat modular protein 1 0.0038 0.0201 0.5933
Loa Loa (eye worm) peptidase family M1 containing protein 0.0394 0.3903 0.6129
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0533 0.5351 0.5351
Trichomonas vaginalis conserved hypothetical protein 0.027 0.2617 1
Toxoplasma gondii aminopeptidase N, putative 0.005 0.0326 0.6068
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0019 0.003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0114 0.0988 0.0988
Entamoeba histolytica aminopeptidase, putative 0.0143 0.1294 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.005 0.0326 0.061
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.055 0.0863
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.024 0.024
Echinococcus multilocularis Niemann Pick C1 protein 0.0389 0.3856 0.3856
Plasmodium falciparum phd finger protein, putative 0.0035 0.0164 0.4715
Brugia malayi Protein kinase domain containing protein 0.0038 0.0201 0.0316
Loa Loa (eye worm) TATA binding protein associated factor 0.005 0.0326 0.0512
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0326 0.0576
Echinococcus granulosus disks large 3 0.0024 0.005 0.0094
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.002 0.0008 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0164 0.2861
Echinococcus multilocularis disks large 3 0.0024 0.005 0.005
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0525 1
Brugia malayi CHE-14 protein 0.027 0.2617 0.4111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0164 0.0258
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0143 0.1294 0.1294
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.024 0.0377
Brugia malayi jmjC domain containing protein 0.0042 0.024 0.0377
Echinococcus multilocularis aminopeptidase N 0.0487 0.487 0.487
Loa Loa (eye worm) hypothetical protein 0.0041 0.023 0.0362
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0062 0.0452 0.071
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0533 0.5351 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.005 0.0326 0.0512
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.005 0.0326 0.061
Brugia malayi TATA binding protein associated factor 0.005 0.0326 0.0512
Schistosoma mansoni hypothetical protein 0.0043 0.0254 0.0475
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0019 0.0036
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0533 0.5351 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0143 0.1294 0.4905
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0019 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0201 0.0342
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0533 0.5351 1
Brugia malayi Angiotensin-converting enzyme family protein 0.063 0.6368 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0143 0.1294 0.2418
Loa Loa (eye worm) hypothetical protein 0.0533 0.5351 0.8403
Schistosoma mansoni jumonji domain containing protein 0.0091 0.0744 0.1391
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.027 0.2617 0.4111
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.025 0.2405 1
Leishmania major hypothetical protein, conserved 0.0038 0.0201 0.0342
Echinococcus multilocularis sterol regulatory element binding protein 0.027 0.2617 0.2617
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0093 0.0769 0.0769
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0143 0.1294 0.1294
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.024 0.0449
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0064 0.0472 0.0741
Loa Loa (eye worm) aminopeptidase N 0.0143 0.1294 0.2032
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0093 0.0769 0.1208
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0143 0.1294 0.2418
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.025 0.2405 0.9182
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0533 0.5351 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.104 0.8009
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.0088 0.0165
Giardia lamblia PHD finger protein 15 0.0035 0.0164 0.0607
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0525 0.0981
Brugia malayi Peptidase family M1 containing protein 0.0143 0.1294 0.2032
Echinococcus granulosus expressed conserved protein 0.0112 0.0965 0.1803
Echinococcus multilocularis protein patched 0.027 0.2617 0.2617
Plasmodium falciparum M1-family alanyl aminopeptidase 0.005 0.0326 1
Schistosoma mansoni hypothetical protein 0.0038 0.0201 0.0376
Trypanosoma brucei aminopeptidase, putative 0.005 0.0326 0.0576
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.025 0.2405 0.9182
Mycobacterium ulcerans aminopeptidase N PepN 0.005 0.0326 0.0596
Loa Loa (eye worm) hypothetical protein 0.0062 0.0453 0.0711
Schistosoma mansoni cell polarity protein 0.0024 0.005 0.0094
Schistosoma mansoni aminopeptidase A (M01 family) 0.005 0.0326 0.061
Toxoplasma gondii aminopeptidase N protein 0.005 0.0326 0.6068
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.024 0.0449
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.104 0.1943
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0143 0.1294 0.1294
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0143 0.1294 0.239
Brugia malayi hypothetical protein 0.0143 0.1294 0.2032
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0143 0.1294 0.239
Schistosoma mansoni ap endonuclease 0.0021 0.0019 0.0036
Mycobacterium ulcerans aminopeptidase N PepN 0.0143 0.1294 0.2406
Echinococcus granulosus leukotriene A 4 hydrolase 0.005 0.0326 0.061
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0164 0.4715
Toxoplasma gondii aminopeptidase n, putative 0.005 0.0326 0.6068
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.1843
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0533 0.5351 1
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0326 0.0576
Echinococcus multilocularis leukotriene A 4 hydrolase 0.005 0.0326 0.0326
Chlamydia trachomatis glutamine binding protein 0.002 0.0008 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0149 0.1349 0.2522
Schistosoma mansoni hypothetical protein 0.0049 0.0314 0.0587
Schistosoma mansoni niemann-pick C1 (NPC1) 0.034 0.3343 0.6249
Loa Loa (eye worm) hypothetical protein 0.0343 0.3378 0.5305
Loa Loa (eye worm) hypothetical protein 0.0239 0.2288 0.3594
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0143 0.1294 0.1294
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0254 0.0475
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.063 0.6368 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0143 0.1294 0.239
Toxoplasma gondii kringle domain-containing protein 0.0038 0.0201 0.36
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0143 0.1294 0.2418
Entamoeba histolytica hypothetical protein 0.0043 0.0254 0.1843
Echinococcus granulosus Niemann Pick C1 protein 0.0389 0.3856 0.7206
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0143 0.1294 0.2418
Echinococcus multilocularis protein dispatched 1 0.0278 0.2693 0.2693
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0143 0.1294 0.1294
Onchocerca volvulus 0.0143 0.1294 0.24

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.82433 um PUBCHEM_BIOASSAY: Thrombin 1536 HTS Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 1046 (Thrombin 1536 HTS; hits were confirmed in this assay)] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.575 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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