Detailed information for compound 1244436

Basic information

Technical information
  • TDR Targets ID: 1244436
  • Name: 4-chloro-N-(8-methyl-[1,3]dioxolo[4,5-g]quina zolin-6-yl)benzamide
  • MW: 341.748 | Formula: C17H12ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 3.55 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)Nc1nc(C)c2c(n1)cc1c(c2)OCO1
  • InChi: 1S/C17H12ClN3O3/c1-9-12-6-14-15(24-8-23-14)7-13(12)20-17(19-9)21-16(22)10-2-4-11(18)5-3-10/h2-7H,8H2,1H3,(H,19,20,21,22)
  • InChiKey: SSMDPFIXUPMLQC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-Chloro-N-(8-methyl-[1,3]dioxolo[4,5-g]quinazolin-6-yl)-benzamide
  • STK203135
  • MLS000331943
  • SMR000221396
  • ZINC02327565
  • BAS 14602169

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0536
Echinococcus granulosus snurportin 1 0.031 0.2403 0.2399
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0277
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.0252 0.0842
Schistosoma mansoni hypothetical protein 0.0045 0.0252 0.0247
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0045 0.0252 0.0247
Entamoeba histolytica Ran family GTPase 0.0021 0.006 0.0136
Schistosoma mansoni ferritin 0.0018 0.003 0.0025
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.1136 0.1131
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0045 0.0252 0.0247
Mycobacterium ulcerans glutaminase 0.0293 0.2267 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Onchocerca volvulus 0.0045 0.0252 0.1204
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0221 0.0959
Echinococcus granulosus allatostatin A receptor 0.0045 0.0252 0.0247
Onchocerca volvulus 0.0041 0.0221 0.105
Schistosoma mansoni importin beta-1 0.0029 0.0123 0.0118
Brugia malayi Thioredoxin reductase 0.0039 0.0202 0.0673
Schistosoma mansoni ran 0.0021 0.006 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0221 0.0852
Onchocerca volvulus 0.0026 0.01 0.046
Brugia malayi Tachykinin-like peptides receptor 99D 0.0045 0.0252 0.0842
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0221 0.0852
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0078 0.0215
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0605 0.289
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis serotonin receptor 0.0045 0.0252 0.0247
Schistosoma mansoni opsin-like receptor 0.0045 0.0252 0.0247
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0045 0.0252 0.0247
Plasmodium vivax importin-beta 2, putative 0.0029 0.0123 0.3883
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0137 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0221 0.0852
Onchocerca volvulus 0.0041 0.0221 0.105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0137 0.0132
Echinococcus multilocularis neuropeptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0178 0.0173
Onchocerca volvulus 0.0045 0.0252 0.1204
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi steroid hormone receptor 0.0031 0.0137 0.0457
Schistosoma mansoni amine GPCR 0.0045 0.0252 0.0247
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0137 0.0132
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Echinococcus granulosus tachykinin peptides receptor 99D 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0137 0.0643
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.01 0.0331
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0061
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0774 0.077
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.0252 0.0247
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0221 0.0736
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0137 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0045 0.0252 0.0842
Brugia malayi Serotonin receptor 0.0045 0.0252 0.0842
Plasmodium vivax glutathione reductase, putative 0.0039 0.0202 0.8815
Onchocerca volvulus 0.0045 0.0252 0.1204
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0005 0.0014
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0148 0.0591
Trichomonas vaginalis esterase, putative 0.0041 0.0221 0.0852
Echinococcus multilocularis allatostatin A receptor 0.0045 0.0252 0.0247
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0137 0.0132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Echinococcus multilocularis dna polymerase eta 0.002 0.0051 0.0046
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0051 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1439 0.1434
Schistosoma mansoni inositol monophosphatase 0.0036 0.0178 0.0173
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0123 0.5559
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0051 0.0167
Leishmania major trypanothione reductase 0.0039 0.0202 0.8882
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0178 1
Echinococcus granulosus ferritin 0.0018 0.003 0.0025
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.0252 0.0247
Brugia malayi Dopamine receptor 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0317
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Schistosoma mansoni hypothetical protein 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0301 0.2328 0.7796
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0106 0.4805
Echinococcus multilocularis lamin dm0 0.0026 0.01 0.0095
Echinococcus granulosus g protein coupled receptor 0.0045 0.0252 0.0247
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0051 0.0167
Echinococcus multilocularis G protein coupled receptor 139 0.0045 0.0252 0.0247
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0019 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0045 0.0252 0.1204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0137 0.0457
Brugia malayi Importin beta-1 subunit 0.0029 0.0123 0.0408
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis lamin 0.0026 0.01 0.0095
Brugia malayi Dopamine receptor protein 2 0.0045 0.0252 0.0842
Loa Loa (eye worm) DR-78 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0736
Schistosoma mansoni ran 0.0021 0.006 0.0055
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0051 0.0046
Schistosoma mansoni alpha-1 adrenergic receptor 0.0045 0.0252 0.0247
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0137 0.0132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0137 0.0132
Brugia malayi nuclear receptor RXR 0.0015 0.0005 0.0014
Schistosoma mansoni amine GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.02
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.0252 0.0842
Schistosoma mansoni biogenic amine (5HT) receptor 0.0045 0.0252 0.0247
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.274
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0736
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.0566
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0019 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0151 0.0146
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.01 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0262 0.1037
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0221 0.0852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0137 0.0457
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0178 0.749
Brugia malayi nuclear receptor NHR-88 0.0031 0.0137 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0161 0.0156
Schistosoma mansoni neuropeptide f receptor 76f 0.0045 0.0252 0.0247
Schistosoma mansoni amine GPCR 0.0045 0.0252 0.0247
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0045 0.0252 0.0247
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0262 0.0257
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0137 0.0132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0123 0.0408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.1137 0.3805
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0045 0.0252 0.0247
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0137 0.0132
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0137 0.0457
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Brugia malayi putative neuropeptide receptor NPR1 0.0045 0.0252 0.0842
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0137 0.0132
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0161 0.0156
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0051 0.0105
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0051 0.0046
Brugia malayi Dopamine receptor protein 1 0.0045 0.0252 0.0842
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.0252 0.0247
Schistosoma mansoni ferritin light chain 0.0018 0.003 0.0025
Brugia malayi larval opioid receptor 0.0045 0.0252 0.0842
Plasmodium vivax SET domain protein, putative 0.0034 0.0161 0.6263
Brugia malayi ecdysone receptor 0.0015 0.0005 0.0014
Echinococcus granulosus dna polymerase eta 0.002 0.0051 0.0046
Echinococcus multilocularis neuropeptide receptor A26 0.0045 0.0252 0.0247
Schistosoma mansoni biogenic amine receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis sex peptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.0252 0.0247
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0106 0.325
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0051 0.0105
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0178 0.0662
Schistosoma mansoni hypothetical protein 0.1245 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0202 0.0863
Echinococcus multilocularis protein patched 0.0046 0.0262 0.0257
Loa Loa (eye worm) hypothetical protein 0.0154 0.1137 0.3805
Loa Loa (eye worm) glutaminase 2 0.0293 0.2267 0.7593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Leishmania major GTP-binding protein, putative 0.0021 0.006 0.0566
Echinococcus granulosus g protein coupled receptor 0.0045 0.0252 0.0247
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0221 0.0959
Brugia malayi nuclear receptor NHR-67 0.0015 0.0005 0.0014
Brugia malayi ecdysteroid receptor 0.0031 0.0137 0.0457
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0045 0.0252 0.0842
Echinococcus multilocularis serotonin receptor 0.0045 0.0252 0.0247
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0106 0.325
Echinococcus granulosus neuropeptide receptor A26 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1439 0.1434
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0137 0.0457
Schistosoma mansoni adenoreceptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0078 0.0215
Brugia malayi nuclear hormone receptor 0.0031 0.0137 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis somatostatin receptor 0.0045 0.0252 0.0247
Brugia malayi glutaminase DH11.1 0.0293 0.2267 0.7593
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0106 0.2844
Onchocerca volvulus 0.0031 0.0137 0.0643
Schistosoma mansoni biogenic amine receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis g-protein coupled receptor 0.0045 0.0252 0.0247
Mycobacterium leprae Probable lipase LipE 0.0041 0.0221 0.2911
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0045 0.0252 0.0247
Echinococcus granulosus sex peptide receptor 0.0045 0.0252 0.0247
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0045 0.0252 0.0842
Toxoplasma gondii ABC1 family protein 0.0041 0.0221 1
Echinococcus multilocularis neuropeptide receptor 0.0045 0.0252 0.0247
Schistosoma mansoni inositol monophosphatase 0.0036 0.0178 0.0173
Schistosoma mansoni coup transcription factor 0.0031 0.0137 0.0132
Schistosoma mansoni myosin xvIII 0.0045 0.0252 0.0247
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.0252 0.0247
Mycobacterium ulcerans hypothetical protein 0.0041 0.0221 0.0852
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0137 0.0132
Schistosoma mansoni eyes absent homolog 0.0094 0.0647 0.0643
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.2304
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0221 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0148 0.1795
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0221 0.2911
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.0761 0.0756
Schistosoma mansoni ferritin 0.0018 0.003 0.0025
Echinococcus granulosus G protein coupled receptor 139 0.0045 0.0252 0.0247
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.2019 1
Loa Loa (eye worm) glutathione reductase 0.0039 0.0202 0.0673
Schistosoma mansoni lamin 0.0026 0.01 0.0095
Schistosoma mansoni ferritin light chain 0.0018 0.003 0.0025
Schistosoma mansoni opsin-like receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) intermediate filament protein 0.0026 0.01 0.0331
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0178 0.0173
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0051 0.0093
Schistosoma mansoni hypothetical protein 0.0044 0.0248 0.0243
Schistosoma mansoni neuropeptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0382 0.2986 0.2983
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0221 0.0959
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0282 0.0943
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0061
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0051 0.0093
Schistosoma mansoni neuropeptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus dna polymerase kappa 0.002 0.0051 0.0046
Brugia malayi ORL1-like opioid receptor 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.0252 0.0247
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0019 0.0061
Echinococcus granulosus peptide allatostatin:somatostatin 0.0045 0.0252 0.0247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0094 0.0647 0.2165
Brugia malayi tailless protein 0.0015 0.0005 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0382 0.2986 1
Brugia malayi nuclear receptor RXR 0.0016 0.0019 0.0061
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0051 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0382 0.2986 0.2983
Plasmodium falciparum importin beta, putative 0.0029 0.0123 0.4405
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0221 0.0959
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0045 0.0252 0.0247
Brugia malayi GnHR receptor homolog 0.0045 0.0252 0.0842
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0045 0.0252 0.0247
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0045 0.0252 0.0842
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis g protein coupled receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis g protein coupled receptor 0.0045 0.0252 0.0247
Brugia malayi nuclear receptor NHR-88 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Trichomonas vaginalis ran, putative 0.0021 0.006 0.0136
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0262 0.0257
Echinococcus granulosus g protein coupled receptor 0.0045 0.0252 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0137 0.0457
Schistosoma mansoni hypothetical protein 0.031 0.2403 0.2399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1439 0.1434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0137 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) G-protein coupled receptor 0.0045 0.0252 0.0842
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0221 1
Plasmodium falciparum thioredoxin reductase 0.0039 0.0202 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0045 0.0252 0.1204
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Echinococcus granulosus neuropeptides capa receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus granulosus lamin dm0 0.0026 0.01 0.0095
Onchocerca volvulus 0.0045 0.0252 0.1204
Brugia malayi neuropeptide F receptor 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi hypothetical protein 0.0027 0.0106 0.0352
Schistosoma mansoni biogenic amine receptor 0.0045 0.0252 0.0247
Brugia malayi follicle stimulating hormone receptor 0.0045 0.0252 0.0842
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0137 0.0457
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0605 0.289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0137 0.0457
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi beta-lactamase family protein 0.0041 0.0221 0.0736
Brugia malayi intermediate filament protein 0.0026 0.01 0.0331
Loa Loa (eye worm) hypothetical protein 0.0094 0.0647 0.2165
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0262 0.0875
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0605 0.289
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.1137 0.3805
Brugia malayi nuclear hormone receptor 0.0015 0.0005 0.0014
Echinococcus granulosus expressed protein 0.0018 0.003 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.1439 0.4817
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0137 0.0457
Echinococcus granulosus dro:myosuppressin receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.006 0.0055
Echinococcus granulosus muscleblind protein 0.0301 0.2328 0.2324
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0019 0.0061
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0005 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0045 0.0252 0.0842
Onchocerca volvulus 0.0268 0.206 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0137 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Brugia malayi hypothetical protein 0.0016 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni lamin 0.0026 0.01 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0005 0.0014
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0178 0.7339
Schistosoma mansoni DNA polymerase eta 0.002 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis geminin 0.1245 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0137 0.0132
Brugia malayi putative neuropeptide receptor 0.0045 0.0252 0.0842
Schistosoma mansoni hypothetical protein 0.1245 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0045 0.0252 0.0247
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0051 0.2304
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0045 0.0252 0.0247
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0736
Loa Loa (eye worm) TYRA-2 protein 0.0045 0.0252 0.0842
Echinococcus granulosus neuropeptide Y receptor 0.0045 0.0252 0.0247
Leishmania major hypothetical protein, conserved 0.0041 0.0221 1
Brugia malayi beta-lactamase family protein 0.0041 0.0221 0.0736
Trichomonas vaginalis glutaminase, putative 0.0293 0.2267 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.006 0.0566
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.0761 0.0756
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0221 0.0852
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0221 0.0216
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0045 0.0252 0.0247
Mycobacterium ulcerans lipase LipD 0.0041 0.0221 0.0852
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni hypothetical protein 0.0044 0.0248 0.0243
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0178 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0736
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0005 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0282 0.0943
Echinococcus multilocularis musashi 0.0026 0.01 0.0095
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0202 0.8815
Onchocerca volvulus 0.0045 0.0252 0.1204
Schistosoma mansoni hypothetical protein 0.0045 0.0252 0.0247
Schistosoma mansoni opsin-like receptor 0.0045 0.0252 0.0247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0019 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0137 0.0132
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0178 0.1792
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0178 0.749
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0137 0.0457
Mycobacterium tuberculosis Conserved protein 0.0041 0.0221 0.0959
Echinococcus granulosus intermediate filament protein 0.0026 0.01 0.0095
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.2403 0.8047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0277
Brugia malayi hypothetical protein 0.0015 0.0005 0.0014
Plasmodium falciparum glutathione reductase 0.0039 0.0202 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0605 0.8777
Brugia malayi glutathione reductase 0.0039 0.0202 0.0673
Onchocerca volvulus 0.0045 0.0252 0.1204
Mycobacterium tuberculosis Conserved protein 0.0041 0.0221 0.0959
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.0252 0.0247
Echinococcus granulosus 7tm_1 domain containing protein 0.0045 0.0252 0.0247
Schistosoma mansoni hypothetical protein 0.0045 0.0252 0.0247
Echinococcus granulosus somatostatin receptor 0.0045 0.0252 0.0247
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.1136 0.1131
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0019 0.0014
Schistosoma mansoni neuropeptide receptor 0.0045 0.0252 0.0247
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0106 0.3227
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0137 0.0457
Onchocerca volvulus 0.0045 0.0252 0.1204
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0137 0.0132
Onchocerca volvulus 0.0045 0.0252 0.1204
Schistosoma mansoni ferritin 0.0018 0.003 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0137 0.0457
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0045 0.0252 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0137 0.0132
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0061
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.6704 0.6703
Brugia malayi beta-lactamase 0.0041 0.0221 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0137 0.0457
Schistosoma mansoni amine GPCR 0.0045 0.0252 0.0247
Echinococcus multilocularis expressed protein 0.0018 0.003 0.0025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0221 0.0736
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0045 0.0252 0.0247
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0045 0.0252 0.0247
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.0761 0.2545
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.0252 0.0247
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0221 1
Brugia malayi G protein-coupled receptor 0.0045 0.0252 0.0842
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0137 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0221 0.0852
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0051 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0178 0.8068
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0277
Brugia malayi Pre-SET motif family protein 0.0235 0.1796 0.6013
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0605 0.289
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0045 0.0252 0.0842
Echinococcus multilocularis expressed conserved protein 0.0101 0.0708 0.0703
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0161 0.6263
Schistosoma mansoni ferritin 0.0018 0.003 0.0025
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0221 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0137 0.0457
Onchocerca volvulus 0.0045 0.0252 0.1204
Trichomonas vaginalis set domain proteins, putative 0.0268 0.206 0.9071
Schistosoma mansoni histamine h1 receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1439 0.1434
Onchocerca volvulus 0.0041 0.0221 0.105
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0221 0.0959
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Onchocerca volvulus 0.0045 0.0252 0.1204
Echinococcus granulosus neuropeptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0221 0.0852
Echinococcus multilocularis g protein coupled receptor 0.0045 0.0252 0.0247
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0137 0.0643
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0685 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0282 0.0277
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Schistosoma mansoni growth hormone secretagogue receptor 0.0045 0.0252 0.0247
Brugia malayi Serotonin receptor 0.0045 0.0252 0.0842
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0137 0.0132
Brugia malayi hypothetical protein 0.0016 0.0019 0.0061
Schistosoma mansoni apoferritin-2 0.0018 0.003 0.0025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0178 0.0662
Loa Loa (eye worm) hypothetical protein 0.0049 0.0282 0.0943
Echinococcus multilocularis fmrfamide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus hypothetical protein 0.0045 0.0252 0.0247
Brugia malayi Inositol-1 0.0036 0.0178 0.0594
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0123 0.3883
Echinococcus multilocularis G-protein coupled receptor, putative 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus granulosus lamin 0.0026 0.01 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.1439 0.4817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0137 0.0457
Echinococcus multilocularis muscleblind protein 0.0301 0.2328 0.2324
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0045 0.0252 0.0842
Onchocerca volvulus 0.0045 0.0252 0.1204
Schistosoma mansoni glutaminase 0.0293 0.2267 0.2264
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0045 0.0252 0.0247
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0005 0.0014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0161 0.0156
Trypanosoma brucei trypanothione reductase 0.0039 0.0202 0.914
Echinococcus granulosus neuropeptide FF receptor 2 0.0045 0.0252 0.0247
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0045 0.0252 0.0247
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0045 0.0252 0.0842
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0382 0.2986 0.2983
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0106 0.2844
Leishmania major importin beta-1 subunit, putative 0.0024 0.0078 0.1605
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis neuropeptides capa receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi Muscleblind-like protein 0.0301 0.2328 0.7796
Brugia malayi Pre-SET motif family protein 0.0034 0.0161 0.0536
Schistosoma mansoni neuropeptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0137 0.0132
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis muscleblind protein 1 0.0301 0.2328 0.2324
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0137 0.0457
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0736
Schistosoma mansoni amine GPCR 0.0045 0.0252 0.0247
Brugia malayi hypothetical protein 0.0094 0.0647 0.2165
Echinococcus multilocularis neuropeptide FF receptor 2 0.0045 0.0252 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1439 0.1434
Brugia malayi AKH receptor 0.0045 0.0252 0.0842
Brugia malayi hypothetical protein 0.0382 0.2986 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0178 0.749
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0137 0.0457
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0202 0.0673
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0282 0.0277
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0685 0.3293
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0046 0.0262 0.0875
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0108 0.0761 0.2545
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0178 0.0662
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0137 0.0132
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0045 0.0252 0.0842
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0137 0.0132
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.0761 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0262 0.0257
Echinococcus multilocularis snurportin 1 0.031 0.2403 0.2399
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0019 0.0061
Onchocerca volvulus 0.0045 0.0252 0.1204
Echinococcus granulosus GPCR family 2 0.0049 0.0282 0.0277
Mycobacterium tuberculosis Probable reductase 0.0088 0.0605 0.289
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi hypothetical protein 0.0017 0.0028 0.0092
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Brugia malayi conserved hypotetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0161 0.0156
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0005 0.0014
Mycobacterium tuberculosis Conserved protein 0.0041 0.0221 0.0959
Echinococcus granulosus serotonin receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0137 0.0457
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) hypothetical protein 0.0057 0.0346 0.1157
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.0252 0.0247
Brugia malayi G-protein coupled receptor 0.0045 0.0252 0.0842
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0301 0.2328 0.7796
Echinococcus multilocularis orexin receptor type 2 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0206 0.0201
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0045 0.0252 0.0247
Echinococcus multilocularis GPCR, family 2 0.0049 0.0282 0.0277
Brugia malayi RNA, U transporter 1 0.0083 0.0557 0.1864
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni intermediate filament proteins 0.0026 0.01 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0352
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0061
Brugia malayi hypothetical protein 0.0015 0.0005 0.0014
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.01 0.0331
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0078 0.1605
Onchocerca volvulus 0.0045 0.0252 0.1204
Brugia malayi CHE-14 protein 0.0046 0.0262 0.0875
Brugia malayi RE15519p 0.0045 0.0252 0.0842
Loa Loa (eye worm) melatonin receptor type 1A 0.0045 0.0252 0.0842
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.006 1
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0741 0.248
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0137 0.0457
Echinococcus granulosus neuropeptide s receptor 0.0045 0.0252 0.0247
Onchocerca volvulus 0.0034 0.0161 0.0758
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0051 0.0093
Echinococcus multilocularis fmrfamide receptor 0.0045 0.0252 0.0247
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0137 0.0132
Loa Loa (eye worm) glutaminase 0.0293 0.2267 0.7593
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0685 0.3293
Echinococcus granulosus alpha 1A adrenergic receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0137 0.0457
Echinococcus multilocularis ferritin 0.0018 0.003 0.0025
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0045 0.0252 0.0247
Echinococcus multilocularis dna polymerase kappa 0.002 0.0051 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0137 0.0132
Brugia malayi sulfakinin receptor protein 0.0045 0.0252 0.0842
Echinococcus granulosus neuropeptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus g-protein coupled receptor 0.0045 0.0252 0.0247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Onchocerca volvulus 0.0026 0.01 0.046
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0685 0.3293
Echinococcus granulosus importin subunit beta 1 0.0029 0.0123 0.0118
Brugia malayi Serine/threonine-protein kinase SULU 0.0382 0.2986 1
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0137 0.0132
Mycobacterium ulcerans beta-lactamase 0.0041 0.0221 0.0852
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0123 0.0118
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0045 0.0252 0.0842
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0137 0.0457
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0167
Schistosoma mansoni hypothetical protein 0.0044 0.0248 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0137 0.0457
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0457
Schistosoma mansoni hypothetical protein 0.0105 0.0741 0.0737
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.006 0.02
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0137 0.0132
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0605 0.289
Onchocerca volvulus 0.0045 0.0252 0.1204
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0221 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.1137 0.3805
Echinococcus multilocularis dro:myosuppressin receptor 0.0045 0.0252 0.0247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0137 0.0457
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0137 0.0132
Brugia malayi neuropeptide F receptor 0.0045 0.0252 0.0842
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0137 0.0643
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.1796 0.6013
Echinococcus multilocularis neuropeptide Y receptor 0.0045 0.0252 0.0247
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0137 0.0132
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0005 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Schistosoma mansoni hypothetical protein 0.0044 0.0248 0.0243
Echinococcus granulosus 7TM GPCR rhodopsin 0.0045 0.0252 0.0247
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0282 0.0943
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0202 0.8882
Echinococcus granulosus rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Brugia malayi Melatonin receptor type 1A 0.0045 0.0252 0.0842
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0078 0.0215
Loa Loa (eye worm) hypothetical protein 0.0045 0.0252 0.0842
Loa Loa (eye worm) beta-lactamase 0.0041 0.0221 0.0736
Echinococcus multilocularis rhodopsin orphan GPCR 0.0045 0.0252 0.0247
Schistosoma mansoni neuropeptide F-like receptor 0.0045 0.0252 0.0247
Echinococcus multilocularis protein dispatched 1 0.0053 0.0315 0.031
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0106 0.3227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1439 0.1434
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Loa Loa (eye worm) hypothetical protein 0.0105 0.0741 0.248
Onchocerca volvulus 0.0045 0.0252 0.1204
Schistosoma mansoni patched 1 0.0046 0.0262 0.0257
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0206 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0137 0.0457
Echinococcus granulosus fmrfamide receptor 0.0045 0.0252 0.0247
Onchocerca volvulus 0.0045 0.0252 0.1204
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0051 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0282 0.0277
Loa Loa (eye worm) inositol-1 0.0036 0.0178 0.0594
Echinococcus granulosus expressed conserved protein 0.0101 0.0708 0.0703
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0123 0.5559
Leishmania major hypothetical protein, conserved 0.0027 0.0106 0.325
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0221 0.0959
Brugia malayi G-protein coupled receptor 0.0045 0.0252 0.0842
Onchocerca volvulus 0.0045 0.0252 0.1204
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0137 0.0132
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0005 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0045 0.0252 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Schistosoma mansoni hypothetical protein 0.0049 0.0282 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.2304
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0282 0.0277
Schistosoma mansoni apoferritin-2 0.0018 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.0736
Trypanosoma brucei unspecified product 0.002 0.0051 0.2304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0161 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0137 0.0457
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0045 0.0252 0.0247
Echinococcus granulosus biogenic amine 5HT receptor 0.0045 0.0252 0.0247
Brugia malayi hypothetical protein 0.0045 0.0252 0.0842
Toxoplasma gondii thioredoxin reductase 0.0039 0.0202 0.8815
Entamoeba histolytica hypothetical protein 0.0024 0.0078 0.0384
Brugia malayi G protein-coupled receptor F59B2.13 0.0045 0.0252 0.0842
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0137 0.0132
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0221 0.0959
Echinococcus granulosus orexin receptor type 2 0.0045 0.0252 0.0247

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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