Detailed information for compound 1258709

Basic information

Technical information
  • TDR Targets ID: 1258709
  • Name: N-(5-furan-2-yl-1,3,4-oxadiazol-2-yl)-3-methy lthiophene-2-carboxamide
  • MW: 275.283 | Formula: C12H9N3O3S
  • H donors: 1 H acceptors: 3 LogP: 2.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1sccc1C)Nc1nnc(o1)c1ccco1
  • InChi: 1S/C12H9N3O3S/c1-7-4-6-19-9(7)10(16)13-12-15-14-11(18-12)8-3-2-5-17-8/h2-6H,1H3,(H,13,15,16)
  • InChiKey: AXFCQVPRYHULEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-3-methyl-thiophene-2-carboxamide
  • N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-3-methyl-2-thiophenecarboxamide
  • N-(5-furan-2-yl-1,3,4-oxadiazol-2-yl)-3-methyl-thiophene-2-carboxamide
  • T5336726
  • MLS000056562
  • ZINC03415290
  • SMR000064666

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.091 0.1462
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.026 0.6225 0.6225
Echinococcus multilocularis enteropeptidase 0.026 0.6225 0.6225
Onchocerca volvulus 0.0048 0.0795 0.0768
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0643 0.0643
Plasmodium vivax multidomain scavenger receptor, putative 0.0048 0.0795 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.026 0.6225 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Echinococcus multilocularis musashi 0.0033 0.041 0.041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.2083 0.2083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Schistosoma mansoni rab6-interacting 0.0048 0.0795 0.1277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0504 0.081
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.026 0.6225 0.6225
Brugia malayi jmjC domain containing protein 0.0036 0.0504 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0362 0.0581
Schistosoma mansoni intermediate filament proteins 0.0033 0.041 0.0659
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.131 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0362 0.0581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.131 1
Echinococcus multilocularis Mastin 0.026 0.6225 0.6225
Plasmodium vivax hypothetical protein, conserved 0.003 0.0343 0.3755
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1158 0.186
Loa Loa (eye worm) hypothetical protein 0.0243 0.5781 0.9287
Brugia malayi Doublecortin family protein 0.0048 0.0795 0.1277
Echinococcus granulosus RUN 0.0048 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0362 0.0581
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0072 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Onchocerca volvulus 0.0243 0.5792 0.9264
Onchocerca volvulus 0.026 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.018 0.4186 0.6724
Echinococcus multilocularis glycoprotein Antigen 5 0.026 0.6225 0.6225
Onchocerca volvulus 0.0033 0.041 0.0114
Schistosoma mansoni hypothetical protein 0.003 0.0343 0.0552
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0343 0.0552
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0643 0.0643
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0133 0.2984 0.2984
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0024 0.0039
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0343 0.9368
Onchocerca volvulus 0.026 0.6225 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.131 0.2105
Echinococcus multilocularis muscleblind protein 0.018 0.4186 0.4186
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Onchocerca volvulus 0.026 0.6225 1
Schistosoma mansoni hypothetical protein 0.0036 0.0489 0.0785
Schistosoma mansoni lamin 0.0033 0.041 0.0659
Echinococcus granulosus lamin dm0 0.0033 0.041 0.041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.091 0.1462
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.041 0.0659
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0362 1
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.7245 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.3324 0.5
Onchocerca volvulus 0.0033 0.041 0.0114
Plasmodium vivax SET domain protein, putative 0.0031 0.0362 0.4008
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0343 0.0552
Echinococcus granulosus muscleblind protein 0.018 0.4186 0.4186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0072 0.0072
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.131 0.131
Loa Loa (eye worm) intermediate filament protein 0.0033 0.041 0.0659
Trichomonas vaginalis set domain proteins, putative 0.0243 0.5792 0.7974
Loa Loa (eye worm) hypothetical protein 0.0032 0.0395 0.0635
Loa Loa (eye worm) hypothetical protein 0.0048 0.0795 0.1277
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.7245 1
Plasmodium falciparum LCCL domain-containing protein 0.0048 0.0795 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.131 0.2105
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.0795 0.0795
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0072 0.0116
Brugia malayi hypothetical protein 0.0243 0.5781 0.9287
Loa Loa (eye worm) hypothetical protein 0.018 0.4186 0.6724
Loa Loa (eye worm) hypothetical protein 0.0052 0.091 0.1462
Schistosoma mansoni loxhd1 0.0048 0.0795 0.1277
Loa Loa (eye worm) trypsin family protein 0.026 0.6225 1
Onchocerca volvulus 0.006 0.1104 0.1293
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.3324 0.5285
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.7245 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0504 0.081
Onchocerca volvulus 0.026 0.6225 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1104 0.1774
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0795 0.0795
Onchocerca volvulus 0.026 0.6225 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0504 0.0504
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0072 0.0116
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Echinococcus granulosus transmembrane protease serine 3 0.026 0.6225 0.6225
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0581 0.0581
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Onchocerca volvulus 0.0048 0.0795 0.0768
Brugia malayi hypothetical protein 0.026 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.041 0.0659
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0133 0.2984 0.2984
Brugia malayi Trypsin family protein 0.026 0.6225 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.3357 0.5124
Loa Loa (eye worm) hypothetical protein 0.0148 0.3357 0.5393
Echinococcus multilocularis transmembrane protease serine 3 0.026 0.6225 0.6225
Brugia malayi PHD-finger family protein 0.003 0.0343 0.0552
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.131 0.131
Schistosoma mansoni ap endonuclease 0.0019 0.0072 0.0116
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0362 0.0362
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.005 0.0844 0.1356
Echinococcus granulosus intermediate filament protein 0.0033 0.041 0.041
Brugia malayi Pre-SET motif family protein 0.0214 0.5038 0.8093
Plasmodium falciparum phd finger protein, putative 0.003 0.0343 0.3755
Echinococcus multilocularis RUN 0.0048 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.0148 0.3357 0.5393
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.026 0.6225 1
Schistosoma mansoni lipoxygenase 0.0048 0.0795 0.1277
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.7245 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.7245 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.0031 0.0362 0.0581
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.091 0.1462
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0795 0.0795
Schistosoma mansoni lipoxygenase 0.0133 0.2984 0.4794
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0795 0.1277
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Echinococcus multilocularis lamin dm0 0.0033 0.041 0.041
Brugia malayi hypothetical protein 0.0048 0.0795 0.1277
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.131 1
Echinococcus granulosus enteropeptidase 0.026 0.6225 0.6225
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.3261 0.5238
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.0795 0.0795
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0362 0.0362
Brugia malayi Trypsin family protein 0.026 0.6225 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0362 0.0581
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0333 0.0333
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0489 0.0785
Schistosoma mansoni hypothetical protein 0.0048 0.0795 0.1277
Onchocerca volvulus Huntingtin homolog 0.0148 0.3357 0.5124
Schistosoma mansoni rab6-interacting 0.0048 0.0795 0.1277
Schistosoma mansoni survival motor neuron protein 0.005 0.0844 0.1356
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.131 0.2105
Brugia malayi Trypsin family protein 0.026 0.6225 1
Brugia malayi Muscleblind-like protein 0.018 0.4186 0.6724
Brugia malayi hypothetical protein 0.0148 0.3357 0.5393
Echinococcus multilocularis lamin 0.0033 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0036 0.0489 0.0785
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Brugia malayi intermediate filament protein 0.0033 0.041 0.0659
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.026 0.6225 1
Echinococcus granulosus peregrin 0.003 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.003 0.0343 0.0552
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0362 0.0362
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0795 0.0795
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.4186 0.4186
Echinococcus granulosus glycoprotein Antigen 5 0.026 0.6225 0.6225
Schistosoma mansoni jumonji domain containing protein 0.0078 0.1568 0.252
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0844 0.1356
Onchocerca volvulus 0.005 0.0844 0.0851
Loa Loa (eye worm) doublecortin family protein 0.0048 0.0795 0.1277
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.131 0.1726
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.5038 0.8093
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.026 0.6225 0.6225
Schistosoma mansoni ap endonuclease 0.0019 0.0072 0.0116
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.2083 0.2083
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.5781 0.5781
Brugia malayi jmjC domain containing protein 0.0098 0.2083 0.3347
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0504 0.081
Brugia malayi Trypsin-like protease protein 5 0.026 0.6225 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0362 0.0581
Schistosoma mansoni cercarial elastase (S01 family) 0.026 0.6225 1
Schistosoma mansoni hypothetical protein 0.026 0.6225 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.3261 0.5238
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0343 0.9368
Onchocerca volvulus 0.026 0.6225 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Giardia lamblia PHD finger protein 15 0.003 0.0343 0.0378
Loa Loa (eye worm) hypothetical protein 0.0051 0.089 0.1429
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0504 0.0504
Brugia malayi Bromodomain containing protein 0.003 0.0343 0.0552
Echinococcus granulosus lamin 0.0033 0.041 0.041
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0343 0.0343
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.041 0.0659
Brugia malayi MH2 domain containing protein 0.0144 0.3261 0.5238
Echinococcus granulosus Mastin 0.026 0.6225 0.6225
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.3324 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 0.6225
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.5781 0.5781
Loa Loa (eye worm) hypothetical protein 0.026 0.6225 1
Mycobacterium ulcerans hypothetical protein 0.026 0.6225 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.131 1
Brugia malayi Trypsin family protein 0.026 0.6225 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1104 0.1774
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.026 0.6225 1
Echinococcus multilocularis peregrin 0.003 0.0343 0.0343
Schistosoma mansoni lamin 0.0033 0.041 0.0659
Brugia malayi hypothetical protein 0.0048 0.0795 0.1277
Schistosoma mansoni polycystin 1-related 0.0048 0.0795 0.1277
Onchocerca volvulus 0.0031 0.0362 0.0031

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2239 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 8.9125 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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