Detailed information for compound 1267695

Basic information

Technical information
  • TDR Targets ID: 1267695
  • Name: 1-(4-tert-butylcyclohexyl)oxy-3-pyrrolidin-1- ylpropan-2-ol hydrochloride
  • MW: 319.91 | Formula: C17H34ClNO2
  • H donors: 1 H acceptors: 1 LogP: 4.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CCCC1)COC1CCC(CC1)C(C)(C)C.Cl
  • InChi: 1S/C17H33NO2.ClH/c1-17(2,3)14-6-8-16(9-7-14)20-13-15(19)12-18-10-4-5-11-18;/h14-16,19H,4-13H2,1-3H3;1H
  • InChiKey: OBIZNHATDRLJLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-tert-butylcyclohexoxy)-3-pyrrolidin-1-yl-propan-2-ol hydrochloride
  • 1-(4-tert-butylcyclohexoxy)-3-1-pyrrolidinylpropan-2-ol hydrochloride
  • 1-(4-tert-butylcyclohexyl)oxy-3-pyrrolidin-1-yl-propan-2-ol hydrochloride
  • T0501-4818
  • 1-[(4-tert-butylcyclohexyl)oxy]-3-(1-pyrrolidinyl)-2-propanol hydrochloride
  • MLS000684237
  • SMR000268042

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0273 0.0151 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1075 0.0731 0.1778
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0146 0.102
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0611 0.0395 0.4613
Onchocerca volvulus 0.0214 0.0108 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0273 0.0151 0.1091
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1075 0.0731 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0108 0.0108
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0273 0.0151 0.2011
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0273 0.0151 0.0151
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1065 0.0724 0.9877
Echinococcus multilocularis 0.0214 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.1053 0.0715 0.9755
Echinococcus multilocularis geminin 0.0205 0.0101 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0146 0.102
Trichomonas vaginalis PIKK family atypical protein kinase 0.1065 0.0724 0.9882
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0671 0.0439 0.5306
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0731 1
Giardia lamblia GTOR 0.1075 0.0731 1
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0086 0.0105
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0453 0.0281 0.2772
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0214 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.046 0.0286 0.391
Trichomonas vaginalis conserved hypothetical protein 0.0661 0.0431 0.5392
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0108 0.0108
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0595 0.0383 0.0383
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1075 0.0731 0.9772
Loa Loa (eye worm) phosphatidylinositol 3 0.1075 0.0731 1
Loa Loa (eye worm) hypothetical protein 0.0397 0.024 0.3284
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.0146 0.195
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0347 0.0204 0.2726
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0214 0.0108 0.0173
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0667 0.0436 0.5466
Mycobacterium leprae conserved hypothetical protein 0.0214 0.0108 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0108 0.1473
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.046 0.0286 0.0286
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0611 0.0395 0.1016
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0214 0.0108 0.0434
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1099 0.0748 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0667 0.0436 0.5261
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0611 0.0395 0.5283
Trichomonas vaginalis PIKK family atypical protein kinase 0.1065 0.0724 0.9882
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1065 0.0724 0.1757
Schistosoma mansoni hypothetical protein 0.0205 0.0101 0.1346
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0214 0.0108 0.1439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0607 0.0392 0.4797
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0731 1
Schistosoma mansoni hypothetical protein 0.0205 0.0101 0.1346
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0108 0.1439
Trypanosoma cruzi target of rapamycin kinase 3 0.1065 0.0724 0.1979
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0273 0.0151 0.2011
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0554 0.0354 0.4209
Toxoplasma gondii FATC domain-containing protein 0.0611 0.0395 0.4685
Trichomonas vaginalis PIKK family atypical protein kinase 0.1065 0.0724 0.9882
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0273 0.0151 0.2058
Brugia malayi hypothetical protein 0.0148 0.006 0.0797
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.048 0.03 0.3089
Trichomonas vaginalis PIKK family atypical protein kinase 0.038 0.0228 0.2279
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0108 0.1439
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0387 0.0232 0.2001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0629 0.0408 0.5042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0108 0.0434
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1075 0.0731 0.2001
Trichomonas vaginalis PIKK family atypical protein kinase 0.1054 0.0716 0.9765
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0214 0.0108 0.1439
Loa Loa (eye worm) hypothetical protein 0.0595 0.0383 0.5239
Leishmania major phosphatidylinositol kinase related protein, putative 0.0231 0.012 0.0035
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0214 0.0108 0.0173
Loa Loa (eye worm) phosphatidylinositol 3 0.1053 0.0715 0.9781
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1099 0.0748 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.1041 0.0706 0.9617
Echinococcus multilocularis serine protein kinase ATM 0.0611 0.0395 0.0395
Schistosoma mansoni hypothetical protein 0.0214 0.0108 0.1439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0399 0.4895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0108 0.0434
Loa Loa (eye worm) phosphatidylinositol 3 0.0792 0.0526 0.7198
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0108 0.1473
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0273 0.0151 0.0151
Leishmania major hypothetical protein, conserved 0.5056 0.3615 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0347 0.0204 0.1544
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0146 0.102
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0151 0.0298
Entamoeba histolytica protein kinase rad3, putative 0.0595 0.0383 0.4417
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0667 0.0436 0.5466
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0866 0.058 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0108 0.1473
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Schistosoma mansoni hypothetical protein 0.0446 0.0276 0.3684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0225 0.0115 0.0551
Echinococcus multilocularis Zinc finger, PHD finger 0.0273 0.0151 0.0151
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0231 0.012 0.0209
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1075 0.0731 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0866 0.058 0.7748
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0595 0.0383 0.0383
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0446 0.0276 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.1041 0.0706 0.9617
Loa Loa (eye worm) hypothetical protein 0.0148 0.006 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.0383 0.4659
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0593 0.0382 0.4403
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0667 0.0436 0.1135
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Loa Loa (eye worm) hypothetical protein 0.0148 0.006 0.0816
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0117 0.0117
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0273 0.0151 0.1091
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0273 0.0151 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.0448 0.5657
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0288 0.0161 0.0857
Trypanosoma cruzi hypothetical protein, conserved 0.4842 0.3459 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0667 0.0436 0.5466
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1099 0.0748 0.2051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1041 0.0706 0.9617
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0347 0.0204 0.1911
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0397 0.024 0.0561
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0117 0.0117
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0446 0.0276 0.0276
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.0146 0.1995
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1075 0.0731 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1053 0.0715 0.1733
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0151 0.0122
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0151 0.0298
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0151 0.0697
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0108 0.1439
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1075 0.0731 0.0731
Leishmania major phosphatidylinositol 3-kinase, putative 0.0273 0.0151 0.0122
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1041 0.0706 0.96
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1099 0.0748 0.2051
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0273 0.0151 1
Echinococcus granulosus geminin 0.0205 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.1054 0.0716 0.9765
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0273 0.0151 0.2011
Echinococcus granulosus serine protein kinase ATM 0.0611 0.0395 0.0395
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1075 0.0731 0.0731
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0347 0.0204 0.1911
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0214 0.0108 0.1439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0399 0.4895
Leishmania major phosphatidylinositol 3-kinase, putative 0.1041 0.0706 0.1707
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1099 0.0748 0.0748
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0347 0.0204 0.0455
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0235 0.0123 0.0246
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0273 0.0151 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0595 0.0383 0.512
Trichomonas vaginalis PIKK family atypical protein kinase 0.1065 0.0724 0.9882
Loa Loa (eye worm) hypothetical protein 0.0661 0.0431 0.5892
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0667 0.0436 0.5823
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0146 0.102
Mycobacterium tuberculosis Conserved hypothetical protein 0.0214 0.0108 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1075 0.0731 0.9772
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0199 0.0097 0.129
Trichomonas vaginalis PIKK family atypical protein kinase 0.1065 0.0724 0.9882
Trichomonas vaginalis conserved hypothetical protein 0.0446 0.0276 0.3011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0273 0.0151 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0554 0.0354 0.4209
Loa Loa (eye worm) hypothetical protein 0.0214 0.0108 0.1473
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0611 0.0395 0.5283
Loa Loa (eye worm) hypothetical protein 0.0207 0.0102 0.1399
Loa Loa (eye worm) phosphatidylinositol kinase 0.0214 0.0108 0.1473
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1075 0.0731 0.2001
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.046 0.0286 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0611 0.0395 0.4847
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0347 0.0204 0.1544
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0214 0.0108 0.0173
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0108 0.0108
Entamoeba histolytica hypothetical protein 0.0611 0.0395 0.4613
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1075 0.0731 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.046 0.0286 0.3821
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0595 0.0383 0.0981
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0273 0.0151 0.0686
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0607 0.0392 0.4561
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0273 0.0151 0.1091
Entamoeba histolytica hypothetical protein 0.0593 0.0382 0.4403
Loa Loa (eye worm) hypothetical protein 0.0446 0.0276 0.377
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0079 0.4111
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1053 0.0715 0.9744
Onchocerca volvulus 0.0214 0.0108 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0214 0.0108 0.0434
Toxoplasma gondii target of rapamycin (TOR), putative 0.1062 0.0722 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0128 0.0046 0.0623
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0347 0.0204 0.1544
Trichomonas vaginalis PIKK family atypical protein kinase 0.1075 0.0731 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0347 0.0204 0.1911
Trichomonas vaginalis PIKK family atypical protein kinase 0.0618 0.04 0.4924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0347 0.0204 0.2726
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Trichomonas vaginalis PIKK family atypical protein kinase 0.1062 0.0722 0.9852
Trichomonas vaginalis PIKK family atypical protein kinase 0.1041 0.0706 0.9617
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Loa Loa (eye worm) phosphatidylinositol 3 0.0133 0.0049 0.0667
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0086 0.0105
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.3872 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0667 0.0436 0.1135
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0146 0.102
Schistosoma mansoni hypothetical protein 0.035 0.0206 0.2754
Brugia malayi Cytochrome P450 family protein 0.0128 0.0046 0.0608
Brugia malayi FAT domain containing protein 0.0446 0.0276 0.3684
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Schistosoma mansoni fkbp-rapamycin associated protein 0.0595 0.0383 0.512
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0214 0.0108 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.038 0.0228 0.2279
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0273 0.0151 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0616 0.0399 0.4895
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0108 0.1473
Trichomonas vaginalis PIKK family atypical protein kinase 0.1051 0.0714 0.9735
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0661 0.0431 0.5264
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1075 0.0731 0.1778
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0146 0.102
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0866 0.058 0.058
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1099 0.0748 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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