Detailed information for compound 1268827

Basic information

Technical information
  • TDR Targets ID: 1268827
  • Name: N-(3-morpholin-4-ylsulfonylphenyl)-1-benzofur an-2-carboxamide
  • MW: 386.422 | Formula: C19H18N2O5S
  • H donors: 1 H acceptors: 3 LogP: 2.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2c(o1)cccc2)Nc1cccc(c1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C19H18N2O5S/c22-19(18-12-14-4-1-2-7-17(14)26-18)20-15-5-3-6-16(13-15)27(23,24)21-8-10-25-11-9-21/h1-7,12-13H,8-11H2,(H,20,22)
  • InChiKey: SNJBIGLSARYXTG-UHFFFAOYSA-N  


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Synonyms

  • N-(3-morpholinosulfonylphenyl)benzofuran-2-carboxamide
  • N-(3-morpholinosulfonylphenyl)-2-benzofurancarboxamide
  • T5392965
  • ZINC05633393
  • MLS000773781
  • SMR000364725

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Onchocerca volvulus 0.0086 0.7281 0.7192
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0024 0.0317 0.0317
Onchocerca volvulus 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Loa Loa (eye worm) serine/threonine protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0086 0.7281 0.7192
Onchocerca volvulus 0.0086 0.7281 0.7192
Brugia malayi hypothetical protein 0.0043 0.2476 0.223
Echinococcus multilocularis signal transduction protein lnk realted 0.0086 0.7281 0.7192
Loa Loa (eye worm) RNA binding protein 0.0076 0.6186 0.6186
Onchocerca volvulus 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.011 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Plasmodium vivax tyrosine kinase-like protein, putative 0.0024 0.0317 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Brugia malayi TAR-binding protein 0.0076 0.6186 0.6062
Echinococcus granulosus expressed conserved protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0813 0.0813
Schistosoma mansoni suppressor of cytokine signaling 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/EGFR protein kinase 0.0024 0.0317 0.0317
Toxoplasma gondii protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0086 0.7281 0.7192
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6186 0.6062
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0317 0.0317
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0813 0.0512
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) hypothetical protein 0.0029 0.0813 0.0813
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0024 0.0317 0.0317
Schistosoma mansoni tensin-related 0.0086 0.7281 0.7192
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Brugia malayi Sex muscle abnormal protein 5 0.0086 0.7281 0.7192
Onchocerca volvulus 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.011 1 1
Schistosoma mansoni SH2A 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Schistosoma mansoni tyrosine kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0813 1
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0086 0.7281 0.7281
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0813 0.0512
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0813 1
Echinococcus multilocularis NCK adaptor protein 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis tyrosine kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0024 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Schistosoma mansoni tyrosine kinase 0.011 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0086 0.7281 0.7192
Echinococcus multilocularis tensin 0.0086 0.7281 0.7192
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Giardia lamblia Protein 21.1 0.0024 0.0317 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.011 1 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0024 0.0317 0.0317
Echinococcus granulosus suppressor of cytokine signaling 6 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein kinase Srms 0.011 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0086 0.7281 0.7281
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0813 0.0512
Schistosoma mansoni nck2/grb4 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0086 0.7281 0.7281
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis tyrosine protein kinase shark 0.011 1 1
Echinococcus granulosus NCK adaptor protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Plasmodium falciparum protein kinase, putative 0.0024 0.0317 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.011 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0086 0.7281 0.7192
Entamoeba histolytica hypothetical protein 0.0043 0.2476 0.223
Echinococcus granulosus tyrosine kinase 0.011 1 1
Brugia malayi RhoGAP domain containing protein 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis protein tyrosine kinase, putative 0.0024 0.0317 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Echinococcus multilocularis tyrosine protein kinase Fgr 0.011 1 1
Schistosoma mansoni tyrosine kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Plasmodium vivax protein kinase, putative 0.0024 0.0317 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TK family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Onchocerca volvulus 0.011 1 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0813 0.0512
Brugia malayi Protein kinase domain containing protein 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0024 0.0317 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0813 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.011 1 1
Loa Loa (eye worm) STAT protein 0.0086 0.7281 0.7281
Giardia lamblia Kinase 0.0024 0.0317 0.5
Echinococcus granulosus tyrosine protein kinase shark 0.011 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0813 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0086 0.7281 0.7192
Trichomonas vaginalis CAMK family protein kinase 0.0024 0.0317 0.5
Trypanosoma brucei Pseudokinase, putative 0.0024 0.0317 0.5
Onchocerca volvulus 0.0029 0.0813 0.0512
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0317 0.0317
Brugia malayi hypothetical protein 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.4357 0.4357
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0813 1
Brugia malayi Tensin 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0813 1
Brugia malayi Protein kinase domain containing protein 0.011 1 1
Schistosoma mansoni tyrosine kinase 0.011 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.011 1 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.011 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.011 1 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0813 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.011 1 1
Echinococcus multilocularis SH2 motif 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.011 1 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.6186 0.6186
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0024 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trypanosoma cruzi protein kinase, putative 0.0024 0.0317 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0813 1
Loa Loa (eye worm) TK/ALK protein kinase 0.0024 0.0317 0.0317
Toxoplasma gondii STE kinase 0.0024 0.0317 0.5
Toxoplasma gondii protein kinase domain-containing protein 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0086 0.7281 0.7192
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0024 0.0317 0.0317
Echinococcus multilocularis c src tyrosine kinase 0.011 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0086 0.7281 0.7281
Onchocerca volvulus 0.0086 0.7281 0.7192
Onchocerca volvulus 0.0086 0.7281 0.7192
Trypanosoma brucei Flagellum attachment zone protein 20 0.0024 0.0317 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0024 0.0317 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0024 0.0317 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6186 0.6062
Schistosoma mansoni growth factor receptor-bound protein 0.0086 0.7281 0.7192
Echinococcus granulosus tyrosine kinase 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0024 0.0317 0.0317
Echinococcus granulosus suppressor of cytokine signaling 7 0.0086 0.7281 0.7192
Schistosoma mansoni hypothetical protein 0.0041 0.2218 0.1964
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.4357 0.4357
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6186 0.6062
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Echinococcus granulosus SH2 motif 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/FAK protein kinase 0.0024 0.0317 0.0317
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Echinococcus multilocularis tar DNA binding protein 0.0076 0.6186 0.6062
Trichomonas vaginalis STE family protein kinase 0.0024 0.0317 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0086 0.7281 0.7192
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.6186 0.6062
Echinococcus granulosus c src tyrosine kinase 0.011 1 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0813 1
Loa Loa (eye worm) TK/CSK protein kinase 0.0024 0.0317 0.0317
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0086 0.7281 0.7192
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.2218 0.1964
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0086 0.7281 0.7192
Echinococcus multilocularis SH2 domain containing protein 7 0.0086 0.7281 0.7192
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0813 0.0512
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0086 0.7281 0.7192
Echinococcus multilocularis SH2 motif 0.0086 0.7281 0.7192
Onchocerca volvulus 0.011 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.4357 0.4172
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0024 0.0317 0.0317
Brugia malayi Variant SH3 domain containing protein 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0813 1
Trypanosoma brucei protein kinase, putative 0.0024 0.0317 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein kinase ABL1 0.011 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.011 1 1
Echinococcus granulosus SH2 motif 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Brugia malayi SH2 domain containing protein 0.011 1 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Echinococcus granulosus tyrosine protein kinase Src42A 0.0086 0.7281 0.7192
Brugia malayi STAT protein, DNA binding domain containing protein 0.0086 0.7281 0.7192
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.2476 0.223
Loa Loa (eye worm) SRC-1 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0086 0.7281 0.7281
Echinococcus granulosus SH2 domain containing protein 7 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus granulosus tar DNA binding protein 0.0076 0.6186 0.6062
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0086 0.7281 0.7192
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0086 0.7281 0.7192
Schistosoma mansoni signal transduction protein lnk-related 0.0086 0.7281 0.7192
Trichomonas vaginalis protein kinase atn1, putative 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Schistosoma mansoni hypothetical protein 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.2218 0.2218
Echinococcus granulosus growth factor receptor bound protein 2 0.0086 0.7281 0.7192
Giardia lamblia Kinase, NEK 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0024 0.0317 0.0317
Brugia malayi Variant SH3 domain containing protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/ROR protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Loa Loa (eye worm) TK protein kinase 0.011 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0086 0.7281 0.7192
Plasmodium falciparum tyrosine kinase-like protein 0.0024 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Echinococcus multilocularis growth factor receptor bound protein 2 0.0086 0.7281 0.7192
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0086 0.7281 0.7192
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0024 0.0317 0.5
Schistosoma mansoni shc transforming protein 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0086 0.7281 0.7192
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0317 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.2476 0.223
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Loa Loa (eye worm) TK/Met protein kinase 0.0024 0.0317 0.0317
Entamoeba histolytica SH2 domain containing protein 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 1 1
Entamoeba histolytica protein kinase, putative 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0086 0.7281 0.7192
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Brugia malayi Protein kinase domain containing protein 0.011 1 1
Schistosoma mansoni tensin-related 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/ACK protein kinase 0.0024 0.0317 0.0317
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0813 1
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Schistosoma mansoni GTPase activating protein 0.0086 0.7281 0.7192
Echinococcus granulosus SHC transforming protein 3 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0086 0.7281 0.7192
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.011 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.2476 0.223
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6186 0.6062
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.011 1 1
Schistosoma mansoni vav2 0.0086 0.7281 0.7192
Echinococcus granulosus tyrosine protein kinase Fyn 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0086 0.7281 0.7192
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.4357 0.4172
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0813 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Loa Loa (eye worm) SH2 domain-containing protein 0.0086 0.7281 0.7281
Echinococcus granulosus hypothetical protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.2476 0.223
Echinococcus granulosus tyrosine protein kinase Fyn 0.011 1 1
Schistosoma mansoni tensin 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Brugia malayi Variant SH3 domain containing protein 0.0086 0.7281 0.7192
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0813 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.011 1 1
Echinococcus multilocularis 0.0086 0.7281 0.7192
Echinococcus multilocularis N chimaerin 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.011 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.6186 0.6062
Brugia malayi Protein kinase domain containing protein 0.011 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0813 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Echinococcus granulosus N chimaerin 0.0086 0.7281 0.7192
Schistosoma mansoni tyrosine kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Brugia malayi protein-tyrosine kinase 0.011 1 1
Schistosoma mansoni tensin 0.0086 0.7281 0.7192
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0024 0.0317 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.6186 0.6186
Entamoeba histolytica hypothetical protein 0.0043 0.2476 0.223
Echinococcus granulosus tyrosine protein kinase Fps85D 0.011 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0086 0.7281 0.7192
Brugia malayi hypothetical protein 0.0086 0.7281 0.7192
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Echinococcus granulosus tyrosine protein kinase Blk 0.011 1 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0086 0.7281 0.7281
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0024 0.0317 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Plasmodium falciparum protein kinase, putative 0.0024 0.0317 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0024 0.0317 0.0317
Plasmodium vivax tyrosine kinase-like protein, putative 0.0024 0.0317 1
Onchocerca volvulus 0.011 1 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0024 0.0317 0.0317
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.2476 0.223
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Echinococcus granulosus tensin 0.0086 0.7281 0.7192
Trypanosoma cruzi protein kinase, putative 0.0024 0.0317 0.5
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.011 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0317 0.5
Brugia malayi Variant SH3 domain containing protein 0.0086 0.7281 0.7192
Brugia malayi SH2 domain containing protein 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.0086 0.7281 0.7281
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0813 0.0512
Echinococcus multilocularis tensin 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.0024 0.0317 0.0317
Brugia malayi SRC-1 0.011 1 1
Echinococcus multilocularis SH2 motif 0.0086 0.7281 0.7192
Brugia malayi RNA binding protein 0.0076 0.6186 0.6062
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0086 0.7281 0.7192
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0086 0.7281 0.7192
Plasmodium falciparum tyrosine kinase-like protein 0.0024 0.0317 1
Onchocerca volvulus 0.0086 0.7281 0.7192
Echinococcus granulosus signal transduction protein lnk realted 0.0086 0.7281 0.7192
Giardia lamblia Kinase, NEK 0.0024 0.0317 0.5
Echinococcus multilocularis SHC transforming protein 3 0.0086 0.7281 0.7192
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus granulosus SH2 domain containing adapter protein F 0.0086 0.7281 0.7192
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Echinococcus multilocularis tyrosine protein kinase Src42A 0.011 1 1
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0086 0.7281 0.7281
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Brugia malayi SH2 domain containing protein 0.011 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0086 0.7281 0.7192
Entamoeba histolytica SH2-protein kinase domain containing protein 0.011 1 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.011 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0813 0.5
Schistosoma mansoni tyrosine kinase 0.011 1 1
Loa Loa (eye worm) TK protein kinase 0.0024 0.0317 0.0317
Entamoeba histolytica hypothetical protein 0.0043 0.2476 0.223
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0317 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Onchocerca volvulus 0.011 1 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0086 0.7281 0.7192
Trichomonas vaginalis TKL family protein kinase 0.0024 0.0317 0.5
Schistosoma mansoni tensin 0.0086 0.7281 0.7192
Loa Loa (eye worm) TK/EPH protein kinase 0.0024 0.0317 0.0317
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.011 1 1
Schistosoma mansoni adapter molecule crk 0.0086 0.7281 0.7192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0813 0.0813
Plasmodium falciparum protein kinase, putative 0.0024 0.0317 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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