Detailed information for compound 1271842

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 443.804 | Formula: C19H17ClF3N3O4
  • H donors: 2 H acceptors: 4 LogP: 2.77 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)C(=O)C(NC(=O)c1ccc(c(c1Cl)C(F)(F)F)OCc1ccccn1)C
  • InChi: 1S/C19H17ClF3N3O4/c1-10(16(27)18(29)24-2)26-17(28)12-6-7-13(14(15(12)20)19(21,22)23)30-9-11-5-3-4-8-25-11/h3-8,10H,9H2,1-2H3,(H,24,29)(H,26,28)
  • InChiKey: IKTYGNJRDVXHJL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin V Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin V 334 aa 357 aa 29.7 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1318 0.4054
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0025 0.0413 0.1438
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0038 0.0083
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0413 0.0912
Echinococcus multilocularis neuropeptide receptor 0.001 0.0038 0.0035
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0038 0.0035
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.1318 0.2216
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Trypanosoma cruzi cruzipain precursor, putative 0.0113 0.2646 0.5467
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0686 0.1526
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0491 0.0488
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0113 0.2646 0.588
Brugia malayi neuropeptide F receptor 0.001 0.0038 0.0083
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0038 0.0035
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0038 0.0035
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0038 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.2646 0.2619
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0038 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0113 0.2646 0.588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0491 0.1086
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0113 0.2646 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0491 0.1086
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0413 0.0377
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2646 0.5467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0491 0.1091
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0116 0.0257
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0491 0.1091
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.0912
Brugia malayi cathepsin L-like precursor 0.0077 0.1741 0.387
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0116 0.0113
Brugia malayi nuclear receptor NHR-88 0.0028 0.0491 0.1091
Echinococcus granulosus neuropeptide receptor 0.001 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0686 0.067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0341
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0491 0.1091
Echinococcus multilocularis serotonin receptor 0.001 0.0038 0.0035
Schistosoma mansoni cathepsin F (C01 family) 0.0113 0.2646 0.2619
Loa Loa (eye worm) hypothetical protein 0.0077 0.1741 0.3866
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0686 0.152
Echinococcus granulosus g-protein coupled receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.0912
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) cysteine protease 0.0113 0.2646 0.588
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0038 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0116 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Plasmodium vivax vivapain-3 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0186 0.4499 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0038 0.0035
Echinococcus granulosus hypothetical protein 0.001 0.0038 0.0035
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0038 0.0035
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0038 0.0035
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0491 0.1091
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0341
Echinococcus granulosus cysteine protease 0.0061 0.1318 0.1316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0413 0.0917
Leishmania major cysteine peptidase A (CPA) 0.0113 0.2646 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Echinococcus granulosus neuropeptide s receptor 0.001 0.0038 0.0035
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0686 0.1526
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0491 0.1091
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0491 0.0488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0116 0.03
Brugia malayi Papain family cysteine protease containing protein 0.0113 0.2646 0.5883
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0038 0.0035
Brugia malayi Cathepsin L-like precursor 0.0113 0.2646 0.5883
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0038 0.0035
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.1108
Onchocerca volvulus Cathepsin F homolog 0.0113 0.2646 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0116 0.0257
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Trypanosoma cruzi cysteine proteinase, putative 0.0061 0.1318 0.2216
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0156 0.0119
Onchocerca volvulus 0.0113 0.2646 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0491 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0491 0.1091
Brugia malayi G-protein coupled receptor 0.001 0.0038 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0491 0.1091
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0038 0.0035
Brugia malayi Serotonin receptor 0.001 0.0038 0.0083
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2646 0.5467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0491 0.0488
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0116 0.0251
Brugia malayi hypothetical protein 0.0015 0.0156 0.0347
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0491 0.0455
Plasmodium falciparum cysteine proteinase falcipain 3 0.0113 0.2646 1
Echinococcus multilocularis cathepsin b 0.0186 0.4499 0.4497
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0491 0.1091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0038 0.0077
Echinococcus granulosus cathepsin L cysteine proteinase 0.0113 0.2646 0.2644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Onchocerca volvulus Cathepsin L homolog 0.0113 0.2646 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.114 0.3257
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Onchocerca volvulus 0.0025 0.0413 0.1438
Echinococcus multilocularis cysteine protease 0.0113 0.2646 0.2644
Echinococcus multilocularis g protein coupled receptor 0.001 0.0038 0.0035
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0491 0.1738
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.2646 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.2646 0.2644
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.0912
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.4499 0.4478
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0038 0.0083
Onchocerca volvulus 0.0113 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0038 0.0035
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0075 0.1676 0.2697
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0491 0.1091
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1318 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0113 0.2646 0.2644
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0025 0.0413 0.0377
Brugia malayi Cathepsin L-like precursor 0.0077 0.1741 0.387
Echinococcus multilocularis cpg binding protein 0.003 0.0539 0.0537
Onchocerca volvulus 0.0113 0.2646 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0116 0.0113
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0038 0.0035
Brugia malayi RE15519p 0.001 0.0038 0.0083
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0491 0.0455
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1318 0.1286
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0116 0.0113
Echinococcus multilocularis cathepsin b 0.0186 0.4499 0.4497
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0491 0.1738
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0038 0.0035
Entamoeba histolytica cysteine protease, putative 0.0113 0.2646 1
Giardia lamblia Cathepsin B precursor 0.0075 0.1676 1
Onchocerca volvulus 0.0028 0.0498 0.1766
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.1318 0.293
Brugia malayi larval opioid receptor 0.001 0.0038 0.0083
Echinococcus granulosus sex peptide receptor 0.001 0.0038 0.0035
Plasmodium falciparum cysteine proteinase falcipain 1 0.0061 0.1318 0.4054
Brugia malayi fibroinase precursor 0.0025 0.0413 0.0917
Echinococcus multilocularis cysteine protease 0.0113 0.2646 0.2644
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0156 0.0153
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0038 0.0035
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0038 0.0035
Onchocerca volvulus 0.0113 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0113 0.2646 1
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0116 0.0251
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Schistosoma mansoni cpg binding protein 0.003 0.0539 0.0504
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0038 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0038 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0491 0.1086
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0075 0.1676 0.1645
Plasmodium vivax vivapain-1 0.0061 0.1318 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0038 0.0035
Echinococcus multilocularis allatostatin A receptor 0.001 0.0038 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0491 0.0455
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0491 0.1086
Onchocerca volvulus Cathepsin L homolog 0.0113 0.2646 1
Giardia lamblia Cathepsin B precursor 0.0075 0.1676 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0025 0.0413 0.0912
Loa Loa (eye worm) ctsf protein 0.0113 0.2646 0.588
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0038 0.0035
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Echinococcus multilocularis orexin receptor type 2 0.001 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0491 0.0455
Brugia malayi conserved hypotetical protein 0.0013 0.0116 0.0257
Echinococcus multilocularis g protein coupled receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0116 0.0079
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0491 0.1091
Onchocerca volvulus 0.0077 0.1741 0.6529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0491 0.0488
Brugia malayi Cathepsin L-like precursor 0.0113 0.2646 0.5883
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0038 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.4499 0.4478
Onchocerca volvulus 0.0013 0.0116 0.03
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0038 0.0077
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0116 0.0113
Brugia malayi GnHR receptor homolog 0.001 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.1102
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0341
Echinococcus granulosus neuropeptide receptor 0.001 0.0038 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0413 0.0377
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0038 0.0035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0491 0.0488
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0038 0.0035
Leishmania major cathepsin L-like protease 0.0113 0.2646 1
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0491 0.0488
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0156 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Brugia malayi Cathepsin L-like cysteine proteinase 0.0077 0.1741 0.387
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0116 0.0113
Toxoplasma gondii cathepsin CPL 0.0113 0.2646 1
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0186 0.4499 0.4478
Brugia malayi nuclear receptor RXR 0.0013 0.0116 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.1741 0.5946
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2646 0.5467
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0038 0.0035
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0686 0.152
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0413 0.0917
Entamoeba histolytica cysteine proteinase, putative 0.0077 0.1741 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0038 0.0083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0491 0.0488
Echinococcus multilocularis g protein coupled receptor 0.001 0.0038 0.0035
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Schistosoma mansoni nuclear receptor 0.0013 0.0116 0.0079
Echinococcus multilocularis fmrfamide receptor 0.001 0.0038 0.0035
Brugia malayi Serotonin receptor 0.001 0.0038 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0156 0.0347
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0491 0.0455
Schistosoma mansoni zinc finger protein 0.0013 0.0116 0.0079
Brugia malayi neuropeptide F receptor 0.001 0.0038 0.0083
Brugia malayi Melatonin receptor type 1A 0.001 0.0038 0.0083
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Brugia malayi Cathepsin L-like precursor 0.0113 0.2646 0.5883
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0038 0.0077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0038 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0491 0.0455
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1318 0.1286
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0491 0.0455
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0491 0.0488
Echinococcus multilocularis dnaJ subfamily B 0.0402 1 1
Echinococcus granulosus g protein coupled receptor 0.001 0.0038 0.0035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0116 0.03
Schistosoma mansoni hypothetical protein 0.0402 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.0912
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0491 0.0488
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Schistosoma mansoni cathepsin s 0.0036 0.0686 0.0651
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0116 0.0113
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0491 0.0488
Entamoeba histolytica cysteine proteinase 2 0.0061 0.1318 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.2646 1
Loa Loa (eye worm) cathepsin B 0.0075 0.1676 0.3722
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0491 0.0455
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.2646 0.2644
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0491 0.1091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Plasmodium vivax vivapain-2 0.0113 0.2646 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0038 0.0077
Giardia lamblia Cathepsin B precursor 0.0075 0.1676 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0413 0.0917
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0116 0.0113
Brugia malayi ecdysteroid receptor 0.0028 0.0491 0.1091
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0413 0.0377
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0116 0.0257
Loa Loa (eye worm) hypothetical protein 0.0015 0.0156 0.0341
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Schistosoma mansoni cathepsin S (C01 family) 0.0025 0.0413 0.0377
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0116 0.0079
Brugia malayi nuclear hormone receptor 0.0028 0.0491 0.1091
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0075 0.1676 0.5658
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Brugia malayi Cathepsin L-like precursor 0.0113 0.2646 0.5883
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0113 0.2646 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0061 0.1318 0.1286
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0491 0.0488
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0491 0.1091
Echinococcus multilocularis cathepsin L 0.0025 0.0413 0.041
Brugia malayi nuclear receptor NHR-67 0.0013 0.0116 0.0257
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0491 0.0488
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0686 0.067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0491 0.1091
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0491 0.0488
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1303 0.127
Loa Loa (eye worm) hypothetical protein 0.0186 0.4499 1
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi Papain family cysteine protease containing protein 0.0061 0.1318 0.293
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0116 0.0251
Brugia malayi hypothetical protein 0.0015 0.0156 0.0347
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Onchocerca volvulus 0.0028 0.0491 0.1738
Echinococcus granulosus cathepsin b 0.0186 0.4499 0.4497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0077 0.1741 0.5946
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0025 0.0413 0.0377
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0061 0.1318 0.4054
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0038 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Schistosoma mansoni nuclear receptor 0.0013 0.0116 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.0912
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0186 0.4499 0.4478
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.2646 0.5467
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Entamoeba histolytica cysteine proteinase, putative 0.0061 0.1318 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Brugia malayi sulfakinin receptor protein 0.001 0.0038 0.0083
Echinococcus granulosus fmrfamide receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) DR-78 0.0013 0.0116 0.0251
Brugia malayi Dopamine receptor protein 2 0.001 0.0038 0.0083
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0491 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Echinococcus granulosus cathepsin l cysteine peptidase 0.0113 0.2646 0.2644
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0038 0.0035
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0491 0.0488
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0491 0.0455
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0038 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Brugia malayi Cathepsin L-like precursor 0.0077 0.1741 0.387
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0413 0.0377
Echinococcus multilocularis somatostatin receptor 0.001 0.0038 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0491 0.1738
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi cathepsin Z-like cysteine proteinase 0.0025 0.0413 0.0917
Schistosoma mansoni coup transcription factor 0.0028 0.0491 0.0455
Plasmodium vivax unspecified product 0.0036 0.0686 0.1225
Brugia malayi Dopamine receptor 0.001 0.0038 0.0083
Schistosoma mansoni cathepsin F (C01 family) 0.0077 0.1741 0.171
Echinococcus multilocularis cathepsin L 0.0061 0.1318 0.1316
Brugia malayi Cathepsin L-like precursor 0.0113 0.2646 0.5883
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi cathepsin L precursor 0.0025 0.0413 0.0917
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0686 0.152
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0491 0.0488
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Brugia malayi ecdysone receptor 0.0013 0.0116 0.0257
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0113 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi cathepsin F-like cysteine proteinase 0.0025 0.0413 0.0917
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0038 0.0035
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0077 0.1741 0.325
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0025 0.0413 0.0912
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0491 0.0488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Plasmodium vivax vivapain-2 0.0113 0.2646 1
Onchocerca volvulus 0.0113 0.2646 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0156 0.0341
Echinococcus multilocularis fmrfamide receptor 0.001 0.0038 0.0035
Brugia malayi Cathepsin L-like precursor 0.0113 0.2646 0.5883
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0038 0.0035
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0186 0.4499 1
Brugia malayi ORL1-like opioid receptor 0.001 0.0038 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0491 0.1091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0491 0.1086
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0025 0.0413 0.0377
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0038 0.0077
Echinococcus multilocularis sex peptide receptor 0.001 0.0038 0.0035
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0116 0.0257
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0116 0.0257
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0061 0.1318 0.2216
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0077 0.1741 0.3866
Brugia malayi cathepsin L-like cysteine proteinase 0.0025 0.0413 0.0917
Echinococcus granulosus g protein coupled receptor 0.001 0.0038 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Plasmodium vivax unspecified product 0.0061 0.1318 0.4054
Toxoplasma gondii cathepsin B 0.0075 0.1676 0.5658
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0413 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus granulosus serotonin receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0113 0.2646 0.588
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0038 0.0035
Schistosoma mansoni cpg binding protein 0.003 0.0539 0.0504
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Echinococcus granulosus allatostatin A receptor 0.001 0.0038 0.0035
Echinococcus multilocularis serotonin receptor 0.001 0.0038 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0156 0.0119
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0116 0.0113
Echinococcus granulosus orexin receptor type 2 0.001 0.0038 0.0035
Onchocerca volvulus 0.0113 0.2646 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0491 0.1086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0025 0.0413 0.0912
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0038 0.0035
Brugia malayi nuclear receptor NHR-88 0.0013 0.0116 0.0257
Brugia malayi nuclear receptor RXR 0.0015 0.0156 0.0347
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Echinococcus granulosus somatostatin receptor 0.001 0.0038 0.0035
Brugia malayi Cathepsin L-like precursor 0.0036 0.0686 0.1526
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0491 0.1086
Echinococcus granulosus g protein coupled receptor 0.001 0.0038 0.0035
Brugia malayi nuclear hormone receptor 0.0013 0.0116 0.0257
Onchocerca volvulus 0.0013 0.0116 0.03
Schistosoma mansoni cathepsin C 0.0025 0.0413 0.0377
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0038 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0038 0.0077
Trypanosoma cruzi cysteine protease, putative 0.0061 0.1318 0.2216
Brugia malayi steroid hormone receptor 0.0028 0.0491 0.1091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0116 0.0113
Onchocerca volvulus 0.0113 0.2646 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0038 0.0035
Brugia malayi hypothetical protein 0.001 0.0038 0.0083
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Brugia malayi hypothetical protein 0.0013 0.0116 0.0257
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Brugia malayi tailless protein 0.0013 0.0116 0.0257
Brugia malayi G-protein coupled receptor 0.001 0.0038 0.0083
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0038 0.0077
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0038 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0038 0.0035
Echinococcus multilocularis cathepsin L cysteine protease 0.0113 0.2646 0.2644
Echinococcus multilocularis neuropeptide receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0491 0.1086
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0116 0.0079
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0038 0.0035
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.0463
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0491 0.0455
Schistosoma mansoni cathepsin B (C01 family) 0.0025 0.0413 0.0377
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0156 0.0347
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0491 0.0455
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0413 0.0377
Echinococcus granulosus cathepsin l1 0.0113 0.2646 0.2644
Brugia malayi AKH receptor 0.001 0.0038 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0025 0.0413 0.0377
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0077 0.1741 0.3866
Entamoeba histolytica cysteine proteinase 1, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0491 0.1086
Echinococcus granulosus cathepsin L 0.0061 0.1318 0.1316
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0038 0.0035
Brugia malayi follicle stimulating hormone receptor 0.001 0.0038 0.0083
Brugia malayi Dopamine receptor protein 1 0.001 0.0038 0.0083
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus granulosus cpg binding protein 0.003 0.0539 0.0537
Brugia malayi putative neuropeptide receptor 0.001 0.0038 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0491 0.0488
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0025 0.0413 0.0917
Entamoeba histolytica cysteine protease, putative 0.0061 0.1318 0.4054
Loa Loa (eye worm) hypothetical protein 0.0036 0.0686 0.152
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Trypanosoma cruzi cysteine peptidase, putative 0.0061 0.1318 0.2216
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0077
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0038 0.0035
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0038 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0116 0.0079
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0116 0.0257
Loa Loa (eye worm) hypothetical protein 0.0013 0.0116 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0113 0.2646 1
Brugia malayi G protein-coupled receptor 0.001 0.0038 0.0083
Echinococcus granulosus cathepsin L cysteine protease 0.0061 0.1318 0.1316
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0038 0.0083
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0038 0.0035
Brugia malayi hypothetical protein 0.0013 0.0116 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0113 0.2646 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0116 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0491 0.1091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0038 0.0035
Echinococcus granulosus cathepsin b 0.0186 0.4499 0.4497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0113 0.2646 1
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0491 0.0455
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0075 0.1676 0.3093
Echinococcus granulosus cathepsin L 0.0025 0.0413 0.041
Loa Loa (eye worm) fibroinase 0.0113 0.2646 0.588
Echinococcus granulosus cathepsin l1 0.0077 0.1741 0.1738

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 19.5 nM Inhibition of human cathepsin S by fluorescence assay ChEMBL. 21030256
IC50 (binding) = 46.8 nM Inhibition of human cathepsin K by fluorescence assay ChEMBL. 21030256
IC50 (binding) = 1122 nM Inhibition of human cathepsin V by fluorescence assay ChEMBL. 21030256
IC50 (binding) > 10000 nM Inhibition of human cathepsin B by fluorescence assay ChEMBL. 21030256
IC50 (binding) > 10000 nM Inhibition of human cathepsin L by fluorescence assay ChEMBL. 21030256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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